ACS Applied Materials & Interfaces
·
2021
·
IF 9.229
Dongxu Zhang,Weixuan Dong,Yanhong Liu,Xiaoqing Gu,Tianyu Yang,Qiang Hong,Di Li,Dongqi Zhang,Hongbo Zhou,Hui Huang,Baodong Mao,Zhenhui Kang,Weidong Shi
Photoassisted electrocatalysis (P-EC) emerges as a rising star for hydrogen production by embedding photoactive species in electrocatalysts, for which the interfacial structure design and charge transfer kinetics of the multifunctional catalysts remain a great challenge. Herein, Zn-AgIn5S8 quantum dots (ZAIS QDs) were embedded into 2D NiFe layered double hydroxide nanosheets through a simple hydrothermal treatment to form 0D/2D composite catalysts for P-EC. With evidence from transient photovoltage spectroscopy, we acquired a clear and fundamental understanding on the kinetics of charge extraction time and extraction amount in the 0D/2D heterojunctions that was proved to play a key role in P-EC. Upon light illumination, for HER, the optimized NiFe-ZAIS exhibits obviously reduced overpotentials of 129 and 242 mV at current densities of 10 and 50 mA cm–2, which are 22 and 33 mV lower than those of dark electrocatalysis, respectively. For OER, the NiFe-ZAIS electrode also shows low overpotentials of 220 and 268 mV at current densities of 10 and 50 mA cm–2, respectively, under light illumination, which were able to almost double the intrinsic activity. Finally, with NF@NiFe-ZAIS as both the cathode and the anode, the assembled electrolyzer only requires 1.62 V to reach the overall water splitting current density of 10 mA cm–2 under P-EC. This work provides a useful example for the profound understanding of the design and the kinetics study of multifunctional P-EC catalysts.
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SOLAR ENERGY
·
2021
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IF 5.742
Ting Wang,Jiayong Zhang,Bin Yao,Yongfeng Li,Zhanhui Ding,Chunkai Wang,Jia Liu
Five types of Cu 2 ZnSn(S,Se) 4 (CZTSSe) films were fabricated by selenization of Cu 2 ZnSnS 4 (CZTS) precursor films preparing through Cu-Zn-Sn-S precursor solutions with nominal Cu + /(Cu + +Cu 2+ ) ratio of 0, 0.2, 0.4, 0.8 and 1. Five types of CZTSSe solar cells were prepared by using the five types of CZTSSe films as absorbers, respectively. The crystal quality and phase composition of the CZTS and CZTSSe films were characterized by XRD, Raman and SEM, and the photovoltaic performance for the CZTSSe solar cells were measured by J-V and EQE. It is found that the CZTS film consists of kesterite CZTS when the ratio is 0 and of kesterite CZTS together with a small amount of SnS when the ratio is 0.2 to 1. All of the CZTSSe films are comprised of kesterite CZTSSe and a small amount of Zn(S,Se). The crystal quality and lattice constants of the kesterite CZTSSe increase with increasing the ratio, while the amount of Zn(S,Se) decreases with increasing the ratio and almost to zero as the ratio is 1. The power conversion efficiency ( PCE ) of the CZTSSe solar cells increases from 5.47% to 8.43% as the ratio increases from 0 to 1, which is due to improvement in short-circuit current density ( J sc ) and filling factor ( FF ) and decrease in open circuit voltage deficit ( V oc , def ). The influence mechanism of the ratio on the PCE is suggested by analyzing effect of the ratio on electrical parameters of the CZTSSe solar cells.
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Cell Reports
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2026
·Vol. 45
·期 9
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IF 7.7
Chen Miao,Zhen Wang,Jian Lin,Ziye Zhu,Jinan Wang,Baoen Chen
Mitochondrial redox homeostasis is fundamental for cellular function, and its dysregulation is associated with various diseases, including cancer. Isocitrate dehydrogenase 2 (IDH2) is a key enzyme that maintains this balance by generating NADPH. However, the mechanisms controlling IDH2 subcellular localization remain incompletely understood. Here, we identify reversible S-acylation as a critical regulator of IDH2 localization. Using chemical reporters, we demonstrate that IDH2 is S-acylated at a conserved cysteine residue, mediated by ZDHHC3 and APT1. Loss of IDH2 S-acylation disrupts its mitochondrial localization by reducing its interaction with the mitochondrial import receptor TOMM20, leading to NADPH deficiency, redox imbalance, and impaired oxidative phosphorylation. Consistently, ZDHHC3 knockout phenocopies IDH2 S-acylation deficiency, impairing its mitochondrial localization and function. Genetic ablation of IDH2 S-acylation suppresses tumor growth in vitro and in vivo . Our work establishes dynamic S-acylation of IDH2 as an essential regulator of mitochondrial redox homeostasis, thereby revealing a potential metabolic vulnerability in cancer.
