INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2023
·
IF 8.2
Guofeng Zhong,Mengyu Qiu,Junbo Zhang,Fuchen Jiang,Xuan Yue,Chi Huang,Shiyi Zhao,Rui Zeng,Chen Zhang,Yan Qu
In this study, a novel nanofiber material with Polylactic acid (PLA), natural plant polysaccharides- Bletilla striata polysaccharide (BSP) and Rosmarinic acid (RA) as the raw materials to facilitate wound healing was well prepared through coaxial electrospinning. The morphology of RA-BSP-PVA@PLA nanofibers was characterized through scanning electron microscopy (SEM), and the successful formation of core-shell structure was verified under confocal laser microscopy (CLSM) and Fourier transform infrared spectroscopy (FTIR). RA-BSP-PVA@PLA exhibited suitable air permeability for wound healing, as indicated by the result of the water vapor permeability (WVTR) study. The results of tension test results indicated the RA-BSP-PVA@PLA nanofiber exhibited excellent flexibility and better accommodates wounds. Moreover, the biocompatibility of RA-BSP-PVA@PLA was examined through MTT assay. Lastly, RA-BSP-PVA@PLA nanofibers can induce wound tissue growth, as verified by the rat dorsal skin wound models and tissue sections. Furthermore, RA-BSP-PVA@PLA can facilitate the proliferation and transformation of early wound macrophages, and down-regulate MPO + expression of on the wound, thus facilitating wound healing, as confirmed by the result of immunohistochemical. Thus, RA-BSP-PVA@PLA nanofibers show great potential as wound dressings in wound healing.
研究领域:
材料科学
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生物医学工程
·
药剂学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF POLYMER RESEARCH
·
2020
·Vol. 27
·期 5
·1-11
·
IF 2.426
Pan Zheng,Lv Yukai,Chen Yulong,Qian Xin
Waterproofing layers play a pivotal role in tunnel engineering and building basements. Magnesium acrylate (CA-Mg 2 ) shot-membrane waterproofing materials- commonly used as a waterproof layer- is a type of hydrogel. Poly(vinyl alcohol) (PVA) solution subjected to freezing/thawing treatment has been added to a CA-Mg 2 monomer, resulting in the formation of a CA-Mg 2 /PVA interpenetrating polymer network (IPN) hydrogel which can produced by a redox initiation system. This new IPN hydrogel contains not only a CA-Mg 2 network formed with Mg 2+ coordination bonds, but also a PVA network created by hydrogen bonding between hydroxyl groups. In comparison to CA-Mg 2 hydrogels, the fracture stress of the CA-Mg 2 /PVA hydrogel increased from 0.45 MPa to 0.72 MPa, elongation from 602% to 854%, and the self-healing efficiency of the IPN hydrogel reached 99.9% over 3 h. A new shot-membrane waterproofing materials based on the CA-Mg 2 /PVA hydrogel was prepared and its fracture stress was 1.44 MPa, and self-healing efficiency 80%, at 3 h. In addition, damage to the hydrogel could be repaired repeatedly.
研究领域:
材料科学
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土木工程
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化学工程
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产品关联
DOI
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2024
·
IF 13.3
Junyu Lu,Mushan Yuan,Xiaochuang Di,Quan Yuan,Long Ni,Yinfu Luo,Yang Chen,Huawei Zou
Lightweight structural/microwave absorption (MA) integrated materials with broadband MA are urgently needed in the aerospace field. In this study, crosslinked PVA/CNF backbone-supported RGO foams were successfully filled into aramid honeycomb structures with significant broadband MA performance and structural enhancement properties through a synergistic strategy of chemical crosslinking, environmental drying and chemical vapor reduction. Flexible tuning of the electromagnetic parameters of the PVA/CNF@GO foam can be achieved by adjusting the number of GO parts. The 30 mm thickness of the PVA/CNF@14GO foam achieves a broadband effective absorption of 13.25 GHz, covering almost all C, X and Ku bands. Microstructural characterization and electromagnetic parameter tests proved that the uniform distribution of RGO was achieved with crosslinked PVA/CNF as the backbone, which resulted in less Debye relaxation and the construction of uniform conductive pathways. Therefore, the PVA/CNF@14GO-filled honeycomb not only enables the composite honeycomb to achieve broadband MA performance, but also achieves a compressive strength of 5.52 MPa, which is an improvement of 262.86 % with respect to that of the pure honeycomb. The obvious overlap of the CST power loss distribution and the electric field distribution region shows that the conductive loss and the 1/4 wavelength interference are the main paths for energy dissipation in the composite of the PVA/CNF@GO-filled honeycomb. The honeycomb-filled PVA/CNF@GO lightweight foams obtained in this chapter have good broadband microwave absorption properties and higher structural strength, which provide important design strategies and practical references for the development of high-performance MA-filled honeycomb structures.
