Journal of Pharmaceutical Analysis
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2026
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IF 11.2
Luyun Yang,Yingchao Li,Chunyan Yin,Litao Wu,Kexin Cheng,Jiafu Liang,Xiaona Cheng,Quan Zhang,Yakun Huang,Haoyun Bai,Wenlong Wang,Kaikai Lu,Rong Zhao,Zizhen Guo,Mingzhen Zhang,Shengli Han,Dongmin Li
Inflammatory bowel disease (IBD) is a chronic intestinal inflammatory condition resulting from complex interactions. With current clinical treatments showing limited efficacy, IBD poses an increasing global health challenge. Analysis of the GEO database, clinical samples from IBD patients, and a dextran sulfate sodium (DSS)-induced murine colitis model consistently reveal elevated Toll-like receptor 2 (TLR2) expression at both transcriptional and protein levels, implicating it in IBD pathogenesis and highlighting its potential as a therapeutic target. Previous studies have shown that Schisandrin B (SchB) protects DSS-induced colitis, but whether it directly targets an upstream immune receptor such as TLR2, and what additional mechanisms beyond its known anti-inflammatory actions exist, remain to be explored. In this study, SchB is identified as a moderate TLR2 ligand using cell membrane chromatography (CMC). By directly binding to TLR2 and inhibiting its heterodimerization with Toll-like receptor 1 (TLR1) or Toll-like receptor 6 (TLR6), SchB exerts significant anti-inflammatory and therapeutic effects in inflammatory cell models and ameliorates both DSS-induced ulcerative colitis and peptidoglycan (PGN)-induced immune colitis in mice. SchB inhibits TLR2 signaling and activates the sequestosome 1 (p62/SQSTM1)/Kelch-like ECH-associated protein 1 (Keap1)/nuclear factor erythroid 2-related factor 2 (Nrf2) axis, concurrently exerting anti-inflammatory, antioxidant, and anti-apoptotic effects and reinforcing intestinal barrier integrity. These findings provide new evidence of molecular mechanisms supporting SchB as a promising therapeutic candidate for IBD.
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高影响因子
Journal of Materials Chemistry A
·
2021
·Vol. 9
·期 43
·24308-24314
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IF 12.732
Mingyue Jiang,Yue Yuan,Yuchen Fang,Shouxin Liu,Jian Li,Zhijun Chen,Qiuying Pang,Shujun Li
Using light-harvesting materials to enhance natural photosynthesis is attracting much attention in both materials and plant research. The working efficiency of most light-harvesting materials is, however, compromised by a narrow light-harvesting range (either ultraviolet (UV) only, or near-infrared (NIR) only) and a short lifetime of the excited state. We have now developed a new light-harvesting material (UCNP@CDs) from upconverting nanoparticles (UCNPs) and carbon dots (CDs), which has good photon up- and down-converting properties, because of the UCNPs and CDs, respectively. UCNP@CDs efficiently absorbed and converted both UV and NIR light to visible light, with a long lifetime for the excited state. UCNP@CDs was incorporated into a carboxymethylcellulose (CMC) matrix to produce a light-harvesting film that enhances natural photosynthesis, both by isolated chloroplasts and by living plants. Our rationally designed UCNP@CDs/CMC composite light-harvesting film was able to enhance photosynthesis by Arabidopsis thaliana by ∼12%.
研究领域:
材料科学
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植物生物学
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生物物理学
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高影响因子
Journal of the Taiwan Institute of Chemical Engineers
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2023
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IF 5.7
Ning Li,Hao Ma,Tongyu Wang,Caixia Sun,Shuqian Xia
Background Water-soluble polymers are increasingly attracting the attention of petroleum engineers for their excellent surface activity and viscosity-reducing properties in enhancing heavy oil recovery. However, the actual formation conditions are highly saline, for which we designed and synthesized a new salt-resistant water-soluble viscosity reducer. Methods Hydrophobically associating terpolymers, poly(Acrylamide/ N-vinyl caprolactam/ quaternary ammonium salt alkyl chains) (ANDs), were synthesized by free radical polymerization in an aqueous solution, and we obtained four different molecular weights of polymers by dialysis. Significant findings The results showed that the heavy oil viscosity reduction rates (VRR) of all four polymer solutions were above 98.3% under highly mineralized formation water and high-temperature reservoir conditions. Polymer AND-4 could show good salt tolerance at a high salt concentration of 5 × 10 4 mg/L NaCl and reached the best viscosity reduction rate of 99.07%. In addition, the polymers' thermal stability, hydrophobicity, surface activity, and salt resistance improved with the increasing molecular weight. Meanwhile, the critical micelle concentration (CMC) and the emulsifying performance improved. This study also discussed the mechanism of viscosity reduction by different molecular weight viscosity reducers. Notably, compared with previous heavy oil viscosity reducers, this work provides a new water-soluble polymeric viscosity reducer with high efficiency and salt tolerance. It also facilitates the design and application of functionalized viscosity reducers for enhancing oil recovery.
