JOURNAL OF ALLOYS AND COMPOUNDS
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2025
·
IF 6.3
Wenlu Pan,Qun Zeng,Kai Li,Wei Lü
Tuning the luminescence properties of efficient near-infrared (NIR) phosphors is critical to expanding their applications in NIR spectroscopy. In this paper, a series of novel Cr 3+ -doped LaZnAl 11 O 19 (LZAO: Cr 3+ ) phosphors are synthesized via a high-temperature solid-phase method. These phosphors exhibit NIR emission in the range of 650–900 nm, with the LZAO: 0.10Cr 3+ achieves an excellent internal quantum efficiency (IQE) of 89.9 %. Notably, it demonstrates excellent thermal stability, maintaining 97.2 % of the initial photoluminescence intensity at 513 K. Through co-doping with Nd 3+ , the NIR emission broadens across the 650–1100 nm range, and leads to a substantial enhancement in Nd 3+ emission intensity due to efficient Cr 3+ →Nd 3+ energy transfer. Remarkably, the optimum LZAO: Cr 3+ , Nd 3+ phosphor exhibits a high IQE (82 %) and an outstanding anti-thermal quenching behavior (118.0 % @ 513 K), with the underlying mechanism of its thermal stability further elucidated through defect level model. In addition, the synthesized phosphors show great promise for multifunctional applications in NIR phosphor-converted light emitting diodes, plant growth lighting, non-destructive testing, luminescence thermometry and solar cells.
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高影响因子
Small
·
2020
·Vol. 16
·期 25
·2001518
·
IF 11.459
Chen Yang,Muhammad Rizwan Younis,Jing Zhang,Junle Qu,Jing Lin,Peng Huang
Chemodynamic therapy (CDT) has attracted considerable attention recently, but the poor reaction kinetics restrict its practical utility in clinic. Herein, glucose oxidase (GOx) functionalized ancient pigment nanosheets (SrCuSi 4 O 10 , SC) for programmable near-infrared II (NIR-II) photothermal-enhanced starvation primed CDT is developed. The SC nanosheets (SC NSs) are readily exfoliated from SC bulk suspension in water and subsequently functionalized with GOx to form the nanocatalyst (denoted as SC@G NSs). Upon laser irradiation, the photothermal effect of SC NSs can enhance the catalytic activity of GOx for NIR-II photothermal-enhanced starvation therapy, which effectively eliminates intratumoral glucose and produces abundant hydrogen peroxide (H 2 O 2 ). Importantly, the high photothermal-conversion efficiency (46.3%) of SC@G NSs in second biological window permits photothermal therapy of deep-seated tumors under the guidance of NIR-II photoacoustic imaging. Moreover, the acidity amplification due to gluconic acid generation will in turn accelerate the degradation of SC NSs, facilitating the release of strontium (Sr) and copper (Cu) ions. Both the elevated H 2 O 2 and the released ions will prime the Cu 2+ /Sr 2+ -H 2 O 2 reaction for enhanced CDT. Thus, a programmable NIR-II photothermal-enhanced starvation primed CDT is established to combat cancer with minimal side effects.
研究领域:
生物医学工程
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肿瘤学
·
纳米医学
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PubMed
高影响因子
Journal of Materials Chemistry C
·
2021
·Vol. 9
·期 16
·5469-5477
·
IF 7.393
Hao Cai,Shengqiang Liu,Zhen Song,Quanlin Liu
The practical application of near-infrared (NIR) phosphors is hindered due to their limited light emitting region and narrow bandwidth. Here, we report a series of Cr3+-doped olivine phosphors, (Mg1−xLix)(Mg1−xScx)GeO4:Cr3+, with tunable luminescence from NIR-I to NIR II based on crystallographic site engineering. By using a [Li+–Sc3+] unit substituting for a [Mg2+–Mg2+] unit, the NIR luminescence can be largely tuned from 940 nm to 1110 nm, and the corresponding FWHM can be modified from 236 to ∼300 nm. The internal quantum efficiency (IQE) and external quantum efficiency (EQE) of Mg2GeO4:1% Cr3+ were measured to be 48.19% and 16.38%, respectively. The photoluminescence of the phosphors matches well with the absorption of several functional groups. By measuring the NIR absorption of different liquids illuminated by NIR light from our phosphors, qualitative and quantitative analysis can be realized. These results suggest that the super-broad NIR luminescence of (Mg1−xLix)(Mg1−xScx)GeO4:Cr3+ has potential applications as light sources for nondestructive food analysis.
