FOOD RESEARCH INTERNATIONAL
·
2017
·
IF 3.086
Taotao Dai,Xiaoyan Yan,Qian Li,Ti Li,Chengmei Liu,David Julian McClements,Jun Chen
Many foods contain mixtures of plant dietary proteins and polyphenols, but there is currently a relatively poor understanding of the nature of the interactions between these components. In this study, the interaction of rice glutelin (RG) and gallic acid (GA) was characterized by spectroscopic and molecular docking techniques. The intrinsic fluorescence of RG quenched after the addition of GA, indicating that an interaction occurred. Thermodynamic analyses indicated that the binding process was spontaneous and the main driving forces were hydrogen bonds and van der Waals forces. The surface hydrophobicity of RG decreased with increasing GA. Furthermore, synchronous fluorescence and circular dichroism spectra provided insights into micro-environmental and conformational changes of RG. In particular, there was a reduction of α-helix structure and an increase of β-sheet structure present in RG after the binding interaction. Finally, molecular docking analysis provided a visual representation of a single binding site where GA interacted with specific amino acid residues located in the active site of the RG.
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高影响因子
FOOD HYDROCOLLOIDS
·
2025
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IF 12.4
Myat Noe Khin,Md Easdani,Tariq Aziz,Ashwag Shami,Nada K. Alharbi,Fahad Al-Asmari,Lin Lin
Gelatin is a versatile biopolymer for bio-packaging, but its poor water resistance and susceptibility to deterioration limit its application. This study addresses these limitations by forming a Schiff's base through crosslinking gelatin with dialdehyde cellulose (DAC) to enhance mechanical properties and water resistance. The crosslinking degree was investigated using the ninhydrin method and, also visually identified through a yellow-brown color formation. Crosslinking increased tensile strength (TS) from 30.2 ± 1.6 MPa to 37.3 ± 3.9 MPa and improved UV barrier properties, with a 30% increase in UV-B and UV-A protection compared to the pure gelatin film. Gallic acid (GA) was incorporated at concentrations ranging from 1% to 5% to improve the antimicrobial properties and shelf life of the film. Films with GA inhibited E. coli and S. aureus and resisted fungal growth on the film for more than 20 months. Furthermore, incorporation of GA further enhanced TS, elongation of break (EBA), barrier and hydrophobic properties of the composite film. The highest tensile strength was achieved with 3% GA (49.4 ± 4.5 MPa). EBA improved with higher GA concentrations, reaching a 44% improvement at 5% GA compared to the non-GA film. Oxygen permeability dropped from 5.7 ± 0.1 to 4.3 ± 0.1 cm 3 /m 2 d 0.1 MPa, and water vapor permeability decreased from 6.7 ± 0.75 × 10 −11 to 4.2 ± 0.07 × 10 −11 g m/m 2 s Pa at 5% GA. Despite these benefits, the films remained vulnerable to high acidic conditions. This study demonstrates that Schiff's base crosslinking of gelatin with DAC, combined with GA, results in durable, antibacterial bio-based packaging films with enhanced strength and barrier properties.
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JOURNAL OF FOOD SCIENCE
·
2019
·Vol. 84
·期 8
·2159-2164
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IF 2.081
Sha Deng,Jing Jin,Qiang He
This study investigated the inhibitory effect of epigallocatechin gallate (EGCG), epigallocatechin (EGC), and gallic acid (GA) on the formation of N -nitrosodiethylamine (NDEA) in vitro . Results show that the three polyphenols are capable to block NDEA formation when the molar ratio of phenols to nitrite is higher than 0.8, and a more acidic environment is prone to promote the inhibitory potential of phenols. It is also found that the inhibitory effect tends to decrease in the order: EGCG, EGC, GA, which is in accordance with the order of their DPPH scavenging activity, suggesting that the inhibitory effect of polyphenols on NDEA formation may work through a free radical way. Kinetic study further revealed the three polyphenols react with nitrite at a much faster rate than diethylamine does ( P < 0.05). By scavenging nitrite at a faster rate than the nitrosation of diethylamine, polyphenols at high concentration can significantly block NDEA formation. These observations may promote a possible application of polyphenol compounds to inhibit the formation of nitrosamines in food processing. Practical Application The presence of N -nitrosamines in human diet should be an etiological risk factor for human cancers. This work may provide a useful guideline for phenolic compounds to inhibit the formation of nitrosamines in food processing, such as in the process of curing meats. Polyphenols have been proved to block NDEA formation under normal gastric juice condition, suggesting the intake of polyphenols is a potential way to prevent diseases caused by nitrite.
