BIOMATERIALS
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2022
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IF 15.304
Guoqing Wang,Xinyue Meng,Peiyan Wang,Xinping Wang,Gaoli Liu,Dong-An Wang,Changjiang Fan
Uncontrolled hemorrhage caused by trauma to internal organs or major arteries poses critical threats to lives. However, rapid hemostasis followed by tissue repair remains an intractable challenge in surgery owing to the lack of ideal internal-use adhesives that can achieve fast and robust wet adhesion and accelerate wound healing. Herein, we develop a robust hemostatic bioadhesive (CAGA) from novel highly-branched aminoethyl gelatin with end-grafted abundant catechol (Gel-AE-Ca). The unique chemical structure of Gel-AE-Ca makes CAGA capable of gelling on wet tissues via synergetic cross-linking of catechol-Fe 3+ chelation and horseradish peroxidase (HRP)/H 2 O 2 -triggered covalent bonds using a dual-channel needle, meeting the key demands of internal medical applications (e.g., instant and strong wet adhesion, injectability , biocompatibility, self-healing, stretching flexibility, infection resistance, and proper biodegradability). It exhibits rapid gelation within 10 s and robust wet tissue adhesion up to 115.0 ± 13.1 kPa of shear strength and 245.0 ± 33.8 mm Hg of sealing strength. In vivo trials demonstrate that CAGA can not only effectively seal anastomosis of the carotid artery, but achieve rapid hemostasis on the sites of liver incisions and penetrating cardiac wounds within 10 s. The wound closure by CAGA and its timely biodegradation promote wound healing of the vital organs.
研究领域:
外科手术
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生物材料
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组织工程
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止血
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伤口愈合
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产品关联
DOI
PubMed
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2023
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IF 8.2
Yuan Xu,Zhicheng Deng,Yun Chen,Fang Fang Wu,Chao Huang,Yong Hu
A novel mussel-inspired adhesive hydrogel with enhanced adhesion based on methacrylated catechol-chitosan (MCCS) and dopamine methacrylate (DMA) was prepared via photopolymerization. The structure and morphology of the MCCS/DMA adhesive hydrogel were investigated by using FTIR , NMR, XRD, TG, and SEM. The rheological and texture properties, swelling and degradation characteristics, as well as the adhesion mechanism of the hydrogels were also examined. These results revealed that the MCCS/DMA hydrogels have a dense double cross-linking network structure with porous internal microstructures, and exhibited controllable swelling and degradation properties, good thermostability , and stable rheological characteristics. Furthermore, the adhesive mechanism of MCCS/DMA hydrogel has been confirmed by the FTIR and 2D correlation FTIR spectroscopy . Additionally, the results of in vitro cytotoxicity assessment indicated that the resulting hydrogels have good cytocompatibility. Overall, the MCCS/DMA adhesive hydrogel may have potential applications in medical bioadhesives.
研究领域:
材料科学
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生物医学工程
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产品关联
DOI
PubMed
高影响因子
JOURNAL OF APPLIED POLYMER SCIENCE
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2023
·Vol. 141
·期 5
·e54873
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IF 3
Ze Liang,Lin Lu,Tingting Gao,Qinze Liu,Zhizhou Yang,Ruoyao Zhou,Guofeng Peng,Jinshui Yao,Changbin Zhang
Wastewater containing dyes is frequently discharged by industrial processes and needs separation and recycling. To solve this problem, it is important to research and develop environmentally friendly, efficient adsorbent materials for pollutant separation and recovery. In this study, a poly(PEI-catechol-tetraethylenepentamine) (PPCT) adsorbent was synthesized using a simple catecholamine reaction. This adsorbent exhibited high adsorption capacity and excellent removal efficiency for Reactive Red 195 (RR-195) in wastewater. The material was characterized using SEM, FT-IR, TGA, EA, and XPS. Its performance was optimized by varying the type of polyethyleneimine and the amount added during the preparation process. The effects of temperature, pH, contact time, and salt concentration on the adsorption were systematically investigated. Additionally, the experimental data showed consistency with both the Langmuir and pseudo-second-order kinetic models, simultaneously. The maximum adsorption capacity can reach 1754 mg g −1 at 303 K, with a retention rate of 86.6% after two cycles. The removal rate exceeds 98% at a concentration of 400 mg g −1 or lower. Additionally, the protonated amine group in PPCT carries a positive charge under acidic conditions, enabling selective adsorption of the anionic dye RR-195. Consequently, PPCT exhibits an excellent adsorption effect on RR-195 and holds promising applications in pollutant removal.
