JOURNAL OF COLLOID AND INTERFACE SCIENCE
·
2018
·
IF 5.091
Jiande Dong,Meiying Liu,Ruming Jiang,Hongye Huang,Qing Wan,Yuanqing Wen,Jianwen Tian,Yanfeng Dai,Xiaoyong Zhang,Yen Wei
Fluorescent probes have long been regarded as tools for imaging living organisms with advantages such as high sensitivity, good designability and multifunctional potential. Many fluorescent probes, especially the probes based on aggregation-induced emission (AIE) dyes, have received increasing attention since the AIE phenomenon was discovered. These AIE dye-based fluorescent probes could elegantly overcome the notorious quenching effect caused by aggregation of conventional organic dyes. However, it is still difficult to directly apply these AIE-active dyes for biomedical applications owing to their hydrophobic nature. Therefore, the development of novel and facile strategies to endow them with water dispersibility is of critical importance. In this work, we exploit an efficient and simple strategy to fabricate an AIE dye-based fluorescent copolymer through the combination of reversible addition-fragmentation chain transfer and the Biginelli reaction . Moreover, the copolymer can self-assemble to fluorescent polymeric nanoparticles (FPNs) in water solution. Hydrophilic poly(PEGMA- co -AEMA) was reacted with the AIE-active dye 4′,4‴-(1,2-diphenylethene-1,2-diyl)bis([1,1′-biphenyl]-4-carbaldehyde (CHO-TPE-CHO) to form amphiphilic luminescent polymers using urea as the connection bridge. The successful synthesis of the final products (poly(PEGMA- co -AEMA-TPE) FPNs) was confirmed by various instruments. Furthermore, Transmission electron microscopy (TEM) images manifest that poly(PEGMA- co -AEMA-TPE) copolymers will self-assemble into spherical nanoparticles in aqueous environments with sizes between 100 nm and 200 nm. The cell uptake and bioimaging experiment confirm that poly(PEGMA- co -AEMA-TPE) FPNs have excellent biocompatibility and emit strong green fluorescence in a cellular environment. Thus, poly(PEGMA- co -AEMA-TPE) FPNs are excellent candidates for biomedical applications.
研究领域:
材料科学
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生物医学工程
·
化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Small
·
2025
·
IF 12.1
Xu Zhang,Zhujun Wang,Yi Huang,Nicholas Kai Shiang Teo,Yexi Mo,Tina Hsia,Jianjun Guo,Min Shao,Jianzhong Shao,San H. Thang
Liquid Photonic Crystals (LPCs) represent a distinctive category of photonic materials that merges the ordered structure of colloidal photonic crystals with the dynamic nature of liquids, allowing for flexibility in tuning their assembly and optical properties in response to external stimuli. However, the requirement of high solid content and high stability of these LPCs continue to pose a significant challenge in their controlled synthesis, efficient assembly, and system stabilization. Herein, highly charged poly (acrylic acid)- b -polystyrene (PAA- b -PS) colloidal nanospheres are synthesized using RAFT-mediated emulsion polymerization. Under the hydration and electrostatic interactions induced by selected polymeric inducers, PAA- b -PS colloidal nanospheres with a uniform carboxylate anion surface are synthesized, capable of forming iridescent LPCs at an overall low solid content (20 wt%) containing localized areas of high solid content. Furthermore, carboxymethyl cellulose (CMC), one of the polymeric inducers, undergoes photosensitive modification to facilitate the digital light processing (DLP) 3D printed LPCs hydrogel models. This strategy offers innovative approaches for the synthesis, assembly, and 3D-printed LPC materials, promising applications in smart displays, sensory systems, and optical devices.
