JOURNAL OF POLYMERS AND THE ENVIRONMENT
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2023
·
IF 5.3
Li Jing,Liu Wan,Jiang Ping
First, biocompatible temperature-responsive polymer chitosan- graft - N -isopropylacrylamide (CS- g -PNIPAm) synthesized via ATRP. Second, mugwort oil (MO) was encapsultated with CS- g -PNIPAm as shell materials to form long-term anti-bacterial agents and temperature responsive microcapsules. The CS- g -PNIPAm@MO (CSPN@MO) microcapsules were prepared via single coacervation method and solvent evaporation method. The chemical structures of CS 0.1 - g -PNIPAm 22 was confirmed by 1 H NMR and FTIR. And the copolymer micelles were characterized by UV, laser particle-size analysis, and TEM. The results indicated that the copolymer had temperature-responsive behaviors. The microcapsules were characterized by laser particle-size analyzers (LPSA), scanning electron microscopy (SEM), TG and anti-bacterial agents performance testing. The results showed that the average particle size of microcapsules was 0.28 μm, and the encapsulation efficiency and drug loading efficiency of MO reached 60.2 and 44.5%. After 48 h of release in media at different temperature (20, 40 and 60 °C) still sequestered 79.2, 92.2 and 96.1% of MO which approved the shell of microcapsules responded to different temperature. The morphology of CSPN@MO microcapsules revealed that the microcapsules presented smooth and firm structure. Antibacterial test for Artemisia argyi of CSPN@MO implied that the bacteriostatic rate reached 99.2 and 96.2% after 1 day and 10 days respectively. Bio-based macromolecular modification strategies can provide inspiration for the development of green microcapsules. Graphical Abstract
研究领域:
材料科学
·
生物医学工程
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DOI
高影响因子
DESALINATION
·
2026
·
IF 9.9
Ruiyun Cai,Hanxue Sun,Rui Jiao,Zhaoqi Zhu,Jiyan Li,An Li
Using the green BF method instead of traditional membrane pore-forming technology • The Janus structure provides optimized water transport and light absorption. • CCPN-PPM delivers an evaporation rate of 1.87 kg m −2 h −1 , 97.7% efficiency. • Resistant to high salt content (20 wt% NaCl) and grease (diesel, motor oil). Solar-driven interfacial evaporation (SDIE) is one of the key technological approaches for alleviating global freshwater shortages. In this study, a porous substrate membrane (PPM) was prepared using the green breath figure (BF) method and combined with a poly(N-isopropylacrylamide) (PNIPAM) hydrogel doped with hollow conjugated microporous carbon microspheres (CCM), successfully constructing a composite photothermal membrane (CCPN-PPM) with Janus wetting properties, designed to yield an evaporator material with both excellent salt resistance and oil repellency. The hollow cavity structure of the CCM significantly enhances light absorption. The PNIPAM hydrogel provides hydrophilic water transport channels and temperature-sensitive self-regulation capabilities, while the underlying BF membrane ensures rapid vapor escape. Experiments demonstrate that CCPN-PPM exhibits an average light absorption rate of up to 97.5% across the 250–2500 nm wavelength range. At an irradiance of 1 kW m −2 , its evaporation rate reaches 1.87 kg m −2 h −1 , with a photothermal conversion efficiency of 97.7%. In an 11-hour continuous day-night alternating evaporation test in simulated seawater, the material maintained stable seawater evaporation performance and exhibited an evaporation capacity comparable to that in pure water under varying light intensities. It achieved a salt-tolerant evaporation rate of 1.62 kg m −2 h −1 even in a high-salt solution containing 20 wt% NaCl. Furthermore, CCPN-PPM has demonstrated a certain degree of pollution control capability when treating dye wastewater, oil-containing dye wastewater, and difficult-to-treat oil contaminants such as diesel and engine oil. This work extends the advantages of the BF in the preparation of functionalized evaporators and provides new material design concepts for treating complex wastewater containing salt and oils. Download: Download high-res image (133KB) Download: Download full-size image
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DOI
高影响因子
Advanced NanoBiomed Research
·
2026
·
IF 4.8
Zhou Liang,Yingjie Wang,Chenyu Bai,Pengfei Li,Xin He,Meng Ma,Xiaoying Luo,Yi Song,Yao Li,Yun Wang
Endometriosis (EM) results in pelvic adhesions and chronic inflammation, which significantly reduce embryo implantation and the clinical pregnancy rates of in vitro fertilization (IVF), affecting 190 million women worldwide. Traditional hormonal and surgical treatments alter ovarian and endometrial function, thereby hindering IVF. An urgent need exists for a localized treatment strategy that does not interfere with IVF procedures, aiming to enhance endometrial receptivity. To address this, we developed an innovative localized drug delivery system that simultaneously targets immune dysregulation and enhances endometrial function. This study reports a dual-drug delivery system based on poly(N-isopropylacrylamide) (PNIPAM) combined with nanocrystalline cellulose (CNC) for the local release of levonorgestrel (LNG) and botropase (BTP) to reprogram uterine natural killer cells and treat EM, overcoming previous drawbacks. The experimental results confirm stable CNC and PNIPAM structures and controlled the release of the composite drug. At concentrations of 0.5 mg/L LNG and 100 mg/L BTP, the release system achieved the highest CD16 – /CD16 + ratio and the most pronounced upregulation of autophagy-related molecules in uNK cells in our in vitro assays, indicating a shift in uNK cells toward an immune-tolerant state. In a mouse model of EM, the CNC–PNIPAM drug delivery system significantly improve endometrial receptivity. The CNC–PNIPAM drug delivery system demonstrates the medical potential of the local release of composite drugs, offering a new immunomodulatory approach for the treatment of EM and broader medical applications.
