CARBOHYDRATE RESEARCH
·
2021
·
IF 2.104
Jianghui Lin,Liyang Zheng,Quntao Liang,Lilong Jiang,Zheng Wei
The O -sulfation, including 2- O - and 6- O -sulfation, in heparan sulfate (HS) have important biological and pathophysiological roles. Therefore, the ability to chemically generate a series of oligosaccharides , which have a similar structure to the naturally-occurring, 2- O - and 6- O -sulfating oligosaccharides from HS, would greatly contribute to investigating their natural role in HS. In this study, a heparin oligosaccharide library, including dp2, dp4 and dp6, were prepared from the chemical modification of the fully sulfated dp2, dp4 and dp6. Chemical reaction conditions were optimized to generate different patterns of 2- O - and 6- O -sulfated oligosaccharides, then the disaccharide composition and structure of the library was detected by high-performance liquid chromatography-ion trap/time-of-flight mass spectrometry (LC-IT-TOF/MS) analysis. This provides a foundation for further structural and functional studies of O -sulfated groups in HS.
研究领域:
生物化学
·
分子生物学
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DOI
高影响因子
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
·
2019
·
IF 3.571
Yu Lu,Jie Liu,Yue Jia,Yuerong Yang,Qinghui Chen,Lujia Sun,Shuang Song,Linjuan Huang,Zhongfu Wang
Human milk oligosaccharides are complex carbohydrates with multibiofunctional health benefits to newborns. Human milk free oligosaccharides (HMOs) are well characterized. However, changes in the N/O-glycome during lactation are poorly reported. Herein, we qualitatively and quantitatively investigated N/O-glycome profiles and their alteration in human milk at different lactation stages. N-Glycans were mainly fucosylated and nonsialylated, nonfucosylated throughout lactation. O-Glycans mainly consisted of sialylated and nonsialylated, nonfucosylated in colostrum and transitional milk, and fucosylated and nonfucosylated, nonsialylated in mature milk. Fucosylated and sialylated N-glycans gradually decreased and increased, respectively, as lactation progressed; O-glycans showed the reverse. Interestingly, changes in HMO abundance decreased during lactation, complementing HMG N/O-glycome changes. In conclusion, temporal HMG glycosylation changes provide the groundwork for developing infant formula that is closer to breast milk at different lactation stages.
研究领域:
生物化学
·
营养学
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DOI
PubMed
高影响因子
JOURNAL OF MATERIALS SCIENCE-MATERIALS IN ELECTRONICS
·
2025
·Vol. 36
·期 4
·1-13
·
IF 2.8
Wang Hanxiao,Zhang Hong,Li Mei,Zhang You,Li Zhicheng,Leng Senlin
NTC thermistors have broad application prospects, and low-temperature sintering of NTC thermistors is of great significance in reducing sintering costs and is beneficial for preparing multi-layer structured components with lower cost internal electrode conductors. In this work, a low-melting point compound basing on Y 2 Ba 2 Cu 2 O 7 is selected as sintering agent for the preparation of Li-doped Ni–Zn–O (Ni 0.97- x Zn x Li 0.03 O 2 , x = 0.1, 0.3, 0.5, 0.7) ceramic thermistors. The sintering temperature can be reduced by more than 250 °C comparing with the one of the related ceramics without sintering aid (NiO ceramics was sintered at 1400 °C). The fabricated Li-doped Ni–Zn–O ceramics consist of single salt-rock NiO phase for x ≤ 0.3 and are composed of NiO-rich and ZnO-rich phases for x = 0.5 or 0.7. All ceramics show typical NTC characteristics with a wide-range adjustable material constant ( B values ranging from 756 to 4967 K). The Ni–Zn–O ceramics have high aging stability with the resistance shift rates induced at 125 °C lower than 1.89%. The microstructure, conduction modes and aging mechanism were investigated using the XRD, SEM, XPS, and electrochemistry impedance spectra.
