INDUSTRIAL CROPS AND PRODUCTS
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2022
·
IF 6.449
Hongyu Tian,Lina Zhang,Xiao Sun,Jing Cui,Jingjing Dong,Liang Wu,Yanfeng Wang,Lingli Wang,Min Zhang,Zhiguang Liu,Panfang Lu
Alkali-hydrolyzed lignocellulose was liquefied into polyols by acid-catalyzed dissolution, and then cross-linked with castor oil to prepare bio-based cross-linked polyurethane . Then, bis (2-hydroxyethyl) disulfide (SS) with self-healing function was used to reduce foaming in the curing process of polyurethane coating. Afterwards, disulfide bond modified cross-linked bio-based polyurethane coating (BCSPU) was applied to controlled-release urea (CRU). The results of excitation-emission matrices indicated that SS made the coating smoother and denser and preventing the release of non-film-forming substances. Cross-linking modification technology significantly extended the controlled release longevity of CRU by 77.3%, and the self-healing modification further prolonged the nitrogen release longevity by 61.5%. In addition, modified coating materials were non-toxic to wheat seeds and easily biodegradable in the soil. Cross-linking, self-healing modified controlled-release urea has enormous application potential in sustainable agriculture .
研究领域:
材料科学
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环境科学
·
农业科学
✓ 已验证
DOI
高影响因子
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
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2025
·
IF 5.4
Yikang Zhang,Maosong Lin,Yuran Wang,Bowei Yin,Jianglan Qu
Plant essential oil-based pesticides are increasingly valued in green agriculture for their efficacy, environmental compatibility, low toxicity, and minimal impact on non-target organisms. However, their practical use remains limited by short efficacy periods, poor photostability, and low solubility. To overcome these limitations, this study developed a pH-responsive hydrogel composed of carvacrol and the natural polysaccharides chitosan (CS) and guar gum (GG), which improved photostability by 126 %. The CS-GG hydrogel exhibited accelerated carvacrol release under acidic conditions, showing a relative increase of 20 % and following a Weibull diffusion model, thereby enabling targeted drug delivery at infection sites. Encapsulation markedly enhanced antifungal performance against anthracnose, achieving superior mycelial inhibition on tomato surfaces in both preventive and curative treatments compared with unencapsulated carvacrol. Moreover, hydrogel encapsulation reduced acute toxicity by minimizing direct exposure, as reflected by zebrafish LC 50 values that increased by approximately 71 % at 48 h and 46 % at 96 h, thereby significantly improving ecological safety. These findings demonstrate that the pH-responsive CS-GG hydrogel offers a promising platform for controlled delivery of botanical pesticides. This approach not only provides an effective, environmentally friendly solution for anthracnose control but also establishes a versatile framework for advancing the application of other plant-derived pesticides in sustainable crop protection.
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产品关联
DOI
高影响因子
ACS Applied Materials & Interfaces
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2012
·
IF 4.525
Yanna Cui,Haiqing Dong,Xiaojun Cai,Deping Wang,Yongyong Li
Hybrid mesoporous silica nanoparticles (MSNs), which were synthesized using the co-condensation method and engineered with unique redox-responsive gatekeepers, were developed for studying the glutathione-mediated controlled release. These hybrid nanoparticles constitute a mesoporous silica core that can accommodate the guests (i.e., drug, dye) and the PEG shell that can be connected with the core via disulfide-linker. Interestingly, the PEG shell can be selectively detached from the inner core at tumor-relevant glutathione (GSH) levels and facilitate the release of the encapsulated guests at a controlled manner. The structure of the resulting hybrid nanoparticles (MSNs-SS-mPEG) was comprehensively characterized by transmission electron microscopy (TEM), Fourier transform infrared spectroscopy (FTIR), powder X-ray diffraction (XRD), and nitrogen adsorption/desorption isotherms analysis. The disulfide-linked PEG chains anchored on MSNs could serve as efficient gatekeepers to control the on–off of the pores. Compared with no GSH, fluorescein dye as the model drug loaded into MSNs showed rapid release in 10 mM GSH, indicating the accelerated release after the opening of the pores regulated by GSH. Confocal microscopy images showed a clear evidence of the dye-loaded MSNs-SS-mPEG nanoparticles endocytosis into MCF-7 cells and releasing guest molecules from the pore inside cells. Moreover, in vitro cell viability test using MTT assay indicated that MSNs-SS-mPEG nanoparticles had no obvious cytotoxicity. These results indicate that MSNs-SS-mPEG nanoparticles can be used in the biomedical field.