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FOOD HYDROCOLLOIDS
·
2026
·
IF 13.8
Zhenjing Huang,Rui Wang,Xiaoyun Fei,Deming Gong,Xing Hu,Guowen Zhang
CMC incorporation induced protein unfolding and hydrophobic group exposure. • CMC grafting increased T d from 97.17 to 109.08 °C. • The ratio of PPI–GA to CMC of 1:1 showed optimal interfacial rearrangement and stability. • QCM-D confirmed the conjugate formed a thick, hydrated and strong interfacial layer. Protein–polyphenol–polysaccharide ternary conjugates represent a promising class of high-efficiency emulsifiers. However, their assembly behavior and stabilization mechanism at the oil–water interface has not yet been systematically clarified. In this study, sodium carboxymethyl cellulose (CMC) was covalently grafted onto potato protein isolate–gallic acid (PPI–GA) conjugate by dry-heating Maillard reaction, and the structural evolution and interfacial functional mechanisms of the resulting conjugates were systematically investigated. The structural characteristics of the conjugates were characterized by SDS-PAGE, fluorescence spectroscopy, FT-IR spectroscopy, circular dichroism, and scanning electron microscopy. The results showed that CMC was successfully introduced by Maillard glycosylation, which significantly altered the secondary structure and micromorphology of PPI–GA conjugate. Consequently, the emulsifying properties, surface hydrophobicity and thermal stability were improved, with the denaturation temperature reaching 109.08 °C. The PPI–GA–CMC conjugate prepared at a 1:1 mass ratio of PPI–GA to CMC exhibited optimal interfacial performance with the highest rearrangement rate ( K r = 16.33 s −1 ) and formed the most stable elastic interfacial film (ΔE/π = 2.548), and a thick, highly hydrated, and mechanically robust interfacial layer (ΔF = −36.62 Hz, ΔD = 22.52 × 10 −6 ) was formed, verified by quartz crystal microbalance with dissipation (QCM-D) analysis. These superior interfacial properties may provide a theoretical basis for designing high-performance plant protein-based emulsifiers. Download: Download high-res image (303KB) Download: Download full-size image
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Food Packaging and Shelf Life
·
2026
·
IF 10.8
Zihang Cai,Yubin Ren,Qiuqin Zhang,Chuang Zhang,Yunbin Lv,Junfeng Shi,Hongmei Xiao
The inherent diversity in chemical composition and microstructure of fruit wax and cuticle layers serves as a core barrier to the universal adhesion of conventional coatings on a range of fruit surfaces ( e . g ., blueberry and grape). Herein, calcium ions were introduced into chitosan-gallic acid (CS-GA) to develop a metal-phenolic networks (MPNs) modified CS coating, which was named CS-GA-Ca. According to microstructural characterization, calcium ions, as a crosslinker, form a coordination with catechol in copolymers and further reconstruct a H-bonding network, resulting in smaller molecular chain spacing and a tighter polysaccharide network structure. Furthermore, the CS-GA-Ca films demonstrated improved vapor barrier and mechanical properties. The CS-GA-Ca coating exhibited improved adhesive capacity on the wax layer of blueberries. The molecular dynamic (MD) stimulation results revealed stronger Van der Waals forces (-64.35 kcal·mol −1 ) and electrostatic interactions binding energies (-28.84 kcal·mol −1 ) between CS-GA-Ca and epicuticular wax components compared to CS-GA (-4.21/0.01 kcal·mol −1 ). Finally, the CS-GA-Ca reduced weigh loss of blueberries and grapes by 17% and 27% compared to uncoated ones over 24 days (4℃) and 10 days (25℃), respectively. Moreover, the blueberries and grapes coated with CS-GA-Ca exhibited 2.0-fold and 1.6-fold prolonged shelf life compared to uncoated ones, respectively. Overall, this study presents a promising approach for developing bio-derived coating materials to prolong the shelf life of fruits.