研究领域:
材料科学
·
电子工程
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产品关联
DOI
高影响因子
Molecular Catalysis
·
2019
·
IF 2.938
Haibin Wang,Shaodong Liu,Tingting Sun,Zhanao Lv,Zhen Zhan,Guochuan Yin,Zhuqi Chen
In catalytic double bond migration reaction, E -configuration olefins were normally generated as the dominant product because E -configuration was thermodynamically favored. However, Z-configuration products are sometimes desired in pharmaceutical chemistry owing to the structure-activity relationship. In this paper, we have demonstrated a new strategy that Lewis acid promoted an widely employed and convenient ruthenium(II) complex for the catalytic isomerization of O-allylethers, leading to thermodynamic-unfavored Z-product under mild conditions. The model substrate of allyl phenyl ether can be simply scaled up to 20 mmol to produce Z-product with TON of 2453 and TOF of 13,430 h −1 at 40–60 °C. The system of Ru(II)/Lewis Acid catalysts was suitable for various substituted O -allylethers and other types of substrates. Through mechanism study including kinetic study, ligand inhibition effect and molecular spectroscopy, the dissociation of PPh 3 ligand by the addition of Lewis acid, and the formation a five-membered Ru complex from anchimeric assistance were both recognized as essential steps to improve the reactivity and to control the stereoselectivity of catalytic double bond migration reaction through metal hydride addition-elimination mechanism. This new strategy may provide a new opportunity to produce thermodynamic-unfavored product in heterocyclic compounds for pharmaceutical chemistry.
研究领域:
有机化学
·
药物化学
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产品关联
DOI
高影响因子
ACS Catalysis
·
2023
·
IF 12.9
Shuai Xu,Qi Gao,Ziyan Hu,Yitong Lu,Yanlin Qin,Yuliang Li
The selective breaking of the Cβ–O bond has great potential for the conversion of lignin into high-value aromatic monomers. In the present work, we designed a CdS–SH/TiO2 heterojunction photocatalyst for the efficient selective breaking of the Cβ–O bond. The surface modification of CdS by –SH promoted close contact between the catalyst and lignin and further promoted the Fermi level matching with TiO2. A type-II heterojunction was constructed by CdS–SH and TiO2 nanosheets to enhance the light absorption range and further increase the separation of photogenerated electron–hole pairs, resulting in high catalytic activity. Finally, 85% phenol and 87% acetophenone yields were obtained under mild light irradiation using 2-phenoxy-1-phenylethanol as the model substrate. Several control experiments, along with DFT calculations, indicate that the reaction pathway is more likely to involve the oxidation of Cα–OH to form Cα═O initially, followed by the activation of Cβ–O, which is then reduced to further form aromatic monomers. This work achieves the efficient selectivity of lignin depolymerization and provides a reference for the design of heterojunction photocatalysts in the valorization of lignin.
研究领域:
化学工程
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材料科学
·
能源化学
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DOI
高影响因子
INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
·
2017
·
IF 2.843
Zhen Sun,Yueer Yan,Gang Li,Yahong Zhang,Yi Tang
A facile and fast microwave-assisted approach without any other pre/post-treatment has been proposed to hydrothermally synthesize six kinds of MFI-type heteroatom (Mn, Ga, Ti, Sn, Cr, Zr) zeolites. By comparing with oven heating mode, it is found that microwave field displays a positive effect on the introduction of partial heteroatoms in the zeolite framework. Moreover, differing from the conventional heating, microwave irradiation displays different influences on the different heteroatom zeolites because different heteroatoms cause different polarities and wave-absorption abilities of M–O bonds under microwave irradiation. Furthermore, this positive effect of microwave is embodied not only on heteroatom zeolite synthesis and heteroatom state in zeolite framework but also the resultant catalytic performance. This finding provides an easy route for the synthesis of novel heteroatom zeolite being difficult to prepare by conventional mode, along with a new direction for the exploration of microwave effect.