研究领域:
石油工程
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高分子科学
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化学工程
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高影响因子
CARBOHYDRATE POLYMERS
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2024
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IF 10.7
Weijie Jiang,Xuelong Hou,Xiangyang Guo,Meng Zhu,Xinsen Lin,Zhaowen Zhang,Zixiang Chen,Xiaobo Lin,Yafei Feng,Junchai Zhao,Jinhui Yang,Min Wu
In medical field, light-weight, superelastic, and super-absorbing aerogels are highly desired for sensitive wounds with persistent exudations. Up to now, superelastic PU porous dressings are commonly employed, which impose environmental concerns both in their preparation and in their pollution after usage. Herein, carboxymethyl cellulose (CMC) was used to construct hierarchical aerogels via a dual-crosslinking and porogen leaching method. The hierarchical aerogel not only disperses stress at multiple scales, endowing the aerogel with superelasticity, but also deeply absorbs bioliquid through its hierarchical porous surfaces and strong wetting forces deriving from the abundant hydrophilic groups such as hydroxyl and carboxyl groups. Moreover, for practical use, the hierarchical CMC (H-CMC) dressing demonstrates superior absorbency than commercial elastic PU foam both in static and dynamic liquid absorption, faster wound healing than commercial CMC fiber dressing, and can fully degrade both in vivo and in soil. Thus, this research offers a universal approach to design hierarchical wound dressings using bio-based polyelectrolyte, presenting a wound dressing that is both environmentally-friendly and highly comfortable when applied in healing human sensitive injuries.
研究领域:
材料科学
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生物医学工程
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伤口护理
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PubMed
高影响因子
JOURNAL OF PETROLEUM SCIENCE AND ENGINEERING
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2021
·
IF 4.346
Qi Wu,Yan Xu
Stimulus-responsive surfactant is becoming a hot research topic with high controllability and excellent emulsifying properties. In this work, an amidine naphthenate surfactant was synthesized for the first time by the reaction between alkyl amidine and naphthenic acid. Surface activity and emulsion performance of this novel surfactant in oil/water emulsion were investigated. Compared with the previously synthesized amidine bicarbonate surfactants, amidine naphthenate surfactants exhibited a superior emulsification performance above 60 °C due to their lower critical micelle concentration (CMC) and interfacial tension (IFT). The presence of two long alkyl groups is recognized as the main reason for its superior properties than amidine bicarbonate having only one long alkyl group. Increased hydrophobic interactions between the long alkyl chains and electrostatic interactions between the ionic head groups lead to the easier formation of micelles. Notably, the amidine naphthenate has a characteristic of CO 2 -responsive property. The amidine naphthenate emulsion can be demulsified by CO 2 bubbling which destroys the chemical structure of amidine naphthenate, accompanied by the formation of amidine cations and naphthenic acids. Then, the emulsion was completely demulsified due to the demulsification effect of naphthenic acid. Therefore, the synthesized amidine naphthenate surfactant possesses not only high interface activity but also CO 2 responsive property, which endows it an extensive application prospect for enhanced oil recovery (EOR) operations in the oil industry.
