Marine Life Science & Technology
·
2021
·Vol. 4
·期 1
·74-87
·
IF 0
Tong Jianan,Zhou Huiyun,Zhou Jingjing,Chen Yawei,Shi Jing,Zhang Jieke,Liang Xinyu,Du Tianyuan
Chitosan/glycerophosphate thermosensitive hydrogel crosslinked physically was a potential drug delivery carrier; however, long gelation time limits its application. Here, chitosan-amino acid (AA) thermosensitive hydrogels were prepared from chitosan (CS), αβ-glycerophosphate (GP), and l -lysine (Lys) or l -glutamic acid (Glu). The prepared CS-Lys/GP and CS-Glu/GP hydrogel showed good thermosensitivity and could form gels in a short time. The optimal parameters of CS-Lys/GP hydrogel were that the concentration of CS-Lys was 2.5%, the ratio of CS/Lys was 3.5/1.0, the ratio of CS-Lys/GP was 4.5/1.0. The optimal parameters of CS-Glu/GP hydrogel were that the concentration of CS-Glu was 3.0%, the ratio of CS/Glu was 2.0/1.0, and the ratio of CS-Glu/GP was 4.0/1.5. Chitosan-amino acid (CS-AA) thermosensitive hydrogel had a three-dimensional network structure. The addition of model drug tinidazole (TNZ) had no obvious effect on the structure of hydrogel. The results of infrared spectroscopy showed that there were hydrogen bonds between amino acids and chitosan. In vitro release results showed that CS-Lys/GP and CS-Glu/GP thermosensitive hydrogels had sustained release effects. Thus, the chitosan-amino acid thermosensitive hydrogels hold great potential as a sustained release drug delivery system.
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BULLETIN OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY
·
2019
·Vol. 104
·期 1
·149-155
·
IF 1.65
Xie Yan-Li,Jiang Wayne,Li Fen,Zhang Yu,Liang Xiao-Yu,Wang Meng,Zhou Xueqing,Wu Shao-Ying,Zhang Cheng-Hui
This study was intended to develop an environment-friendly controlled release system for spirotetramat in an alginate matrix. Four formulations, starch–chitosan–calcium alginate (SCCA), starch–calcium alginate (SCA), chitosan–calcium alginate (CCA), and calcium alginate (CA) complex gel beads, were prepared by the extrusion–exogenous gelation method. The properties of the formulations were studied. The results showed that the release behaviors of the formulations in water could be well described by the logistic model, and the release occurred through Fickian diffusion. Among the four formulations, SCCA showed the highest entrapment efficiency, drug loading and the slowest release rate. Degradation studies revealed that the SCCA formulation exhibited an obvious slower degradation rate of spirotetramat in soils than the commercially available formulation. The estimated half-life of the SCCA formulation was 2.31, 3.25, and 4.51 days in waterloggogenic paddy soil, purplish soil, and montmorillonite, respectively, when the soils were moistened to 60% of its dry weight. This study provided a possible approach to prolong the duration of spirotetramat and to reduce environmental contamination.
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高影响因子
JOURNAL OF POLYMER RESEARCH
·
2019
·Vol. 26
·期 12
·1-9
·
IF 1.53
Chen Jiewei,Shang Jingqi,Xue Feng,Wei Qiushi,Xu Ning,Ding Enyong
This article reports on the high-efficiency preparation of few layers h-BN nanosheets (BNNSs) by a high-pressure homogenizer. Then, the BNNSs/chitosan microspheres (BN-CS-M) are finally prepared by mixing BNNSs with chitosan under alkaline conditions. The BNNSs dispersion is investigated by UV-vis spectrophotometer and Transmission Electron Microscopy. In addition, we use Scanning Electron Microscopy and Laser particle size analyzer to characterize the microscopic and macroscopic morphology of BN-CS-M composites. Raman spectroscopy and Specific surface area testing are also used to explore the intrinsic properties of BN-CS-M. Thermal gravimetric analysis shows that composites with high content of BNNSs possess higher thermal stability. The results show that BNNSs is dispersed in the network of chitosan microspheres, and the higher the rate of centrifugation, the fewer BNNSs dispersed in the microspheres. The chitosan microspheres composite with pore diameters in the range of 1.7–2.9 nm belongs to the type IV adsorption curve.
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LWT-FOOD SCIENCE AND TECHNOLOGY
·
2017
·
IF 2.329
Suwei Jiang,Zhenyu Yu,Hailiang Hu,Jian Lv,Hualin Wang,Shaotong Jiang
Polyphenolic bioflavonoids are easily oxidized when exposed to oxygen during the processing or storage. This research developed a porous chitosan-modified starch for the adsorption of procyanidins . The modified starch was fabricated by a facile surface modification of chitosan on porous rice starch. Besides the investigation of the morphologies and structures of starches, the adsorption kinetics of procyanidins onto starches was evaluated. The modified starch was mesoporous with a relative moderate specific surface area at 1.13 ± 0.05 m 2 /g, and the interactions between starch and chitosan were intermolecular hydrogen bonds. The modification of chitosan resulted in the positive zeta potential of starch at pH 2-10. The enzymolysis reduced starch size slightly and induced a decrease in the apparent viscosity of starch suspension, while the modification of chitosan increased starch size and induced an increase in the apparent viscosity of the suspension. The adsorption capacity of the modified starch towards procyanidins was significantly improved and reached 96 ± 3% of the total amount of procyanidins, and the adsorption was chemisorption or strong surface complexation rather than mass transport. The results suggested that the porous chitosan-modified starch might be used as an efficient adsorbent for polyphenols.