研究领域:
材料科学
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光学
·
化学工程
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产品关联
DOI
PubMed
高影响因子
BIOSENSORS & BIOELECTRONICS
·
2014
·
IF 6.451
Lijuan Zhao,Faqiong Zhao,Baizhao Zeng
A novel water-compatible fenitrothion imprinted polymer was prepared on Au nanoparticles (AuNPs) by click chemistry and reversible addition–fragmentation chain transfer (RAFT) precipitation polymerization (RAFTPP). The RAFT chain-transfer agent was synthesized on the surface of AuNPs using click chemistry, then an imprinted polymer with hydrophilic polymer brushes was prepared on the RAFT chain-transfer agent modified AuNPs by RAFTPP, mediated by hydrophilic polyethylene glycol macromolecular cochain-transfer agent. The obtained molecularly imprinted material showed improved accessibility to fenitrothion and recognition property in water medium. When the material was immobilized on an ionic liquid functionalized graphene coated glassy carbon electrode for the electrochemical determination of fenitrothion, the resulting electrochemical sensor presented linear response in the range of 0.01−5 μM, with a sensitivity of 6.1 μA/μM mm 2 . The low limit of detection was 8 nM (S/N=3). The sensor was successfully applied to the determination of real samples and the recovery for standard added was 95−108%.
研究领域:
分析化学
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环境科学
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材料科学
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产品关联
DOI
PubMed
高影响因子
Polymer Chemistry
·
2012
·Vol. 4
·期 6
·1815-1825
·
IF 5.321
Jiucun Chen,Mingzhu Liu,Honghong Gong,Guangjun Cui,Shaoyu Lü,Chunmei Gao,Feng Huang,Tongtong Chen,Xinyu Zhang,Zhen Liu
Well-defined linear amphiphilic tetrablock quaterpolymers with dual stimulus response, poly(ethylene glycol)-b-poly(styrene)-b-poly(N-isopropylacrylamide)-b-poly(2-(dimethylamino)ethyl methacrylate) (PEG-b-PS-b-PNIPAM-b-PDMAEMA), were successfully synthesized through the combination of ATRP and RAFT by a click chemistry site transformation approach. Bromine-terminated diblock copolymer PEG-b-PS-Br was first prepared by ATRP of styrene initiated with macro-initiator PEG-Br, which was prepared from the esterification of PEG and 2-bromoisobutyryl bromide. PEG-b-PS-Br can then be converted into the azido-terminated diblock copolymer, PEG-b-PS-N3, by nucleophilic substitutions. Site transformation of PEG-b-PS-N3 into a macro-chain transfer agent (CTA) for RAFT polymerization was accomplished using a copper-catalyzed click chemistry approach. Afterwards, the novel linear tetrablock quaterpolymers, PEG-b-PS-b-PNIPAM-b-PDMAEMA, were synthesized by successive RAFT polymerizations of NIPAM and DMAEMA. The polymerization data indicated that both RAFT processes were well controlled. The structures of the linear amphiphilic tetrablock quaterpolymers and the corresponding precursors were characterized by 1H NMR, FTIR and GPC. Containing thermoresponsive PNIPAM and pH-responsive PDMAEMA blocks, the obtained amphiphilic PEG-b-PS-b-PNIPAM-b-PDMAEMA tetrablock quaterpolymers self-assembled into spherical micelles with hydrophobic PS cores and hydrophilic PEG/PNIPAM/PDMAEMA shells at acidic pH and room temperature but self-assembled into PS/PDMAEMA-core micelles at alkaline pH and room temperature, and PS/PNIPAM-core micelles at acidic pH and elevated temperatures.
研究领域:
高分子化学
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纳米材料
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药物递送
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智能响应材料
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生物医用高分子
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自组装
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聚合物化学
✓ 已验证
DOI
高影响因子
Polymer Chemistry
·
2024
·
IF 4.1
Huangbing Xu,Teng Qiu,Haotian Shi,Xiaoqian Tian,Xiaoyu Li,Longhai Guo
RAFT-mediated polymerization-induced self-assembly (RAFT-PISA) has been undergoing fast development currently, promoting research toward more diverse morphologies and more cutting-edge applications. Herein, we demonstrate a polymerization-pH tailored RAFT-PISA (pH-PISA) process, which can conveniently harvest abundant nano/micro-scale morphologies using popular monomers N,N-dimethylacrylamide (DMAA) and diacetone acrylamide (DAAM). The process proceeded through ordinary RAFT dispersion polymerization in an aqueous medium but under different pH conditions. With the use of pH-sensitive bi-carboxylic acid-capped trithiocarbonate as the chain transfer agent (CTA), it was found that the PISA of propagating amphiphilic ABA triblock copolymers was highly affected by the different ionization of the CTA. When the polymerization pH was adjusted to 2.5, an especially wide spectrum of morphologies was detected, including spheres, worms, lamellae, single or double-head tadpoles, vesicle strings and large spheres with surface protrusions. However, the diversity in morphology gradually declined when the polymerization pH was increased to 6 or 8. Diverse structures with same monomer compositions provide an ideal model to explore the influence of particle morphology on ice recrystallization inhibition (IRI) activities. The variations in mean largest grain sizes (MLGS) and growth rates of a single ice crystal were related to packing parameters (P), bridging the interface geometry of the packing of amphiphilic molecules and ice-controlling activities.
