ACS Biomaterials Science & Engineering
·
2025
·
IF 5.5
Yaru Han,Chuanwen Wang,Meitong Liu,Baojin Ma,Shaohua Ge,Yang Yu
Postextraction wound healing under inflammatory conditions remains a crucial clinical challenge due to persistent oxidative stress and compromised bone regeneration. To address this critical issue, injectable hydrogel dressings offer a promising strategy for inflammatory wound healing after tooth extraction. Herein, we developed an epigallocatechin gallate (EGCG)-loaded sodium alginate/zinc ion (SA/Zn2+) composite hydrogel (designated SZE) through ionic cross-linking and multiple physical bonding interactions. The SZE hydrogel with high cytocompatibility could effectively scavenge intracellular ROS, protect mitochondria, inhibit the expression of inflammatory factors, and modulate macrophage polarization, as well as enhance the osteogenic differentiative potential of bone marrow mesenchymal stem cells. Meanwhile, the SZE hydrogel demonstrated good bactericidal effects against Staphylococcus aureus and Escherichia coli. Based on in vivo rat extraction socket models with/without S. aureus infection, SZE accelerated socket healing by eliminating infection, alleviating oxidative stress, inhibiting excessive inflammation, and promoting bone regeneration and effectively augmented infected socket healing. Overall, our research indicates that the developed SZE hydrogel offers a promising strategy for achieving accelerated and ideal healing of extraction sockets, especially under bacteria-infected inflammatory conditions.
研究领域:
生物材料
·
牙科材料
·
组织工程
·
伤口愈合
·
再生医学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Processes
·
2023
·Vol. 11
·期 12
·3355
·
IF 3.5
Xuequan Li,Liting Lai,Fangdi Wu,Wenju Xie,Junshao Liu
To improve the performance of electrochemical capacitors, there is a notable focus on carbon materials characterized by a large surface area, reasonable pore size, pore size distribution, appropriate electronic conductivity, and excellent chemical durability. Herein, the hierarchical porous carbon aerogel originating from sodium alginate (SA) with well-defined porosity are proposed. The resultant hierarchical porous carbon aerogel shows a substantial specific surface area of 2050.6 m2g−1with macropores, mesopores and micropores confirmed by techniques such as TEM, SEM, BET, etc., resulting from a sequence of aerogel formation-carbonization-activation. By electrochemical measurement, the hierarchical porous carbon aerogel exhibits a specific capacitance of 204 F g−1at an operating current density of 0.2 A g−1employing 6 M KOH aqueous solution. The hierarchical carbon aerogel displays outstanding cycling stability with a 96.2% capacity maintenance for 10,000 cycles at an operating current density of 1 A g−1. This study presents a viable method for for preparing hierarchical porous carbon aerogel derived from biopolymer for electrochemical capacitors.Keywords:hierarchical porous carbon aerogel;sodium alginate;electrochemical capacitor
研究领域:
材料科学
·
能源存储
✓ 已验证
DOI
高影响因子
Water
·
2025
·Vol. 17
·期 5
·631
·
IF 3
Weiyuan Cao,Zixuan Yang,Ren Liu,Zilin Zhang,Guokuan Chen,Zilin Zhou,Liwei Xu
A novel composite biomass aerogel adsorbent (HSA) was prepared by dual physical and chemical cross-linking using sodium alginate (SA) as an organic biomass template and hydroxyapatite nanowires (HAPNWs) as an inorganic biomass skeleton. The structure of the HSA was characterized by scanning electron microscopy (SEM), X-ray powder diffractometry (XRD), Fourier transformed infrared spectroscopy (FTIR), and stress testing. One-factor experiments were conducted focusing on adsorption conditions at a Pb ion concentration of 300 mg/L, and the adsorption conditions were optimized using the response surface method. The optimal conditions obtained by numerical optimization using Design-Expert 13 were as follows: pH of 7.23, adsorption temperature of 35.42 °C, and adsorption time of 1050.73 min; the optimal adsorption capacity was 278.874 mg/g. To further reveal the adsorption mechanism of HSA, its adsorption model and kinetics were analyzed. Adsorption was most consistent with the Langmuir isothermal adsorption model, while the kinetics were most consistent with the pseudo-secondary kinetic model. R2reached 0.9986, indicating a mono-molecular layer of adsorption by heat, while the main adsorption mechanism was chemisorption.