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DOI
高影响因子
ENERGY AND BUILDINGS
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2026
·
IF 7.1
Kai Zhang,Xinlong Tai,Siying Jiao,Yichi Zhang,Qingchuang Zou
This study proposed a temperature adaptive regulation window that can be fabricated on a large scale for building energy savings. We first synthesized the modified PNIPAM hydrogel, and then the temperature adaptive regulation window was fabricated by incorporating the modified PNIPAM hydrogel with a PVDF membrane (TAR PP window) in a square acrylic glass mold. Then, the micromorphology, thermal response characteristics, and infrared spectroscopy of the modified PNIPAM hydrogel as well as the optical properties of the TAR PP window were characterized. Finally, the experiments were conducted to determine the thermal response characteristics of the TAR PP window, and preliminary calculations were also performed to derive the energy-saving potential and heat gain of the TAR PP window. By incorporating PVDF with the modified PNIPAM hydrogel, the TAR PP window not only achieves 80 % visible light modulation and 73 % solar modulation but also exhibits an emissivity of > 90 % within the atmospheric transparency window. In addition, the preliminary evaluation indicates that the energy consumption of the experimental chamber with the TAR PP window can be decreased by 31.6 % compared with that with the conventional double-glazed (CDG) window.
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DOI
高影响因子
Soft Matter
·
2014
·Vol. 10
·期 20
·3578-3586
·
IF 4.151
Lei Hou,Peiyi Wu
The self-aggregation behavior of poly(N-isopropylacrylamide)-b-poly(N-vinylcaprolactam) (PNIPAM-b-PVCL) during the thermal-induced phase transition in water was explored by a combination of calorimetric, turbidity, dynamic light scattering (DLS) and FTIR measurements. Only one transition can be observed via all detecting methods, revealing the cooperative aggregation of the two distinct temperature-sensitive segments. What is more, the combination of strong hydrophobic interactions among the entire polymer chains and hydrogen bonds of CO…H–N within PNIPAM segments results in the sharp variations at the LCST and gradual variations above the LCST during the phase transition of PNIPAM-b-PVCL aqueous solution upon heating. Additional analysis by perturbation correlation moving window (PCMW) and two-dimensional correlation spectroscopy (2Dcos) indicates that the hydrophobic C–H groups have an earlier response than the relatively hydrophilic CO groups during the LCST transition.
研究领域:
高分子化学
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软物质物理
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生物材料
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药物递送
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纳米医学
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分子自组装
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光谱分析
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DOI
高影响因子
ULTRASONICS SONOCHEMISTRY
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2019
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IF 7.279
F. Chen,C. Dong,C. Chen,W.D. Yin,W. Zhai,X.Y. Ma,B. Wei
Ultrasonic synthesis has shown great potential applications in preparing varieties of nanostructured materials. However, fabrication of nanomaterials with tunable structures and desirable properties is still challenging because of the instability and nonuniform distribution of cavitation effect in liquid phase. In this study, a novel aeration tuned ultrasonic synthesis approach is proposed for optimizing the cavitation effect in both time and space scales and fabricating SiO 2 @PNIPAm NPs. By alternation of ultrasonication and N 2 aeration, more and more gas bubbles are formed in the reaction liquid, and the collapse of those bubbles is further enhanced by the reactants of solid SiO 2 and intermediate functionalized SiO 2 NPs. As a result, SiO 2 @PNIPAm NPs with various grafting ratios are successfully synthesized simply by changing the number of ultrasonic synthesis cycle. The SiO 2 @PNIPAm NPs are subsequently used as stabilizer to form Pickering emulsions with different temperature response. This work provides a potential facile sonochemical synthesis method with high efficiency in obtaining inorganic/organic NPs of well determined structures.