研究领域:
高分子化学
·
材料科学
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胶体与表面化学
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低温生物学
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产品关联
DOI
高影响因子
Polymer Chemistry
·
2018
·Vol. 10
·期 2
·228-234
·
IF 4.927
Chao Chen,Xiaofeng Guo,Jinhong Du,Bonnie Choi,Houliang Tang,Anchao Feng,San H. Thang
Miktoarm star (MAS) polymers are polymers with a number of distinct arms connected to a central core. Owing to their exclusive structure, MAS polymers have been extensively studied in recent years. To exploit their biomedical applications the combination of nucleic acids, peptides and saccharides are desired. In this study, RAFT polymerization of three monomers with markedly different properties, N,N-dimethylaminoethyl methacrylate (DMAEMA, cationic), n-butyl methacrylate (BMA, hydrophobic) and oligo(ethylene glycol) methyl ether methacrylate (OEGMA, hydrophilic) was conducted using an RGD peptide based RAFT agent as a chain transfer agent (RGD-CTA). With a disulphide dimethacrylate (DSDMA) redox-cleavable cross-linker, the above linear polymers were combined via an “arm-first” technique to access MAS polymers containing peptide arms. These MAS polymers showed excellent biocompatibility, cell staining performance and rapid redox responsiveness. The novel MAS polymers have potential as a prospective platform for intracellular drug/gene delivery for cancer therapy.
研究领域:
高分子化学
·
材料科学
·
生物医学工程
·
药学
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF POLYMER SCIENCE
·
2024
·
IF 3.9
Jingwen Yao,Jiaying Tong,Dan Zhao,Dong Chen,Yuhong Ma,Wantai Yang
The reversible addition-fragment chain transfer (RAFT) alternating copolymerization of 2-hydroxyethyl vinyl ether (HEVE) and dimethyl maleate (DMM) is achieved with S -(cyanomethyl) O -ethyl carbonodithioate (CMX) as medaitor and 2,2′-azobis(2-methylpropionitrile) (AIBN) as radical initiator. The effects of monomer concentrations, comonomer feeding ratios, molar ratio of monomer to CMX and solvent on the copolymerization and copolymer structure are systematically investigated. The living feature of the HEVE and DMM copolymerization is demonstrated by the linear increasement of the molecular weights with the monomer conversions, and relatively narrow molecular weight distributions of the copolymers. With dimethyl carbonate as solvent, poly(HEVE- alt -DMM) with M n = 5200 and M w / M n = 1.34 are synthesized at [HEVE]/[DMM]/[CMX]/[AIBN] = 100/100/3/1. The alternating structure of the copolymer is demonstrated by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) and proton nuclear magnetic resonance spectroscopy ( 1 H NMR). The both α, ω-end groups are mainly originated from the moiety of CMX. To further demonstrate the living feature of the alternating copolymerization, chain extension and block copolymerization are also carried out. With poly(HEVE- alt -DMM) as macro-CTA ( M n = 5200, M w / M n = 1.34), the chain-extension reaction has been successfully realized ( M n = 9600, M w / M n = 1.70), and the block copolymer with vinyl neonanoate as monomer also successfully synthesized ( M n = 9800, M w / M n = 1.42). Graphical
研究领域:
高分子化学
·
材料科学
✓ 已验证
DOI
高影响因子
BIOSENSORS & BIOELECTRONICS