研究领域:
材料科学
·
光学
·
分析化学
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高影响因子
CERAMICS INTERNATIONAL
·
2024
·
IF 5.1
Fan Xiao,Chen-xiao Huang,Jun-hao Dai,Jun-hui Ye,Kang-jie Cheng,Xu Xu,Li-quan Deng,Jia You,Wei Wang,Wan-bing Jin
Titanium implants, widely used in orthopedic and dental applications, often face challenges due to inadequate osseointegration and the risk of postoperative infections , which can potentially lead to implant failure. To address this issue, we developed a titanium implant with an in-situ fabricated anatase TiO 2 metasurface , characterized by a subwavelength thickness and a preferential orientation of the (001) facets. This metasurface, which consists of uniformly distributed nano-crystallites of approximately 30 nm in size, aims to enhance both osseointegration and antibacterial properties. The addition of isopropanol (IPA) to the precursor solution used in the fabrication process played a crucial role in controlling the grain size and coating thickness of the metasurface. This process led to a redshift of the light absorption peak into the near-infrared (NIR)-II region, thereby increasing the penetration depth of photothermal therapy . The implants with TiO 2 metasurface exhibited increased hydrophilicity, rapid apatite formation in simulated body fluid, and an effective photothermal response under NIR-II light, showing significant antibacterial activity against E. coli and S. aureus . In vivo experiments in rabbits indicated superior bone regeneration and osseointegration around the implants with TiO 2 metasurface compared to the control titanium implants. At 4 weeks postoperatively, the bone volume to tissue volume (BV/TV) ratio within the implant was 53.94 %, and by 8 weeks, the implants were nearly entirely filled with new bone, with a BV/TV ratio of approximately 70 %. The findings suggest that the TiO 2 metasurface, which combines antibacterial and bioactive features, has the potential to reduce the risk of postoperative infections and improve clinical outcomes.
研究领域:
生物医学工程
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材料科学
·
医学
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高影响因子
Science China-Chemistry
·
2024
·
IF 10.4
Li Jiangao,Niu Niu,Wang Deliang,Liu Xue,Qin Yi,Wang Lei,Tang Ben Zhong,Wang Dong
Exploration of single molecular species synchronously featured by long excitation/emission wavelength, accurate diagnosis, and effective therapy, remains supremely appealing to implement high-performance cancer phototheranostics. However, those previously established phototheranostic agents are undiversified and stereotyped in terms of structural skeleton, and generally exhibit insufficient phototheranostic outcomes. Herein, we innovatively utilized indanone-condensed thiadiazolo[3,4-g]quinoxaline (ITQ) as electron acceptor to construct novel photosensitizer with second near-infrared (NIR-II) emission. Experimental study and theoretical calculation demonstrated that comparing with the counterparts constituting by widely employed NIR-II building block benzobisthiadiazole (BBTD) and 6,7-diphenylthiadiazoloquinoxaline (DPTQ), ITQ-based photosensitizer (TITQ) showed superior aggregation-induced emission (AIE) characteristics, much stronger type-I reactive oxygen species (ROS) production, and prominent photothermal conversion capacity. Furthermore, TITQ nanoparticles with excellent biocompatibility were capable of effectively accumulating in the tumor site and visualizing tumor through fluorescence-photoacoustic-photothermal trimodal imaging with highly spatiotemporal resolution, and completely eliminating tumor by type-I photodynamic-photothermal therapy.
