INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2026
·
IF 8.7
Yiren Wang,Tian Zhang,Mo Zhu,Haotian Deng
Cation–anion synergy boosts KC/KGM double-network gels, breaking single-ion regulation limits. • KGM deacetylation at high temperature and KC helical cross-linking at low temperature. • K + + CO₃ 2− /PO₄ 3− forms dense 3D network with enhanced hardness, water retention and stability. • Synergistic gels show non-Fickian diffusion and excellent water-holding capacity. Binary gels composed of κ-carrageenan (KC) and konjac glucomannan (KGM) possess broad application prospects in the food industry, pharmaceuticals and other fields. Current studies mainly focus on single-ion regulation strategies, which fail to realize the precise performance optimization of binary gels and limit their high-performance applications. This work proposed a cation-anion synergistic enhancement hypothesis and constructed high-performance KC-KGM double-network gels. With multiple characterization techniques, the regulation rules and intrinsic mechanism of different cation-anion combinations on gel properties were systematically explored. The results revealed that the synergistic system followed a two-step gelation pathway: high-temperature deacetylation of KGM and subsequent low-temperature helical cross-linking of KC. The alkaline environment induced KGM deacetylation, while K + strengthened hydrogen bonding between KC and KGM to form a dense and homogeneous three-dimensional network. For the K 2 CO 3 group, gel hardness increased significantly from 308.41 g to 1034.69 g. Moreover, the gel swelling behavior conformed to non-Fickian diffusion ( n = 0.63) mechanism, exhibiting excellent water retention capacity and structural stability. This study clarified the cation-anion-driven dual-network coupling mechanism of rigid KC network and elastic KGM network, providing theoretical basis and feasible regulation strategies for the precise design and high-performance application of such materials.
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Foods
·
2026
·Vol. 15
·期 7
·1131
·
IF 6
Jiyu Nie,Danying Chen,Chengfeng Yu,Zengliang Jiang,Haibo Pan,Xingqian Ye,Shiguo Chen
Carrageenan (CGN) is widely used in processed foods and is typically supplied as a commercial preparation blended with other hydrocolloids to improve gelling properties, rather than as a single purified polymer. However, safety evaluations and mechanistic studies have largely focused on CGN in isolation; as a result, the biological effects of commercial CGN preparations (CGNPs) under realistic exposure conditions are still insufficiently characterized. In this study, the structural characteristics of three commercial food-grade CGNPs intended for meat products, soft sweets, and jelly were investigated. Furthermore, their effects on colitis were assessed, along with their impacts on the gut microbiota and related metabolites. The results indicated that all three CGNPs were κ-type, but differed in monosaccharide composition and molecular weight, which may contribute to their biological differences. In vivo, the CGNP intended for soft sweets significantly reduced the disease activity index (n= 6/group,p< 0.05) and helped maintain colon length (n= 6/group,p< 0.05). This CGNP also markedly reduced the abundance ofEscherichia-ShigellaandHelicobacter, while increasing propionate levels (n= 6/group,p< 0.05). In contrast, CGNPs intended for meat products and jelly tended to exacerbate colitis and increased the abundance ofEnterococcus, a genus associated with colitis. These findings reveal the application-specific biological effects of commercial food-grade CGNPs and provide a basis for optimizing the application of these preparations in the food industry.
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高影响因子
Food Chemistry-X
·
2026
·
IF 9.2
Lihua Zhang,Zhenwei Li,Siqi Yu,Guanchen Wu,Jiawei Xue,Lala Li,Wei Xu
KGM addition decreases droplet size and improves uniformity in CAS-based emulsions. • CRG addition transformed the emulsion into gel, improving the system's stability. • The emulsion gel has excellent textural properties and water-holding capacity. • The emulsion gel improved β-carotene storage stability and photostability. This study investigated the effect of κ-carrageenan (CRG) concentration on konjac glucomannan (KGM)/sodium caseinate-based emulsion gels and evaluated their protective effect on β-carotene. Adding CRG induced a sol-gel transition, resulting in structured emulsion gels. Microstructural analysis showed that the synergistic interaction between CRG and KGM facilitated the formation of a denser and more stable gel network, within which oil droplets were uniformly distributed. These structural enhancements enhanced the rheological and textural properties of the gel and increased its water-holding capacity to 98.1%. Furthermore, the gels effectively protected β-carotene during storage and ultraviolet exposure. At 1.5% CRG, 62% of the β-carotene was retained after 15 days of storage, indicating reduced oxidative degradation. Notably, 1.0% CRG provided superior photoprotection, with more than 50% of the β-carotene retained after 8 h of ultraviolet irradiation. Overall, these findings highlight the potential of KGM/CRG emulsion gels as a delivery system for lipophilic nutrients.