研究领域:
材料科学
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化学工程
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产品关联
DOI
PubMed
高影响因子
Polymers
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2019
·Vol. 11
·期 10
·1716
·
IF 3.164
Feng Guo,Guiying Li,Songmei Ma,Hengquan Zhou,Xinyi Chen
A temperature, glutathione (GSH), and H2O2multi-responsive composite nanocarrier (MSN-SS-Fc@β-CD-PNIPAM) based on β-cyclodextrin-poly(N-isopropylacrylamide) (β-CD-PNIPAM) star polymer capped ferrocene modified mesoporous silica nanoparticles (MSN-SS-Fc) was successfully prepared. The surface of the mesoporous silica was first modified by ferrocene (Fc) via a disulfide bond (–SS–) to form an oxidizing and reducing site and then complexed with a β-CD-PNIPAM star shaped polymer through host–guest interactions as a nano-valve to provide temperature responsive characteristics. The structure and properties of the complex nanoparticles were studied by FTIR, TGA, EDS, Zeta potential, and elemental analysis. Doxorubicin (DOX) and Naproxen (NAP), as model drugs, were loaded into nanocarriers to assess drug loading and release behaviour. The release of drugs from nanocarriers was enhanced with an increase of the GSH, H2O2concentration, or temperatures of the solution. The kinetics of the release process were studied using different models. This nanocarrier presents successful multi-stimuli responsive drug delivery in optimal stimuli and provides potential applications for clinical treatment.Keywords:disulfide bond;ferrocene;multi-responsive;nanocarrier;MSNs
研究领域:
材料科学
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药物递送
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生物医学工程
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产品关联
DOI
PubMed
高影响因子
ELECTROANALYSIS
·
2020
·Vol. 32
·期 6
·1354-1363
·
IF 2.544
Pengcheng Zhao,Meijun Ni,Chao Chen,Chenxi Wang,Pingping Yang,Xiahui Wang,Chunyan Li,Yixi Xie,Junjie Fei
A novel self-protection sensor was successfully constructed based on an interesting thermo-sensitive triblock polymer PS-PNIPAm-PS. At low temperatures (<24 °C), the analyte was able to undergo the redox process at the modified electrode. However, the polymer shrunk and accumulated at high temperatures (>30 °C), which dramatically increased the electron transfer resistance (Rct) of the modified electrode and consequently blocked the occurrence of the redox reaction to protect the electrode from high temperatures and enhance its stability. Under optimized conditions, the proposed sensor showed a good detection range for hydroquinone (6×10 −7 to 2.35×10 −3 M) and a low LOD (490 nM). The sensor was also successfully applied for detecting hydroquinone in real samples. The present work may provide a novel method for electrode protection, high-temperature alarm, high-temperature protection of batteries and new sensors production.
研究领域:
分析化学
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材料科学
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电化学传感器
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DOI
高影响因子
Advanced Sustainable Systems
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2022
·Vol. 6
·期 6
·2100265
·
IF 6.737
Xinran Xu,Ping-Ping He,Xiaoxue Du,Weiwei Guo
The regulation of the catalytic activities of DNAzymes is of great significance for their biosensing and biomedical applications. Herein, thermoregulation of the catalytic activity of DNAzyme is achieved through the immobilization of DNAzymes into the crosslinked polymeric matrix of poly- N -isopropylacrylamide (pNIPAM) microgels prepared with a microfluidic device. At a temperature lower than the lower critical solution temperature (LCST) of pNIPAM, the immobilized DNAzymes exhibit lower catalytic performance due to the restricted entry of DNA substrates into the polymeric networks; while at a temperature higher than the LCST, the hydrophilic DNAzyme structures are exposed to exhibit high catalytic activity due to the shrinking of the pNIPAM networks. Results show a more than 60% of increase in catalytic activity by raising the temperature from 29 to 34 ° C and reversible regulation of the DNAzyme catalytic activity is achieved by cyclic raising and lowering of the solution temperature. Through a simple heating-centrifugation process, the DNAzyme/pNIPAM microgels can be recycled for further applications. Moreover, by introducing photothermal MXene nanosheets, the remote control of the catalytic activity of the DNAzyme by near-infrared light irradiation is achieved. These DNAzyme/pNIPAM microgels as low-cost, stable, reversible, and recyclable biocatalyst may have potential in biosensing and biomedical applications.