研究领域:
癌症研究
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光疗
·
纳米医学
·
生物医学工程
·
分子成像
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高影响因子
Advanced Healthcare Materials
·
2022
·Vol. 11
·期 23
·2202126
·
IF 11.092
Hanhan Xie,Shengyong Geng,Jundong Shao,Guanghong Luo,Qian Liu,Jiahong Wang,Yue Chen,Paul K. Chu,Zhibin Li,Xue-Feng Yu
As a prominent class of 2D transition metal dichalcogenides (TMDCs), niobium diselenide nanosheets (NbSe 2 NSs) have garnered tremendous interest on account of promising applications pertaining to optoelectronics and energy storage. Although NbSe 2 NSs have many unique advantages such as inherent biocompatibility and broad absorption in the NIR region, their biomedical applications have rarely been reported, especially as therapeutic agents for the second near-infrared (NIR-II) range. Herein, a biodegradable nanotherapeutic platform consisting of NbSe 2 NSs is designed and demonstrated for NIR-II light-triggered photothermal therapy. NbSe 2 NSs synthesized by grinding and liquid exfoliation exhibit superior photothermal conversion efficiency (48.3%) and remarkable photothermal stability in the NIR-II region. In vitro assessment demonstrates that NbSe 2 NSs have favorable photothermal cell ablation efficiency and biocompatibility. After intravenous injection in vivo, the NbSe 2 NSs accumulate passively in tumor sites to facilitate fluorescence imaging and tumor ablation by NIR-II illumination. Furthermore, as a result of gradual degradation in the physiological environment, NbSe 2 NSs can be excreted from the body to avoid potential toxicity caused by long-term retention in vivo. The results reveal a promising NIR-II light-triggered PTT strategy with the aid of NbSe 2 NSs and the platform is expected to have large potential in cancer theranostics.
研究领域:
材料科学
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纳米技术
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生物医学工程
·
癌症研究
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PubMed
高影响因子
MATERIALS & DESIGN
·
2026
·
IF 8.2
Ajing Wu,Wenxuan Wang,Rui Liu,Huifang Hao,Xiaochun Zheng,Mingxin Zhao,Haonan Chen,Yanchun Ma,Weiwei Kang,Ziliang Zheng
A synergistic nanoprobe enables precise, safe, non-radiative skeletal imaging. • Multi-targeting enables precise enrichment throughout the skeleton. • AA@TFN provides a versatile platform for bone disease diagnosis and monitoring. Early diagnosis of bone-related diseases remains a critical clinical challenge, attributable to persistent limitations in imaging accuracy and safety. While near-infrared Region II fluorescence (NIR-II FL) imaging confers substantial advantages for deep-tissue visualization, its clinical translation is hampered by the inadequate targeting specificity of conventional contrast agents. Here, we developed Au-Ag@Apo-Tf/-N 3 (AA@TFN), a synergistic targeting gold–silver nanocluster probe engineered with glutathione and azide functionalities, which achieved bone-specific enrichment via a hierarchical multi-targeting mechanism. AA@TFN first anchored to hydroxyapatite in the bone matrix through glutathione carboxyl-mediated chelation, then targeted transferrin receptors highly expressed in bone marrow, and finally endured macrophage-mediated uptake facilitated by azide-enhanced bone affinity. A synergistic targeting strategy enabled real-time, high-resolution NIR-II FL imaging across the complete skeleton, with enhanced probe enrichment at lesion sites driven by microenvironmental changes. AA@TFN enabled visualization of synovial inflammation in rheumatoid arthritis models and millimeter‑scale microlesions in multiple myeloma models. Furthermore, the probe exhibited excellent biocompatibility and favorable safety profiles, underscoring its strong translational potential. A versatile platform was established for the diagnosis of bone diseases and non-invasive monitoring of therapeutic efficacy. Download: Download high-res image (129KB) Download: Download full-size image
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高影响因子
ADVANCED FUNCTIONAL MATERIALS
·
2026
·
IF 19
Yize Wu,Yang He,Tao Liang,Zheng Wang,Ying Yuan,Weixing Wang,Zhewen Sun,Ziyi Jiang,Ting Rao,Chao Jian,Zhen Li,Zhihong Liu,Aixi Yu
