CHEMICAL ENGINEERING SCIENCE
·
2024
·
IF 4.1
Qi Li,Senlin Deng,Junyang Liu,Tingting Yan,Jinguo Hao,Gang Wang,Guoliang Zhang,Jie Li,Chunshan Li
The dispersion of active sites plays an imperative role in the promotion of catalytic performance on methyl acrylate synthesis via direct vaporous aldol condensation. Herein, a novel PEG-assisted impregnation method was proposed to synthesize Cs/Zr-SiO 2 catalyst with high dispersion of acid and base sites. A series of characterization techniques including NMR, TEM, physical N 2 adsorption isotherms, XRD, XPS, NH 3 -/CO 2 -TPD, and Py-IR were used to investigate the physico-chemical properties of these prepared catalyst series. The introduction of PEG improved the specific surface area, dispersion of active sites, and density of acid and base sites, resulting in superior catalytic performance of Cs/PEG@Zr-SiO 2 by comparison with that of Cs/SiO 2 and Cs/Zr-SiO 2 . The kinetic experiments revealed that the activation energy of aldol condensation was 80.8 kJ/mol over the Cs/PEG@Zr-SiO 2 catalyst. The deactivation behavior derived from carbon deposition was discovered, and the spent catalyst could be regenerated by simple thermal treatment.
研究领域:
催化化学
·
材料科学
✓ 已验证
产品关联
DOI
高影响因子
POLYMER COMPOSITES
·
2023
·
IF 5.2
Yao Peng,Yao Wang,Yingdi Dan,Zengkun Li,Quankai Sun,Yanxin Wang,Wei Wang,Zhonglin Du,Linjun Huang,Matt J. Kipper,Laurence A. Belfiore,Jianguo Tang
In this work, innovative hybrid poly(ethylene terephthalate) (PET) materials with strong luminescence were successfully synthesized by doping PET with silicon-linked poly(ethylene glycol)-PET copolymer nanostructures either with (Si-PEG-PET) or with (ETP@Si-PEG-PET) luminescent Eu 3+ -complexes. The chemical properties and nanostructures of the hybrid materials were characterized by Fourier-transform infrared spectroscopy, nuclear magnetic resonance spectroscopy, x-ray photoelectron spectroscopy, and high-resolution transmission electron microscopy. PET composites ranging from 0.25 to 4 wt% silicon additive were prepared by the melt blending method. The crystal properties, mechanical properties, and fluorescence properties of the composites were systematically studied by differential scanning calorimetry, x-ray diffractometry, tensile testing, and fluorescence spectrometry. When the addition of Si-PEG-PET or ETP@Si-PEG-PET was 0.75 wt%, the relative crystallinity and maximum tensile strength increase substantially. Moreover, the fluorescence intensity of hybrid luminescent PET materials is the strongest at 0.75 wt% loading. ETP@Si-PEG-PET not only endows PET polyester with stronger fluorescence properties and mechanical properties but also acts as an effective nucleation additive for PET. Highlights Silicon-linked poly(ethylene glycol)-poly(ethylene terephthalate) (PEG-PET) nanostructures generate hybrid luminescent PET materials. ETP@Si-PEG-PET improves the crystallization rate and crystallinity of PET. The composite with 0.75% addition showed the best fluorescence performance. Three-dimensional-grid structure of ETP@Si-PEG-PET enhances the mechanical property of PET.
