Asian Journal of Pharmaceutical Sciences
·
2022
·
IF 9.273
Yanjuan Huang,Tao Zhang,Qin Wei,Zishan Zeng,Yujun Gong,Xiaoyu Xu,Meixu Chen,Chunshun Zhao
Posterior capsular opacification (PCO) is the leading cause of vision loss after cataract, mainly caused by the adhesion, proliferation and trans-differentiation of post-operative residual lens epithelial cells (LECs). Effective PCO prevention remains a huge challenge to ophthalmologists and researches for decades. Herein, we developed a “NIR-triggered ROS storage” intraocular implant (CTR-Py-PpIX) based on capsular tension ring (CTR), which is concurrently linked with photosensitizer protophorphyrin IX (PpIX) and energy storage 2-pyridone derivative (Py), to guarantee instantaneous and sustainable ROS generation for LECs killing, aiming to achieve more efficient and safer photodynamic therapy (PDT) to effectively prevent PCO. The silylated PpIX-Si and Py-Si were covalently conjugated to the plasma activated CTR surface to obtain CTR-Py-PpIX. Results demonstrated that CTR-Py-PpIX had dual functions of PDT and battery, in which PpIX could generate ROS extracellularly under irradiation, with one part directly inhibiting LECs by lipid peroxidation (LPO) induction of cell membranes. Meanwhile, the excess ROS stored in Py could be continuously released to amplify LPO levels after the irradiation was removed. Ultimately, the proliferation of LECs in capsular bag was completely inhibited under mild irradiation conditions, achieving a sustainable and controlled PDT effect for effective PCO prevention with good biocompatibility. This NIR-triggered ROS storage intraocular implant would provide a more efficient and safer approach for long-term PCO prevention.
研究领域:
眼科学
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光动力疗法
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生物医学工程
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材料科学
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DOI
PubMed
高影响因子
ACS Applied Materials & Interfaces
·
2017
·
IF 7.504
Xiaojun Cai,Haofang Zhu,Yanmei Zhang,Zhongwei Gu
RNA interference (RNAi) has a great promise in treating various acquired and hereditary diseases. However, it remains highly desirable to develop new delivery system to circumvent complex extra- and intracellular barriers for successful clinical translation. Here, we report on a versatile polymeric vector, bioreducible fluorinated peptide dendrimers (BFPD), for efficient and safe small interfering RNA (siRNA) delivery. In virtue of skillfully integrating all of the unique advantages of reversible cross-linking, fluorination, and peptide dendrimers, this novel vector can surmount almost all extra- and intracellular barriers associated with local siRNA delivery through highly improved physiological stability and serum resistance, significantly increased intratumoral enrichment, cellular internalization, successful facilitation of endosomal escape, and cytosolic siRNA release. BFPD polyplexes, carrying small interfering vascular endothelial growth factor (siVEGF), demonstrated excellent VEGF silencing efficacy (∼65%) and a strong capability for inhibiting HeLa cell proliferation. More importantly, these polyplexes showed superior performance in long-term enrichment in the tumor sites and had a high level of tumor growth inhibition. Furthermore, these polyplexes not only exhibited excellent in vivo antitumor efficacy but also demonstrated superior biocompatibility, compared with LPF2000, both in vivo and in vitro. These findings indicate that BFPD is an efficient and safe siRNA delivery system and has remarkable potential for RNAi-based cancer treatment.