研究领域:
化学
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材料科学
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石油工程
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高影响因子
JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES
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2026
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IF 2.5
Wenhao Chen,Haoyun Bai,Quan Zhang,Jingjing Yang,Shengyu Zhou,Du Feng,Shengli Han
Established a universal screening platform for CD147-targeted therapeutics. • Integrated the CMC-HPLC system with mass spectrometry (MS) for the identification of unknown compounds. • Two bioactive constituents from Magnolia officinalis, directly interact with CD147. Hepatocellular carcinoma (HCC) is one of the most prevalent digestive malignancies, with CD147 emerging as a promising therapeutic target for HCC. To date, no natural bioactive components targeting CD147 for anti-HCC therapy have been explicitly reported. Given the low toxicity and favorable efficacy of natural small-molecule drugs, identifying and investigating CD147-targeted natural agents is imperative. In this study, based on cell membrane chromatography (CMC) and SNAP-tag protein labeling technology, we constructed a CD147-SNAP-tag-CMC/HPLC-MS two-dimensional coupled system to screen CD147-binding components from Magnolia officinalis , followed by ligand-receptor affinity verification, in vitro pharmacological evaluation, and downstream molecular mechanism validation. Two bioactive compounds, honokiol and magnolol, were successfully identified: both exhibit strong CD147 binding affinity, effectively suppress HCC cell migration, and exert their functions by regulating the CD147/integrin-FAK-paxillin pathway as confirmed by Western blotting. Collectively, the established two-dimensional system serves as a universal platform for CD147-targeted component screening. This study is the first to reveal the strong CD147 affinity of honokiol and magnolol and their anti-migratory effect on HCC cells via modulating the aforementioned pathway.
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PubMed
高影响因子
Food Packaging and Shelf Life
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2025
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IF 10.6
Yanqing Li,Xuchen Li,Shaomei Li,Jiao Li,Xiang Zou,Hongwei Zhan,Guanyuan Qu,Lixiu Zhang,Yongjun Sun,Wenming Ju,Mengqi Ye,Pengdong Sun,Jingyuan Li,Yang Deng,Ting Ding
Aeromonas sobria , recognized as a psychrotrophic specific spoilage organism in refrigerated aquatic products, facilitates its proliferation by metabolizing proteins, lipids, and carbohydrates, thereby generating spoilage-associated metabolites and compromising product quality. Quorum sensing (QS), a bacterial cell-to-cell communication mechanism, orchestrates the secretion of virulence and spoilage factors in A. sobria via the LuxI/R QS system. Targeting this regulatory pathway presents a novel strategy to mitigate spoilage and extend the shelf life of aquatic products. Previous studies have demonstrated that zingerone (ZRN) exhibits quorum-quenching activity at sub-inhibitory concentrations; however, its practical application is constrained by limited solubility and bioavailability. To overcome these challenges, ZRN was encapsulated within halloysite nanotubes (HNTs) and incorporated into a self-assembled composite film composed of chitosan (CS) and sodium carboxymethyl cellulose (CMC-Na). The fabricated film was characterized for its structural, thermal, and mechanical properties and subsequently evaluated for its preservation efficacy on refrigerated perch fillets. The composite film exhibited a homogeneous surface morphology with uniformly dispersed HNTs, alongside adequate thermal stability, tensile strength, and physicochemical attributes suitable for refrigerated aquatic product preservation. Notably, the film suppressed spoilage indicators, including total volatile basic nitrogen (TVB-N) accumulation, lipid peroxidation, and bacterial spoilage potential, without inhibiting A. sobria growth. Furthermore, it mitigated muscle tissue degradation and biogenic amine formation in perch fillets during refrigerated storage. Molecular docking simulations revealed that ZRN competitively binds to the LuxR-type receptor at the same binding pocket as the endogenous autoinducer C 4 -HSL, thereby disrupting QS signaling. Collectively, this ZRN-loaded composite film represents a promising biodegradable packaging solution for enhancing the quality and shelf life of refrigerated aquatic foods.