研究领域:
材料科学
·
高分子化学
·
纳米技术
✓ 已验证
产品关联
DOI
高影响因子
RSC Advances
·
2016
·Vol. 6
·期 34
·28331-28342
·
IF 3.289
Lu Wang,Xi Xie,Di Liu,Xiao-Bin Fang,Peng Li,Jian-Bo Wan,Cheng-Wei He,Mei-Wan Chen
Reduction-sensitive micelles with crosslinked cores were developed to load the lipophilic chemotherapeutic drug docetaxel (DTX) in order to overcome the issues of toxicity, water insolubility, and rapid metabolism of DTX. These DTX-loaded micelles (MM(DTX/Crosslink)) provide efficient incorporation and sustained release of DTX. Using independently synthesized LA–PLGA–TPGS and DSPE–PEG polymers as vehicles, MM(DTX/Crosslink) was found to be reduction-responsive, and possessed desirable drug entrapment efficiency (84.17 ± 1.15%) and drug loading efficiency (6.21 ± 0.07%). The MM(DTX/Crosslink) quickly dissociated under reduction conditions that mimicked the reductive intracellular environment, suggesting that it can rapidly release the encapsulated DTX in vitro. Furthermore, to target MM(DTX/Crosslink) to tumors for cancer therapy, iRGD was conjugated to the surface of MM(DTX/Crosslink). The iRGD-MM(DTX/Crosslink) micelles significantly increased the cellular uptake of DTX and inhibited cell proliferation, compared to the micelles without iRGD modification. Moreover, the iRGD-MM(DTX/Crosslink) micelles presented enhanced antitumor effects based on the analyses of apoptosis and cell cycle arrest. The micelles developed in this work may constitute a stable, efficient, and powerful system to deliver DTX into cancer cells.
研究领域:
药剂学
·
肿瘤学
·
生物材料学
✓ 已验证
产品关联
DOI
高影响因子
ACS Applied Nano Materials
·
2025
·
IF 5.5
Meng Tao,Wei Guo,Jixiang Zhang,Cui Liu,Nian Li,Min Xi,Shudong Zhang,Zhenyang Wang
Composite fabrics with integrated photothermal conversion, heat collection, and antibacterial properties are urgently needed to enhance personal thermal management in northern cold regions. Herein, a designed sandwich-like structure, in which PEG@SiO2 microcapsules were intercalated into the MXene interlayers (PEG@SiO2/MXene), was proposed to achieve the fast solar-thermal conversion and the surplus solar-generated heat storage and release and even further corresponding fabrics with antibacterial properties for the personal thermal management. Remarkably, the prepared PEG@SiO2/MXene (PSM) exhibited fast solar-to-heat conversion, followed-on heat storage ability, with an average temperature rising rate of 8.1 °C/min under one-sunlight irradiation and a phase change enthalpy of 155.7 J/g. Furthermore, under one-sunlight irradiation, the designed antibacterial composite fabrics with PSM coatings could greatly increase the local working temperature from 1 °C to 27.3 °C compared with the reference traditional cotton fabrics (from only 1 °C to 6.5 °C). This work provides a potential multifunctional composite material/fabric for the development of personal thermal management in outdoor sunlight applications.
研究领域:
材料科学
·
纺织工程
·
能源技术
·
生物医学工程
✓ 已验证
产品关联
DOI
高影响因子
Biomedical Materials
·
2021
·Vol. 16
·期 3
·035006
·
IF 3.715
Yuecheng Cui,Ronghua Jin,Yang Zhou,Meirong Yu,Yun Ling,Li-Qun Wang
Temperature-sensitive hydrogels with mild gel-forming process, good biocompatibility and biodegradability have been widely studied as bioinks and biomaterial inks for 3D bioprinting. However, the hydrogels synthesized via copolymerization of aliphatic polyesters and polyethylene glycols have low mechanical strength and cannot meet the needs of 3D printing. In this paper, we propose a strategy of enhancing the strength of hydrogels by introducing crystallization between blocks to meet the requirements of 3D bioprinting inks. A series of polycaprolactone-polyethylene glycol-polycaprolactone (PCL-PEG-PCL) triblock polymers were prepared by ring-opening polymerization, of which the strong crystallinity of polycaprolactone blocks improved the printability and enhanced the mechanical properties of the ink. It was found that the resulted hydrogels were temperature-responsive, and the PCL blocks could form a crystalline phase in the state of the hydrogel, thereby significantly increasing the modulus of the hydrogel. Moreover, the mechanical strength of the hydrogel could be adjusted by changing the composition ratio of each block of the copolymer. The 3D printing results showed that the PCL-PEG-PCL hydrogel with crystallinity can not only be extruded and printed via temperature adjustment, but also the three-dimensional structure can be effectively maintained after 3D printing. The gels demonstrated good cell compatibility, and the cell survival rate was maintained at a high level.
