Food Bioscience
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2025
·
IF 5.9
Zhe Xu,Jiale Chang,Zijin Qin,Hanxiong Liu,Xu Yan,Shuang Guan,Xiufang Dong,Jianping Wu,Tingting Li
The effective modulation of pancreatic lipase activities is critical in maintaining blood triglycerides and cholesterol levels within normal physiological ranges. This study investigated the inhibitory effect of peptides from sea cucumber collagen on pancreatic lipase activity through interaction with the Ca-binding sites on the enzyme. Among the five sea cucumber collagen digests (SCCD), the pepsin-digested 2h+trypsin-digested 3h digest (SDP2h+T3h) showed the strongest inhibitory effect on pancreatic lipase. A peptide RDDPEPSYK (RDD), with a sequence of Arg-Asp-Asp-Pro-Glu-Pro-Ser-Tyr-Lys from SDP2h+T3h, was found to target the Ca-binding site of pancreatic lipase, interacting with certain residues including Asp184, Glu187, Lys163, etc. Additionally, a cell study on 3T3-L1 preadipocytes indicated RDD's capability to inhibit adipocyte differentiation, as well as decrease intracellular triglycerides, total cholesterol, and lipid content. The results from this study suggest that RDD is a targeted pancreatic lipase inhibitor with potential applications for obesity control.
研究领域:
生物化学
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药理学
·
营养科学
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高影响因子
ENVIRONMENTAL RESEARCH
·
2025
·
IF 7.7
Li-Xin Kou,Xiao-Yu Zhang,Zi-Cen Zuo,Na Liu,Zhen He,Gui-Peng Yang
Polyhalogenated carbazoles (PHCZs), an emerging class of halogenated organic pollutants, have been widely detected in various environmental media, including sediments, soil, air, and organisms. The East China Sea (ECS) is a vital region for marine and fishery resource development in China, yet research on the pollution levels and sources of PHCZs in its sediments remains limited. This study reports the occurrence of seven PHCZs in the surface sediments of the ECS, with detection rates exceeding 90%. The concentrations of Σ 7 PHCZs ranged from 3.5 to 27 ng/g, with an average of 9.9 ng/g. The predominant congeners were 1368-BCZ and 3-ICZ. The sources of PHCZs included a non-specific source transported via terrestrial runoff (39%), industrial wastewater discharge (35%), and optoelectronic material pollution (26%), as identified by the positive matrix factorization model. The ecological risk assessment, based on TEQ, indicated a range of 0.18–5.0 pg TEQ/g across the study area. These findings highlight the potential ecological concerns associated with PHCZs in the ECS and emphasize the need for enhanced environmental monitoring and source mitigation efforts to reduce their potential environmental impacts.
研究领域:
环境科学
·
海洋学
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PubMed
高影响因子
JOURNAL OF HAZARDOUS MATERIALS
·
2024
·
IF 12.2
Jing Gong,Yanlong Chen,Wenwei A.,Xingyuan Zhang,Juanqiong Ma,Zhiyong Xie,Pei Li,Aihua Huang,Shusheng Zhang,Qiongfeng Liao
Persistent organic pollutants (POPs), such as perfluoroalkyl and polyfluoroalkyl substances (PFASs), polychlorinated biphenyls (PCBs), and bisphenols (BPs), have been raising global concerns due to their toxic effects on environment and human health. The monitoring of residues of POPs in seafood is crucial for assessing the accumulation of these contaminants in the study area and mitigating potential risks to human health. However, the diversity and complexity of POPs in seafood present significant challenges for their simultaneous detection. Here, a novel multi-component fluoro-functionalized covalent organic framework (OH-F-COF) was designed as SPE adsorbent for simultaneous extraction POPs. On this basis, the recognition and adsorption mechanisms were investigated by molecular simulation. Due to multiple interactions and large specific surface area , OH-F-COF displayed satisfactory coextraction performance for PFASs, PCBs, and BPs. Under optimized conditions, the OH-F-COF sorbent was employed in a strategy of simultaneous extraction and stepwise elution (SESE), in combination with HPLC−MS/MS and GC−MS method, to effectively determined POPs in seafood collected from coastal areas of China. The method obtained low detection limits for BPs (0.0037 −0.0089 ng/g), PFASs (0.0038 −0.0207 ng/g), and PCBs (0.2308 −0.2499 ng/g), respectively. This approach provided new research ideas for analyzing and controlling multitarget POPs in seafood. Environmental implications Persistent organic pollutants (POPs), such as perfluoroalkyl and polyfluoroalkyl substances (PFASs), polychlorinated biphenyls (PCBs), and bisphenols (BPs), have caused serious hazards to human health and ecosystems. Hence, there is a need to develop a quantitative method that can rapidly detect POPs in environmental and food samples. Herein, a novel multi-component fluorine-functionalized covalent organic skeletons (OH-F-COF) were prepared at room temperature , and served as adsorbent for POPs. The SESE-SPE strategy combined with chromatographic techniques was used to achieve a rapid detection of POPs in sea foods from the coastal provinces of China. This method provides a valuable tool for analyzing POPs in environmental and food samples.