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COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
·
2026
·
IF 5.4
Zhaodi Liu,Liying Qin,Honglin Lin,Yuanyuan Yu,Huirong Liu,Li Zhou,Li Cui,Ping Wang
Gallic acid-modified chitosan is anchored on silk fibers via metal ion coordination. • Anthocyanin-dyed silk exhibits deeper color depth and improved colorfastness. • The finishing provides durable antibacterial activity and effective UV protection. • High performance is achieved under mild conditions without compromising comfort. Anthocyanins are water-soluble natural pigments widely distributed in plants, exhibiting multiple functions, including antibacterial, antioxidant, and UV-protective properties. However, the molecular structure of anthocyanins is sensitive to environmental conditions and exhibits a weak binding force to textiles, thereby severely limiting their practical application in textile dyeing. Herein, we demonstrate a mild yet effective strategy to enhance the colorfastness and multifunctional performance of anthocyanin-dyed silk fibers using polyphenol-modified chitosan. Firstly, we investigated the effects of temperature, light, and pH on anthocyanin stability and, accordingly, established an optimized dyeing process for silk fabric. Subsequently, gallic acid-modified chitosan (mCS) was immobilized onto anthocyanin-dyed silk fabric via Fe²⁺-mediated coordination, forming a stable network on the silk fibers. The results reveal that mCS@Fe 2 + treatment of anthocyanin-dyed silk fabric exhibited the highest K/S value and superior colorfastness, while further delivering enhanced UV protection, achieving a UPF value of 66.5 while preserving favorable wearability. Moreover, it exhibited antibacterial inhibition rates of 99.42% and 98.33% against E. coli and S. aureus , with the inhibition rate against S. aureus remaining above 85% even after 50 consecutive washing cycles. This work provides new insights into achieving both high colorfastness and multifunctional performance in natural dye-based textile finishing. Download: Download high-res image (204KB) Download: Download full-size image
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FOOD RESEARCH INTERNATIONAL
·
2026
·
IF 8.8
Meiyu Chen,Tengyue Wu,Tianyi Yan,Tin Nyawe Nyawe Hlaing,Shahzad Farooq,Teng Li,Xiangyu Wang,Yucheng Zou,Hui Zhang
GA reinforced FOBs proteins via hydrogen bonding and hydrophobic interactions. • GA-modified FOBs emulsions enabled stable electrospinning of core–shell nanofibers. • Core–shell nanofibers reduced peroxide value by 49.2% and TBARS by 66.3% in 7 days. • Nanofiber encapsulation regulated lipid release kinetics via Fickian diffusion. • GA interfacial engineering enhanced oxidative stability and bioaccessibility of FOBs. Flaxseed oil bodies (FOBs) are natural lipid assemblies rich in α-linolenic acid (ALA), but their high degree of unsaturation makes them susceptible to oxidation. To address this, the present study employed gallic acid (GA)-mediated interfacial engineering to reinforce the FOBs surface, providing a molecular shield against pro-oxidants. The GA-modified FOBs emulsions were subsequently incorporated with pullulan to fabricate core–shell nanofibrous delivery systems via emulsion electrospinning. Results showed that GA-engineered interface of FOBs not only fortified the oxidative barrier but also imparted a favorable rheological profile to the emulsions, thereby facilitating the stable production of uniform nanofibers. Structural characterization confirmed that GA interacted with FOBs membrane proteins via hydrogen bonding and hydrophobic interactions, inducing conformational rearrangements that anchored the antioxidant at the interface. This dual-protective strategy, combining interfacial reinforcement with core–shell matrix encapsulation, resulted in a 49.2% reduction in peroxide value (POV) and a 66.3% decrease in TBARS values during 7 days of storage. In vitro digestion studies demonstrated that the core-shell structure of the nanofibers effectively regulated lipid release via Fickian diffusion, as confirmed by the Ritger–Peppas model (R 2 ≥ 0.94), with bioaccessibility reaching 62.8% after 120 min. These findings indicate that the combined strategy of GA-mediated interfacial engineering and emulsion electrospinning offers an effective strategy to enhance the oxidative stability and digestive performance of ALA-rich oil body delivery systems. Download: Download high-res image (180KB) Download: Download full-size image