研究领域:
食品微生物学
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食品保鲜
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纳米技术
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细菌通讯
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材料科学
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水产品加工
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高影响因子
MINERALS ENGINEERING
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2025
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IF 5
Ting Xiao,Wenjie Zou,Congzhong Tian,Wentao Hu,Zhijun Zhang,Chengyan Xu,Fang Zhou
Green and efficient flocculants are crucial for the effective treatment and recycling of mine wastewater. Herein, the flocculation performance and mechanism of a novel amphoteric chitosan-based flocculant CMC-g-CPAM on kaolinite suspensions were investigated through settling tests, zeta potential measurements, floc size distribution, quartz crystal microbalance with dissipation (QCM-D) and atomic force microscopy (AFM) measurements. Settling tests results revealed that CMC-g-CPAM displayed exceptional flocculation performance, achieving a settling rate of 18.21 m/h for kaolinite at natural pH, higher than that of chitosan-grafted-cationic acrylamide Chi-g-CPAM (11.19 m/h). The in-situ adsorption layer of CMC-g-CPAM on silica and alumina surfaces was more rigid than that of Chi-g-CPAM. Subsequently, more kaolinite particles were flocculated by CMC-g-CPAM, and formed a denser floc layer. The adsorption amounts of CMC-g-CPAM and Chi-g-CPAM on silica surfaces were found to be greater than those observed on alumina surfaces at natural pH. This phenomenon was related to the different surface charges of silica and alumina, electrostatic interactions between the polymers and surfaces. From AFM measurements, an attraction between the CMC-g-CPAM functionalized probe and the functional substrate as they approached each other and a weak adhesion force among CMC-g-CPAM (0.31 nN over 50 nm) were observed. These indicated the presence of intermolecular interactions among CMC-g-CPAM, which contributed to the formation of compact flocs. In contrast, an obvious repulsion was detected when the Chi-g-CPAM functionalized probe approached the functional substrate, inhibited the entanglement of polymer chains. Meanwhile, the interactions between multiple molecules and the substrate displayed a large adhesion force (2.10 nN over 150 nm), attributed to the less rigid adsorption layer of Chi-g-CPAM. Our findings would provide new insights into the design of flocculants and effective wastewater treatment.
研究领域:
环境工程
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高分子科学
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胶体与界面科学
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矿物加工
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废水处理
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高影响因子
Gels
·
2022
·Vol. 8
·期 5
·279
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IF 4.432
Hang Yang,Xianyu Lan,Yuzhu Xiong
Although many advances have been made in medicine, traumatic bleeding and wound infection are two of the most serious threats to human health. To achieve rapid hemostasis and prevent infection by pathogenic microbes, the development of new hemostatic and antibacterial materials has recently gained significant attention. In this paper, safe, non-toxic, and biocompatible polyvinyl alcohol (PVA); carboxymethyl cellulose (CMC), which contains several carboxyl and hydroxyl groups; and polyethylene glycol (PEG), which functions as a pore-forming agent, were used to prepare a novel PVA/CMC/PEG-based composite hydrogel with a macroporous structure by the freeze-thaw method and the phase separation technique. In addition, a PVA/CMC/PEG@ZIF-L composite hydrogel was prepared by the in situ growth of zeolitic imidazolate framework-L (ZIF-L). ZIF-L grown in situ on hydrogels released Zn2+and imidazolyl groups. They elicited a synergistic antibacterial effect in hemostasis with PVA and CMC, rendering the PVA/CMC/PEG@ZIF-L hydrogel with a good antibacterial effect againstStaphylococcus aureus. At the same time, the macroporous structure enabled the rapid release of Zn2+and imidazolyl groups in ZIF-L and promoted cell proliferation at an early stage, enhancing the coagulation efficiency. A rat liver injury model was used to confirm its rapid hemostasis capacity.Keywords:in situ growth;macroporous structure;synergistic antibacterial;rapid hemostatic;carboxymethyl cellulose;wound dressing;hydrogel;ZIF-L;polyvinyl alcohol;phase separation technique
研究领域:
生物医学工程
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材料科学
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创伤修复
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PubMed
高影响因子
Environmental Technology & Innovation
·
2020
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IF 3.356
Xiaomin Huang,Hanghai Zhou,Qiliang Ni,Chuhan Dai,Chunlei Chen,Yanhong Li,Chunfang Zhang
This work investigated the effects of biosurfactant at varied dose on the bioremediation of hydraulic fracturing flowback wastewater (HFFW) and explored the associated mechanism. Initially, a biosurfactant-producing strain Pseudomonas sp. CH1 was isolated from oily sludge . The glycolipid biosurfactant produced by CH1 have a critical micelle concentration (CMC) of 80 mg/L, and showed high stability over a wide range of temperature (0–120 °C), pH (4–12), and salinity (0%–16%, w/v). Addition of sub-CMC dose of biosurfactant to HFFW greatly enhanced the microbial growth and activity, upregulated the expression levels of degradation-related genes, and effectively promoted the biodegradation of n -alkanes (reduction from 272.21 to 56.93 mg/L) and PAHs (reduction from 61.6 to 16.36 μ g/L) in 7 days. The results suggested the feasibility of applying biosurfactant with sub-CMC dose to remediate HFFW and contribute significantly to the optimization of surfactant-facilitated bioremediation strategies.