研究领域:
材料科学
·
化学工程
·
催化研究
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DOI
高影响因子
NEW JOURNAL OF CHEMISTRY
·
2024
·Vol. 48
·期 46
·19508-19518
·
IF 2.7
Yuanyuan Wang,Yingjing Xia,Xingshen Dong,Wenyi Wang,Xueqin Wang,Yanxiu Liu,Peng Qiao,Geng Zhang,Shetian Liu
Supercapacitors, an innovative energy storage technology, combine the strengths of batteries and capacitors, enabling diverse applications in sectors such as communications, transportation, and aerospace. Porous carbon materials derived from biomass have excellent electrical conductivity, customizable dimensions, high surface area, and robust electrochemical stability, rendering them ideal candidates for supercapacitor electrodes. This research utilized edamame shells as the carbon precursor and KOH as the activating agent to synthesize a series of N/O co-doped porous carbons (ESC-x-800) through a combined pre-carbonization and activation process. This study thoroughly investigated the effect of KOH addition on the morphology, structure, and electrochemical performance of the materials. The result showed that the ESC-3-800 stood out as the top performer, distinguished by its unique self-doping characteristic with N and O atoms and a unique hierarchical porous structure. The ESC-3-800 boasted an impressive specific surface area of 3188.98 m2 g−1, coupled with a substantial pore volume of 1.86 cm3 g−1. When evaluated in a three-electrode system, ESC-3-800 demonstrated a remarkable specific capacitance of 301 F g−1, and a capacitance retention rate of 73.1% at a high current density of 20 A g−1. In a two-electrode setup, the ESC-3-800 achieved a notable high energy density of 37.6 W h kg−1 (at a power density of 200 W kg−1) in the 1 M Na2SO4 electrolyte. Remarkably, after enduring 12 000 charge–discharge cycles in 6 M KOH, it maintained an impressive 96.68% of its initial capacity (8 A g−1), demonstrating exceptional long-term stability and durability. The straightforward preparation method and outstanding performance of the edamame shell-derived N/O co-doped porous carbon underscore its immense potential for practical applications in supercapacitors.
研究领域:
材料科学
·
能源存储技术
·
生物质利用
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产品关联
DOI
高影响因子
Reaction Kinetics Mechanisms and Catalysis
·
2021
·Vol. 133
·期 1
·371-382
·
IF 2.081
Song Wenjing,Song Mengxue,Jiang Xingmao,Yi Xiaodong,Lai Weikun
Hydrolytic cleavage of C–O bond was systematically studied in acidic/alkaline aqueous solution. For phenethoxybenzene (PEB) hydrolysis, 2-phenylethanol and phenol were formed as main products in AlCl 3 solutions, whereas styrene was preferred with Na 2 CO 3 . After a quantitative evaluation of the kinetics of elementary steps, it was concluded that both AlCl 3 and Na 2 CO 3 promoted protons assisted C–O bond scission in H 2 O, whereas alkaline enhanced the dehydration of produced 2-phenylethanol. Kinetic and isotope labeling experiments demonstrated that the hydrolytic rates of PEB were first order with respect to substrate concentrations, hydrolytic cleavage of C–O bond was rate-determining step. The study shed light on the promotional effects and hydrolytic mechanism over acid/base-catalyzed lignin depolymerization in water. Graphic abstract
研究领域:
化学
·
生物质能
·
催化科学
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产品关联
DOI
高影响因子
Environmental Technology & Innovation
·
2020
·
IF 3.356
Chao Zhu,Zarak Mahmood,Abdul Saboor Arshad,Jia Liu,Hongrui Ma
Wastewater treatment has become a major global issue due of undegradable pollutants. As toxic water pollutants , namely o-toluidine and p-toluidine are difficult to treat, this study uses the silicon rubber technology to treat them. A pair of modules having single tabular nonporous silicon rubber tube and HCl stripping solution were set up to extract o-toluidine and p-toluidine from high-saline wastewater. Reaction quotient ( Q C ) was calculated after every 12 h intervals to evaluate the equilibrium reaction. The effect of concentration, pH, temperature, ionic strength, and flow rate on the permeability (P) and removal efficiency ( η ) were investigated to illustrate the process parameters and mechanisms of recovery of both elements from wastewater. The results showed that the recovery efficiency was more than 96% with concentration of 2–10g/L. When pH of the extraction solution was 2 or less, the pollutant permeability efficiency was nearly 95%. Moreover, when the salting strength was over 10%, the recovery efficiency increased quickly to some extent. Permeability, which mainly influenced by membrane resistance and desorption rate, initially increased and then decreased when the water flow increased from 2 and 20 mL/min. Aging of silicon rubber tube was also studied with respect to salinity , temperature, and acidity. Acidity and temperature was found to have a significant effect on the tube, permeability increased with an increase in aging, and aging had a minor effect on the elastic properties of the silicon rubber tube. Absorption and diffusion of water in silicon rubber tubes decreased when salinity increased more than 10%, which increased separation of p-toluidine and water. Due to this, there is no need of desalination before membrane extraction in treatment of p-toluidine wastewater with high saline. Thus, this study demonstrates that membrane extraction is a highly energy-efficient process for the effective recovery of o-toluidine and p-toluidine from wastewater with high salinity.