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PubMed
高影响因子
MACROMOLECULES
·
2022
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IF 6.057
Jiangli Li,Shengqi Ji,Xiaoliang Yu,Xiaoyan Yuan,Ke Zhang,Lixia Ren
Magnetic poly(ionic liquid)s (MPILs) with FeCl4– as counterions show phase transition from paramagnetism to ferromagnetism by introducing strong π–π stacking groups. The neighboring Fe(III)–Fe(III) distance and the ordering degree of magnetic ions are crucial for the phase transition. In this work, linear and bottlebrush magnetic polymers are synthesized to study the effect of topological structure on the magnetic property of MPILs. Magnetic studies show that the bottlebrush MPILs are ferromagnetic at low temperature while the linear analogue is paramagnetic. With increasing of the grafting ratio, the phase transition temperature from paramagnetism to ferromagnetism is increased. Compared with linear structure, the bottlebrush polymers show high ordering and crowding of the side chains which are favorable to the ferromagnetic phase transition.
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POLYMER
·
2026
·
IF 5.1
Zhiqi Lin,Wenjie Zhou,Zijian Yang,Chao Chen,Yihan Qiu,Yiyun Cheng,Mingquan Chen,Jingjing Hu
Fungal infections remain a major health burden due to limited treatment options, biofilm-associated tolerance, and increasing emergence of drug-resistant strains. Antifungal polymers have gained growing interest because their molecular structures can be rationally tuned to optimize antifungal activity. Herein, we prepared a series of side-chain-functionalized oligo(α-lipoic acid)s and identified the primary amine-bearing oligomer OLA-EDA as the lead candidate, based on its favorable balance between antifungal activity and cytocompatibility. Mechanistic assays showed that OLA-EDA induced relatively limited fungal membrane depolarization and permeabilization, but markedly increased intracellular reactive oxygen species (ROS) levels. NAC pretreatment partially rescued fungal viability, supporting the involvement of oxidative stress or redox imbalance in the OLA-EDA-mediated antifungal activity. In addition, OLA-EDA inhibited hyphal development and biofilm formation and downregulated related virulence-associated genes. In murine vulvovaginal candidiasis model, OLA-EDA treatment reduced fungal burden and alleviated local inflammation, indicating its potential for topical antifungal therapy.
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Communications Biology
·
2026
·
IF 5.8
Liu Lu,Wang Zhuolin,Xiang Qin,Rong Huan,Xie Chunyang,Tian Rui,Zheng Zeze,Xu Ruqing,Mei Ligang,Song Jiong,Lin Changhai,Yang Feng,Huang Xue,Xiang Tingxiu,Yang Aimin
Protein S -palmitoylation is catalyzed by a family of zinc finger Asp-His-His-Cys (ZDHHC) domain-containing palmitoyl acyltransferases, most of which are widely expressed in normal tissues and aberrantly increased in diverse malignant tumor tissues. However, the mechanisms of action of S -palmitoylation in tumor development are not fully understood. Here we profile interacting proteins of ZDHHC4, a member of the ZDHHC family, and further characterize the immune checkpoint CD276 as a substrate of ZDHHC4. ZDHHC4 mediates S -palmitoylation of CD276 at Cys488 and Cys496, which is reversed by palmitoyl-protein thioesterases (PPT1/2). Consequently, S -palmitoylation enhances the plasma membrane targeting of CD276 and increases its protein stability. Moreover, S -palmitoylation of CD276 promotes breast cancer cell proliferation and migration, and contributes to tumor growth in murine xenograft models. Thus, our study reveals an important molecular mechanism of S -palmitoylation in the regulation of CD276 function, highlighting the therapeutic potential of targeting ZDHHC4-CD276 signaling axis in breast cancer.
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高影响因子
Sensing and Bio-Sensing Research
·
2015
·
IF 0
Ruirui Wang,Qingnan Kong,Jie Zhou,Lili Zhang,Shuhua Zhu
S -Nitrosylation has recently emerged as an important posttranslational modification of proteins and is becoming an intensive field of research in plants. Protein S -nitrosation, a reversible post-translation modification of cysteine, affects many cell signaling pathways and plays critical roles in redox-sensitive cell signaling. Changes in protein function effectively transmit biological signals and thus provide a framework for elucidating signaling networks. This paper presented a new, universal immunosensor for detection of S -nitrosylated proteins. Electrochemical impedance spectroscopy (EIS) and atomic force microscope (AFM) were used to estimate the formation of self-assembled film. This method was based on the specific binding characteristics of biotin–streptavidin, using Biotin-HPDP labeled protein sulfhydryl group as the substrate to detect proteins. The sensor was used to detect bovine serum albumin (BSA), nitrosylated BSA and denitrosylated BSA. The results showed that 90.61% of nitrosylated BSA were reduced, verifying that protein S -nitrosylation is a reversible and effective post-translation modification. This method was successfully applied to detect S -nitrosylated protein in Feicheng peach. The results showed good repeatability and precision. This method provided a molecular basis for further exploring the mechanism of S -nitrosylation of proteins in plants.