·
2018
·
IF 8.173
Jintao Cai,Tao Chen,Yuanhong Xu,Shuang Wei,Weiguo Huang,Rui Liu,Jingquan Liu
Molecularly imprinted technique (MIT) has proven to be a significant tool in the analyzing area in virtue of its obvious advantages such as specific recognition, favorable stability to high temperature and higher sensitivity. Electrochemiluminescence (ECL) technology has also been receiving enormous attention as a powerful tool in sensing fields. However, sensors based on the combination of MIT and ECL technologies have seldom been reported yet. Herein, we find that Ru(bpy) 3 2+ cannot only work as an efficient catalyst for photo-induced electron transfer–reversible addition–fragmentation chain transfer (PET-RAFT) polymerization, but also as a sensing probe for ECL sensor. Based on this, we successfully construct ECL sensors via the combination of MIT and ECL techniques. In details, poly(methacrylic acid) (PMAA) and cross-linked PMAA were synthesized first via a well-controlled PET-RAFT polymerization using Ru(bpy) 3 2+ as catalyst under illumination of visible light with a wavelength of 460 nm, as confirmed by 1 H NMR and gel permeation chromatography (GPC). Then, negatively-charged Au nanoparticles (AuNPs) with average sizes of 20 nm were prepared and modified with Ru(bpy) 3 2+ via electrostatic incorporation. MIPs were prepared on the surface of AuNPs using melamine (MEL) as the template via PET-RAFT controlled cross-linking polymerization. The MIPs modified AuNPs (AuNPs-MIPs) were then fixed on the surface of working electrode with Nafion to achieve a solid-state ECL sensing platform employing Ru(bpy) 3 2+ as the ECL probes. The as-prepared sensor showed a wide detection range of 5.0 × 10 –13 − 5.0 × 10 −6 mol/L and a low detection limit of 1.0 × 10 –13 mol/L (S/N ≥ 3) was reached in the detection of MEL. Moreover, further tests for analyzing MEL structural analogues proved that the constructed ECL sensing platform could be utilized to detect various substances via specific recognitions.
研究领域:
分析化学
·
传感技术
✓ 已验证
产品关联
DOI
PubMed
高影响因子
EUROPEAN POLYMER JOURNAL
·
2020
·
IF 3.862
Zhonghan Feng,Huining Wang,Maosheng Liu,Tao Chen,Yan Liu,Wenying Xu,Haiyan Wang,Jingquan Liu
Despite the fact that mitoxantrone (MTX) is an effective prescription drug for cancer therapy, its poor water solubility is a great challenge that limits its practical applications. Herein, to overcome this shortcoming, a drug/polymer conjugate of MTX with poly (ethyleneglycol) acrylate (PEG-A) (MTX/PPEG-A) was developed via in situ reversible addition-fragmentation chain transfer (RAFT) polymerization. Impressively, the MTX/PPEG-A conjugate shows highly improved water solubility, which is about 550% that of the unmodified MTX. The synthesized MTX/PPEG-A conjugate drug efficacy can be maintained and cytotoxicity reduced slightly compared with the unmodified MTX. In addition, the MTX/PPEG-A can be hydrolyzed by the esterase into pristine MTX with restored drug efficacy in vivo. All in all, the significant improvement of the water solubility and the slightly improved biocompatibility of MTX/PPEG-A will be well-suited for the administration and delivery of anti-cancer drugs in cancer therapy.