研究领域:
材料科学
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生物医学工程
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聚合物化学
·
3D打印
✓ 已验证
产品关联
DOI
PubMed
高影响因子
APPLIED PHYSICS A-MATERIALS SCIENCE & PROCESSING
·
2025
·Vol. 131
·期 10
·1-11
·
IF 2.8
Kuang Xuanfei,Xiao Yao,Qian Kun,Han Muyun,Liang Zongcun,Fu Wuyou
Perovskite solar cells (PSCs) have developed rapidly, however, the high cost of materials, inadequate device stability, and stringent manufacturing conditions still hinder their large-scale commercialization. In this study, we demonstrate that polyethylene glycol (PEG) modification of the hole transport layer enhances the efficiency (with power conversion efficiency (PCE) increasing from 8.41 to 9.01%) and stability. After continuous illumination for 16 days under unencapsulated conditions, the device maintains 89% of its initial efficiency. The incorporation of PEG reduces defects in the hole transport layer, decreases the non-radiative recombination rate of charge carriers, and minimizes the damage caused by moisture to the perovskite light-absorbing layer, thereby improving the overall performance of the PSCs. The materials used are inexpensive and easy to fabricate, and the entire process is conducted in an ambient atmosphere.
研究领域:
光伏学
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材料科学
·
可再生能源
✓ 已验证
产品关联
DOI
高影响因子
International Journal of Nanomedicine
·
2018
·
IF 4.37
Fei Tong,Suhuan Liu,Bing Yan,Xuejun Li,Shiwei Ruan,Shuyu Yang
Introduction Insulin has shown antioxidation and cytoprotective effects to decrease heart ischemia/reperfusion injury (HI/RI) in diabetes mellitus (DM), but the role of insulin/poly(ethylene glycol)-carboxymethyl chitosan (PEG-CMCS) on HI/RI in DM is not known. This research explored whether insulin/PEG-CMCS revealed a protective effect on HI/RI in DM through ornithine decarboxylase (ODC)/polyamine systems.Materials and methods Diabetes was induced via streptozotocin (STZ) in Sprague Dawley (SD) rats, which suffered from HI via blocking the left circumflex artery for 45 minutes, followed by 2 hours of reperfusion. α-Difluoromethylornithine-ethylglyoxal bis (guanylhydrazone) (DFMO-EGBG) and insulin/PEG-CMCS were administered to diabetic rats to explore their roles on severity of HI/RI.Results Insulin could be fleetly and efficiently loaded via the nanocarrier PEG-CMCS at pH =6, showing efficient loading and stable release. In addition, insulin/PEG-CMCS showed significant hypoglycemic activity in diabetic rats. On the other hand, ischemia/reperfusion obviously augmented the contents of creatine kinase (CK), lactic dehydrogenase (LDH), putrescine (Pu), myocardial infarct size, and NF-κB and spermidine/spermine N′-acetyltransferase (SSAT) expressions and decreased the levels of spermine (Sp), polyamine pools (PAs), heart rate (HR), coronary blood flow (CF), left ventricular developed pressure (LVDP), and ODC expression, compared with Sham. Administration of insulin and insulin/PEG-CMCS both reduced the contents of CK, LDH, Pu, myocardial infarct size, and NF-κB and SSAT expressions and increased the levels of Sp, PAs, HR, CF, LVDP, and ODC expression, while insulin/PEG-CMCS significantly indicated the protective results, and DFMO-EGBG showed the opposite effects.Conclusion The research showed that insulin/PEG-CMCS could play a protective effect on HR/RI in diabetic rats via its antioxidative, antiapoptotic, and anti-inflammatory roles and modulating ODC/polyamine systems.
