Theranostics
·
2020
·
IF 8.579
Chao Fang,Dong Cen,Yifan Wang,Yongjun Wu,Xiujun Cai,Xiang Li,Gaorong Han
Abnormal tumor microenvironment, such as hypoxia, interstitial hypertension and low pH, leads to unexpected resistance for current tumor treatment. The development of versatile drug delivery systems which present responsive characteristics to tumor microenvironment (TME) has been extensively carried out, but remains challenging. In this study, zeolitic imidazolate framework-8 (ZIF-8) coated ZnS nanoparticles have been designed and prepared for co-delivery of ICG/TPZ molecules, denoted as ZSZIT, for H 2 S-amplified synergistic therapy. Methods: The ZSZ nanoparticles were characterized using SEM, TEM and XRD. The in vitro viabilities of cancer cells cultured with ZSZIT under normoxia/hypoxia conditions were evaluated by cell counting kit-8 (CCK-8) assay. In addition, in vivo anti-tumor effect was also performed using male Balb/c nude mice as animal model. Results: ZSZIT shows cascade PDT and hypoxia-activated chemotherapeutic effect under an 808nm NIR irradiation. Meanwhile, ZSZIT degrades under tumor acidic environment, and H 2 S produced by ZnS cores could inhibit the expression of catalase, which subsequently favors the hypoxia and antitumor effect of TPZ drug. Both in vitro and in vivo studies demonstrate the H 2 S-sensitized synergistic antitumor effect based on cascade PDT/chemotherapy. Conclusion: This cascade H 2 S-sensitized synergistic nanoplatform has enabled more effective and lasting anticancer treatment.
研究领域:
纳米医学
·
肿瘤学
·
药物递送系统
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产品关联
DOI
PubMed
高影响因子
JOURNAL OF ALLOYS AND COMPOUNDS
·
2025
·
IF 6.3
Boyang Qin,Jiao Chen,Fan Xu,Jinxin Zou,Wenfang Wang,Yu Lv,Luyu Tian,Lan Zhou,Jun Feng
Developing efficient heterojunction structures is of critical importance for boosting solar energy conversion in photocatalysis. Herein, a ZnS-ZnO heterojunction is fabricated via pyrolysis of zeolitic imidazolate framework-8 (ZIF-8) followed by in-situ sulfidation. Due to the formation of heterojunction, the separation efficiency of photogenerated carriers can be efficiently enhanced. As a result, the as-fabricated ZnS-ZnO heterojunction exhibited a H 2 O 2 formation rate of 6.88 mmol g⁻¹ h⁻¹ , which is 3.75-fold that of ZnO. The mechanism revealed that •OH and •O 2 - were active species involved in the photocatalytic H 2 O 2 production process. Moreover, the as-prepared samples have been successfully applied to degrade norfloxacin and exhibited excellent removal efficiency. This work provides an efficient route to develop highly efficient photocatalyst based on metal-organic frameworks (MOF).
研究领域:
材料科学
·
环境科学
·
纳米技术
·
催化
·
化学工程
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产品关联
DOI
高影响因子
Polymer Chemistry
·
2013
·Vol. 4
·期 14
·3963-3967
·
IF 5.231
Guoyan Zhang,Jibin Zhang,Bai Yang
Polymerizable ZnS nanoparticles (NPs) were fabricated in N,N′-dimethylacrylamide via a novel facile and effective strategy, and a series of transparent bulk nanocomposites were also prepared based on such polymerizable ZnS NPs. The structure, surface chemistry and distribution of the polymerizable ZnS NPs were studied by powder XRD, FTIR, 1H NMR and TEM. The results indicated that we have successfully synthesized the polymerizable ZnS NPs with an average size of 4–5 nm by the innovatory method and the surface of these NPs were terminated with phenyl and vinyl groups which made sure of the good dispersion in the monomers. The polymerizable ZnS NPs could be easily polymerized with the monomers and fabricated a series of bulk nanocomposites. The obtained bulk nanocomposites (3 mm) exhibit good transmittance in the visible range and its refractive index are in the range from 1.527 to 1.598 in 632.8 nm by changing the content of the polymerizable ZnS NPs from 0 to 11.1 wt%. This novel strategy opens a new gate to produce transparent bulk nanocomposites with tunable refractive indices for potential optical device applications.