研究领域:
环境科学
·
材料科学
·
化学工程
·
吸附技术
✓ 已验证
产品关联
DOI
高影响因子
Materials
·
2025
·Vol. 18
·期 24
·5491
·
IF 3.2
Biao Yang,Xue Wang,Cong Du
Blow spinning is a low-cost and versatile method that permits the large-scale production of fibrous membranes. However, polysaccharides that show numerous merits such as biocompatibility and biodegradability often have a low spinnability due to their high chain rigidity and low ability to form sufficient entanglements. Here, we report the fabrication of polysaccharide micro-fibrous membranes from sodium alginate/polyethylene oxide solutions formulated in solvent mixtures of water and ethanol. The shear and extensional rheological responses of the solutions are characterized, and parameters including specific shear viscosity, reptation time, extensional relaxation time, and maximum stretch ratio are correlated with the concentrations of polymer, polyethylene oxide, and ethanol. It is found that flexible polyethylene oxide and poorer solvent ethanol can synergistically delay the chain relaxation during stretch and increase the stretchability of the solutions. A processability map of the solutions for blow spinning is constructed, enabling the fabrication of fibrous membranes with a fiber diameter of ~1 μm, tensile strength of 4.89 MPa, elongation at break of 15.24%, and Young’s modulus of 45.43 MPa. This study presents a new strategy to fabricate sodium alginate-based membranes, which should provide insights into the design of other polysaccharide membranes with specific functions and applications.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
RSC Advances
·
2022
·Vol. 12
·期 20
·12600-12606
·
IF 4.036
Shuxin Zhang,Hai Fan,Chunrong Yi,Ying Li,Kunmei Yang,Shenglong Liu,Ziqiang Cheng,Jianchao Sun
Zinc finger antiviral proteins (ZAP) can significantly inhibit the replication of avian leukosis virus subgroup J (ALV-J), but the traditional method of ZAP administration is by injection, which can easily cause stress effects in chickens. In this work, we established a sodium alginate/atractylodis macrocephalae system for the encapsulation of CCCH-type zinc finger antiviral protein (CCCH-ZAP). Because of the high cost of ZAP, we first chose bovine serum albumin (BSA) as a model protein to investigate the encapsulation performance. The SEM images clearly confirmed that BSA and the sodium alginate/atractylodis macrocephalae system can assemble easily to form relatively stable nanostructures, and the encapsulation amount of BSA can reach 68%. Subsequently, the encapsulation of ZAP was studied. The SEM and the encapsulation experiments confirmed that ZAP can also be assembly encapsulated in the sodium alginate/atractylodis macrocephalae system with the encapsulation amount of 80%. Release studies showed that the SA/AM-ZAP nanocomposite was able to achieve a release rate of 32% of ZAP. This work successfully confirms the assembly encapsulation of ZAP, which will be beneficial for the usage of ZAP-based animal drugs.
研究领域:
兽医学
·
药学
·
纳米技术
✓ 已验证
DOI
PubMed
高影响因子
ENZYME AND MICROBIAL TECHNOLOGY
·
2021
·
IF 3.493
Hao Zhang,Xiuzhu Li,Zheng-Ming Qian,Shengpeng Wang,Feng-Qing Yang
In this study, a paper-based sensor, combined with a visual distance-readout method, was developed to determine glucose in fruit samples based on the glucose oxidase-mediated sodium alginate gelation. The type of filter paper, the concentration of sodium alginate and the enzymatic reaction conditions were systematically investigated. Under optimal conditions, the increase in diffusion diameter showed a good linear relationship with glucose concentration between 1.4–7.0 mM, and the limit of quantification was 1.4 mM. Finally, the applicability of the proposed strategy was successfully verified by measuring glucose concentrations in fruit samples. The results generated by the developed paper-based sensor were in good agreement with the results obtained from a glucose assay kit. The recoveries were 91.8%–99.1%. In short, the present study developed a simple, low-cost and efficient method for assessing fruit quality and for guiding fruit intake for diabetic patients, especially in remote or resource-limited regions.