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INTERNATIONAL JOURNAL OF PHARMACEUTICS
·
2014
·
IF 3.785
Chenxi Li,Chunyan Li,Zheshuo Liu,Qiuhong Li,Xueying Yan,Yu Liu,Weiyue Lu
The objective of this study was to construct a new in situ gel system based on the combination of poloxamer 407 and carrageenan (carrageenan–poloxamer 407 hydrogel, CPH) for intranasal delivery of ketorolac tromethamine . CPH showed potassium ion concentration - dependent erosion characteristics which ensured slow erosion in aqueous environment containing potassium ion at the physiological level. Loading with ketorolac tromethamine influenced erosion, drug release and thermosensitive properties of CPH. CPH containing 15% ketorolac tromethamine showed suitable gelation temperature (near 35 °C) and in vitro sustained release profiles. Pharmacokinetic study of intranasal CPH containing 15% ketorolac tromethamine in rats demonstrated enhanced absolute bioavailability (68.8 ± 23.3%) and prolonged mean residence time (8.8 ± 3.5 h) in comparison with the intranasal solution group (24.8 ± 13.8%, 3.9 ± 0.6 h). Nasal ciliotoxicity evaluation on an in situ toad palate model preliminarily showed the safety of CPH for intranasal use. All results suggested the potential of CPH as a new sustained - release platform for the intranasal delivery of ketorolac tromethamine.
研究领域:
药剂学
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药物递送系统
·
药代动力学
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Polymers
·
2018
·Vol. 11
·期 1
·6
·
IF 2.935
Rongfei Zhang,Xiangyou Wang,Juan Wang,Meng Cheng
In this study, thekonjac glucomannan(KGM)/carrageenan(KC)/nano-silica film was prepared and characterized by scanning electron microscopy (SEM), Fourier-transform infrared spectroscopy (FTIR), and X-ray diffraction (XRD). The preservation quality of white mushrooms (Agaricus bisporus) packed using the films was also determined. The nano-silica dosage was found to affect the properties of the nanocomposite KGM/KC films. The results indicated that the properties of the films were significantly improved with the addition of nano-silica. The water vapor permeability, water solubility, moisture absorption, and light transmittance of KGM/KC/nano-silica films were significantly affected by the nano-silica dosage. In this study, the optimal nano-silica dosage to incorporate into the film in order to achieve excellent performance was 0.3%. Strong intermolecular hydrogen bonds were also observed between KGM/KC and nano-silica in the KGM/KC/nano-silica film by FTIR. In addition, the KGM/KC/nano-silica film markedly reduced the browning index, delayed the weight loss and softening, and extended the shelf life of mushrooms during storage at 4 °C. The KGM/KC film modified using nano-silica can provide a potential method for improving the preservation quality of white mushrooms during storage.