Fat embolism syndrome (FES) is a serious complication following bone fracture, primarily resulting from the release of fat microparticles into circulation. Its diagnosis remains challenging due to the absence of specific imaging techniques and laboratory tests. Near-infrared II (NIR-II, 1000–1700 nm) fluorescence imaging (FI) has gained significant attention owing to its high tissue penetration and low background signal. While FI has been widely employed in basic research and clinical practice, its application in FES has not been explored. In this study, a NIR-II organic fluorescent small molecule, FD-1080-C6, which exhibits fat affinity and viscosity responsiveness, is designed to enable FES diagnosis, for the first time. In the high-viscosity microenvironment of FES, the lipophilic molecule FD-1080-C6, which possesses a donor–acceptor–donor (D–A–D) structure, undergoes restricted single-bond rotation, promoting the formation of a rigid planar conformation and resulting in enhanced fluorescence intensity. In vitro evaluation confirms its responsiveness to lipid droplets, affinity for adipose tissue, and viscosity-dependent fluorescence changes. Furthermore, its specificity for NIR-II FI of FES is validated in the mouse. Additionally, FD-1080-C6 exhibits stable photothermal properties. FD-1080-C6 enables early diagnosis and longitudinal monitoring of disease progression in FES mice, offering a promising strategy for the management of FES.
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Journal of Materiomics
·
2026
·
IF 10.6
Gaochao Liu,Shuai Zhang,Yuzhen Wang,Zhiguo Xia
Near-infrared-II (NIR-II) photons hold great potential in assisting non-invasive imaging and optical signal sensing. However, the integration of broadband NIR-II light sources with photodetectors to improve the imaging sensitivity and spatial resolution is highly demanded. Herein, we have developed MgO-Li 2 SrGeO 4 :Cr 4+ composite ceramics, which demonstrate a broad NIR-II emission band centered at 1160 nm originating from spin-allowed 3 T 2 → 3 A 2 ( 3 F) transition of Cr 4+ . The incorporated nano-MgO particles serve as light-guiding channels while filling the pores and prevents the reduction of Cr 4+ , enhancing the external quantum efficiency and thermal conductivity of the composite ceramics to 53% and 17.8 W·m –1 ·K –1 , respectively. The dynamic wafer-scale luminescent ceramic wheel delivers a record broadband NIR-II emission output power of 1.9 W under 20 W·mm -2 red laser excitation, which facilitates imaging sensing of commercial PbS photodetectors by enhancing their photocurrents and signal-to-noise ratios. These results establish the feasibility of high-power broadband NIR-II light sources integrated with photodetectors, and further demonstrate the combination of intelligent algorithms toward high-resolution optical imaging.
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Laser & Photonics Reviews
·
2026
·
IF 9.7
Xuan You,Xiaolong Liu,Wei Liu,Peijin Zhang,Yuhuang Zhang,Yalun Wang,Jianguo Wang,Jun Qian
Temporal compressive imaging enables the reconstruction of multi-frame dynamic scenes from a single exposure by multiplexing spatially encoded temporal slices. This approach mitigates integration time loss and facilitates high-speed imaging via low-frame-rate cameras. Herein, a second near-infrared (NIR-II) temporal compressive wide-field microscope (TCWM) is established, utilizing the EfficientSCI algorithm for frame reconstruction. Simulations initially verify the transferability of EfficientSCI to biological microscopic imaging. Furthermore, mask acquisition with a spectrally matched NIR backlight proves effective for the high-fidelity reconstruction of fluorescent targets. Utilizing a conventional NIR camera of 25 frames per second (FPS), NIR-II TCWM achieves a maximum in vitro reconstruction rate of 333.3 FPS, surpassing the native frame rate by over 13-fold. Additionally, its robust anti-scattering capability for dynamic imaging at significant depths is substantiated using Intralipid. Finally, NIR-II TCWM is applied to in vivo cerebrovascular imaging at depths up to 300 µm. With a 100 FPS reconstruction frame rate, NIR-II TCWM successfully demonstrates simultaneous, high-speed tracking of multiple fluorescent particles across multiple vessels, highlighting the potential for comprehensive deep-tissue hemodynamic research in living organisms.