研究领域:
食品科学
·
生物化学
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JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY
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2017
·Vol. 17
·期 6
·3873-3879
·
IF 1.483
Hu Gaoli,Song Botao,Zhu Jie
The aim of this study was to implement a novel bioinspired process based on the superhydrophobic surface to produce organic solvent-free spheres for drug controlled release. Firstly, superhydrophobic substrate with large area was successfully constructed in one step by the electrospray
approach. Then, by utilizing the as-synthesized superhydrophobic substrate the chitosan (CS) spheres with controllable sizes and drug loading contents were fabricated. The drug encapsulation efficiency was further carefully studied, and it was found that the encapsulation efficiencies were
very high and could reach up to 92% and above. Finally, the drug release behaviors of the drug-loaded CS spheres were systematically investigated, and the results demonstrated that both the diameter of the CS spheres and the drug loading content influenced the drug release characteristics.
This present approach opened up a new possibility for the development of novel drug delivery systems with controllable drug delivery property for a broad range of pharmaceutical and biomedical applications.
研究领域:
生物材料学
·
药剂学
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高影响因子
Micro & Nano Letters
·
2017
·Vol. 12
·期 6
·386-390
·
IF 0.723
Lv Ming-zhe,Wang Li-feng,Fang Lei,Li Pu-wang,Li Si-dong
Chitosan microspheres were prepared by ion induction and chemical cross-linking using water as the medium. Natural rubber/chitosan microsphere blends were then prepared by blending the chitosan microsphere suspension with natural rubber latex. An infrared spectrometer, particle size analyser, scanning electron microscope, surface contact angle analyser, thermogravimetric analyser, and differential scanning calorimeter were employed for structure and property characterisation. The results showed that the average particle diameter and the polydispersity index of chitosan microspheres were 323.8 nm and 0.283, respectively. The thermal stability and mechanical properties of natural rubber/chitosan blends were enhanced by introducing chitosan microspheres into natural rubber latex. The water contact angle was significantly decreased, from 94.64° to 55.47°, indicating improved hydrophilic properties for the natural rubber/chitosan film. The natural rubber/chitosan blends showed excellent antibacterial properties when the chitosan microsphere content was >4.00% w/w.
研究领域:
材料科学
·
生物医学
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高影响因子
CARBOHYDRATE POLYMERS
·
2017
·
IF 4.811
Lin Yue,Jingru Li,Wanwen Chen,Xiaoli Liu,Qixing Jiang,Wenshui Xia
The novel derivatives of geraniol grafted chitosan oligosaccharide were synthesized via substitution and deprotection reaction, respectively. The products were identified by Fourier transform infrared (FT-IR), 1 H nuclear magnetic resonance (NMR), X-ray diffraction analysis (XRD), Thermogravimetric analysis (TGA) and UV–vis absorption spectroscopy. It is revealed that the derivatives exhibited a good solubility, thermal stability and antibacterial properties.
研究领域:
生物材料学
·
微生物学
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高影响因子
CARBOHYDRATE POLYMERS
·
2017
·
IF 4.811
Xun Sun,Zonghao Tang,Meng Pan,Zhengchao Wang,Hongqin Yang,Haiqing Liu
The hemostatic performance of chitosan was greatly improved by blending it with kaolin to fabricate porous composite microspheres (CSMS-K) through inverse emulsion method combining with thermally induced phase separation. The CSMS-K had high amount of interior and surface pores. The synergetic hemostatic competence of chitosan and kaolin components made the hemostatic efficacy of CSMS-K superior to chitosan porous microspheres (CSMS). The hemostatic time of CSMS-K3 in the rat tail amputation and liver laceration models was down to respective 120 and 99 s from 183 and 134 s of CSMS, and the blood loss of CSMS-K3 was respectively 65% and 36% of that of CSMS in the rat tail amputation and liver laceration models. The whole blood clotting kinetics proved that CSMS-K3 formed larger blood clots than CSMS and Celox within a same time period. Our results suggested that the CSMS-K is a potential quick pro-coagulant agent for traumatic hemorrhaging control.