研究领域:
药剂学
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分子生物学
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癌症研究
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纳米医学
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DOI
PubMed
高影响因子
ACS Applied Materials & Interfaces
·
2018
·
IF 8.097
Xiangzhen Zhu,Qingfeng Fu,Lingfei Tang,Chunfu Lin,Jian Xu,Guisheng Liang,Renjie Li,Lijie Luo,Yongjun Chen
M–Nb–O compounds are advanced anode materials for lithium-ion batteries (LIBs) due to their high specific capacities, safe operating potentials, and high cycling stability. Nevertheless, the found M–Nb–O anode materials are very limited. Here, Mg2Nb34O87 is developed as a new M–Nb–O material. Mg2Nb34O87 porous microspheres (Mg2Nb34O87-P) with primary-particle sizes of 30–100 nm are fabricated based on a solvothermal method. Mg2Nb34O87 has an open 3 × 4 × ∞ Wadsley–Roth shear structure and a large unit-cell volume, leading to its largest Li+ diffusion coefficients among all the developed M–Nb–O anode materials. In situ X-ray diffraction analyses reveal its high structural stability and intercalating characteristic. These architectural, conductivity, and structural advantages in Mg2Nb34O87-P lead to its most significant intercalation pseudocapacitive contribution (87.7% at 1.1 mV s–1) among the existing M–Nb–O anode materials and prominent rate capability (high reversible capacities of 338 mAh g–1 at 0.1C and 230 mAh g–1 at 10C). Additionally, this new material exhibits a safe operating potential (∼1.68 V), an ultrahigh initial Coulombic efficiency (94.8%), and an outstanding cycling stability (only 6.9% capacity loss at 10C over 500 cycles). All of these evidences indicate that Mg2Nb34O87-P is an ideal anode material for high-energy, safe, fast-charging, and stable LIBs.
研究领域:
材料科学
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电化学
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DOI
PubMed
高影响因子
Sustainable Energy & Fuels
·
2022
·Vol. 6
·期 5
·1281-1288
·
IF 6.813
Xiaofei Wang,Wenjun He,Haoliang Xue,Daoming Zhang,Jin Wang,Lina Wang,Jun Li
Lithium (Li) metal batteries (LMBs) have been considered as promising candidates for next-generation energy storage devices due to the tremendous advantages of Li-metal anodes. However, poor cycling stability and severe safety issues impede the practical application of LMBs. Herein, a nonflammable phosphate-based localized high-concentration electrolyte composed of lithium difluoro(oxalato)borate/dimethyl methyl phosphonate/1,1,2,2-tetrafluoroethyl-2,2,3,3-tetrafluoropropylether (LiDFOB–DMMP/HFE) is proposed to improve the safety and reversibility of high-voltage LMBs simultaneously. Replacing highly flammable conventional solvents in the electrolyte with flame-retardant DMMP greatly reduces the fire risks of the electrolyte. The dominant reduction of DFOB− anions induces a robust and LiF-rich solid-electrolyte interphase on the Li-metal anode, stabilizing the Li metal/electrolyte interface and leading to dendrite-free Li deposition. An effective cathode electrolyte interphase is generated as well to inhibit structural degradation and transition-metal dissolution of the high-voltage LiNi6Mn2Co2O2 (NMC622) cathode. Moreover, the electrolyte displays a high oxidative stability potential of >5.0 V. Thus, the Li‖NMC622 battery using LiDFOB–DMMP/HFE electrolyte exhibits a superior cyclability with no capacity loss and a high average coulombic efficiency of 99.6% over 100 cycles under a high cutoff voltage of 4.5 V. This emerging electrolyte offers great potential to realize the stable cycling of high-voltage LMBs with fine safety for future applications.
研究领域:
材料科学
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电化学
·
能源存储技术
✓ 已验证
DOI
高影响因子
Scientific Reports
·
2015
·Vol. 5
·期 1
·1-10
·
IF 5.578
Wen Wei,Wu Jin-ming,Jiang Yin-zhu,Yu Sheng-lan,Bai Jun-qiang,Cao Min-hua,Cui Jie
Lithium-ion batteries (LIBs) are promising energy storage devices for portable electronics, electric vehicles and power-grid applications. It is highly desirable yet challenging to develop a simple and scalable method for constructions of sustainable materials for fast and safe LIBs. Herein, we exploit a novel and scalable route to synthesize ultrathin nanobelts of anatase TiO 2 , which is resource abundant and is eligible for safe anodes in LIBs. The achieved ultrathin nanobelts demonstrate outstanding performances for lithium storage because of the unique nanoarchitecture and appropriate composition. Unlike conventional alkali-hydrothermal approaches to hydrogen titanates, the present room temperature alkaline-free wet chemistry strategy guarantees the ultrathin thickness for the resultant titanate nanobelts. The anatase TiO 2 ultrathin nanobelts were achieved simply by a subsequent calcination in air. The synthesis route is convenient for metal decoration and also for fabricating thin films of one/three dimensional arrays on various substrates at low temperatures, in absence of any seed layers.