研究领域:
材料科学
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航空航天工程
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产品关联
DOI
高影响因子
NANOTECHNOLOGY
·
2020
·Vol. 32
·期 1
·015101
·
IF 3.551
Baoe Li,Xiaomei Xia,Jiatian Chen,Dan Xia,Ruodan Xu,Xianrui Zou,Hongshui Wang,Chunyong Liang
Electrospun composite nanofibrous scaffolds have been regarded as a potential carrier for local drug delivery to prevent tumor recurrence. Herein, a model drug (paclitaxel) was creatively loaded into lignin nanoparticles (PLNPs) and then encapsulated into the polymer of poly (vinyl alcohol)/polyvinyl pyrrolidone which has been fabricated into a composite nanofibrous membrane (PVA/PVP-PLNPs) for use as a drug carrier using the electrospinning technique. The fabricated PVA/PVP-PLNPs membranes exhibited good particle distribution, mechanical properties, thermal stability and biocompatibility. In vitro experiments showed that combining lignin nanoparticles by electrospinning not only improved the drug release profile, but also enhanced the hydrophilicity of nanofibrous membranes which was beneficial to cell adhesion and proliferation. Cellular experiments demonstrated that PVA/PVP-2%PLNPs membrane showed good cell inhibition ability, and the cell survival rate was only 21% at day 7. It indicates that the as-prepared PVA/PVP-PLNPs composite nanofibers are promising candidates for local anticancer therapy.
研究领域:
药学
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生物医学工程
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癌症研究
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材料科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ACS Applied Polymer Materials
·
2024
·
IF 4.4
Guangxin Ma,Weiman Li,Xin Zhou,Xiaoze Wang,Mengjie Cao,Wenjun Ma,Jingjing Wang,Hang Yu,Shigang Li,Yunfa Chen
A hygroscopic layer plays an important role in improving the output abilities of energy generation from ubiquitous moisture, whose mechanism is unclear. Herein, three kinds of hydrogels with different pore structures/functional groups are designed as hygroscopic layers, and a universal strategy was proposed to assemble them into hydrogel-based moisture-electric generators (HMEGs). The hydrogels’ pore structure affects the moisture absorption rate, while the functional groups regulate the diffusion path of water. HMEG’s power generation is a synergistic effect of ionic diffusion and streaming potential, which is closely related to the water diffusion within the material and is not directly related to the amount of moisture absorption. HMEG, which absorbs moisture quickly, stores water efficiently, and releases moisture slowly, has an excellent performance and stable voltage output. Based on this mechanism, HMEG employed the calcium chloride-poly(vinyl alcohol)-poly(N-isopropylacrylamide) (CPVPN), semi-interpenetrating network (semi-IPN) hydrogel as the hygroscopic layer showed an open-circuit voltage as high as 0.34 V and a power density of 33.23 μA cm–3. This study opens a perspective on hydrogel HMEG and provides insights into high-performance HMEG design.
研究领域:
材料科学
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能源工程
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化学工程
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环境科学
✓ 已验证
产品关联
DOI
高影响因子
SOLAR ENERGY
·
2024
·
IF 6
Kefan Chen,Lijing Ma,Jinwen Shi,Dengwei Jing
Solar-driven interfacial evaporation (SIE) receives much attention nowadays. At present, efficient thermal management and salt resistance during operation are still the difficulties of SIE technology. In this work, a new composite hydrogel for SIE has been reported. This composite hydrogel uses polyvinyl acetate (PVA) and chitosan (CS) as the framework, carbon nanoparticles (CB) as the photothermal material, modified with hydrophilic/hydrophobic fumed nano-silica. The addition of fumed nano-silica reduces the thermal conductivity and effectively immobilizes heat energy on the evaporator’s top surface, which reduces heat loss and improves the evaporation rate. The CSPC (CB/Nano-silica PVA-CS) evaporator modified with hydrophobic nano-silica exhibits Janus structure with transition from a hydrophobic top to a hydrophilic bottom. The Janus-structured CSPC evaporator has the characteristics of excellent salt resistance, simple preparation process, low heat loss with self-floating property. The CSPC evaporator containing 0.5 g hydrophobic fumed nano-silica has a maximum evaporation rate of 1.58 kg/(m 2 ·h), about 1.6 times higher than the evaporator without fumed nano-silica, which proves that the introduction of fumed nano-silica can effectively improve the evaporation performance of hydrogel. The overall efficiency of CSPC evaporator in simulated seawater is 88.63 %. The evaporation rate of CSPC evaporator has reached a high level in the evaporators using carbon black as photothermal material which was prepared by simple and low-cost method. It should be a promising category of material to be employed for solar desalination.