研究领域:
纳米技术
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生物医学工程
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材料科学
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药物递送系统
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癌症治疗
✓ 已验证
DOI
PubMed
高影响因子
BIOCONJUGATE CHEMISTRY
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2017
·
IF 4.818
Luping Zheng,Yunfei Wang,Xianshuo Zhang,Liwei Ma,Baoyan Wang,Xiangling Ji,Hua Wei
Dendrimer with hyperbranched structure and multivalent surface is regarded as one of the most promising candidates close to the ideal drug delivery systems, but the clinical translation and scale-up production of dendrimer has been hampered significantly by the synthetic difficulties. Therefore, there is considerable scope for the development of novel hyperbranched polymer that can not only address the drawbacks of dendrimer but maintain its advantages. The reversible addition–fragmentation chain transfer self-condensing vinyl polymerization (RAFT-SCVP) technique has enabled facile preparation of segmented hyperbranched polymer (SHP) by using chain transfer monomer (CTM)-based double-head agent during the past decade. Meanwhile, the design and development of block-statistical copolymers has been proven in our recent studies to be a simple yet effective way to address the extracellular stability vs intracellular high delivery efficacy dilemma. To integrate the advantages of both hyperbranched and block-statistical structures, we herein reported the fabrication of hyperbranched block-statistical copolymer-based prodrug with pH and reduction dual sensitivities using RAFT-SCVP and post-polymerization click coupling. The external homo oligo(ethylene glycol methyl ether methacrylate) (OEGMA) block provides sufficient extracellularly colloidal stability for the nanocarriers by steric hindrance, and the interior OEGMA units incorporated by the statistical copolymerization promote intracellular drug release by facilitating the permeation of GSH and H+ for the cleavage of the reduction-responsive disulfide bond and pH-liable carbonate link as well as weakening the hydrophobic encapsulation of drug molecules. The delivery efficacy of the target hyperbranched block-statistical copolymer-based prodrug was evaluated in terms of in vitro drug release and cytotoxicity studies, which confirms both acidic pH and reduction-triggered drug release for inhibiting proliferation of HeLa cells. Interestingly, the simultaneous application of both acidic pH and GSH triggers promoted significantly the cleavage and release of CPT compared to the exertion of single trigger. This study thus developed a facile approach toward hyperbranched polymer-based prodrugs with high therapeutic efficacy for anticancer drug delivery.
研究领域:
聚合物化学
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药学
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材料科学
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肿瘤学
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产品关联
DOI
PubMed
高影响因子
AAPS PHARMSCITECH
·
2018
·Vol. 19
·期 3
·1308-1319
·
IF 2.666
Huang Yaping,Zhang Sisi,Shen Huifen,Li Jinqing,Gao Chongkai
The present study was intended to develop a controlled released osmotic pump capsule based on Nimodipine (NM)-loaded self-microemulsifying drug delivery systems (SMEDDSs) in order to improve the low oral bioavailability of NM. To optimize the NM-loaded SMEDDS composition, the experiments of NM solubility in different oils, the pseudo-ternary phase diagram experiments and the different drug loading experiments were conducted in the preliminary screening studies. Controlled release of NM required an osmotic pump capsule comprising a coated semi-permeable capsule shell, plasticizer, and pore-forming agent. NM release follows zero-order kinetics after oral administration. Polyethylene glycol content, used as a pore-forming agent, coating mass, and drug release orifice size were key factors affecting drug release behavior according to the single methods and were optimized through response surface methodology. The NM-loaded SMEDDS droplet size and the 1 H NMR mass spectrogram of the novel capsule were determined. The droplet size of the reconstituted microemulsion was 39.9 nm and 1 H NMR analysis showed NM dissolution in the microemulsion. The dissolution test performed on three batches of NM-SMEDDS capsules—prepared using optimal preparation methods—indicated the capsule to deliver a qualified drug delivery with a zero-order release rate. The results demonstrated that NM-loaded SMEDDSs were successfully developed and displayed a qualified release rate in vitro .
研究领域:
药剂学
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药物递送系统
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产品关联
DOI
PubMed
高影响因子
Journal of Environmental Chemical Engineering
·
2021
·
IF 5.909
Jie Ma,Yao Ma,Xun Rong,Quanwei Song,Baichun Wu,Xingying Lan,Yuan Feng,Xiaoyuan Qiu,Ping Zhang
Groundwater contamination by organic pollutants is a growing threat to the environment and human health. As a cost-effective method, in situ chemical oxidation (ISCO) treatment has become a popular technical method to degrade groundwater pollutants. However, conventional ISCO treatment can suffer from a number of operational issues, such as tailing and concentration rebound, and thus the long-term treatment effectiveness is less desirable. As an alternative approach to the conventional ISCO method, controlled release materials are designated to gradually release oxidant chemicals to treat polluted groundwater with an extended chemical release duration and a reduced peak release rate. In this study, novel persulfate-paraffin based controlled release bead (CRB) materials were prepared and tested in a laboratory setting for their applicability in groundwater organic pollution remediation. It shows that bead size and temperature can substantially affect the release kinetics of persulfate from the CRBs, while the impact of solution pH and the presence of matrix anions are insignificant. Moreover, degradation experiments of benzene, toluene, ethylbenzene , and xylene pollutants show that the performance of CRBs, particularly within a short period after being delivered in situ, is on par with the conventional ISCO method using aqueous persulfate. This study expands our understanding and capacity in adopting controlled release materials for groundwater remediation . This study promotes the potential field application of such novel controlled release materials for environmental remediation of groundwater.