研究领域:
环境科学
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分析化学
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食品安全
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PubMed
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SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
·
2023
·
IF 4.4
Xin Lin,Li-Jun Li,He-Yuan-Xi Guo,Rui Li,Jun Feng
In this paper, 3D nano-silver trees/sea urchin-like gold Surface Enhanced Raman Spectroscopy (SERS) substrates were prepared by chemical reduction method, characterized by SEM, EDS, UV–Vis and XRD et.al, and the preparation process was optimized using Rhodamine B (RB) as the Raman signal molecule. The SERS characteristics of Uric Acid on this substrate were investigated and the results showed that the SERS substrate had a Raman enhancement factor of 1.9 × 10 7 for RB, and also had a significant Raman enhancement effect on Uric Acid. The SERS intensity ( I SERS ) at 1400 cm −1 showed a good linear relationship with the logarithm value of uric acid concentration (log C ) between the range of 5 × 10 −4 M to 1 × 10 −7 M. The linear fitting equation was I SERS = 890 (log C ) + 8066 (R 2 = 0.983), and the LOD = 2.8 × 10 − 8 M. The spiked test was performed in human serum with recoveries ranging from 82.86% to 125.13% and RSD (n = 3) < 3.5%.
研究领域:
分析化学
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材料科学
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医学诊断
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DOI
高影响因子
Journal of Functional Foods
·
2026
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IF 3.9
Jieqiong Lin,Ting Lu,Dahua Chen,Zhonghua Wang,Jun Zhou,Jiaojiao Han
Ulcerative colitis (UC) is a chronic inflammatory bowel disease with limited therapeutic options. This study investigates the protective effects of bioactive peptides derived from sea anemone (ACPs), prepared by enzymatic hydrolysis, in a dextran sulfate sodium (DSS)-induced murine model of UC. Notably, the peptide ERRK was identified as a dominant component of the ACPs mixture. Remarkably, low-dose ACPs (200 mg/kg) demonstrated superior efficacy over higher doses in ameliorating disease severity, as evidenced by reduced disease activity index (DAI) scores, increased colon length, and improved histopathology. ACPs significantly downregulated pro-inflammatory cytokines (TNF-α, IL-1β, IL-6) and upregulated anti-inflammatory cytokines (TGF-β, IL-10), while restoring intestinal barrier integrity via increased expression of tight junction proteins (ZO-1, Occludin, Claudin-1). Multi-omics analyses revealed that ACPs remodeled gut microbiota composition, enriched beneficial genera ( Muribaculum , Prevotella ), and modulated host serum metabolites, particularly pathways related to butyrate and tryptophan metabolism. These findings underscore the potential of ACPs, especially at low doses, as a novel functional food for UC management through integrated modulation of the gut microbiota-metabolite-immune axis.
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Journal of Materials Chemistry A
·
2019
·Vol. 7
·期 7
·3190-3196
·
IF 10.733
Rajaiah Dhilip Kumar,Ziqiang Wang,Chunjie Li,Alam Venugopal Narendra Kumar,Hairong Xue,You Xu,Xiaonian Li,Liang Wang,Hongjing Wang
Shape-controlled fabrication of metallic nanostructures is vital for the development of highly efficient catalysts for electrochemical synthesis of ammonia. Herein, we present a facile one-pot reduction method for the fabrication of trimetallic PdCuIr with long-spined sea-urchin-like morphology (PdCuIr-LS) in an aqueous solution. The PdCuIr-LS assembled with nanothorns as building blocks possesses highly branched and self-supported nanostructures. Benefiting from its hyperbranched structure and trimetallic composition, the PdCuIr-LS exhibits superior catalytic activity for the nitrogen reduction reaction with a high NH3 yield (13.43 μg h−1 mgcat.−1) and faradaic efficiency (5.29%) in 0.1 M Na2SO4. Compared with the traditional multistep approaches, the proposed one-pot synthetic route is more facile to prepare multimetallic Pd-based catalysts with highly branched morphology and desired compositions for electrocatalytic nitrogen reduction to ammonia.