研究领域:
分析化学
·
生物传感器
·
食品科学
·
糖尿病管理
✓ 已验证
DOI
PubMed
高影响因子
ACS Applied Bio Materials
·
2019
·
IF 0
Xinyan Mao,Xinying Li,Wenjie Zhang,Lun Yuan,Lei Deng,Liming Ge,Changdao Mu,Defu Li
Bioactive peptide drugs are mostly delivered by parenteral administration, which brings great pain and risks to patients. Oral administration is an acceptable alternative form. However, peptide drugs are extremely sensitive to the strong acidic environment in the stomach after oral administration. They would be degraded by pepsin and trypsin in the gastrointestinal tract. Herein, we present microspheres for intestinal-targeted peptides drug delivery through oral administration. Sodium alginate was reacted with l-cysteine to bring it into thiol groups. Then sodium alginate-l-cysteine conjugates were mixed with native sodium alginate and emulsified by an improved method. Ca2+ was used to fix the emulsion to get the microspheres. Bovine serum albumin was used as the simulating drug to assess the feasibility of microspheres as intestinal delivery carriers. The results showed that the microspheres exhibited spherical properties and narrow size distribution. The drug-loading capacity of microspheres was not compromised after thiol-modification. It is interesting that the microspheres can maintain structural integrity and hold drugs in the strong acidic environment in the stomach. Conversely, the microspheres presented sustained intestinal-targeted drugs release ability as expected. Moreover, thiol-modification further improved the adherence ability of microspheres on the inner walls of the small intestine, which is good for enhancing drug permeability. In sum, the microspheres based on thiol-modified sodium alginate have promising applications as intestinal-targeted macromolecular drug carriers.
研究领域:
药剂学
·
生物材料
·
药物递送
✓ 已验证
DOI
PubMed
REACTIVE & FUNCTIONAL POLYMERS
·
2026
·
IF 5.1
Xiyuan Guo,Yuanfeng Pan,Yuanjian Xie,Pingxiong Cai
Pesticides are essential for agricultural production; however, their improper application can result in ecological damage and potential threats to human health. Therefore, the development of pesticide-controlled-release systems is crucial for the sustainable progress of agriculture and society. This work presents a novel strategy for fabricating a polyelectrolyte hydrogel bead-based pesticide-controlled-release system. The process involves blending a sodium alginate/carboxymethyl chitosan (SA/CMCS) solution with cystine dihydrochloride (CYS), followed by introducing the mixture into a citric acid (CA) solution. The abundant protonated amino groups (-NH 3+ ) and carboxylate anions (-COO-) within the system facilitate the formation of CMCS/SA-CYS/CA composite hydrogel beads (CHGB), subsequently loaded with thiamethoxam (TMX) to create TMX-loaded CHGB (TCHGB) for investigations into drug loading and responsive release. The CHGB exhibits remarkable swelling properties (up to 4200%), along with pH and redox sensitivity. And the release of TMX from TCHGB displays favorable responsiveness to pH and redox stimuli. Under alkaline conditions (pH 9.0) and reductive surroundings (containing glutathione), the cumulative release ratio of TMX surpasses 95%. Furthermore, it has been demonstrated that the release kinetics of TMX comply with Fickian diffusion described by the Korsmeyer-Peppas model. The discoveries of this study hold considerable research and practical value in the domain of controlled-release agricultural chemicals.
✓ 已验证
产品关联
DOI
高影响因子
Journal of Macromolecular Science Part B-Physics
·
2022
·
IF 1.366
Mengxiang Zeng,Wei Wu,Jianjun Fang,Zhihua Zhou,Ying Lan,Bingrong Lin,Qian Ye
The adsorption method is recognized as an effective technology for dealing with water pollution caused by heavy metal ions. For a highly efficient, eco-friendly and low-cost adsorption process, the adsorbent is the deciding factor. In this study a porous sodium alginate scaffold was prepared by the method of freeze-drying as a heavy metal ion adsorbent. The parameters affecting the morphology and adsorption characteristics of the scaffolds were investigated. The results showed that sodium alginate porous scaffolds could be prepared under the concentration in the range of 1–5%. After calcium ion pre-crosslinking, the sodium alginate scaffold was used to adsorb the heavy metal ions of Cd2+, Pb2+, and Cu2+ from aqueous solution and the maximum adsorption efficiency under optimized adsorption conditions were 99.43%, 73.67%, and 59.25%, respectively. At the same time, the scaffold could be used for desorption and recycling. After five cycles, the removal percentages of Pb2+, Cd2+, and Cu2+ by the sodium alginate scaffold decreased by 25%, 25%, and 16%, respectively.
