CATALYSIS COMMUNICATIONS
·
2018
·
IF 3.463
Chengwu Dong,Changlong Yin,Tongtong Wu,Zhuyan Wu,Dong Liu,Chenguang Liu
An unsupported Ni Mo catalyst was modified by β-zeolite nanoclusters synthesized by the hydrothermal method. The effect of the nanoclusters on the acidity of unsupported catalyst was studied. Results showed that the Lewis acid and the total acid amount of the unsupported catalyst were improved. Indicating that the β-zeolite nanoclusters was successfully introduced into the unsupported catalyst. And the catalytic activity results showed that the introduction of β-zeolite nanoclusters not only led to the higher desulphurization and isomerization activity, but also improved the ratio of direct desulfurization paths (DDS), which is in favor of reducing hydrogen consumption.
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SEPARATION AND PURIFICATION TECHNOLOGY
·
2024
·
IF 8.1
Shuang Sun,Yuefeng Deng,Ji Chen,Dan Zou,Yaxing Han,Mingyang Liu
Lithium has become increasingly important because of its irreplaceable role in lithium-ion batteries. Addressing the complex process and high energy consumption of the current adsorption-membrane integrated process for lithium extraction from high Mg/Li ratio salt lake brine, this study put forward an integrated process of adsorption-solvent extraction. Taking the desorption solution of adsorption method as raw material, the process parameters and extraction mechanism of lithium by the novel extraction system were investigated. A novel process of lithium recovery from the desorption solutions of salt lakes by solvent extraction was proposed for the first time. The composition of the extraction system was studied and determined to be HTTA-P113-kerosene. Compared with the previously reported neutral ligands (TOPO, Cyanex923), P113 not only exhibited excellent synergistic extraction ability but also had good miscibility and a green synthesis process. The effects of saponification degree, extraction time, temperature and phase ratio on lithium extraction and β Li/Na were systematically investigated. Through the four-stage countercurrent extraction, more than 99.2 % of lithium could be extracted by the organic phase consisting of 0.4 mol L −1 HTTA, 0.4 mol L −1 P113, saponification degree of 80 % at O/A ratio of 1:1 and equilibrium pH of 6.78. Furthermore, after the scrubbing and stripping process, the lithium-rich solution containing 21.64 g L −1 Li + and 0.037 g L −1 Na + was obtained. The Li 2 CO 3 products with a purity of 99.5 % were successfully prepared from the lithium-rich solution by precipitation method. Finally, the extraction mechanism was studied via the slope analysis method and FT-IR spectra. It was indicated that the extracted lithium species were Li(TTA)(P113).
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FOOD CHEMISTRY
·
2024
·
IF 8.5
Yan Tian,Xinxin Zhao,Zhiguo Wang,Weimin Zhang,Zhiguo Jiang
In this work, we investigated structural characteristics and stability analysis of the coconut oil body (COB) and its application for loading β-carotene (β-CA). The COB contained neutral lipids (81.1 ± 2.1 %), membrane proteins (0.6 ± 0.0 %), and moistures (18.3 ± 3.2 %), in which the molecular weights of membrane proteins ranged from 12 kDa to 40 kDa, as analyzed by the SDS-PAGE. The COB exhibited a small droplet diameter (5.1 ± 0.3 µm) with a monomodal diameter distribution, as reflected by the dynamic light scattering. The COB showed stable states at alkaline pH values (pH 8–10) and instability against ionic strengths (50–200 mmol/L) and thermal treatment (30-90℃) after analyzing the instability indexes. COB-based emulsions were favorable for the loading and retention of β-CA, as reflected by free fatty acids release rates and bioaccessibility in the simulated gastrointestinal digestion . This study will contribute to using the coconut oil bodies for loading bioactive nutraceuticals to enhance their bioaccessibility.