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DOI
高影响因子
International Journal of Electrochemical Science
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2023
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IF 1.5
Yongqing Liang,Jian Li,Yanjun Zhao
A novel carbon paste electrode (CPE) modified by the poly(sulfosalicylic acid) and multi-walled carbon nanotubes (MWCNTs) composite (poly-SA/MWCNTs) has been easily constructed as an electrochemical sensor for the catechol determination. The electrochemical behaviors of catechol are investigated by cyclic voltammetry (CV) and differential pulse voltammetry (DPV) at the modified electrode. It is found that (i) poly-SA/MWCNTs/CPE exhibits a better electrical conductivity than bare CPE and MWCNTs/CPE; (ii) the anodic peak current of catechol at the poly-SA/MWCNTs/CPE electrode is about 8-fold larger than that at the bare CPE electrode; (iii) the detection limit of concentrate of catechol is 0.16 μmol L -1 (S/N = 3) and the linear dynamic range varies from 3 to 240 μmol L -1 . The newly developed sensor exhibits many advantages for catechol detection, such a low-cost, easy preparation, high sensitivity, good anti-interference ability, excellent reproducibility and long-term stability and so on, which will be a potential candidate for the detection of phenolic derivatives.
研究领域:
分析化学
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环境科学
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产品关联
DOI
高影响因子
International Journal of Electrochemical Science
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2023
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IF 1.5
Yuting Wang,Xiangfei Chen,Dejuan Huang,Tianxiang Jin
Three-dimensional graphene (3DG) is presented as an excellent electrocatalyst for the simultaneous detection of hydroquinone (HQ) and catechol (CC) by cyclic voltammetry (CV) and differential pulse voltammetry (DPV). Morphology and structure of 3DG were characterized by scanning electron microscopy (SEM), X-ray diffraction (XRD), and X-ray photoelectron spectroscopy (XPS). Compared with the bare glassy carbon electrode (GCE), the 3DG-modified GCE exhibits better electrocatalytic activity in the redox reaction of HQ and CC. The 3DG-modified GCE detects both isomers selectively and sensitively by DPV and CV, latter showing a peak-to-peak separation of 190 mV. The detection limits for HQ and CC can reach 0.35 and 0.6 μM (S/N = 3), respectively, with wide linear ranges of 1-1000 μM in the presence of 50 μM of the respective other isomer. This work provides a strategy for the development of high-performance electrochemical sensors.
研究领域:
材料科学
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分析化学
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电化学
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产品关联
DOI
高影响因子
ACS Applied Polymer Materials
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2023
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IF 5
Jing Li,Yining Sun,Xiaodong Yang,Zhuan Fu,Xiangxiang Zhu,Hui Sun,Bin Yu
The superwetting membrane with superhydrophilic/underwater superoleophobic properties is one of the ideal materials for treating oily wastewater. We combined a catechol/silane biomimetic composite coating system and a metal-phenolic network structure to co-deposit a dopamine-like superhydrophilic coating on polypropylene nonwoven fabrics. The modified fabric separated oil–water mixtures with a filtration efficiency of up to 99%. Besides, the as-prepared material has the property of nonstick oil underwater and outstanding stability. After 30 cycles of separation tests, the pure water flux can be restored to 94.5% of the initial value after rinsing with deionized water. It maintained underwater superoleophobic properties after being immersed in a harsh environment of pH 1 or 13 for 1 h. Compared with dopamine hydrophilic modification, this method was more economical and time-consuming and could fabricate a full-scale separation material.