研究领域:
环境科学
·
材料科学
·
水处理
·
吸附技术
✓ 已验证
DOI
高影响因子
Journal of Macromolecular Science Part B-Physics
·
2017
·
IF 0.828
Huabo Huang,Junlong Yao,Yulan Liu,Xin Tuo,Yumin Da,Xiaoping Zeng,Liang Li
Due to their possible ideal three dimensional (3D) nanostructures and excellent electrochemical properties, conducting hydrogels have attracted much attention in recent years. Herein, pyrrole monomer was directly dissolved in an aqueous solution of sodium alginate (SA), and was allowed to undergo in-situ polymerization to form polypyrrole (Ppy), resulting in formation of Ppy/SA, a conducting hydrogel, via self-assembly between the polymers. Observation by SEM indicated that the microstructure of the Ppy/SA hydrogel was a typical 3D nano-cylinder network, with the cylinders formed by entanglements of the Ppy and SA molecular chains (cylinder diameter was ∼100 nm). The electrochemical measurements of cyclic voltammetry, galvanostatic charge/discharge and electrochemical impedance spectroscopy indicated that the Ppy/SA hydrogel possessed typical pseudocapacitance, good charging and discharging rate performance, and favorable capacitive behavior; the specific capacity reached up to 249 F/g at the current density of 0.2 A/g. We suggest it has great potential in the field of high-performance electrode materials for supercapacitors.
研究领域:
材料科学
·
电化学
·
储能
·
纳米技术
✓ 已验证
DOI
高影响因子
CARBOHYDRATE POLYMERS
·
2018
·
IF 5.158
Yiying Yue,Xianhui Wang,Jingquan Han,Lei Yu,Jianqiang Chen,Qinglin Wu,Jianchun Jiang
In this study, interpenetrating polymer network (IPN)-structured hydrogels were fabricated through the crosslinking of neutral polyacrylamide (PAM, the first flexible network) and the polyelectrolyte sodium alginate (SA, the second rigid network). Three types of nanocellulose, including cellulose nanocrystals (CNCs), bacterial cellulose fibers (BCs) and 2,2,6,6-tetramethylpiperidine-1-oxy radical (TEMPO)-oxidized cellulose nanofibers (TOCNs), were well-dispersed in the SA-PAM gel matrix. The hydrogels, obtained with a high water content (∼83%), exhibit a macroporous structure with a mean pore size of 60 ± 51 μm and high transparency. Comparative studies indicate that BCs are more effective for enhancing the hydrogels due to their higher aspect ratio, and the compressive strength of SA-PAM-BC hydrogel is 6.59 times higher than that of neat SA-PAM. Meanwhile, TOCNs are the best fillers for improving the adsorption capacity owing to the presence of a carboxyl group, and the adsorption capacity of SA-PAM-TOCN is more than 1.3-fold that in SA-PAM. Prepared hydrogels with high mechanical strength and adsorption capacity are advantageous for their applications in wastewater treatments.
研究领域:
材料科学
·
高分子科学
·
环境工程
·
纳米复合材料
·
水处理
✓ 已验证
DOI
高影响因子
Frontiers of Materials Science
·
2026
·Vol. 20
·期 3
·260778
·
IF 2.3
Fan Yuli,Li Zongyi,Liu Xuanyu,Yang Ruofeng,Lyu Jiaxuan,Wu Qilong,Wei Yan,Liang Ziwei,Han Weimo,Zhao Liqin,Huang Di
Bone tissue regeneration engineering aims to construct scaffolds with natural bone biological characteristics. Traditional autologous/allogeneic bone transplantation has limited donor sources and carries immunological risks. Stem cell injection, due to its minimally invasive nature and bone repair-promoting effects, has emerged as an alternative strategy. However, direct injection faces challenges such as cell migration and low survival rates. To address this, researchers have employed hydrogels and microspheres as delivery carriers. Among these, sodium alginate (ALG) microspheres, with their excellent biocompatibility and injectability, are widely used for cell encapsulation. Combining the osteogenic-promoting properties of black phosphorus (BP), this study utilized electrospray injection to prepare ALG-BP composite microspheres encapsulating MC3T3-E1 cells (ALG-BP@MC3T3-E1). The results showed that ALG-BP microspheres had no effect on the activity of MC3T3-E1 cells, while ALG-BP@MC3T3-E1 microspheres exhibited excellent bone healing promotion and osteoporosis inhibition capabilities, significantly reducing bone healing time. This hydrogel microsphere achieves a dual effect of stimulating endogenous cell secretion and providing exogenous cells, representing a cell tissue engineering strategy with promising application prospects.
✓ 已验证
DOI
高影响因子
危险品化学品经营许可证（带存储）