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Journal of Materials Chemistry A
·
2025
·
IF 9.5
Han Liu,Jun Zhang,Quanlong Xu,Hong Tao,Tingmin Di,Quanrong Deng,Shenggao Wang
Artificial photosynthesis offers a viable strategy for sustainable and environmentally friendly H2O2 production. However, conventional inorganic semiconductor photocatalysts often face limitations such as restricted light absorption, inadequate redox ability, small specific surface area and poor stability, which greatly restrict their practical applications. Herein, an innovative inorganic/organic S-scheme heterojunction is fabricated by an electrostatic self-assembling method. The optimized BT-12 composite demonstrates a significantly enhanced photocatalytic H2O2 production rate of 723 μmol L−1, surpassing the rates achieved by pure Bi2WO6 and TpPa-Cl-COF by factors of 10 and 2.9, respectively. This improvement can be attributed to the synergistic effects of enhanced light absorption, increased specific surface area, and effective separation of charge carriers and redox active sites, as well as the strong redox ability induced by the S-scheme heterojunction. Density functional theory (DFT) calculations along with X-ray photoelectron spectroscopy (XPS) measurements and electron paramagnetic resonance (EPR) characterization confirm the step-by-step charge transfer pathway. The active species trapping experiments validate that H2O2 is predominantly produced by a two-step one-electron process. This work highlights an innovative and promising strategy for constructing a highly efficient photocatalytic system based on inorganic/organic heterojunctions.
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ACS Applied Nano Materials
·
2024
·
IF 5.3
Jun Xiu Chen,Agul Bao,Dalai Siqin
In this study, we prepared N/S-codoped porous carbon materials via a one-step doping method using lignin as the carbon source, thiourea as the N and S source, and KOH as the activator. The synthesized material exhibited a rich N content and a certain S content. The important reason the CO2 adsorption characteristic of the carbon materials were investigated by modulating the thiourea proportion and doping temperature. Results indicate that at a thiourea ratio of 1:4 and a doping temperature of 700 °C, the material exhibited an outstanding CO2 adsorption capacity of 3.49 mmol/g. Various characterizations revealed that such a high adsorption capacity is attributed to the combination of a microporous structure and excellent surface chemical properties. The doping of S atoms resulted in the formation of effective active sites, increased the defect density of the material, and promoted the generation of N functional groups, thereby enhancing the efficiency of CO2 adsorption. In addition, the material exhibits high CO2/N2 selectivity and cycling stability. The overall results indicate that lignin-derived N/S-codoped porous carbon can serve as a potential adsorbent for CO2 capture.
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高影响因子
SEPARATION AND PURIFICATION TECHNOLOGY
·
2022
·
IF 9.136
Ziwei Zhao,Qi Ling,Ziliang Li,Kui Yan,Chunsheng Ding,Peng Chen,Lei Yang,Zhaoqi Sun,Miao Zhang
The combination of light energy and mechanical energy is thought to be an effective way to manage environmental resources and create sustainable energy. In this study, thin-film catalysts compounded with photocatalytic material TiO 2 and piezoelectric material BaTiO 3 were successfully prepared by a simple hydrothermal method on glass sheets, avoiding the possibility of secondary contamination of powder catalysts. The synergistic effect of light and ultrasound enhanced the degradation of norfloxacin by heterojunction BaTiO 3 /TiO 2 . After 60 min, the norfloxacin degradation was 91.7 % complete, with a rate constant of 43 × 10 −3 min −1 . This rate constant was 2.69 times higher than the rate constant for TiO 2 at 16 × 10 −3 min −1 . The built-in electric field generated by ultrasound is thought to improve the catalytic and optoelectronic properties of the composite by separating photogenerated electrons and holes. In addition, the stability and general usability of the composites were investigated. The effects of norfloxacin concentration, solution pH, and anions on the experiments were also analyzed. Free radical trapping experiments were conducted on the composites to identify the active species. The results showed that h + and ·OH were the main active species. In addition, it was determined that S-Scheme heterojunctions were likely involved in the catalytic process.
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DYES AND PIGMENTS
·
2022
·
IF 5.122
Yuewei Zhang,Xuchao Jin,Weiran Zhang,Chang Gu,Xuesong Liu,Yu-Mo Zhang
A bistable electrochromic device based on poly(viologen)s is demonstrated with good overall performance, including bistability (4981 s), switch-on voltage (−1.0 V) and reversibility (≥1000 cycles). Overall, these results imply that the control of the diffusivity of viologens is an effective methodology for achieving excellent bistability and low energy consumption.
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高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2021
·
IF 13.273
Pengfei Sang,Jiahan Song,Wei Guo,Yongzhu Fu
Organosulfur polymers are a unique class of cathode materials for rechargeable lithium batteries. They are abundant, rich in structure, and easy for synthesis. Here, we report a new class of organosulfur polymers synthesized by condensation reactions between 1,3,5-benzenetrithiol (BTT) and elemental sulfur with three different molar ratios ( i.e. , 1:1.5, 1:3.0, and 1:4.5) in carbon disulfide solution without heating and additional catalyst. Removal of H 2 S leads to the linkage of S-S bonds, forming hyperbranched polymers. When the BTT: sulfur molar ratio is 1:4.5, the polymer has a high theoretical specific capacity of 901.7 mAh g −1 . We have studied their structures and compositions through a series of material characterizations, and conducted an in-depth discussion on their electrochemical behavior in rechargeable lithium batteries. Excellent cycling performance of these materials shows great potential for practical application.
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高影响因子
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