研究领域:
环境工程
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生物修复
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微生物学
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废水处理
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高影响因子
Nutrients
·
2024
·Vol. 16
·期 3
·443
·
IF 4.8
Tianhe Zhang,Lijun Liu,Qiqi Chen,Yifei Wang,Xiujun Gao,Xingyi Ma,Peisheng Yan
Panax ginseng, a traditional Chinese medicine with a history spanning thousands of years, faces overexploitation and challenges related to extended growth periods. Tissue-cultured adventitious roots and stem cells are alternatives to wild and field-cultivated ginseng. In this study, we assessed the in vitro xanthine oxidase and α-glucosidase inhibitory activities of saponin extracts among cultured cambial meristematic cells (CMC), adventitious ginseng roots (AGR), and field-cultivated ginseng roots (CGR). The xanthine oxidase (XO) and α-glucosidase inhibitory activities were determined by uric acid estimation and thep-NPG method, respectively. Spectrophotometry and the Folin–Ciocalteu, aluminum nitrate, and Bradford methods were employed to ascertain the total saponins and phenolic, flavonoid, and protein contents. The calculated IC50values for total saponin extracts against XO and α-glucosidase were 0.665, 0.844, and >1.6 mg/mL and 0.332, 0.745, and 0.042 mg/mL for AGR, CMC, CGR, respectively. Comparing the total saponin, crude protein, and total phenolic contents revealed that AGR > CMC > CGR. To the best of our knowledge, this study presents the first report on the in vitro comparison of xanthine oxidase and α-glucosidase inhibitory activities among AGR, CMC, and CGR. The findings offer valuable insights into the development of hypoglycemic and antihyperuricemic medicinal, nutraceutical, and functional products utilizing AGR and CMC.Keywords:cambial meristematic cells (CMC);adventitious ginseng roots (AGR);field-cultivated ginseng roots (CGR);xanthine oxidase (XO);α-glucosidase
研究领域:
药理学
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植物科学
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药物化学
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PubMed
高影响因子
SEPARATION AND PURIFICATION TECHNOLOGY
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2025
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IF 9
Xuanwei Chang,Xinru Gao,Xiufang Wen,Pihui Pi,Jiang Cheng,Shouping Xu
The advancement of sustainable solar-driven interfacial evaporation systems for seawater desalination continues to be hindered by intrinsic trade-offs among rapid water transport, effective salt rejection, and mechanical robustness in conventional photothermal materials. In this study, a hierarchically porous poly(vinyl alcohol)-propionaldehyde-glutaraldehyde sponge (PVPG) was synthesized via a mixed-acetal reaction. The three-dimensionally interconnected hierarchical pore network significantly enhanced capillary-driven water transport. The PVPG/CB/CMC sponge (PCB) was fabricated by integrating hydrophobic carbon black (CB) and hydrophilic sodium carboxymethyl cellulose (CMC) into the PVPG sponge. The hydrophobic-hydrophilic synergy between CB and CMC optimized water state and reduced the evaporation enthalpy of water. This enabled the evaporator to achieve an impressive evaporation rate of 3.56 kg m −2 h −1 under 1 sun irradiation. Simultaneously, spontaneous salt crystallization inhibition through the Donnan effect ensured that the system maintained a long-term evaporation rate of 3.08 kg m −2 h −1 even in 20 wt% high-salinity brine. Importantly, covalent crosslinking between CMC and the sponge matrix endowed the composite with exceptional mechanical durability, preserving structural integrity after 100 compression cycles, thereby addressing the brittleness limitation commonly observed in polyelectrolyte-based evaporators. This innovative architecture establishes a new framework for designing robust solar evaporators that integrate high efficiency, salt resistance, and structural stability, providing a practical solution for applications in challenging marine environments.
研究领域:
材料科学
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化学工程
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环境科学
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能源技术
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高分子科学
·
海水淡化技术
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高影响因子
危险品化学品经营许可证（带存储）