研究领域:
材料科学
·
纳米技术
·
光学
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF ALLOYS AND COMPOUNDS
·
2025
·
IF 6.3
Zecheng Cao,Xiaojiao Kang,Wei Lü,Weiliang Guan
In this study, we present a novel synthesis system for AgInS 2 /ZnS (AIS/ZnS) core/shell quantum dots (QDs) terminated with carboxymethyl chitosan (CMC) as a ligand, which has not been previously documented. By varying the Ag/In ratio, we achieved emission wavelengths ranging from 590 to 697 nm, with the maximum photoluminescence quantum yield (PLQY) of 33.1 %. The synthesized AIS/ZnS QDs powder was mixed with YAG phosphor and combined with a blue gallium nitride (GaN) chip to produce a warm white light-emitting diode (WLED), resulting in the color rendering index (CRI) increase from 74 to 82 and the correlated color temperature (CCT) decrease from 6486 K to 3873 K. Additionally, the AIS/ZnS QDs powder can be directly utilized with a blue GaN chip to create a near-infrared light-emitting diode (NIR-LED) capable of night vision. By adjusting the concentration of CMC in the AIS/ZnS QDs solution, the material can be directly used for writing and screen printing, or dried to obtain a highly transparent and luminescent flexible composite film. This research demonstrates the significant potential of CMC-ligated AIS/ZnS core/shell QDs in display technologies and flexible device applications.
研究领域:
材料科学
·
光学工程
·
纳米技术
✓ 已验证
产品关联
DOI
高影响因子
DYES AND PIGMENTS
·
2012
·
IF 3.126
Lijuan Feng,Chunyu Wang,Zhonglin Ma,Changli Lü
8-Hydroxyquinolines (HQs) functionalized ZnS nanoparticles (NPs) with an amine-capping layer (ZnS–NH 2 –Q NPs) were prepared by a ligand-exchange process. FT-IR, XRD , NMR, TEM and fluorescence spectrometer were used to characterize the novel ZnS–NH 2 –Q NPs. Upon the addition of 2,4,6-trinitrotoluene (TNT), the amino groups on the surface of ZnS–NH 2 –Q NPs can bind TNT molecule from solution by forming Meisenheimer complex. This complex absorbs the green part of visible light, and strongly suppresses the fluorescence emission of the ZnS–NH 2 –Q NPs through Fluorescence Resonance Energy Transfer (FRET). The observed linear fluorescence intensity response for TNT in the range of 0–1.89 μM allows the quantitative detection TNT, with a detection limit down to 10 nM.
研究领域:
化学
·
材料科学
·
分析化学
✓ 已验证
产品关联
DOI
高影响因子
SEPARATION AND PURIFICATION TECHNOLOGY
·
2019
·
IF 5.107
Jian Liu,Ming Xia,Rong Chen,Xun Zhu,Qiang Liao,Dingding Ye,Biao Zhang,Wei Zhang,Youxu Yu
Photocatalytic fuel cell (PFC) is a promising wastewater treatment technology, which cannot only purify wastewater but also generate electricity using solar energy. In this study, a membrane-less visible-light responsive micro PFC was developed, where the CdS/ZnS-TiO 2 deposited on a conductive glass as a photoanode and CuO deposited on the porous carbon paper as an air-breathing photocathode were laterally arranged. Such design allows for both the photoanode and photocathode to be irradiated simultaneously from one side and enhances photon and mass transport. It was found that the developed micro PFC with dual photoelectrodes well responded to light illumination and exhibited good long-term performance. Experimental results also showed that upgrading the light intensity and methanol and electrolyte concentrations could improve the discharging performance because of larger amount of generated electron-hole pairs and more hole scavengers resulting from the enhanced transport. Besides, it was also found that although the increase of the liquid flow rate from extremely low rate to a moderate one caused the residence time to be lowered, positive contribution resulting from enhanced mass transport was more significant, leading to the improved performance. However, too high liquid flow rate resulted in critical low residence time, which made the discharging performance worse. The feasibility of the developed micro PFC with dual photoelectrodes toward the applications of using solar energy to remove organic pollutants contained in wastewater and simultaneously generate electricity is demonstrated in this work.