研究领域:
生物催化
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材料科学
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生物工程
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纳米技术
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分析化学
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产品关联
DOI
高影响因子
Regenerative Biomaterials
·
2022
·
IF 5.763
Wang Zizhen,Hou Zishuo,Wang Peiwen,Chen Fan,Luo Xianglin
Copper sulfide nanoparticles (CuS NPs) have shown great potential in various application fields, especially in biomedical engineering fields. CuS NPs, with the ability to actively capture and kill bacteria and without the worry of biocompatibility, will greatly expand their applications. Herein, a four-arm star thermo-sensitive polyisopropylacrylamide (4sPNIPAm) was used to modify CuS NPs (CuS-PNIPAm NPs). The obtained NPs displayed the controlled release of copper ions and higher photothermal conversion ability in comparison with contrast materials CuS-PEG NPs and CuS NPs. Aggregation of CuS-PNIPAm NPs at above 34°C resulted in capturing bacteria by forming the aggregates of NPs-bacteria. Both Staphylococcus aureus and Escherichia coli co-cultured with CuS-PNIPAm NPs were completely killed upon near-infrared irradiation in minutes. Furthermore, CuS-PNIPAm NPs were verified to be a photothermal agent without toxic effect. In in vivo experiment, the NPs effectively killed the bacteria in the wound and accelerated the process of wound repairment. Overall, photothermal treatment by CuS-PNIPAm NPs demonstrates the ability to actively capture and kill bacteria, and has a potential in the treatment of infected skin and the regeneration of skin tissues. The therapy will exert a far-reaching impact on the regeneration of stubborn chronic wounds.
研究领域:
生物医学工程
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纳米医学
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材料科学
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产品关联
DOI
PubMed
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2023
·
IF 15.1
Yingying Li,Yanqiu Wang,Jing Lu,Wenwen Wang,Dong Wang
Smart windows are highly desired as emerging optical devices based on appealing sunlight modulation, however, some prevailing limitations remain with low photothermal conversion and narrow spectral adjusting ranges, which drastically restrict energy-saving performance. Herein, a strategically designed smart window achieves significant breakthroughs, containing photothermal fillers of Au nanoprisms (AuNPRs) hybrid MXene nanosheets, and copolymerized thermochromic poly( N -isopropyl acrylamide)-doped hyaluronic acid (HA) hydrogels. By harness of AuNPR@MXene nanocomposites as photo-trapped nanoheaters, stimulating thermo-responsive behaviors of hydrogels boosts solar transmittance switching. The compelling photothermal features depend on the amalgamation: thermoplasmonic effect of AuNPRs, broad-band-absorbed AuNPRs endowed by MXene, and thermal conductivity from AuNPRs to MXene, generating synergistic effects. We maximize the advancing transmittance regulation by controlling the proportion gain of HA to increase hydrogen-bonded interaction. The resulting device with low-loadings AuNPR@MXene composites (0.9 wt% and 0.98 vol%) is capable of allowing 78 % of the maximum visible light through before thermochromism and blocking 98.04 % of sunlight penetration when photothermal stimulation. Besides, outdoor measurements show an achievable great indoor temperature drop of about 7 °C only 30 min irradiation, and a skin-cooling performance in the wearable, illustrating the potential of adaptive solar modulation application.
研究领域:
材料科学
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能源技术
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纳米技术
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产品关联
DOI
高影响因子
Polymer Chemistry
·
2016
·Vol. 8
·期 5
·865-878
·
IF 5.687
Gehong Su,Tao Zhou,Xifei Liu,Yanan Ma
In this study, the micro-dynamics mechanism of the volume phase transition behavior of the poly(N-isopropylacrylamide-co-2-hydroxyethyl methacrylate) (PNIPAM-co-HEMA) hydrogel was investigated by temperature-dependent FTIR spectroscopy in combination with the perturbation correlation moving window (PCMW2D) technique and generalized two-dimensional correlation analysis. In conventional 1D FTIR spectra analysis, Boltzmann fitting curves showed that the volume phase transition temperature and the phase transition degree of the PNIPAM-co-HEMA hydrogel were lower than those of the pure PNIPAM hydrogel. They also showed that the PHEMA segments exhibit a similar “phase transition” behavior to the PNIPAM segments, which can be ascribed to the driving effect of the phase transition of PNIPAM segments. Furthermore, we found that the rate at which water molecules were expelled out of the gel structure during phase transition changed in an anti-S shape. PCMW2D spectra revealed that the phase transition can be divided into two processes (named I and II) upon heating, and further determined the temperature regions of processes I and II to be 21.8–31.4 °C and 31.4–36.5 °C, respectively. Finally, generalized 2D correlation analysis found that both processes I and II can be further divided into nine steps. From the deduced nine steps of process I, the significant role of PHEMA in the phase transition of PNIPAM segments was revealed. As for the deduced nine steps of process II, the driving effect of the phase transition of PNIPAM segments for PHEMA segments was confirmed.
研究领域:
材料科学
·
生物医学工程
·
高分子化学
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DOI
高影响因子
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