研究领域:
环境科学
·
化学工程
✓ 已验证
产品关联
DOI
高影响因子
SENSORS AND ACTUATORS B-CHEMICAL
·
2017
·
IF 5.401
Xu Hun,Yan Meng,Shanshan Wang,Hui Zhang,Xiliang Luo
Catalytic hairpin assembly (CHA) is an enzyme-free amplification method that it has been proved to be useful in signal amplification. In this work, hydroxylamine- O -sulfonic acid (HOSA) is used as an oxide for LumAuNPs chemiluminescence (CL) in mismatched catalytic hairpin assembly (MCHA) for the first time. Functionally, this system consists of two hairpin species, the biotin-labeled hairpin H1 and LumAuNPs-labeled hairpin H2, which are stable and unable to hybridize in the absence of target DNA. However, the MCHA is initiated in the presence of target DNA, which regenerates the target DNA to catalyze another new cyclic reuse and leads to the formation of numerous H1-H2 complexes. In this case, HOSA serves as an oxidizing agent reacted with LumAuNPs, which can generate strong CL. In this fascinating hairpin assembly amplification strategy, mismatched base sequences are designed in hairpin H2 to decrease nonspecific CHA products, which reduce the background signal significantly. Under the optimal experimental conditions, this approach shows high selectivity even toward single-base mismatch and improves sensitivity greatly for target DNA with a linear range of 2.5 fM–1 pM, achieving a detection limit as low as 0.8 fM. The developed method holds a great promise for further applications in early clinical diagnosis and therapy.
研究领域:
生物化学
·
分子诊断学
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF CHEMICAL AND ENGINEERING DATA
·
2019
·
IF 2.298
Kui Wu,Yajun Li
The solid–liquid equilibrium data of o-toluenesulfonamide in 16 pure organic solvents, including methanol, ethanol, n-propanol, isopropanol, n-butanol, isobutanol, n-pentanol, isopentanol, acetone, ethyl acetate, acetonitrile, cyclohexanone, cyclopentanone, methyl acetate, ethyl formate, and dichloromethane, were measured by a static gravimetric method with the temperature ranging from 273.15 to 323.85 K under atmospheric pressure. The results showed that the solubility of o-toluenesulfonamide increased with the increasing temperature in all the solvents studied. The experimental solubility data were correlated by the modified Apelblat equation, λh equation, nonrandom two-liquid (NRTL) equation, and Wilson equation. All the models could be well employed, and the NRTL model gave the best fitting results.
研究领域:
化学工程
·
热力学
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF MEMBRANE SCIENCE
·
2025
·
IF 9
Zheng Wang,Keizo Nakagawa,Kecheng Guan,Aiwen Zhang,Yasunao Okamoto,Atsushi Matsuoka,Eiji Kamio,Tomohisa Yoshioka,Hideto Matsuyama
s The stability of solvent-resistant nanofiltration (SRNF) membranes, such as integrally skinned asymmetric (ISA) and thin-film composite (TFC) membranes, in polar aprotic solvents must be improved if they are to meet increasingly complex industrial demands. The stability of the former membranes can be improved by forming crosslinked rigid chains, such as polybenzimidazoles and polyimides, but this requires time-consuming treatment processes. Conversely, the latter membranes are easy to fabricate but lack efficient active sites for crosslinking and structural rigidity. Herein, we present a fabrication strategy combining the characteristics of both types of membranes. We first utilize amino-functional porphyrins as polyaromatic units to form rigid polyamide networks by vacuum-assisted interfacial polymerization, simultaneously providing active sites for further crosslinking, which is accomplished by immersion in FeCl 2 /dimethyl sulfoxide (DMSO) solution to directly establish Fe-O-Fe bridges between porphyrin centers to form a stable network. The Fe-O-Fe-bridged porphyrin networks are solvent-stable in DMSO. Furthermore, they achieve outstanding molecular separation (96.2% rejection of methyl orange, 327 Da) and limited molecular-weight-cutoff change (from 360 to 420 Da) during alternating MeOH and DMSO filtration, along with long-term recovery efficiency (> 96.7% over seven days). Thus, our study provides a promising strategy for the facile development and fabrication of efficient, robust SRNF membranes.
研究领域:
膜科学
·
材料工程
·
化学分离
·
高分子化学
·
纳米技术
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）