研究领域:
环境科学
·
能源技术
·
材料科学
✓ 已验证
DOI
高影响因子
Acta Metallurgica Sinica-English Letters
·
2022
·Vol. 36
·期 1
·167-176
·
IF 3.024
Wang Wei,Guan Mingyu,Wang Qinghua,Chen Yangyang,Chen Liang,Yin Hong,Zhu Yucan,Li Gangyong,Hou Zhaohui
ZnS is a promising material for lithium-ion battery anodes due to its abundant natural resources, simplicity of synthesis, and high theoretical lithium storage capacity. However, it needs to be optimized for its low conductivity and volume effect during the charge–discharge process. The traditional method of combining with carbonaceous materials is usually laborious, and the required sulfuration process may possibly result in the destruction of materials morphology. In this study, hybrid materials formed by the combination of ZnS nanocrystals and high porosity carbon fibers were synthesized by one-step electrospinning using zinc diethyldithiocarbamate and polyacrylonitrile as raw materials and poly (ethylene glycol)—block-poly (propylene glycol)—block-poly (ethylene glycol) as template. The method is simple and avoids the influence of sulfuration process on the morphology of materials. The composite presents a specific capacity of 592.2 mAh g −1 under a current density of 1 A g −1 after 1000 cycles. The porous structure significantly decreases the diffusion mean-free path of Li + and inhibits the volume effect associated with the lithium storage process of ZnS. In addition, the 3D cross-linked carbon fibers improve the conductivity of materials. This study can serve as an inspiration for the development of other lithium storage composites.
研究领域:
材料科学
·
纳米技术
·
储能
·
电化学
✓ 已验证
DOI
高影响因子
CHEMOSPHERE
·
2014
·
IF 3.499
Jie Mei,Li-Yun Yang,Lu Lai,Zi-Qiang Xu,Can Wang,Jie Zhao,Jian-Cheng Jin,Feng-Lei Jiang,Yi Liu
The interactions between quantum dots (QDs) and biological systems have attracted increasing attention due to concerns on possible toxicity of the nanoscale materials. The biological effects of CdSe QDs and CdSe/ZnS QDs with nearly identical hydrodynamic size on Saccharomyces cerevisiae were investigated via microcalorimetric, spectroscopic and microscopic methods, demonstrating a toxic order CdSe > CdSe/ZnS QDs. CdSe QDs damaged yeast cell wall and reduced the mitochondrial membrane potential. Noteworthy, adhesion of QDs to the yeast cell surface renders this work a good example of interaction site at cell surface, and the epitaxial coating of ZnS could greatly reduce the toxicity of Cd-containing QDs. These results will contribute to the safety evaluation of quantum dots, and provide valuable information for design of nanomaterials.
研究领域:
纳米技术
·
生物科学
·
毒理学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ACS Applied Nano Materials
·
2024
·
IF 5.3
Li Luo,Zhen Fan,Zhaobin Zhang,Danyang Liu,Guofa Li,Lishuang Wang,Bingsuo Zou
SnO2 nanoparticles (NPs) have been used as an electron transport layer (ETL) in quantum dot light-emitting diodes (QLEDs) to achieve stable and high-performance devices. However, SnO2 NPs with high electron mobility cause the problem of imbalanced charge injection and transport in QLEDs. Meanwhile, the SnO2 NPs synthesized at low temperature have hydroxyl (−OH) groups, which could damage the performance of QLEDs. Here, Zn doping was applied to modulate the properties of SnO2 NPs and achieve better carrier balance in green CdSe/ZnS QLED. The maximum current efficiency (CE) of QLED with 5 wt % Zn-doped SnO2 NPs is 2.3-fold higher than that of SnO2-based QLED. In addition, a small-molecule 4,4′-bis(carbazole-9-yl)-1,1′-biphenyl (CBP)-mixed poly(9-vinylcarbazole) (PVK) layer was used as a hole transport layer to facilitate the hole injection and charge balance. As a result, a maximum external quantum efficiency (EQE) of 5.03% is obtained for the best performance device. The T50 lifetime at a luminance of 100 cd/m2, for a device based on 5 wt % Zn-doped SnO2 ETL, is 9141 h, which is 2.29-fold longer than the reference one. This work provides a new strategy to obtain high-performance and stable display arrays.