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高影响因子
Nature Communications
·
2026
·
IF 18.1
Yang Lijuan,Li Man,Peng Yisheng,Zhou Yu,Zou Junjie,Liu Huanhuan,Zhang Wenxiang,Liu Jie,He Peng,Dai Fan,Zheng Jingwen,Lin Jing,Qu Songnan,Lu Zhixiang,Liu Gang
Near-infrared-II carbon dots offer exceptional deep-tissue penetration for biomedical imaging, but challenges remain in their synthesis and photoluminescence mechanisms. Here, we report three carbon dots (CDs-1, CDs-2, CDs-3) with tunable emission from the visible to the Near-infrared-II (480–1265 nm), synthesized by constructing extended aniline-based frameworks from p -phenylenediamine. Combined structural and density functional theory analyses reveal that the Near-infrared-II redshift arises from the enhanced molecular dipole moments and electron-acceptor ability of the precursor, as well as the accumulation of graphene domains and pyrrolic nitrogen doping during carbonization polymerization, which collectively drive the narrowing of the energy gap. CDs-3 shows 15 mm penetration depth in gallbladder Near-infrared-II imaging (vs. clinically used indocyanine green 2 mm). With 1.44 signal-to-noise ratio and 334.5 μm resolution, it enables precise monitoring of biliary strictures/leakage. Selenium-doping-derived functionalized composite nanomaterials (CDs-3@pPB) exhibit potent reactive oxygen species scavenging and theranostic efficacy in liver fibrosis. This work elucidates the mechanism underlying the redshift of carbon dots emission into the Near-infrared-II and establishes a nanoplatform for hepatobiliary theranostics, demonstrating substantial clinical potential.
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高影响因子
Materials Today Bio
·
2026
·
IF 11
Na Zhou,Wenjing Wang,Lian Xu,Aining Zhang,Xiaohuan Lu,Yu-Pei Chen,Shiwen Fan,Tianhao Zhang,Changjiang Yu,Xiao-Qiang Wang,Daan Fu
Photothermal therapy (PTT) is widely recognized for the treatment of infected wounds. However, the wound hyperpathia caused by infection and heat from PTT is often overlooked, which might affect wound healing significantly. In this study, we systematically investigate the management of pain in bacteria-infected wounds using PTT, and develop a photothermal antibacterial hydrogel capable of sustained and controlled analgesia system (STB-Lid Gel), aiming to simultaneously achieve efficient anti-infection and precise pain management. STB-Lid Gel is constructed from a silk fibroin (SF) hydrogel matrix co-loaded with lidocaine (Lid) as an analgesic and supramolecular stable radicals (TPT-B 12 ) as a novel second near-infrared-window (NIR-II) photothermal agent. During the treatment phase, the sustained release of Lid stored in STB-Lid Gel extends localized analgesic effects beyond 30 h. Under NIR-II laser irradiation, STB-Lid Gel mediates PTT for bacterial eradicating and enhancement of Lid release. These dual effects of anti-infection and pain management, effectively eradicates bacteria, alleviates PTT-induced acute pain, reduces local inflammation, and ultimately accelerates wound healing. This innovative approach highlights the importance of pain relief from PTT-associated acute pain in healing processes, presenting a viable strategy for combining antibacterial and analgesic treatment in infected wounds.
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