研究领域:
材料科学
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环境工程
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纳米技术
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太阳能
✓ 已验证
DOI
高影响因子
CARBOHYDRATE POLYMERS
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2023
·
IF 11.2
Jun Ye,Luying Liu,Wu Lan,Jian Xiong
Carboxymethyl cellulose (CMC)/polyvinyl alcohol (PVA) hydrogels loaded with soybean peptide (SPE) were fabricated via a freeze-thaw method. These hydrogels conquer barriers in simulated gastric fluid (SGF), and then release SPE in simulated intestinal fluid (SIF). The results of in vitro SPE release from these hydrogels showed that in SGF only a little of the SPE released, but in SIF the SPE was completely released. The released SPE had scavenging rates for DPPH and ABTS free radicals of 41.68 and 31.43 %. The pharmacokinetic model of SPE release from the hydrogels in SIF was studied. When the hydrogels are moved from SGF to SIF, the sorption of the shrinkage hydrogel network is entirely controlled by stress-induced relaxations. There are swollen and shrunken regions during SPE release. For SPE release into the SIF, SPE has to be freed from the weak bonds in the swollen regions by changes in the conformation of CMC and PVA. The release rate of SPE was found to be governed by the diffusion and swelling rate of the shrinkage hydrogel network. The Korsmeyer-Peppas equation diffusion exponents (n) for SPE release from the hydrogels are >2.063, indicating a super case II transport. These data demonstrate CMC/PVA hydrogels have potential applications in oral peptide delivery.
研究领域:
药学
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材料科学
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生物技术
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药理学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF MATERIALS SCIENCE-MATERIALS IN ELECTRONICS
·
2023
·Vol. 34
·期 20
·1-8
·
IF 2.8
Wang Fenjing,Chen Kejian,Yi Xuran,Shen Yang,Lin Yanni,Zhou Zheqi
Self-healing memristor devices were fabricated in this study using a cost-effective and structurally uncomplicated hydrogel consisting of polyvinylalcohol, sodium alginate, and sodium tetraborate. The device is environmentally friendly, biocompatible, possesses a good switching ratio (~ 50), stable memristor under long time run (> 2000 s), and is able to mimic the learning and forgetting functions. In addition, the device could complete the self-healing process at room temperature to rapidly recover its structure and the memristor function. Therefore, it shows great potential for bioelectronics, data storage, and data encryption.
研究领域:
材料科学
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电子学
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生物电子学
✓ 已验证
产品关联
DOI
高影响因子
LWT-FOOD SCIENCE AND TECHNOLOGY
·
2024
·
IF 6
Xiuying Liu,Binbin Guan,Min Yang,Xinwen Bai,Wei Zhang,Pingping Wang,Zaixi Shu,Yiwei Tang,Lijie Zhu
In this study, a novel intelligent water-absorbent cellulose pad with a specified area was developed for the visual and non-destructive monitoring of fish freshness. The pad's substrate was composed of wood pulp cellulose (WPC), and the specified area contained a ratiometric mixture of brilliant blue (BRI) and alizarin (Alz)., fixed with Polyvinyl alcohol (PVA). During the freshness monitoring process, the Alz/BRI-PVA WPC pad exhibited a color transition from green to brown, followed by a shift to purple-red, corresponding to the increasing levels of total volatile base nitrogen (TVB-N) and total viable count (TVC). After testing, a BRI/Alz ratio of 1:8 was selected as the optimal ratio. Compared to the volatile gas-based sensing tags, the pad developed in this study demonstrated a high sensitivity of 53.4% by interacting with the sample exudate to produce signal changes. This study demonstrates the feasibility of using the developed dual-functional pad for water absorption and freshness indications.