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高影响因子
FOOD RESEARCH INTERNATIONAL
·
2022
·
IF 7.425
Liyuan Rong,Xiaoyao Ji,Mingyue Shen,Xianxiang Chen,Xing Qi,Yulin Li,Jianhua Xie
The widely use of petroleum-based plastics causes serious environmental pollution and oil resource shortage. In this work, biodegradable films were prepared based on gallic acid (GA)-induced Chinese yam starch (YS) and chitosan (CS). The fresh-keeping effect of biodegradable films on the pork meat preservation were investigated. The prepared GA/YS/CS biodegradable films exhibited thinner thickness and better light transmittance, because CS effectively decreased the viscosity of film-forming solution and weaken its internal link structure. The SEM results and mechanical results revealed that the YS, GA, and CS had a good compatibility, GA modification and adding CS markedly improved the tensile strength of YS-based film, because the interaction between CS and starch molecular was facilitate owing to the NH 3 + of CS tended to form hydrogen bonds with the hydroxyl group of starch. Sensory analysis results suggested that GA/YS/CS films can effectively improve the quality of pork during storage compared to the package of polyethylene film. In summary, the prepared GA/YS/CS film in this work had practical application potential in pork preservation due to its excellent mechanical, antibacterial, oxidation resistance properties, and the development and application of biodegradable starch film can greatly reduce the increasingly serious environmental pollution pressure.
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高影响因子
Processes
·
2023
·Vol. 11
·期 7
·2048
·
IF 3.5
Xi Lin,Yuchen Zhou,Zhenfeng Lei,Rui Chen,Wanchun Chen,Xiangying Meng,Yanxia Li
In this study, a facile electrochemical biosensing platform was fabricated with Laccase (Lac) immobilized on laser-induced graphene (LIG) electrode by glutaraldehyde covalently binding for the effective determination of gallic acid (GA). The patterned graphene for the LIG electrode was prepared by a one-step laser direct writing on the polyimide film in ambient air. The sheet layer and spatial mesh structures of LIG give the prepared LIG electrode a large specific surface area and good conductivity. The oxygen enrichment and good hydrophilicity cause LIG to favor covalent crosslinking with laccase through glutaraldehyde. The electrochemical sensor of GA on the prepared electrode was determined by chronoamperometry. Results show that the current signals of the laccase electrodes had an excellent linear relationship with GA in the concentration range of 0.1–20 mmol/L with a detection limit of 0.07 mmol/L under optimized experimental conditions. The prepared GA sensor with good selectivity, regeneration, and stability can be applied to biological samples such as sweat, urine and serum without needing sample pretreatment.Keywords:laser induced graphene;laccase;gallic acid;electrochemical biosensor
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高影响因子
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
·
2020
·
IF 4.192
Peifei Wang,Songbai Liu
In this study, development of the gemini gallate (GG) interfacial antioxidant for oil in water (O/W) emulsion was performed employing Steglich esterification with gallic acid and dodecyl gemini chains through a prepacked column and peristaltic pump-based purification system. The structural identity and purity of the prepared GG and monogallate (MG) were confirmed by NMR, Fourier transform infrared spectroscopy, and high-performance liquid chromatography–mass spectrometry. Further evaluation revealed that the GG possessed excellent radical scavenging activity and superior antioxidant activity in an O/W emulsion relative to the MG, especially under the condition of a reduced amount of the emulsifier. Microscopic investigation by a fluorescent probe and transmission electron microscopy (TEM) unveiled that the extraordinary antioxidant performance in the O/W emulsion was presumably attributed to preferable interfacial location because of the unique gemini molecular architecture. The superior antioxidant activity of the gemini antioxidant holds great promise for antioxidation in O/W emulsions.