研究领域:
药学
·
聚合物化学
·
癌症研究
✓ 已验证
DOI
高影响因子
Science of Advanced Materials
·
2016
·Vol. 8
·期 10
·1901-1907
·
IF 1.812
Yang Zhenglong,Liu Xinyan,Xu Xiaoli,Chen Sai,Li Feng,Zhu Xingyi,Du Yuchuan
The temperature and pH dual-responsive polyhedral oligomeric silsesquioxane/poly[2-(dimethylamino)-ethyl methacrylate]-b-poly(N-isopropylacrylamide) hybrid materials (POSS/PDMAEMA-b-PNIPAM) were synthesized via combination of reversible addition-fragmentation chain
transfer (RAFT) polymerization and thiol-ene "Click Chemistry." Their structures and self-assembly behaviors were characterized by 1HNMR, TEM, UV-vis absorbance and DLS measurements. POSS/PDMAEMA-b-PNIPAM could self-assemble into thermo- and pH-sensitive micelles with the
POSS heads forming as a core and the PDMAEMA-b-PNIPAM chains as a corona. Hydrophobic dyes could be encapsulated in the micelles, so it can be used to absorb dyes. It was found that POSS/PDMAEMA-b-PNIPAM aqueous solution (5 mg/mL, 2 mL) could rapidly remove 98% of methyl red
and 90% of diphenylthiocarbazone in petroleum ether with the initial concentrations of 50 mg/L (2 mL). In view of the good adsorption efficiency of POSS/PDMAEMA-b-PNIPAM hybrid materials, they will be a potential candidate for absorption of organic dyes.
研究领域:
材料科学
·
化学工程
✓ 已验证
DOI
高影响因子
Journal of Inorganic and Organometallic Polymers and Materials
·
2024
·
IF 3.9
Liu Xuemei,Wang Peng,Wan Mengting,Li Songjun,Zhang Yuan
In this study, the photoresponsive monomer of 2-nitrobenzyl methacrylate (NBMA) was introduced into the dispersion polymerization of benzyl methacrylate (BzMA) monomer mediated by poly[ N , N -(dimethylamino) ethyl methacrylate] (PDMAEMA) macro-RAFT agent, and the PDMAEMA- b -P(BzMA- co -NBMA) block copolymer nanoparticles were prepared. The effects of the introduction of NBMA on the polymerization kinetics and the morphology of formed copolymer nanoassemblies were studied in detail. Then, the light response of PDMAEMA- b -P(BzMA- co -NBMA) block copolymer nanoparticles was verified. Moreover, the copolymer nanoparticles after irradiation could be used as the templates for loading silver nanoparticles, and it is proved that the template has advantage of regulating the amount of loaded silver by changing the UV light irradiation time. Graphical Abstract
研究领域:
高分子科学
·
材料科学
·
纳米技术
·
光化学
✓ 已验证
产品关联
DOI
高影响因子
MACROMOLECULAR RESEARCH
·
2019
·Vol. 27
·期 11
·1144-1154
·
IF 1.758
Zhou Jinsheng,Lin Yanming,Ye Lin,Wang Ling,Zhou Li,Hu Huiyuan,Zhang Qilong,Yang Hui,Luo Zhongkuan
To solve the biofouling problem of polyvinyl alcohol (PVA) hydrogel as the artificial cornea, glycidyl methacrylate (GMA) and 2-hydroxypropyltrimethyl ammonium chloride chitosan (HACC) were grafted on the surface of PVA hydrogel via a new method of photoinduced electron transfer—reversible addition fragmentation chain transfer (PET-RAFT) polymerization and ring-open reaction. Both attenuated total reflectance Fourier transform infrared spectroscopy (ATR-FTIR), X-ray photoelectron spectroscopy (XPS), atomic force microscopy (AFM), scanning electron microscope (SEM), and thermogravimetric analysis (TGA) confirmed that GMA and HACC were successfully grafted on the surface of PVA hydrogel. A series of experiments to test the hydrophilicity of PVA hydrogel showed that it became hydrophobic due to the introduction of hydrophobic groups after grafting with GMA and HACC. In addition, cytotoxicity in vitro of PVA-g-p(GMA-HACC) hydrogel could be considered as not cytotoxicity according to ISO 10993-5: 2009. The anti-fouling property of hydrogel decreased after grafting with GMA due to the hydrophobic surface, while increased after grafting with HACC due to the steric repulsion of p(GMA-HACC) polymer brush. It’s no doubt that PET-RAFT was a feasible and reliable surface modification method which could be used in many biomolecules due to the excellent advantages.
研究领域:
生物材料学
·
表面化学
·
医学工程
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）