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产品关联
DOI
高影响因子
ACS Applied Polymer Materials
·
2024
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IF 4.4
Liuxin Yang,Pengfei Ren,Dandan Wei,Min Liang,Li Xu,Yinghua Tao,Guanhua Jiao,Tianzhu Zhang,Qianli Zhang
Temperature-responsive poly(N-isopropylacrylamide) (PNIPAM) polymers have been studied in many fields due to their “on–off” adjustable properties under temperature stimulation. In this work, the “on–off” mechanism for poly(N-isopropylacrylamide-co-dopamine methacrylamide) (PNIPAM-co-DMA) microgels for cell culture and nonenzymatic cell harvest was explored. Thermoresponsive surfaces were developed on silica wafers using microgels with different DMA contents using a simple spin-coating method. Experiments showed that the microgels showed an “on” state above the lower critical solution temperature (LCST), and PNIPAM-co-DMA (PND) microgels shrank to expose catechol groups for enhanced cell adhesion and proliferation. Conversely, the microgels showed an “off” state below LCST, and the hydrophobic and cell-repellent properties of DMA contributed to the rapid hydration of microgels for accelerated cell disassociation. The developed microgels presented DMA content and distribution-related cell detachment efficiency, with PND (100:0.5) and PND (100:2) showing better results. The failure of cell harvest caused by too much DMA restricted the shrinkage and swelling of microgels due to the strong hydrogen-bonding adhesion of catechol moieties for PND (100:10). Overall, the presented strategy exhibits a wide-ranging utility to construct thermoresponsive surfaces with “on–off” functionalization by introducing catechol chemical monomers.
研究领域:
材料科学
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生物医学工程
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细胞生物学
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产品关联
DOI
高影响因子
INDUSTRIAL CROPS AND PRODUCTS
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2024
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IF 5.6
Xiaoyong An,Yida Wang,Zhenghao Chen,Jiafei Zhang,Shuangbao Zhang
This study explores a cost-effective and environmentally friendly surface modification of bamboo fibers to improve their interfacial compatibility with poly (β-hydroxybutyric acid). Laccase catalyzed the oxidation of bamboo fibers, increasing their active reaction sites and surface roughness so that the deposition of catechol and tetraethylenepentamine (TEPA) reactions on the bamboo fiber surface was promoted. The FTIR , XPS , and XRD results of bamboo fibers indicate that laccase can effectively oxidize lignin, generating oxygen radicals and promoting the reactive deposition of catechol and TEPA on the surface of the bamboo fibers, without destroying the structure of bamboo fibers. The TGA results of bamboo fibers indicate that when the concentrations of both catechol and TEPA are 15 mM, a laccase concentration of 150 U/L is more effective in enhancing the thermal stability of bamboo fibers. Furthermore, the mechanical properties of BFs/PHB composites showed that the addition of 200 U/L of laccase led to relatively good interfacial compatibility between bamboo fibers and PHB, tensile strength , flexural strength , flexural modulus and impact strength of the composite material respectively increased by 18.4%, 14.1%, 13.4% and 10.4%, while the tensile modulus decreased by 9.4%, compared to the composite material prepared with unmodified bamboo fibers.
研究领域:
材料科学
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生物技术
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环境科学
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产品关联
DOI
高影响因子
CHEMICAL ENGINEERING JOURNAL
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2024
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IF 13.3
Delai Jiao,Hengji Zhao,Haofei Sima,Chunzu Cheng,Bo Liu,Chunling Zhang
In this work, we synthesized a 9,10-dihydro-9-oxa-10-phosphaphenanthrene-10-oxide (DOPO) derivative flame retardant dopamine modified DOPO (DOPO-DA) for flame retardant thermosetting epoxy resins (EP). The effects of different amounts of flame retardants on the flame retardancy, thermal properties, and mechanical properties of EP composites were studied. Compared with the control EP, the peak heat release rate (PHRR) of EP/5 wt% DOPO-DA decreased by 26.1%. In addition, EP/5 wt% DOPO-DA reached V-0 level. It can be attributed to the quenching effect of P element and catechol groups in DOPO-DA, reducing the active free radicals. N element can release non-combustible gases to dilute the concentration of oxygen. Meanwhile, P element can promote the formation of a dense carbon protective layer and slow down the heat and oxygen transfer on the surface. In addition, DOPO-DA can also participate in the crosslinking reaction of EP as a curing promoter, reducing crosslinking density and improving tensile properties.