研究领域:
环境科学
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化学工程
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产品关联
DOI
高影响因子
Journal of Materials Chemistry B
·
2019
·Vol. 7
·期 19
·3134-3142
·
IF 5.047
Can Wu,Jing Liu,Bin Liu,Suyun He,Guoru Dai,Bo Xu,Wenying Zhong
The design of light-responsive peptide hydrogels with controllable drug release characteristics is still a challenge. Here, we fabricated a NIR light-responsive short peptide hydrogel by using a thermo-responsive short peptide hydrogel and PEGylated NbSe2 nanosheets, namely, the NbSe2–PEG@YD hydrogel. Under NIR light irradiation, the hydrogel began to collapse owing to the local heating, leading to the release of the cargos. The hydrogel exhibited recoverability and the release rate of the cargos could be accurately modulated by the NIR light irradiation according to the requirement. The excellent biocompatibility of this hydrogel ensured that it could be further developed as a drug carrier for clinical application.
研究领域:
生物材料
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药剂学
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纳米医学
✓ 已验证
产品关联
DOI
高影响因子
FOOD CHEMISTRY
·
2021
·
IF 7.514
Hujun Xie,Chengzhi Liu,Jian Gao,Jieyu Shi,Fangfang Ni,Xin Luo,Ying He,Gerui Ren,Zisheng Luo
The Zein-Lecithin-Epigallocatechin gallate (EGCG) complex nanoparticles were fabricated by anti-solvent coprecipitation method. The Zein-Lecithin (Z-L) nanocomplexes exhibited great encapsulation efficiency of 68.5% for EGCG, and the encapsulated EGCG still had good antioxidative capacity. The cumulative release of EGCG in simulated gastric fluid (SGF) and simulated intestinal fluid (SIF) were 19% and 92%, respectively, and the release was closest to Fick release in SGF and First release in SIF. Fluorescence spectroscopy (FL), Fourier transform infrared spectroscopy (FTIR) and X-ray diffraction (XRD) experiments revealed that the EGCG was successfully encapsulated by Z-L nanocomplexes through electrostatic, hydrophobic and hydrogen bonding interactions. The Zein-Lecithin-EGCG complex nanoparticles exhibited excellent stability and great sustained-release performance, which will be the alternative for potential application in the food industry.
研究领域:
纳米技术
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食品科学
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药学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
FIBERS AND POLYMERS
·
2021
·Vol. 23
·期 1
·28-36
·
IF 2.153
Lu Yishen,Li Xianglong,Hou Teng,Yang Bin
Highly absorbent alginate/polyethylene oxide submicron fibers containing the hydrophilic model drug tetracycline hydrochloride were prepared through centrifugal spinning. Pre-treatment with ethanol before crosslinking with calcium chloride solution maintained the structure of submicron fibers. The crosslinked submicron fibers could absorb phosphate buffer over 8 hours continuously, and they absorbed more phosphate buffer than commercial alginate dressing (Kaltostat and Algisite M). The morphology and chemical structures of submicron fibers were also investigated. In-vitro drug release tests revealed that more than 70 % (86 % 75 % and 73 % for drug loaded CA1, CA2 and CA3 fibers, respectively) of the loaded drug could be released continuously from the fibers in 24 hours, which matches well with the change frequency guidance of wound dressing for exuding wounds with heavy to moderate exudate. TCH loaded submicron fibers maintained the inhibition effect on Gram-positive S. aureus (31.25±0.71 mm (TCH-CA1), 30.85±0.27 mm (TCH-CA2) and 28.75±1.01 mm (TCH-CA3)) and Gram-negative E. coli . (29.8±0.35 mm (TCH-CA1), 29.28±0.87 mm (TCH-CA2) 27.38±0.64 mm (TCH-CA3)). These drug-loaded alginate submicron fibers may have application in wound dressing for exuding wounds.