研究领域:
材料科学
·
能源存储
✓ 已验证
DOI
PubMed
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2018
·
IF 3.909
Yilin Wang,Xuelian Huang,Chao He,Yupei Li,Weifeng Zhao,Changsheng Zhao
Safe and efficient carboxymethyl chitosan (CMC)-based heparin-mimicking cross-linked beads (CMC/PAMPS) as adsorbents for the clearance of low-density lipoprotein-cholesterol (LDL-c) in blood purification were prepared through hydrogen bonding interactions followed with in situ cross-linking with 2-acrylamido-2-methyl-1-propanesulfonicacid (AMPS). Fourier transform infrared spectra (FTIR), two-dimensional correlation FTIR spectroscopy (2D IR), thermal gravimetric analysis (TGA) and energy dispersive X-ray spectrometer (EDS) demonstrated the successful synthesis of CMC/PAMPS beads. The porous structures of the beads may contribute to the adsorption of toxins. Owing to their favorable hydrophilicity, when contacted with blood, the beads showed excellent hemocompatibility. The hemolysis ratios for all the beads were less than 5%, the thromboplastin time of CMC/PAMPS 10 beads exceed 600 s, and they can suppress contact activation and complement activation effectively. Additionally, the beads have no obvious cytotoxicity with endothelial cells, thus could be used as a safe adsorbent for blood purification. Moreover, the CMC/PAMPS 10 beads possessed a LDL-c adsorption capacity of 24.8 mg/g under static adsorption and a LDL-c adsorption capacity of 8.2 mg/g in the simulation of hemoperfusion for whole blood, due to the large surface areas and high density of functional groups. Meanwhile, the concentration of high-density lipoprotein-cholesterol (HDL-c) was almost unaffected. In general, the safe adsorbent with high LDL-c adsorption capacity has great potentials for hemoperfusion and other clinical applications.
研究领域:
生物材料学
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医学工程
·
分子生物学
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DOI
PubMed
高影响因子
ACS Applied Materials & Interfaces
·
2021
·
IF 9.229
Xingyu Hu,Li Xie,Zhaoyu Xu,Suru Liu,Xinzhi Tan,Ruojing Qian,Ruitao Zhang,Mingyan Jiang,Wenjia Xie,Weidong Tian
The growing demand for charming smiles has led to the popularization of tooth bleaching procedures. Current tooth bleaching products with high-concentration hydrogen peroxide (HP, 30–40%) are effective but detrimental due to the increased risk of enamel destruction, tooth sensitivity, and gingival irritation. Herein, we reported a less-destructive and efficient tooth whitening strategy with a low-concentration HP, which was realized by the remarkably enhanced Fenton-like catalytic activity of oxygen-deficient TiO2 (TiO2–x). TiO2–x nanoparticles were synthesized with a modified solid-state chemical reduction approach with NaBH4. The Fenton-like activity of TiO2–x was optimized by manipulating oxygen vacancy (OV) concentration and further promoted by the near-infrared (NIR)-induced photothermal effect of TiO2–x. The TiO2–x sample named BT45 was chosen due to the highest methylene blue (MB) adsorption ability and Fenton-like activity among acquired samples. The photothermal property of BT45 under 808 nm NIR irradiation was verified and its enhancement on Fenton-like activity was also studied. The BT45/HP + NIR group performed significantly better in tooth whitening than the HP + NIR group on various discolored teeth (stained by Orange II, tea, or rhodamine B). Excitingly, the same tooth whitening performance as the Opalescence Boost, a tooth bleaching product containing 40% HP, was obtained by a self-produced bleaching gel based on this novel system containing 12% HP. Besides, negligible enamel destruction, safe temperature range, and good cytocompatibility of TiO2–x nanoparticles also demonstrated the safety of this tooth bleaching strategy. This work indicated that the photothermal-enhanced Fenton-like performance of the TiO2–x-based system is highly promising in tooth bleaching application and can also be extended to other biomedical applications.