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PubMed
高影响因子
Journal of Pharmaceutical Analysis
·
2024
·
IF 6.1
Wen Guo,Xinyue Zhang,Long Wan,Zhiqi Wang,Meiqi Han,Ziwei Yan,Jia Li,Ruizhu Deng,Shenglong Li,Yuling Mao,Siling Wang
Particle size and surface properties are crucial for lymphatic drainage (LN), dendritic cell (DC) uptake, DC maturation, and antigen cross-presentation induced by nanovaccine injection, which lead to an effective cell-mediated immune response. However, the manner in which the particle size and surface properties of vaccine carriers such as mesoporous silica nanoparticles (MSNs) affect this immune response is unknown. We prepared 50, 100, and 200 nm of MSNs that adsorbed ovalbumin antigen (OVA) while modifying β -glucan to enhance immunogenicity. The results revealed that these MSNs with different particle sizes were just as efficient in vitro , and MSNs with β -glucan modification demonstrated higher efficacy. However, the in vivo results indicated that MSNs with smaller particle sizes have stronger lymphatic targeting efficiency and a greater ability to promote the maturation of DCs. The results also indicate that β -glucan-modified MSN, with a particle size of ∼100 nm, has a great potential as a vaccine delivery vehicle and immune adjuvant and offers a novel approach for the delivery of multiple therapeutic agents that target other lymph-mediated diseases.
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PubMed
高影响因子
ACTA PHARMACOLOGICA SINICA
·
2024
·
IF 6.9
Su Qi,Wang Jing-jing,Ren Jia-yan,Wu Qing,Chen Kun,Tu Kai-hui,Zhang Yu,Leong Sze Wei,Sarwar Ammar,Han Xu,Zhang Mi,Dai Wei-feng,Zhang Yan-min
Parkin ( PARK2 ) deficiency is frequently observed in various cancers and potentially promotes tumor progression. Here, we showed that Parkin expression is downregulated in liver cancer tissues, which correlates with poor patient survival. Parkin deficiency in liver cancer cells promotes migration and metastasis as well as changes in EMT and metastasis markers. A negative correlation exists between TMEFF1 and Parkin expression in liver cancer cells and tumor tissues. Parkin deficiency leads to upregulation of TMEFF1 which promotes migration and metastasis. TMEFF1 transcription is activated by Parkin-induced endogenous TGF-β production and subsequent phosphorylation of Smad2/3 and its binding to TMEFF1 promotor. TGF-β inhibitor and TMEFF1 knockdown can reverse shParkin-induced cell migration and changes of EMT markers. Parkin interacts with and promotes the ubiquitin-dependent degradation of HIF-1α/HIF-1β and p53, which accounts for the suppression of TGF-β production. Our data have revealed that Parkin deficiency in cancer leads to the activation of the TGF-β/Smad2/3 pathway, resulting in the expression of TMEFF1 which promotes cell migration, EMT, and metastasis in liver cancer cells.
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高影响因子
JOURNAL OF WUHAN UNIVERSITY OF TECHNOLOGY-MATERIALS SCIENCE EDITION
·
2025
·Vol. 40
·期 1
·232-239
·
IF 1.1
Liu Peng,Mao Junpeng,Fang Yanfeng,Yu Yunwu,Chen Changxiu,Tang Ning,Wan Ye,Gu Yaxin,Liu Yunxue,Wang Lihua
A new modified blend ultrafiltration (UF) membrane with good hydrophilicity, high porosity and excellent anti-fouling performance was developed by using carboxylic multi-walled carbon nanotube (CMWCNT) as casting solution additive. Furthermore, a composite nanofiltration (NF) membrane with large water flux and good retention rate was fabricated by using the PVDF/CMWCNT blend UF membrane as the substrate, and polyvinyl alcohol (PVA), β -cyclodextrin ( β -CD) and polyethylenimine (PEI) as the coating solution. The results show that with the appropriate addition of CMWCNT in the casting solution, the surface roughness, porosity and recovery rate of the PVDF/CMWCNT blend UF membrane is obviously increased. The water flux of blend UF membrane is significantly improved when the CMWCNT content increases from 0 wt% to 0.2 wt%. The water flux of blend UF membrane with 0.2 wt% CMWCNT is 162.7 L/(m 2 ·h), which is 44.3% higher than that of the pure PVDF membrane. When β -CD content is 0.8 wt%, the retention rate of Congo red by PVDF/CMWCNT/ β -CD composite NF membrane reaches 98.7%, which is 28.3% higher than that of single PVA/PEI modified membrane. This research will provide a new idea and simple method for developing novel high-performance composite NF membranes.