研究领域:
材料科学
·
光电子学
·
纳米技术
✓ 已验证
产品关联
DOI
高影响因子
FOOD CHEMISTRY
·
2024
·
IF 8.5
Cheng Xin,Jingming Zhou,Yumei Chen,Yankai Liu,Hongliang Liu,Chao Liang,Xifang Zhu,Ying Zhang,Zhuting Chen,Xueyuan Tang,Bingxue Zhang,Mengjun Lu,Jiaojiao Wei,Hua Xue,Yanhua Qi,Gaiping Zhang,Aiping Wang
Florfenicol (F), an antimicrobial agent exclusive to veterinary use within the chloramphenicol class, is extensively applied as a broad-spectrum remedy for animal diseases. Despite its efficacy, concerns arise over potential deleterious residues in animal-derived edibles, posing threats to human health. This study pioneers an innovative approach, introducing a quantum dot fluorescence-based immunoassay (FLISA) for the meticulous detection of F residues in animal-derived foods and feeds. This method demonstrates heightened sensitivity, with a detection limit of 0.3 ng/mL and a quantitative detection range of 0.6–30.4 ng/mL. Method validation, applied to diverse food sources, yields recoveries from 90.4 % to 109.7 %, featuring RSDs within 1.3 % to 8.7 %, the results showed high consistency with the national standard HPLC-MS/MS detection method. These findings underscore the method's accuracy and precision, positioning it as a promising tool for swift and reliable F residue detection, with substantial implications for fortifying food safety monitoring.
研究领域:
兽医学
·
食品安全
·
分析化学
·
生物技术
✓ 已验证
产品关联
DOI
PubMed
高影响因子
SENSORS AND ACTUATORS B-CHEMICAL
·
2025
·
IF 7.7
Shiqing Luo,Xiaojie Sun,Lifang Zhang,Yanming Miao,Guiqin Yan
The excessive use of antibiotics has accelerated the rise of antimicrobial resistance (AMR), and rapid antimicrobial susceptibility testing (AST) is very important for the early detection, early prevention and treatment of AMR. On this basis, we combined manganese-doped zinc sulfide quantum dots (Mn-ZnS QDs) with aminated dendritic mesoporous silica nanoparticles (DMSNs-NH 2 ) to prepare Mn-ZnS QDs@DMSNs-NH 2 room-temperature phosphorescent (RTP) nanocomposites. H 2 O 2 can quench the RTP of Mn-ZnS QDs@DMSNs-NH 2 nanocomposites, while catalase-positive bacteria can cause the hydrolysis of H 2 O 2 . Hence, RTP detection of different antibiotic tolerance for Staphylococcus aureus ( S. aureus ) and methicillin-resistant Staphylococcus aureus (MRSA) was achieved. This sensing system can achieve rapid bacterial detection and AST through the difference in RTP intensity. Experimental results demonstrated that the linear detection range for bacteria is 0×10 5 -64×10 5 CFU·mL -1 , with a limit of detection (LOD) of 1×10 5 CFU·mL -1 for MRSA and 0.7×10 5 CFU·mL -1 for S. aureus . The pore confinement effect of DMSNs-NH 2 can induce the aggregation of Mn-ZnS QDs, which strengthens the RTP of Mn-ZnS QDs@DMSNs-NH 2 nanocomposites and improves the sensitivity of RTP detection. This method is not only free from sample background fluorescence interference, but also shortens the AST time (less than 90 min), making antibacterial treatment more time-saving and efficient and reducing patient pains. This nanosensor provides a new strategy for rapid clinical bacterial detection and effective assessment of antimicrobial susceptibility.
研究领域:
材料科学
·
生物医学工程
·
微生物学
✓ 已验证
产品关联
DOI
高影响因子
SENSORS AND ACTUATORS B-CHEMICAL
·
2014
·
IF 3.84
Jing Wang,Na Li,Feng Shao,Heyou Han
Highly luminescent, good stable and low toxic N-acetyl- l -cysteine (NAC) capped CdTe/CdS@ZnS–SiO 2 near-infrared (NIR)-emitting quantum dots (QDs) were successfully fabricated in aqueous solution via a microwave irradiation reduction route, in which thiol-capped CdTe/CdS QDs were employed as core templates and ZnCl 2 , NAC and tetraethyl orthosilicate as shell precursors. This presented ZnS-like clusters filled hybrid SiO 2 model not only greatly improved the brightness and stability of original CdTe/CdS QDs, but also tremendously decreased the cytotoxicity towards HeLa cells. Furthermore, it was found that Hg 2+ could effectively selective quench the QD NIR emission based on electron transfer process. On the basis of this fact, a simple, rapid and specific method for trace Hg 2+ determination was proposed. Under optimal conditions, the fluorescence intensity decreased linearly with the concentration of Hg 2+ ranging from 5.0 × 10 −9 to 1.0 × 10 −6 M and the limit of detection for Hg 2+ was 1.0 × 10 −9 M ( S / N = 3). As practical applications, the novel NIR sensor has been demonstrated to monitor and image Hg 2+ level in milk power and HeLa cells respectively with satisfactory results obtained.
研究领域:
材料科学
·
生物医学
·
分析化学
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）