研究领域:
材料科学
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电化学
·
催化反应
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高影响因子
CHIRALITY
·
2018
·Vol. 30
·期 8
·1027-1035
·
IF 1.833
Yilong Wang,Yongkai Xu,Yun Zhang,Aijun Sun,Yunfeng Hu
We previously identified and characterized 1 novel deep-sea microbial esterase PHE21 and used PHE21 as a green biocatalyst to generate chiral ethyl (S)-3-hydroxybutyrate, 1 key chiral chemical, with high enantiomeric excess and yield through kinetic resolution. Herein, we further explored the potential of esterase PHE21 in the enantioselective preparation of secondary butanol, which was hard to be resolved by lipases/esterases. Despite the fact that chiral secondary butanols and their ester derivatives were hard to prepare, esterase PHE21 was used as a green biocatalyst in the generation of (S)-sec-butyl acetate through hydrolytic reactions and the enantiomeric excess, and the conversion of (S)-sec-butyl acetate reached 98% and 52%, respectively, after process optimization. Esterase PHE21 was also used to generate (R)-sec-butyl acetate through asymmetric transesterification reactions, and the enantiomeric excess and conversion of (R)-sec-butyl acetate reached 64% and 43%, respectively, after process optimization. Deep-sea microbial esterase PHE21 was characterized to be a useful biocatalyst in the kinetic resolution of secondary butanol and other valuable chiral secondary alcohols.
研究领域:
生物化学
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有机化学
·
酶工程
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MATERIALS & DESIGN
·
2019
·
IF 5.77
Hui Yu,Jianlin Li,Jianbao Li,Yongjun Chen,Xue Hou,Shuaifeng Chen,Haotian Yang
Multibiological multiscale biomimetic design is a novel bionic idea that involves multi-mechanisms. Porous ceramics with a sea urchin stereom structure on a micrometre scale and a nacre mineral bridge structure on a submicron scale have been fabricated via organic foam impregnation and controlled crystallisation. The microstructure and mechanical properties of biomimetic ceramics are, respectively, characterised using scanning electron microscopy and universal testing machine. Moreover, the porosity, reliability and grain boundary stress of biomimetic ceramics are calculated via Archimedes method, Weibull theory and finite element method, respectively. Results show that the ceramic produced in this work has a porosity of 88.16% and an average pore size of 284.65 μm. Mineral bridges of Al 2 TiO 5 with a thickness of 30–230 nm are widely and randomly distributed in the grain boundary glass phase of Al 2 O 3 and improved the compressive strength (2.32 MPa) and Weibull modulus (7.85) of ceramics by the multi-mechanisms of crack deflection, reducing maximum stress and homogenising stress on the grain boundary. These investigations would be of great value to the design and synthesis of novel biomimetic materials.
研究领域:
材料科学
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仿生学
·
生物医学工程
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CHEMICAL ENGINEERING JOURNAL
·
2026
·
IF 12.5
Jiwei Cui,Jiayin Gao,Yuan Zhuang,Longben Huo,Zhiheng Meng,Hui Feng,Pei Sun,Xinyuan Zhu,Xin Jin
All-polymer PVDF/PVA sea-island hydrogels are engineered by LLPS and NIPS. • Uniform PVDF islands improve stress transfer and promote electroactive phase formation. • Electroactive PVDF phase exceeds 95% with an effective piezoelectric response of 40.9 ± 1.6 pC N −1 . • Stable electromechanical sensing is maintained over 1600 loading cycles. • LSTM-assisted sensors enable personalized recognition of exercise patterns. Flexible piezoelectric materials are promising for wearable electronics and biosensing applications, yet achieving high electromechanical sensitivity while maintaining mechanical softness remains challenging for hydrogel-based systems. Herein, we report an all-polymer piezoelectric hydrogel with a controlled sea-island structure, engineered via coupled liquid-liquid phase separation and non-solvent-induced phase separation. The resulting architecture consists of uniformly dispersed PVDF islands embedded in a continuous PVA matrix. PVDF islands provide electroactive crystalline domains and contribute to stress transfer within the hydrated network, while the sea–island architecture and interfacial interactions synergistically enhance the effective piezoelectric response ( d 33,eff = 40.9 ± 1.6 pC N −1 ). The hydrogel sensors exhibit stable and sensitive responses to subtle biomechanical signals, including finger, face, throat and pulse monitoring. For exercise-related limb movements, the sensor signals were analyzed using a Long Short-Term Memory (LSTM) neural network under subject-independent validation, demonstrating the feasibility of signal-based discrimination between standard and non-standard movements. This work establishes a microstructure-engineering strategy for improving the mechanical and piezoelectric performance of PVDF/PVA hydrogels, enabling their application in wearable motion monitoring. Download: Download high-res image (214KB) Download: Download full-size image
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Frontiers in Oncology
·
2023
·
IF 4.7
Guangchun Liu,Shenglin Zhang,Ruoyan Lin,Xudong Cao,Lihong Yuan