研究领域:
牙科材料
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催化
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纳米技术
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生物医学工程
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材料科学
✓ 已验证
DOI
PubMed
高影响因子
CARBOHYDRATE POLYMERS
·
2024
·
IF 10.7
Penghui Wang,Ruixue Li,Juping Ma,Wenjie Zhang,Haifeng Shen,Yanhan Ren,Xun Zhang,Shuang Li,Bo Chi
Traditional submucosal filling materials frequently show insufficient lifting height and duration during clinical procedures. Here, the anionic polysaccharide polymer sodium carboxymethyl starch and cationic Laponite to prepare a hydrogel with excellent shear-thinning ability through physical cross-linking, so that it can achieve continuous improvement of the mucosal cushion through endoscopic injection. The results showed that the hydrogel (56.54 kPa) had a lower injection pressure compared to MucoUp (68.56 kPa). The height of submucosal lifting height produced by hydrogel was higher than MucoUp, and the height maintenance ability after 2 h was 3.20 times that of MucoUp. At the same time, the hydrogel also showed satisfactory degradability and biosafety, completely degrading within 200 h. The hemolysis rate is as low as 0.76 %, and the cell survival rate > 80 %. Subcutaneous implantation experiments confirmed that the hydrogel showed no obvious systemic toxicity. Animal experiments clearly demonstrated the in vivo feasibility of using hydrogels for submucosal uplift. Furthermore, successful endoscopic submucosal dissection was executed on a live pig stomach, affirming the capacity of hydrogel to safely and effectively facilitate submucosal dissection and mitigate adverse events, such as bleeding. These results indicate that shear-thinning hydrogels have a wide range applications as submucosal injection materials.
研究领域:
生物医学工程
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材料科学
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胃肠病学
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生物相容性
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产品关联
DOI
PubMed
高影响因子
JOURNAL OF MEMBRANE SCIENCE
·
2024
·
IF 8.4
Mohammed Kamal Hadi,Xiangya Wang,Meimei Yu,Manasa Pantrangi,Zhijiang Sun,Fen Ran
Blood biocompatibility and permeability are major challenges that limit the wide implementation of polyethersulfone membranes for hemodialysis and bio-related applications. In this regard, polyethersulfone's surface modification is a commonly used strategy to improve permeability/selectivity, prevent protein-based fouling, and suppress the inflammation of the immune response. As a new approach to enhancing blood biocompatibility, this paper reports a feasible and effective method for the synthesis of heparin-like structures by modifying the polysaccharide guar gum macromolecule with magnetic nanoparticles and metanilic acid. The prepared magnetic, sulphated polysaccharide was blended with polyethersulfone to obtain a hydrophilic and biocompatible membrane surface. The modified membranes show an improved permeability of 144 L m −2 h −1 bar −1 . A comprehensive and in-depth analysis of the protein adsorption on the membrane surface is also conducted. Blood compatibility tests reveal that the polyethersulfone-modified membrane demonstrates a low hemolysis rate, prolonged activated partial thromboplastin time, and low platelet adhesion. It is also performed simulation studies based on molecular docking between different guar gum-modified structures and each of human serum albumin and immunoglobulin. Accordingly, the docking results are in line with the practically obtained biocompatibility analyses. Through the obtained results, this study uniquely affirms that the modification of polyethersulfone membranes with magnetic and negatively charged guar gum has promising potential for effective usage in bio-related applications.