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JOURNAL OF ALLOYS AND COMPOUNDS
·
2025
·
IF 6.3
Xue-Min Yang,Jin-Xiang Lv,Fen Xie,Meng-Ting Zheng,Xue-Qing Xiao,Qian-Ting Wang,Dan Xiao
To construct the fast photothermal and fire monitoring in real time, a facile β - cyclodextrin-immobilized graphene oxide (CIGO) was prepared via self-assembly method. Additionally, surface morphology of CIGO with wrinkled structure was used to improve the thermal stability and carbon-forming properties. In the treatment of CIGO by infrared light, a controllable photothermal switch was obtained due to swelling interactions of intermolecular, hydrogen bond and host-guest. Interestingly, graphene oxide (GO) reduction and stable carbon layer of cyclodextrin contributed to high-efficient fire-warning response time (only 0.15 s). Related photothermal and fire early warning mechanisms of CIGO were explored systematically. Overall, this strategy not only provides a facile multifunctional bio-modified GO, but also offers potential applications in smart windows, hazard warning, smart sensing and human-computer interaction.
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Molecular Horticulture
·
2025
·Vol. 5
·期 1
·1-22
·
IF 8.1
Wang Zhiling,Yuan Yixin,Dong Rui,Zeng Ruihong,Zhao Xin,Xu Yanjie,Gao Junping,Hong Bo,Gu Zhaoyu
Floral fragrance is essential for the attraction of pollinators and responses to biotic and abiotic stresses. It also enhances the quality and economic value of plants. Phytohormones, acting as key signaling molecules, are crucial roles in regulating plant growth and development. However, the molecular mechanisms underlying the biosynthesis of fragrance-related volatiles and their crosstalk with other endogenous signals within plants remain largely unknown. Here, we identified a sesquiterpene synthase gene, CmEβFS , in chrysanthemum, which encodes a catalytic enzyme responsible for synthesizing the key fragrance-related compound ( E )-β-farnesene. We demonstrated that CmEβFS is negatively regulated by CmWRKY1, thereby inhibiting ( E )-β-farnesene biosynthesis. Furthermore, CmWRKY1 interacts with the salicylic acid (SA) receptor CmNPR3 to regulate SA-mediated CmEβFS transcription. Our findings reveal that SA regulates ( E )-β-farnesene biosynthesis by controlling CmEβFS expression via the CmWRKY1-CmNPR3 module during floral development. These findings enhanced our understanding of the mechanisms underlying SA-mediated regulation of volatile organic compounds (VOCs) biosynthesis and provided insights into improving floral fragrance.
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JOURNAL OF FOOD COMPOSITION AND ANALYSIS
·
2025
·
IF 4.6
Mintong Tian,Huan Gao,Purui Yu,Mingming Li,Zehua Li,Qipeng Yuan
Sulforaphane (SFA), an isothiocyanate compound derived from cruciferous plants, has garnered significant attention owing to its cancer-preventive, anti-inflammatory, and antibacterial properties. However, the presence of complex impurities, including hydrolysis by-products of glucosinolates, structural analogues of SFA, and 5-vinyl-2-thioxazolidinone (VOT), in plant extracts significantly hinders both the efficiency of purification and the safety of application. In this study, 14 compounds were successfully isolated and identified from broccoli seed extracts using preparative high-performance liquid chromatography. Additionally, an efficient separation method was developed for removing the crucial impurity VOT based on the temperature-responsive properties of β-cyclodextrin (β-CD). The results demonstrated that the selective binding of β-CD to SFA at elevated temperatures achieved a VOT removal efficiency exceeding 97% following low-temperature precipitation. Additionally, the purity of SFA was enhanced from 55.8% to 90.1%. The separation mechanism at the molecular level was validated through density functional theory calculations. The binding energy of β-CD-SFA (-81.2 kJ/mol) was significantly higher than that of β-CD-VOT (-25.6 kJ/mol). The scanning electron microscopy and energy dispersive spectroscopy results confirmed the homogeneous distribution of SFA within the complexes. This study provides an innovative approach for the large-scale preparation of high-purity SFA and ensures its safe application in functional foods.