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BIOMACROMOLECULES
·
2022
·
IF 6.978
Guangchao Zheng,Wei Gao,Xue Li,Zhiqiang Wu,Lin-An Cao,Enke Feng,Zhiming Yang
Gel polymers are widely used in different fields due to their unique properties, especially in flexible electronic devices. However, developing multienvironmentally-tolerant (antifreezing, antidrying, and solvent-resistant) gel polymer-based soft electronics is still a significant challenge. Herein, a binary solvent system-based versatile organohydrogel is designed and successfully prepared, which exhibits superior stretchability, favorable self-adhesive properties, prominent temperature tolerance, and excellent solvent-resistant capabilities. Furthermore, the as-assembled organohydrogel-based sensor demonstrates a satisfied sensitivity (GF = 1.8), wide strain range (5–500%), and outstanding human motion detection. Meanwhile, the obtained organohydrogel can also serve as an all-weather sensor for achieving precise and reliable mechanical sensing in a wide temperature range from −50 to 50 °C and diverse liquid media consisting of water, toluene, and carbon tetrachloride. Interestingly, the organohydrogel displays a repeatable transmittance change behavior in water and dimethyl sulfoxide, based on this feature, which could realize the functional applications for recording and erasing information. It is envisioned that these superior performances render the as-prepared organohydrogel suitable to develop future advanced soft electronics with multienvironmental tolerance.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2022
·
IF 8.025
Songmao Zhang,Yichun Wang,Yawen Li,Long Miao,Keliang Wang
Primary quasi-solid Al-air batteries using hydrogels have attracted increasing research attention owing to their high energy density, good handling, safety and reliability. However, it is still difficult to develop hydrogel electrolytes with high ionic conductivity and water retention owing to limited capacity of single material hydrogels. Herein, we report a hydrogel electrolyte of poly (acrylic acid) (PAA) is modified by κ-carrageenan (KC) for solid-state Al-air batteries. The result suggests that the hydrogels not only exhibit outstanding water retention but also high ionic conductivity, which is attributed to the amorphous phase and hydrophilic group of the KC. Additionally, the lifespan of solid-state Al-air battery is extended at a current density of 5 mA cm −2 owing to adding KC. Further, the lifetime of open Al-air batteries is improved by self-corrosion inhibition of Al anode.
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高影响因子
JOURNAL OF FOOD SCIENCE
·
2022
·Vol. 87
·期 6
·2463-2473
·
IF 3.693
Daojiu Zhang,Huibin Chen,Ledao Zhang,Ji-Li-Te Wang,Steve W Cui,Mingchun Wang,Ji Kang,Biao Wang,Hao Wang
This research aims to prepare capsules emulsion using gallic acid (GA), dextran (DEX), bovine serum albumin (BSA), sodium alginate, and K-carrageenan (K-Car) as the biological delivery system of lycopene. The stability and bioaccessibility of lycopene were further improved through encapsulation of covalent complex of sodium alginate and K-Car. The molecular weight distribution and secondary structure of the conjugates were analyzed by sodium dodecyl sulfate–polyacrylamide gel electrophoresis (SDS–PAGE) and Fourier transform infrared spectroscopy (FTIR). The storage stability of the emulsion stabilized by conjugates was measured with Turbiscan stability index (TSI) and fluctuation of the particle size. The TSI value of ternary conjugates was 18.7 (37℃) with particle sizes ranging from 208 to 319 nm. Then, the changes of three-dimensional reticulate structures and physical properties of sodium alginate-K were analyzed by scanning electron microscopy (SEM) and TPA. The thermal stability of the sodium alginate–K-Car composite systems was increased compared with sodium alginate. The bioaccessibility of lycopene was significantly improved under the dual embedding of BSA–DEX–GA conjugate emulsion and sodium alginate–K-Car composite systems.
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高影响因子
JOURNAL OF FOOD SCIENCE
·
2022
·Vol. 87
·期 7
·2953-2964
·
IF 3.693
Jia-Nan Yan,Xiao-Fan Cui,Xin-Yu Jiang,Lin Li,Wen Sun,Hai-Tao Wu
The combination of κ -Carrageenan (KC) and konjac gum (KGM) were introduced to examine the impact on gelation and microstructural behaviors of scallop male gonads hydrolysates (SMGHs) and the involvement of intermolecular forces. In terms of G ′ response of SMGHs/KGM/KC, it obviously enhanced by 3.6- and 108.5-fold than controls of KGM/KC and SMGHs/KC at 0.1 Hz, accompanying increasing melting temperatures from 27.9 (KGM/KC) and 30.0 (SMGHs/KC) to 33.7°C (SMGHs/KGM/KC), respectively. Additionally, SMGHs/KGM/KC with decreasing relaxation time T 23 and blue shift of hydroxyl group than controls suggested higher water retention capacity and ordered conformation. Moreover, SMGHs/KGM/KC formed compact networks with thick walls as reflected by cryo-SEM and showed rougher surface with more aggregation as reflected by AFM. Furthermore, electrostatic in couple with hydrophobic interactions were dominant interactions, while hydrogen bonds were involved in subordinately in SMGHs/KGM/KC. Practical Application Scallop ( Patinopecten yessoensis ) male gonads are always discarded during processing despite high-protein content and edibility. In the current research, scallop male gonad hydrolysates (SMGHs) exhibited gelation behavior, which have a potential role in developing marine source protein as a functional food base such as kamaboko gels, can, sausage and spread and even delivery vehicles for bioactive compounds.