研究领域:
材料科学
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生物医学工程
✓ 已验证
产品关联
DOI
高影响因子
ACS Sustainable Chemistry & Engineering
·
2024
·
IF 7.1
Yaning Wang,Ruimin Xie,Jielin Xu,Zhenguang Li,Mingfa Guo,Fenghuan Yang,Jing Wu,Huaping Wang
Bisphenol-A polycarbonate (BPA-PC) has been widely used, but it has been restricted from use in several food-contact products due to the estrogen-like and antiandrogen effects of BPA. With the aim of developing novel, biobased, and ecologically safe high-performance polycarbonates with the potential to replace BPA-PC, in this work, a series of novel biobased copolycarbonates, viz., poly(isosorbide carbonate-co-isoidide-2,5-dimethylene carbonate) (PIsIeC), were designed and successfully synthesized via melt polymerization. The combination of two isohexide building blocks, the highly rigid isosorbide (IS) and the semirigid isoidide-2,5-dimethanol (IIDML), afforded an optimal candidate (PIsIeC-39) with a nice balance of high Tg (120.5 °C), high tensile strength (72.6 MPa), and also a high elongation at break (75.2%), which are comparable or even surpass the properties of BPA-PC and a few oil-based commercial benchmarks. The SEC/viscosity results and also a DFT simulation jointly revealed that the molecular weights of these copolycarbonates were significantly enhanced when using the two isohexide building blocks together due to a possible autocatalytic effect induced by the hydrogen bonding between IIDML and IS. These polymers were obtained with number-average molecular weights of 27,300–113,200 g/mol and intrinsic viscosities of 54–83 mL/g, which are also comparable to those of BPA-PC. Meanwhile, all copolycarbonates have good transparency similar to BPA-PC and also exhibit similar γ-relaxation and higher biobased content (72–84%). These biobased copolycarbonates with superior thermal and mechanical properties have high potential to be an ecologically safe alternative for BPA-PC.
研究领域:
材料科学
·
环境科学
·
化学工程
✓ 已验证
产品关联
DOI
高影响因子
INTERNATIONAL JOURNAL OF PHARMACEUTICS
·
2026
·
IF 6
Xu Zhang,Lei Wang,Xutang Tao,Huimin Li,Yaqian Qu,Peizhuo Han,Weiguo Song
Polymorphism, a common phenomenon in solid-state drugs, poses significant challenges to clinical drug application while offering valuable opportunities for formulation alternatives. Metastable forms generally exhibit higher solubility and dissolution rates than their stable forms, making them attractive candidates for active pharmaceutical ingredients (APIs). However, the use of metastable forms may result in polymorphic transformation during manufacture and storage, which diminishes their bioavailability. Thus, improving the stability of metastable forms has emerged as a key challenge in expanding pharmaceutical applications. In this study, Baricitinib (BRT) was selected as a model drug. Its metastable Form II with higher solubility and dissolution rates could easily undergo rapid conversion to the stable Form I in solution. Previous studies have shown that introducing organic small-molecule additives can effectively inhibit polymorphic transformation. We found that saccharin (SAC) and L-malic acid (MA), both of which are Generally Recognized as Safe (GRAS) food additives, effectively suppressed the phase transformation from BRT Form II to Form I, whereas citric acid (CA) showed a negligible effect on the transformation process. Our study elucidates the multifunctional mechanisms and demonstrates a safe, practical strategy for stabilizing metastable crystal forms, thereby paving the way for their industrial application.
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产品关联
DOI
PubMed
高影响因子
COMPOSITES PART A-APPLIED SCIENCE AND MANUFACTURING
·
2026
·
IF 8.2
Na He,Shaoming Zheng,Panpan Gong,Luyao Lei,Jinhan Lu,Kaiyuan Li,Fei Xiao
The development of sustainable, multifunctional flame retardants that do not compromise the inherent mechanical properties of polymers remains a formidable challenge. Herein, we report a novel guest–host architecture engineered by encapsulating a flame retardant (PCU) within a bio-derived metal–organic framework (Bio-MOF) to fabricate robust, fire-safe thermoplastic polyurethanes (TPU). The resultant PCU@BioMOF nanocomposite exhibits exceptional fire retardancy at a low loading of 6 wt%, achieving a UL-94 V-0 rating, a limiting oxygen index (LOI) of 28%, and remarkable reductions in peak heat release rate (62.3%) and total heat release (51.1%).Mechanistically, this molecular confinement promotes synergistic gas- and condensed-phase interactions, facilitating robust char formation to extinguish combustion and drastically suppress smoke production (38.6% reduction). Crucially, bypassing the traditional trade-off between fire safety and mechanical performance, the PCU@BioMOF acts as a multifunctional nano-reinforcement. It simultaneously enhances the tensile strength of the TPU by 16.2% (at 2 wt% loading) while imparting excellent UV-shielding capabilities. This molecular encapsulation strategy provides a highly efficient, sustainable platform for designing next-generation, multifunctional polymer nanocomposites.
✓ 已验证
DOI
高影响因子
危险品化学品经营许可证（带存储）