Cancer remains the leading cause of death worldwide. In spite of significant advances in targeted and immunotherapeutic approaches, clinical outcomes for cancer remain poor. The aim of the present study was to investigate the potential mechanisms and therapeutic targets of Frondoside A for the treatment of liver, pancreatic, and bladder cancers. The data presented in our study demonstrated that Frondoside A reduced the viability and migration of HepG2, Panc02, and UM-UC-3 cancer cell in vitro . Moreover, we utilized the GEO database to screen and identify for differentially expressed genes (DEGs) in liver, pancreatic, and bladder cancers, which resulted in the identification of 714, 357, and 101 DEGs, respectively. Gene Ontology (GO) analysis and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway annotation were performed using the Metascape database for DEGs that were significantly associated with cancer development. The protein-protein interaction (PPI) networks of the identified DEGs in liver, pancreatic, and bladder cancers were analyzed using Cytoscape 3.9.0 software, and subsequently identified potential key genes that were associated with these networks. Subsequently, their prognostic values were assessed by gene expression level analysis and Kaplan-Meier survival analysis (GEPIA). Furthermore, we utilized TIMER 2.0 to investigate the correlation between the expression of the identified key gene and cancer immune infiltration. Finally, molecular docking simulations were performed to assess the affinity of Frondoside A and key genes. Our results showed a significant correlation between these DEGs and cancer progression. Combined, these analyses revealed that Frondoside A involves in the regulation of multiple pathways, such as drug metabolism, cell cycle in liver cancer by inhibiting the expression of CDK1, TOP2A, CDC20, and KIF20A, and regulates protein digestion and absorption, receptor interaction in pancreatic cancer by down-regulation of ASPM, TOP2A, DLGAP5, TPX2, KIF23, MELK, LAMA3, and ANLN. While in bladder cancer, Frondoside A regulates muscle contraction, complement and coagulation cascade by increase FLNC expression. In conclusion, the present study offers valuable insights into the molecular mechanism underlying the anticancer effects of Frondoside A, and suggests that Frondoside A can be used as a functional food supplement or further developed as a natural anti-cancer drug.
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SEPARATION AND PURIFICATION TECHNOLOGY
·
2023
·
IF 8.6
Weijie Wei,Jingjing He,Lan He,Xinyu Qi,Xiaqing Zhang,Wubo Wan,Zhuwei Gao
The use of solar desalination is expected to solve the problem of water scarcity. Based on this, MWCNTs were loaded on filter paper and assembled into a MWCNTs disc evaporator using cotton threads as water channels in this paper. MCED with different loadings were prepared, and the photothermal conversion performance of MCED was evaluated through experiments. The results showed that the evaporation rate of 0.7-MCED at one solar intensity could reach 1.3134 kg/m 2 h; the efficiency of solar separation of vapor and salt was 77.63 %. Meanwhile, after a 7-day evaporation cycle of 0.3-MCED, salt crystallizes at the edge of MCED under light and is recovered by gravity shedding during darkness, and the freshwater collection rate and salt recovery rate are 0.82 kg m −2 h −1 and 38.24 g m −2 h −1 , realizing efficient and continuous water collection and salt recovery. In addition, MCED can generate voltage through water evaporation. This work demonstrates a solar evaporator that can be used for continuous seawater desalination as well as salt recovery and power generation, and provides a new direction for the design of photothermal modulation of MWCNTs and solving the salt crystallization problem for solar desalination.
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JOURNAL OF COLLOID AND INTERFACE SCIENCE
·
2023
·
IF 9.9
Meng Xia,Shuyang Hu,Wenqi Luo,Yang Guo,Peng Zhao,Jiakai Li,Guiqiu Li,Lulu Yan,Wei Huang,Meng Li,Juanxiu Xiao,Yijun Shen,Qi Chen,Dong Wang
Solar-driven steam generation (SSG) is regarded as a feasible solution to the problem of fresh water scarcity. Although several attempts have been devoted to increase the efficiency of solar-to-steam conversion, it remains difficult to fabricate cost-effective, steady, and multi-angle sunlight-absorbing evaporators from readily available biomass materials. Herein, a novel hierarchical structured SSG evaporator (PDA@Shell-NaClO) is developed through a simple, low-cost, and scalable etching treatment on discarded sea urchin (SU) shells. Attributing to the dedicatedly designed microneedles array structure and porous skeleton structure of the SU shell, this PDA@Shell-NaClO evaporator shows an outstanding average light absorption performance (>90%) in a broad range of angles from 0° to 60° and exceedingly high evaporation rate of 2.81 kg m -2 h −1 under one sun condition. Furthermore, the prepared evaporator also maintains an overall stable evaporation performance and exhibits an excellent durability for a long time of up to two weeks in actual seawater. This full-ocean biomass-based SSG evaporator with plentiful raw material availability offers innovative opportunities for large-scale fresh water production.
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危险品化学品经营许可证（带存储）