研究领域:
食品科学
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材料科学
·
传感器
✓ 已验证
产品关联
DOI
高影响因子
Acta Biomaterialia
·
2021
·
IF 8.947
Jiaojiao Li,Jihua Wang,Jianye Li,Xin Yang,Jiangling Wan,Chuansheng Zheng,Qing Du,Guofeng Zhou,Xiangliang Yang
Magnetic resonance imaging (MRI) has attracted increasing attention as a feasible alternative or adjunctive imaging modality for X-ray digital subtraction angiography because of the high tissue resolution and non-ionization radiation. In this study, a one-step electrospray method was developed to fabricate PVA microspheres encapsulated with in situ synthesized Fe 3 O 4 nanoparticles . Fe 3 O 4 @PVA microspheres were mono-dispersed black spheres with a wide range of sizes (262–958 µm). The in situ -synthesized Fe 3 O 4 nanoparticles were used as the contrast agent of MRI and the cross-linkers of PVA matrixes for the embolization purpose. In vivo evaluation of renal arteries of normal rabbits showed that Fe 3 O 4 @PVA microspheres had good embolic effect and enhanced capability of MRI. In vitro and in vivo biosafety assessment confirmed that Fe 3 O 4 @PVA microspheres had favorable biocompatibility. The DOX-loaded Fe 3 O 4 @PVA microspheres showed a typical drug-sustained release profile. These results suggest that the prepared DOX-loaded Fe 3 O 4 @PVA microspheres have the function of MRI, embolotherapy and chemotherapy. We expect our study could provide a simple and useful approach for the systematic design , fabrication, and application of a new type of magnetic microspheres as a triple-functional embolic agent for the development of MRI-guided TACE. Statement of significance Due to the low tissue resolution and hazardous ionization radiation of X-ray digital subtraction angiography, it is beneficial to study MR imaging embolic microspheres for the development of MRI-guided TACE. In this study, a one-step electrospray method was firstly developed to fabricate PVA microspheres encapsulated with in situ synthesized Fe 3 O 4 nanoparticles. Then, chemotherapeutic agent (DOX), contrast media of MRI (Fe 3 O 4 ) and embolic agent (PVA matrix) were combined together in one body (DOX-loaded Fe 3 O 4 @PVA microspheres) to achieve the triple effects of chemotherapy, MR imaging and embolization. This triple-functional embolic agent offers potential for the future development of MRI-guided TACE.
研究领域:
材料科学
·
医学影像
·
纳米技术
·
生物医学工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
CARBOHYDRATE POLYMERS
·
2025
·
IF 12.5
Zepeng Liang,Zelin Sang,Yumei Li,Zhenhua Chen,Xifan Mei,Xiuli Ren
Design of tough and functional hydrogel based on carbohydrate polymers is always attracting. Injectable hydrogel based on polyvinyl alcohol (PVA) and sodium alginate (Alg) have great potential for wound repair. However, simple hydrogel lacks functionality, such as antibacterial, which limits its application. Herein, we proposed a strategy of using Ag@MXene nanozyme to functionalize hydrogel and construct a near-infrared laser (NIR) responsive, reactive oxygen species (ROS) generating, and antibacterial platform for wound repair. Epigallocatechin gallate (EGCG) and Ag cluster modified Ti 3 C 2 (E-Ag@Ti 3 C 2 ) was prepared to enhance the performance of injectable PVA-alginate hydrogel (E-Ag@Ti 3 C 2 @H). The functionalized hydrogel presents porous structures (67 % porosity percentage) and excellent compressive and tensile properties (elongation up to 157 %). Under NIR laser irradiation, E-Ag@Ti 3 C 2 @H showed photothermal conversion efficiency and ROS generation ability. The inhibition rate for Methicillin-resistant Staphylococcus aureus (MRSA) and Escherichia coli ( E. coli ) can reach to 91.2 % and 90.3 %, respectively. Molecular biology experiments showed that the composite hydrogel could promote angiogenesis and wound healing by upregulating the expression of anti-inflammatory factors. The obtained injectable E-Ag@Ti 3 C 2 @H hydrogel is potential in accelerating diabetic wound healing.
研究领域:
生物材料学
·
医学工程
·
纳米医学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Nano Energy
·
2022
·
IF 19.069
Jin Yang,Jie An,Yanshuo Sun,Jianjun Zhang,Lulu Zu,Hao Li,Tao Jiang,Baodong Chen,Zhong Lin Wang
Human-machine interaction (HMI) has made great progress in the intelligent medical system, realizing the interaction between patients, medical staff and medical equipment . Here, we report a triboelectric nanogenerator with the flexible-stretchable polyvinyl alcohol/phytic acid (PVA/PA) hydrogel for self-powered HMI sensing in intelligent medical system. Benefiting from effective optimization design of materials, it possesses excellent mechanical and electrical properties, such as over 20,000 cycles durability, transparency, flexibility, and power density up to 1.33 W·m −2 . The device has a linearity of up to 0.949 in the tensile range of 200% and 0.992 in the bending angle range from 30° to 90°, respectively. Through processing and encoding the electrical signals collected by multiple channels in independent or synergistic mode, a self-powered medical nursing HMI system attached to patient fingers was developed to provide real-time help and assistance for both patients and medical staff, which the demand for distress calls can be successfully transmitted with just gently bending fingers in diagnosis. This work exhibits the application value of the self-powered triboelectric sensor to the medical HMI field, and can be extended to other aspects, showing a broad impact in brain computer interface .
研究领域:
生物医学工程
·
材料科学
·
智能医疗
✓ 已验证
DOI
高影响因子
危险品化学品经营许可证（带存储）