研究领域:
材料科学
·
生物医学工程
·
止血
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高影响因子
COLLOIDS AND SURFACES B-BIOINTERFACES
·
2014
·
IF 4.287
Fang Yuan,Shasha Wang,Gaojian Chen,Kehua Tu,Hongliang Jiang,Li-Qun Wang
A novel approach to design pH-sensitive and disintegrable polyelectrolyte nanogels composed of citraconic-based N -(carboxyacyl) chitosan (polyanion) and quaternary chitosan (polycation) was reported. Firstly, the hydrolysis of citraconic-modified chitosan was monitored using fluorescamine assay and it could selectively dissociate in acidic media (e.g., pH ∼5.0) due to the isomerization during the addition of citraconic anhydride to chitosan. Secondly, the self-assembly behaviors of different polyelectrolyte pairs between citraconic-based chitosan and quaternary chitosan were investigated via colloidal titration assay. It was indicated that the difference in molecular weight (MW) of opposite charged polyelectrolytes played an important role on the formation of polyelectrolyte nanogels. Results showed that polyelectrolyte nanogels (ca. 300 nm in size) only formed when polyanion and polycation had a very large difference in MW. The pH-sensitive behavior of polyelectrolyte nanogels was comprehensively investigated by dynamic light scattering (DLS) and transmission electron microscope (TEM). The incorporation of charge-conversional citraconic-based chitosan into polyelectrolyte complexes has provided an effective approach to prepare polyelectrolyte nanogels which were very stable at neutral pH but disintegrated quickly in acidic media.
研究领域:
材料科学
·
生物医学工程
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高影响因子
BIORESOURCE TECHNOLOGY
·
2014
·
IF 5.039
Changlong Dong,Wei Chen,Cheng Liu
A kind of amphoteric chitosan-based flocculant (quaternized carboxymethyl chitosan, denoted as QCMC) has been prepared. QCMC presented significant improvement of water solubility in the whole pH range. The effects of pH, dosage, temperature and original turbidity of algal water on the flocculation performance were investigated. The optimal dosages of QCMC at pH 5, 9 and 12 with original turbidity of 20 NTU at 20 °C were 0.1, 0.6 and 2.0 mg/L, respectively, which were much less than that of chitosan, PAM, Al 2 (SO 4 ) 3 and FeCl 3 . The floc properties during grow, breakage and regrow period were also evaluated at different pH values in terms of floc size, strength and density. It was demonstrated that QCMC produced larger, stronger and denser flocs than Al 2 (SO 4 ) 3 . There is every indication that QCMC is more suitable for algal harvesting than other traditional coagulants or flocculants.
研究领域:
环境科学
·
水处理
·
化学工程
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高影响因子
SCIENCE OF THE TOTAL ENVIRONMENT
·
2018
·
IF 4.61
Muhammad Zaheer Afzal,Xue-Fei Sun,Jun Liu,Chao Song,Shu-Guang Wang,Asif Javed
Biochar is effective in water treatment but it is hard to retrieve or separate biochar powder from aqueous solutions. In this study, the removal of ciprofloxacin from aqueous solutions was investigated using chitosan/biochar hydrogel beads (CBHB). The results showed that the adsorption rate was almost independent of the temperature and occurred at the homogeneous sites of adsorbent thus obeying the Langmuir model. The equilibrium time was varying for different initial concentrations and found to be 48 h for maximum one. The maximum sorption was found to be >76 mg/g of adsorbent out of 160 mg/L as initial concentration. Adsorption obeyed the second-order mechanism with leading role of intra-particle diffusion and outer diffusion. Adsorption capacity decreased from 34.90 mg/g to 15.77 mg/g in the presence of 0.01 N Na 3 PO 4 whereas other electrolytes such as NaCl, Na 2 SO 4 , NaNO 3 with same concentration did not affect the sorption capacity. However, increased concentration of NaCl reduced the sorption capacity to some extent. CBHB showed a mixed mechanism by removing CIP through π-π electron donor-acceptor (EDA) interaction, hydrogen bonding and hydrophobic interaction. The reformation of CBHB with methanol and ethanol instead of water decreased its sorption capacity to 32.69 mg/g and 29.29 mg/g. Adsorption decreased by little after every regeneration of CBHB and was still >64 ± 0.68% (25.73 mg/g) after 6th regeneration. The efficacy of CBHB for CIP removal proved that CBHB is an economical and sustainable adsorbent.
研究领域:
环境科学
·
材料科学
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高影响因子
APPLIED SURFACE SCIENCE
·
2015
·
IF 2.711
Heqing Fu,Yin Wang,Weifeng Chen,Jing Xiao
Waterborne polyurethane/halloysite nanotubes nanocomposites were prepared by modified halloysite nanotubes (HTs) with chitosan (CS). Modified HTs were characterized by Fourier transform infrared spectroscopy, elemental analysis, and thermogravimetry, which verified that CS was successfully assembled onto the HTs surface. The chitosan-modified halloysite nanotubes (CHTs) were uniformly dispersed in WPU matrix through the reaction with polyurethane prepolymer, and acted as chain cross-linker as well as reinforcing filler, which increased the cross-linking density of nanocomposites. The experimental results showed that the strong interfacial interaction and hydrogen bonding interaction between CHTs and WPU improved the degree of micro-phase separation, thermal properties, mechanical properties and surface properties of nanocomposites. The tensile strength and elongation at break were simultaneously enhanced when the CHTs loading was below 2 wt%.
研究领域:
材料科学
·
高分子化学
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高影响因子
危险品化学品经营许可证（带存储）