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高影响因子
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
·
2025
·
IF 4.9
Yuhang Wang,Jiang Yu,Xuejing Li,Haolin Zhang,Tengfei Zhou,Yiguo Jiang,Yongjun Wang
Inflammatory arthritis primarily involves rheumatoid arthritis (RA) and inflammatory osteoarthritis (OA), both characterized by shared inflammation in the articular joints and cartilage degeneration. These conditions lead to joint pain, loss of function, and a decline in quality of life. Triamcinolone acetonide (TA), an intermediate-acting synthetic glucocorticoid, is widely used as an anti-inflammatory agent for the treatment of inflammatory arthritis. However, its clinical application faces challenges such as rapid clearance from the joint cavity following intra-articular (IA) administration, the risk of joint damage with repeated injections, and the invasive nature of the IA injection route. To address these drawbacks, we propose sucrose acetate isobutyrate (SAIB), a biocompatible matrix, as a promising strategy for sustained drug release via intramuscular (IM) injection. Building on this approach, we designed a gallic acid-modified triamcinolone acetonide derivative (TA-GA) and incorporated it into the SAIB matrix to create the TA-GA-SAIB depot. The modification of TA with gallic acid (GA) effectively mitigates the burst release commonly observed in SAIB formulations, attributed to hydrogen bonding interactions between TA-GA and the SAIB matrix. Benzyl alcohol (BA) was selected as the optimal solvent to achieve minimal burst release during the in vitro drug release study. The TA-GA-SAIB depot exhibited sustained in vivo drug release, enhanced anti-inflammatory effects, and significant improvement in cartilage damage, along with excellent safety and biocompatibility. The synergy between the SAIB matrix and TA-GA not only enables sustained drug release but also improves therapeutic efficacy, making it a promising system for the treatment of inflammatory arthritis via intramuscular administration.
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JOURNAL OF MOLECULAR LIQUIDS
·
2024
·
IF 5.3
Yong Zeng,Yingdi Dong,Xiongxing Zhang,Zhongbao Hua,Xiqing Wu,Wei Sun,Haisheng Han,Li Wang,Honghu Tang
In the flotation separation of Mo-Pb bulk concentrate and the purification process of Pb-containing molybdenite concentrate, depressants are typically added to depress galena or molybdenite, aiming to obtain high-quality flotation products. Previous studies have focused on the depression of galena. In this study, gallic acid (GA) was utilized as a molybdenite depressant during Mo-Pb flotation separation. Single mineral flotation experiments showed that pH notably influenced galena and molybdenite flotation with GA, particularly at pH 10, displaying the most substantial recovery difference. Mixed mineral flotation experiments revealed GA’s selective depression on molybdenite. At the optimal dosage of GA, the Mo recovery was reduced by 76.62 percentage points, while the Pb recovery remained unaffected. The depression and separation mechanisms of GA were investigated using contact angle, infrared spectroscopy, Zeta potential, inductively coupled plasma optical emission spectrometer (ICP-OES), X-ray photoelectron spectroscopy (XPS) analysis, first-principles calculations analysis, and interface interaction free energy calculations. The results indicate that GA treatment significantly reduces the hydrophobicity of molybdenite surfaces; however, it slightly enhances the hydrophobicity of galena surfaces. At pH 10, the primary species in GA solution is HGA 3- . It adsorbs on PbO species of the galena surface as Pb-GA complexes and tends to detach from the surface at high adsorption capacity, resulting in galena not being depressed by GA. Differently, GA adsorbs on the molybdenite surface through hydrophobic attraction force, rendering it hydrophilic. Additionally, after treatment with potassium butyl xanthate (PBX), the hydrophobicity of GA-treated galena is significantly enhanced, while the hydrophobicity of GA-treated molybdenite is not restored. This is because PBX can adsorb stably on GA-treated galena, but its adsorption on GA-treated molybdenite is hindered by the pre-adsorbed GA.
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危险品化学品经营许可证（带存储）