研究领域:
药理学
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分子生物学
·
心血管病学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
RSC Advances
·
2018
·Vol. 8
·期 17
·9334-9343
·
IF 2.936
Hailong Huang,Lifeng Hou,Feng Zhu,Juan Li,Min Xu
A series of controllable thermal and pH dual-responsive copolymeric hydrogels (PMA) were prepared by a one-pot reaction with poly(ethylene glycol) methyl ether acrylate (PEGA), 2-methoxyethyl acrylate (MEA) and acroleic acid (AA). The hydrogels exhibited good mechanical properties and a sensitive response to pH and temperature. Besides, the Lower Critical Solution Temperature (LCST) of the hydrogels can be adjusted from 37 °C to 58 °C by changing the content of AA. The hydrogels also showed excellent selective adsorption properties. The maximum adsorption quantity of organic cationic dye brilliant green and methylene blue were 0.49 mg mg−1 and 0.42 mg mg−1 respectively, much better than previous reports. Furthermore, using the thermal and pH responsibility, the PMA hydrogels can release the adsorbed molecules with control. Nearly 95% of carriers could be released at pH 4.01 and 65 °C over 8 h. The regeneration ability makes the materials easy to reuse many times. Due to these properties, these dual-responsive hydrogels have great potential applications in various fields for adsorption, drug delivery, release and tissue engineering.
研究领域:
材料科学
·
化学工程
·
环境科学
·
生物医学工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
IONICS
·
2017
·Vol. 24
·期 3
·787-795
·
IF 2.062
Wang Ping,Zhang Di,Zhou Yiyang,Li Yu,Fang Huagao,Wei Haibing,Ding Yunsheng
A novel biodegradable 1,2,3-triazolium-functionalized PEG- b -PCL copolymer (TAPEC) was synthesized by the “click” coupling of methoxypolyethylene glycol azide and α-propargyl-ω-hydroxyl-poly(ε-caprolactone), followed by the quaternization of the 1,2,3-triazole moiety with iodomethane. All the intermediates and TAPEC were characterized by 1 H NMR, FT-IR, and gel permeation chromatography (GPC). Taking advantage of the characteristics of ionic liquid and block copolymer, this ion-containing diblock copolymer is expected to be used as a novel compatibilizer in mixed biopolyester for regulating the interface and crystallization behaviors. Hence, the TAPEC was evaluated as a compatibilizer and an interface emulsifier in the blends of polylactic acid (PLA) and poly(ε-caprolactone) (PCL). Non-isothermal crystallization experimental results showed that the TAPEC with the higher amount of ε-caprolactone units induces a plasticization and nucleate effect that increased the crystallization ability of the PLA phase; meanwhile, in the PCL phase, the agminated ionic cluster acting as a nucleating agent significantly increased the crystalline of PCL.
研究领域:
材料科学
·
高分子化学
✓ 已验证
产品关联
DOI
高影响因子
DALTON TRANSACTIONS
·
2020
·Vol. 49
·期 7
·2209-2217
·
IF 4.174
Wenyan Kong,Qi Wang,Guoying Deng,Hang Zhao,Linjing Zhao,Jie Lu,Xijian Liu
Photothermal therapy (PTT) is a promising treatment for tumors due to its efficiency and non-invasiveness. However, during the PTT treatment, reactive oxygen species (ROS) are produced in response to hyperthermia and thus harm the neighboring normal cells. In this work, a multifunctional theranostic agent (Se@SiO2@Au-PEG/DOX NCs) was exploited to solve this problem by introducing selenium, which can efficiently prevent normal cells from oxidative damage by scavenging reactive oxygen species during photothermal therapy. In addition, the Se@SiO2@Au-PEG/DOX nanocomposites (NCs) not only exhibited excellent properties of combined chemo-thermal synergistic therapy, but also showed no appreciable toxicity towards normal tissues due to the protective effect for continuous release of selenium. Thus, the fabricated Se@SiO2@Au-PEG/DOX NCs provide an integrated solution to overcome the limitations of selenium and PTT, and demonstrate great prospects as a safe and highly reliable theranostic agent.