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高影响因子
JOURNAL OF POLYMERS AND THE ENVIRONMENT
·
2021
·Vol. 30
·期 5
·1995-2006
·
IF 3.667
Shen Jian,Xu Xinyi,Ouyang Xiao-kun,Jin Mi-cong
Based on the excellent performances of nanocrystalline cellulose, sodium alginate, or K-carrageenan in Pb 2+ adsorption, nanocrystalline cellulose/sodium alginate/K-carrageenan composite hydrogel beads were prepared to adsorb Pb(II) from aqueous solutions. The objective of this study was to demonstrate the excellent potential of the composite hydrogel beads for heavy metal ion adsorption. We successfully prepared ecofriendly Fe-modified nanocrystalline cellulose/sodium alginate/K-carrageenan composite hydrogel beads and characterized them. The structure and adsorption mechanism were investigated using scanning electron microscopy, Fourier-transform infrared spectroscopy, and X-ray photoelectron spectroscopy, and the optimal adsorption conditions were determined. The tricomponent hydrogel beads were robust and exhibited improved adsorption capacity for Pb 2+ and good reusability. The adsorption results could be fitted well with a pseudo-second-order kinetic model and the Langmuir adsorption model. The maximum adsorption capacity obtained by fitting was 351.04 mg g −1 . Recycling experiments revealed that the adsorption capacity of the adsorbent remained high after five cycles of reuse.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2020
·
IF 5.162
Jingkun Zhao,Ce Sun,Haiyan Li,Xu Dong,Xiaodong Zhang
A series of agar/κ-carrageenan mixed hydrogels with different mass ratios were prepared, and their physicochemical properties, gelling behavior and drug release performance were determined and analyzed. The results showed that the gel strength, the gelling temperature and the gel melting temperature decreased with the increase of κ-carrageenan, while the apparent viscosities increased. Optical rotation and differential scanning calorimetry (DSC) indicated that there did exist intermolecular interactions between agar and κ-carrageenan, and the detailed gelling mechanism of the mixed hydrogels was proposed, which was different from that of the previous research. Besides, agar/κ-carrageenan mixed hydrogels were used as carriers for the delivery of metformin hydrochloride (MET). The results showed that the drug loading efficiency and the sustained release capacity of agar hydrogels could be enhanced by the addition of κ-carrageenan, and the release profile was mainly dominated by the electrostatic interaction between the MET and the polysaccharides . These results indicated that κ-carrageenan had the potential to improve the physicochemical properties and drug release performance of agar hydrogel.
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高影响因子
FOOD HYDROCOLLOIDS
·
2023
·
IF 10.7
Mingrui Zhou,Yahong Han,David Julian McClements,Cheng Cheng,Shuai Chen
Nanoparticle-filled films were fabricated as smart and active packaging materials to monitor and preserve the freshness of foods (fish). Antisolvent precipitation was used to produce zein nanoparticles containing anthocyanin in their hydrophobic cores and cinnamaldehyde on their surfaces. These nanoparticles were then coated with a layer of carrageenan , resulting in the formation of anthocyanin-zein-cinnamaldehyde-carrageenan (AZCC) composite nanoparticles. Dynamic light scattering, electrophoresis , infrared spectroscopy, and scanning electron microscopy were used to characterize the properties of these composite nanoparticles. The particles formed were spherical and had relatively small diameters (563 nm) and high negative charges (−24.6 mV). The particles were mainly held together by hydrophobic, hydrogen bonding, and electrostatic interactions. The impact of nanoparticle concentration on the physical, structural, and functional properties of nano-composite films was investigated. Increasing the nanoparticle concentration led to changes in the opacity (17.42 A mm −1 ), microstructure, thermal stability (65.3%), and antioxidant activity of the films, as evaluated through DPPH (48.39%) and ABTS (92.77%) assays. The changes in color (S Lab : 16.98%–85.98%) of the nanoparticle-loaded films was sensitive to pH and ammonia content, which meant that they could be used as quality sensors. The release of anthocyanins from the films depended on the polarity of the model food they were in contact with. Optimized films significantly extended the freshness of Mandarin fish, resulting in a 13.3% reduction in total volatile base-nitrogen levels, which highlights their potential for monitoring and controlling the freshness of packaged foods.
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