研究领域:
材料科学
·
药学
·
生物医学工程
✓ 已验证
产品关联
DOI
高影响因子
Materials Science & Engineering C-Materials for Biological Applications
·
2021
·
IF 7.328
Mingyue Wang,Chenxi Wang,Yu Zhang,Ye Lin
Bone diseases, for example, osteoporosis, cause excessive differentiation of osteoclasts and decreased bone formation, resulting in imbalance of bone remodeling and poor osseointegration, which can be considered a relative contraindication for titanium implants. Dopamine (DA) might provide a solution to this problem by inhibiting osteoclasts and promoting osteoblasts at different concentrations. However, current commercial implants cannot load bone-active molecules, such as DA. Therefore, this study aimed to develop a surface modification method for implants to achieve a controlled release of DA and enhance the resistance of titanium implants to bone resorption and bone regeneration. DA-loaded alginate-arginine-glycine-aspartic acid (RGD) (AlgR) coatings on a vaterite-modified titanium surface were successfully assembled, which continuously and steadily released DA. In vitro studies have shown that materials showing good biocompatibility can not only inhibit receptor activator of nuclear factor-kappa B (NFκB) ligand (RANKL)-induced osteoclastogenesis but also enhance the adhesion and osteogenic differentiation of human bone marrow mesenchymal stem cells (hBMSCs). The optimal DA-loaded concentration of this bidirectional regulation is 100 μM. Interestingly, DA more effectively attenuated osteoclastogenesis when released in a sustained manner from titanium coatings than it did via traditional, free administration, and the alginate-RGD coating and DA clearly exhibited great synergy. This study provides a design of titanium implant surface modification to improve bone remodeling around implants.
研究领域:
生物材料
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组织工程
·
骨科
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生物医学工程
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细胞生物学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Polymers
·
2020
·Vol. 12
·期 10
·2268
·
IF 3.426
Song Feng,Junqin Wang,Lihua Zhang,Qin Chen,Wang Yue,Ni Ke,Haibo Xie
Currently, controlled release formulations (CRFs) of pesticides in response to biotic and/or abiotic stimuli have shown great potential for providing “on-demand” smart release of loaded active ingredients. In this study, amphiphilic biopolymers were prepared by introducing hydrophobic (7-diethylaminocoumarin-4-yl)methyl succinate (DEACMS) onto the main chain of hydrophilic carboxymethylchitosan (CMCS) via the formation of amide bonds which were able to self-assemble into spherical micelles in aqueous media and were utilized as light-responsive nanocarriers for the controlled release of pesticides. FTIR and NMR characterizations confirmed the successful synthesis of the CMCS-DEACMS conjugate. The critical micelle concentration (CMC) decreased with the increase in the substitution of DEACMS on CMCS, which ranged from 0.013 to 0.042 mg/mL. Upon irradiation under simulated sunlight, the hydrodynamic diameter, morphology, photophysical properties and photolysis were researched by means of dynamic light scattering (DLS), transmission electron microscopy (TEM), UV-vis absorption spectroscopy and fluorescence spectroscopy. Moreover, 2,4-dichlorophenoxyacetic acid (2,4-D) was used as a model pesticide and encapsulated into the CMCS-DEACMS micelles. In these micelle formulations, the release of 2,4-D was promoted upon simulated sunlight irradiation, during which the coumarin moieties were cleaved from the CMCS backbone, resulting in a shift of the hydrophilic–hydrophobic balance and destabilization of the micelles. Additionally, bioassay studies suggested that this 2,4-D contained which micelles showed good bioactivity on the target plant without harming the nontarget plant. Thereby, the light-responsive CMCS-DEACMS micelles bearing photocleavable coumarin moieties provide a smart delivery platform for agrochemicals.Keywords:carboxymethyl chitosan micelles;light-responsive;coumarin;2,4-D;controlled release;pesticide
研究领域:
材料科学
·
农业化学
·
药学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
International Journal of Polymeric Materials and Polymeric Biomaterials
·
2018
·
IF 2.127
Fangqing Weng,Jing Yin,Feng Bao,Jie Gao,Rui Ma,Shuang Yan,Yanping Liu,Hao Ding
Functionalized graphene oxide-modified poly(ε-caprolactone) composites ((graphene oxide)GO/PCL) were successfully synthesized by Steglich esterification for drug applications of controlled release. Lomefloxacin (LMF) was selected as a model drug to investigate its controlled release properties. The controlled release effect of the LMF-contained pills of the GO/PCL and polylactic acid blend was evaluated. In contrast to the pure PCL, GO/PCL could effectively adjust the time of drug release and release the drug at a constant rate, achieving the controlled release requirements. Furthermore, different additive amounts of graphene oxide have different effects on adjusting the time of controlled release, while the best result obtained under the ratio is 4% GO/PCL as carrier of drug. Thus, high-quality drug carrier materials are obtained which are more suitable for clinical use. Exploring the optimum addition of graphene oxide is very significant for the development of GO/PCL carrier material.
研究领域:
材料科学
·
药学
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）