研究领域:
癌症治疗
·
材料科学
·
纳米医学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ACS Applied Materials & Interfaces
·
2016
·
IF 7.145
Xingye Feng,Di Jiang,Ting Kang,Jianhui Yao,Yixian Jing,Tianze Jiang,Jingxian Feng,Qianqian Zhu,Qingxiang Song,Nan Dong,Xiaoling Gao,Jun Chen
The combination of photodynamic therapy (PDT) and chemotherapy holds great potential in combating drug-resistant cancers. However, the major challenge that lies ahead is how to achieve high coloading capacity for both photosensitizer and chemo-drugs and how to gain efficient delivery of drugs to the drug-resistant tumors. In this study, we prepared a nanovehicle for codelivery of photosensitizer (pyropheophorbide-a, PPa) and chemo-drugs (paclitaxel, PTX) based on the synthesis of PPa-conjugated amphiphilic copolymer PPa-PLA-PEG-PLA-PPa. The obtained nanoparticles (PP NP) exhibited a satisfactory high drug-loading capacity for both drugs. To achieve effective tumor-targeting therapy, the surface of PP NP was decorated with a tumor-homing and penetrating peptide F3. In vitro cellular experiments showed that F3-functionalized PP NP (F3-PP NP) exhibited higher cellular association than PP NP and resulted in the strongest antiproliferation effect. In addition, compared with the unmodified nanoparticles, F3-PP NP exhibited a more preferential enrichment at the tumor site. Pharmacodynamics evaluation in vivo demonstrated that a longer survival time was achieved by the tumor-bearing mice treated with PP NP (+laser) than those treated with chemotherapy only or PDT only. Such antitumor efficacy of combination therapy was further improved following the F3 peptide functionalization. Collectively, these results suggested that targeted combination therapy may pave a promising way for the therapy of drug-resistant tumor.
研究领域:
肿瘤学
·
药学
·
纳米技术
·
癌症治疗
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Biomaterials Science
·
2020
·Vol. 8
·期 12
·3334-3347
·
IF 6.183
Haoqi Tan,Junjie Sun,Dawei Jin,Jialin Song,Miao Lei,Artem Antoshin,Xin Chen,Meng Yin,Xue Qu,Changsheng Liu
Poor mechanical performances severely limit the application of hydrogels in vivo; for example, it is difficult to perform a very common suturing operation on hydrogels during surgery. There is a growing demand to improve the mechanical properties of hydrogels for broadening their clinical applications. Natural polyphenols can match the potential toughening sites in our previously reported PEG-lysozyme (LZM) hydrogel because polyphenols have unique structural units including a hydroxyl group and an aromatic ring that can interact with PEG via hydrogen bonding and form hydrophobic interactions with LZM. By utilizing polyphenols as noncovalent crosslinkers, the resultant PEG-LZM-polyphenol hydrogel presents super toughness and high elasticity in comparison to pristine PEG-LZM with no obvious changes in the initial shape, and it can even withstand the high pressure from sutures. At the same time, the mechanical properties could be widely adjusted by varying the polyphenol concentration. Interestingly, the PEG-LZM-polyphenol hydrogel has a higher water content than other polyphenol-toughened hydrogels, which may better meet the clinical needs for hydrogel materials. Besides, the introduction of polyphenols endows the hydrogel with improved antibacterial and anti-inflammatory abilities. Finally, the PEG-LZM-polyphenol (tannic acid) hydrogel was demonstrated to successfully patch a rabbit myocardial defect by suturing for 4 weeks and improve the wound healing and heart function recovery compared to autologous muscle patches.
研究领域:
材料科学
·
生物材料
·
组织工程
·
生物医学工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）