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FOOD CHEMISTRY
·
2025
·
IF 9.8
Ziyue Chen,Qi Lin,Cheng Peng,Kunpeng Yu,Yanling Lin,Shuyi Weng,Lijun Li,Hui Ni,Feng Chen
Tea aroma is largely shaped by volatile compounds released from glycosidic aroma precursors. This study investigated the effects of two Aspergillus niger β-glucosidases, An-G3987 and An-G8816, on modulating the aroma profile of instant Oolong tea powder. Quantitative descriptive analysis (QDA), gas chromatography–mass spectrometry (GC–MS), and odor activity value (OAV) assessments revealed that An-G3987 significantly enhanced floral, sweet, and grassy aromas by releasing key volatile compounds such as benzyl alcohol, (Z)-3-hexen-1-ol, and 1-hexanol. In contrast, An-G8816 generated a broader spectrum of volatile compounds but had a less pronounced impact on overall aroma enhancement. Kinetic studies and molecular docking analyses demonstrated that An-G3987, compared to An-G8816, exhibited higher catalytic efficiency and stronger binding affinity for typical glycosidic aroma precursors, driven by hydrogen bonding networks (e.g., Arg107/Tyr254) and hydrophobic interactions (e.g., Pro428/Tyr497). These findings indicate that An-G3987 is better suited for targeted aroma intensification, while An-G8816 may be preferable for balanced flavor modulation.
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Food and Bioprocess Technology
·
2026
·Vol. 19
·期 11
·532
·
IF 5.6
Li Qiwen,Ding Fuya,Gao Shisong,Jiang Xingyi,Gao Rui,Cui Xiuming,Ge Feng,Li Na
β-Glucosidases are important biocatalysts for upgrading glycosylated phytochemicals into high-value functional ingredients, but practical bioprocessing is often constrained by insufficient stability and poor substrate selectivity. Herein, a thermostable β-glucosidase (CB-glu) from Caldicellulosiruptor bescii was immobilized on zirconium-based metal–organic frameworks (MOFs) bearing tunable surface functionalities (–H, –NH 2 , –OH, and –2OH). In addition to catalytic characterization, N 2 adsorption–desorption, water-contact-angle, zeta-potential, X-ray photoelectron spectroscopy (XPS), and fluorescence emission analyses were introduced to clarify how carrier physicochemical properties and interfacial microenvironments influence immobilized-enzyme performance. Interfacial analyses showed that CB-glu adsorption reduced the accessible BET area of UiO-66-OH from 1026.4 to 796.7 m 2 g −1 , introduced 11.78 at.% surface N, and occurred despite net-negative zeta potentials of both components, supporting adsorption dominated by interfacial rather than long-range electrostatic interactions. Among the tested supports, UiO-66-OH showed the best compatibility with CB-glu, broadening pH adaptability, improving activity at elevated temperatures, and enhancing tolerance to metal ions and organic solvents. Most importantly, CB-glu@UiO-66-OH selectively hydrolyzed the outer C20-linked glucose of PPD-type ginsenosides and completely converted ginsenosides Rb 1 , Rb 2 , and Rb 3 into ginsenoside Rd without further formation of F 2 or CK. The immobilized biocatalyst maintained 100% conversion over eight consecutive cycles. These findings establish surface-functionalized UiO-66 as a practical microenvironment-engineering platform for regulating β-glucosidase robustness and substrate selectivity, providing a reusable bioprocess for the targeted production of ginsenoside Rd as a high-value functional ingredient.
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JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
·
2016
·Vol. 97
·期 7
·2230-2237
·
IF 2.076
Xi-Xiang Deng,Ning Zhang,Chuan-He Tang
BACKGROUND The incorporation of β -carotene, one of the most common pigments or bioactives, into food formulations has attracted increasing interest from the food industry, due to its good nutrition and potential health effects. However, it is poorly soluble and unstable in water, which greatly limits its applications in foods. This work presented an effective approach to improve the water dispersibility, stability and even bioaccessibility of β -carotene, using soy protein isolate (SPI) to perform as effective nanocarriers for this molecule. RESULTS The complexation with SPI remarkably improved the water dispersibility and stability against heating and freeze-drying of β -carotene. However, the encapsulation efficiency and stability of β -carotene in the nanocomplexes with SPI were closely dependent on the applied β -carotene-to-protein ratio, at which the complexation occurred. The best improvement of stability was observed at appropriate β -carotene-to-protein ratios, e.g. 10–20 g kg −1 . The complexation with β -carotene mainly occurred on the surface of SPI nanoparticles, through hydrophobic interactions. The complexation resulted in inter-particle aggregation, in a concentration-dependent manner. Almost all of the β -carotene molecules in the nanocomplexes could be progressively released into the aqueous phase. CONCLUSION SPI exhibits a good potential to perform as a nanocarrier for enhanced water dispersibility, stability and bioaccessibility of β -carotene. © 2016 Society of Chemical Industry
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