研究领域:
材料科学
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化学工程
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产品关联
DOI
高影响因子
CHEMICAL ENGINEERING JOURNAL
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2025
·
IF 13.2
Yuanying Li,Han Shao,Yunxiu Zhang,Qiang Liu,Changhan Yan,Xiyin Liu,Yaolan Tao,Renhao Nie,Jianhong Zhang,Qingyan Jia,Peng Li
Due to the heightened nutritional consumption resulting from aberrant metabolism of tumor cells, starvation therapy, which involves blocking or depleting key nutrients in tumors, has gained popularity as an attractive approach to treating cancer. Herein, the catechol-containing polymer, P(DMA-co-MAA)-BTZ, was successfully synthesized via the copolymerizing dopamine methacrylamide (DMA) with polymethacrylic acid (MAA), followed by grafted with chemotherapy drug bortezomib (BTZ). The P(DMA-co-MAA)-BTZ exhibited pH-responsive behavior in the acidic tumor microenvironment, facilitating controlled release of BTZ for chemotherapy. Additionally, the liberated phenolic groups could form a membranal coating on the surface of tumor cells in response to overexpressed H 2 O 2 , thereby impeding the uptake of external nutrients and enabling starvation therapy. The efficacy of P(DMA-co-MAA)-BTZ in inhibiting glucose uptake by tumor cells has been demonstrated through both in vitro and in vivo experiments, resulting in a reduction of intracellular lactate, GSH, and ATP synthesis as well as the accumulation of reactive oxygen species as metabolic waste. This synergistic strategy of combining starvation therapy with chemotherapy yielded efficient anti-tumor effects while suppressing tumor metastasis and invasion, presenting a promising alternative approach for clinical tumor treatment.
研究领域:
肿瘤学
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生物化学
·
药物化学
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产品关联
DOI
高影响因子
JOURNAL OF THE ELECTROCHEMICAL SOCIETY
·
2023
·Vol. 170
·期 7
·077509
·
IF 3.9
Qi Wang,Wenjing Liu,Jinjin Zhang,Jianying Qu
In this work, Cu/N-C derived from MOF composites were synthesized and characterized by SEM, XRD, FTIR, XPS and EIS, which was modified on the glassy carbon electrode (GCE) to construct a novel electrochemical sensor (Cu/N-C/GCE). Due to the good electrical conductivity and abundant catalytic active sites of Cu/N-C, Cu/N-C/GCE exhibited excellent electrocatalytic performance for catechol (CC) and hydroquinone (HQ) with the oxidation peak potential difference of 112 mV. The proposed sensor could realize the simultaneous detection of CC and HQ successfully. Under optimal conditions, the redox peak currents of both CC and HQ have good linear relationship with their concentrations in the ranges of 0.50–100.00 μM and 0.50–150.00 μM with the detection limits for CC and HQ of 0.12 μM and 0.09 μM, respectively. At the same time, the sensor exhibits good stability, reproducibility and selectivity in the analysis of practical samples.
研究领域:
分析化学
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材料科学
·
环境科学
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DOI
高影响因子
MICROCHEMICAL JOURNAL
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2021
·
IF 4.821
Xin-Yang Lu,Sheng-Feng Zhang,Fen-Ying Kong,Zhong-Xia Wang,Heng-Ye Li,Hai-Lin Fang,Wei Wang
In this paper, a glassy carbon electrode (GCE) modified with TiO 2 -ZnO-reduced graphene oxide (TiO 2 -ZnO-rGO) nanocomposites was designed for the selective and simultaneous quantification of hydroquinone (HQ) and catechol (CA). The TiO 2 -ZnO-rGO nanocomposites were prepared by a simple ultraviolet irradiation method for the first time. In the process of ultraviolet radiation, the photogenerated electrons in TiO 2 and ZnO were transfered into GO which was then reduced to form rGO. Benefiting from functional properties of different components and synergistic effect, the TiO 2 -ZnO-rGO nanocomposites exhibited excellent sensing performance for the selective and simultaneous determination of HQ and CA. Under the optimized conditions, the linear ranges for selective assay of HQ or CA in the existence of 40 µM of the respective isomer are 5–500 µM. The linear ranges for simultaneous assay of HQ and CA are obtained from 0.1 to 100 µM with the detection limits of 0.03 µM (HQ) and 0.05 µM (CA), respectively. The TiO 2 -ZnO-rGO/GCE also displayed excellent stability and satisfactory recovery when applied for real water samples analysis.
研究领域:
分析化学
·
环境科学
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DOI
高影响因子
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