Journal of Materials Chemistry C
·
2024
·
IF 5.7
Guanfeng Liu,Yaoyu Liu,Zongshuai Ji,Tianyu Wang,Shuai Zhang,Bing Teng,Shaohua Ji
Organic–inorganic hybrid perovskite materials possess broad application prospects in photodetectors, light-emitting diodes (LEDs), and anti-counterfeiting due to their excellent optoelectronic properties; however, their development is still restricted by stability. In this paper, a new type of (NH4)2MnBr4(H2O)2 perovskite single crystal was synthesized using a simple solvent evaporation method. The thermally induced loss of water molecules in the crystal results in a reversible phase transition, accompanied by a change in photoluminescence (PL) from non-emission to red emission (660 nm), and the red emission originates from the d–d transition of Mn2+ (4T1–6A1). Additionally, the structure and luminescence behavior of the sample remain stable after 30 dark–red–dark cycles. (NH4)2MnBr4(H2O)2 demonstrates excellent environmental stability, as evidenced by the unchanged structure after 180 days and resistance to interference from various solvents. Notably, by exploiting the characteristics of the material and combining it with Cs3Cu2Br5, we demonstrated a multi-dimensional information encryption anti-counterfeiting label based on temperature and time gradients. This material offers a new option for thermochromic materials in anti-counterfeiting applications.
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高影响因子
ADVANCED MATERIALS
·
2018
·Vol. 30
·期 38
·1802489
·
IF 21.95
Ming Zhao,Hongxu Liao,Lixin Ning,Qinyuan Zhang,Quanlin Liu,Zhiguo Xia
The discovery of high efficiency narrow-band green-emitting phosphors is a major challenge in backlighting light-emitting diodes (LEDs). Benefitting from highly condensed and rigid framework structure of UCr 4 C 4 -type compounds, a next-generation narrow green emitter, RbLi(Li 3 SiO 4 ) 2 :Eu 2+ (RLSO:Eu 2+ ), has emerged in the oxide-based family with superior luminescence properties. RLSO:Eu 2+ phosphor can be efficiently excited by GaN-based blue LEDs, and shows green emission at 530 nm with a narrow full width at half maximum of 42 nm, and very low thermal quenching (103%@150 °C of the integrated emission intensity at 20 °C), however its chemical stability needs to be improved later. The white LED backlight using optimized RLSO:8%Eu 2+ phosphor demonstrates a high luminous efficacy of 97.28 lm W −1 and a wide color gamut (107% National Television System Committee standard (NTSC) in Commission Internationale de L'Eclairage (CIE) 1931 color space), suggesting its great potential for industrial applications as liquid crystal display (LCD) backlighting.
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ACS Nano
·
2022
·
IF 18.027
Yuyue Mo,Feng Zhang,Hefeng Dong,Xingzhen Zhang,Shoujian Gao,Shenxiang Zhang,Jian Jin
Membrane fouling is a persistent and crippling challenge for oily wastewater treatment due to the high susceptibility of membranes to contamination. A feasible strategy is to design a robust and stable hydration layer on the membrane surface to prevent contaminates. A hydrogel illustrates a distinct category of materials with outstanding antifouling performance but is limited by its weak mechanical property. In this research, we report a reinforced hydrogel on a membrane by in situ growing ultrasmall hydrophilic Cu3(PO4)2 nanoparticles in a copper alginate (CuAlg) layer via metal-ion-coordination-mediated mineralization. The embeddedness of hydrophilic Cu3(PO4)2 nanoparticle with a size of 3–5 nm endows the CuAlg/Cu3(PO4)2 composite hydrogel with enhanced mechanical property as well as reinforced hydrate ability. The as-prepared CuAlg/Cu3(PO4)2 modified membrane exhibits a superior oil-repulsive property and achieves a nearly zero flux decline for separating surfactant stabilized oil-in-water emulsions with a high permeate flux up to ∼1330 L m–2 h–1 bar–1. Notably, it is capable of keeping similar permeate flux for both pure water and oil-in-water emulsions during filtration, which is superior to the currently reported membranes, indicating its super-antifouling properties.
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Cell Reports Medicine
·
2024
·
IF 11.7
Chao Zhang,Yu-Xuan Sun,Ding-Cheng Yi,Ben-Yuan Jiang,Li-Xu Yan,Ze-Dao Liu,Li-Shan Peng,Wen-Jie Zhang,Hao Sun,Zhi-Yong Chen,Dan-Hua Wang,Di Peng,Song-An Chen,Si-Qi Li,Ze Zhang,Xiao-Yue Tan,Jie Yang,Zhang-Yi Zhao,Wan-Ting Zhang,Jian Su,Yang-Si Li,Ri-Qiang Liao,Song Dong,Chong-Rui Xu,Qing Zhou,Xue-Ning Yang,Yi-Long Wu,Ze-Min Zhang,Wen-Zhao Zhong
The clinical efficacy of neoadjuvant immunotherapy plus chemotherapy remains elusive in localized epidermal growth factor receptor (EGFR)-mutant non-small cell lung cancer (NSCLC). Here, we report interim results of a Simon’s two-stage design, phase 2 trial using neoadjuvant sintilimab with carboplatin and nab-paclitaxel in resectable EGFR-mutant NSCLC. All 18 patients undergo radical surgery, with one patient experiencing surgery delay. Fourteen patients exhibit confirmed radiological response, with 44% achieving major pathological response (MPR) and no pathological complete response (pCR). Similar genomic alterations are observed before and after treatment without influencing the efficacy of subsequent EGFR-tyrosine kinase inhibitors (TKIs) in vitro . Infiltration and T cell receptor (TCR) clonal expansion of CCR8 + regulatory T (Treg) hi /CXCL13 + exhausted T (Tex) lo cells define a subtype of EGFR-mutant NSCLC highly resistant to immunotherapy, with the phenotype potentially serving as a promising signature to predict immunotherapy efficacy. Informed circulating tumor DNA (ctDNA) detection in EGFR-mutant NSCLC could help identify patients nonresponsive to neoadjuvant immunochemotherapy. These findings provide supportive data for the utilization of neoadjuvant immunochemotherapy and insight into immune resistance in EGFR-mutant NSCLC.
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高影响因子
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
·
2025
·
IF 3.8
Zhu Dan,Zhong Hanyan,Shi Jingzhan,Liu Qiang,Wang Yiping
As a precursor to cancer metastasis, the matrix metalloproteinase (MMP) family can degrade almost all protein components of the extracellular matrix, disrupting the histological barrier and promoting tumor invasion. Therefore, the sensitive and reliable detection of MMP activity in the tumor microenvironment is of great importance for the diagnosis and prognosis of malignant tumors. Here, a ratiometric surface-enhanced Raman scattering (SERS) sensing strategy based on interference-free internal standard was proposed for the accurate quantification of MMP-2 activity. A plasmonic substrate with core-satellite structure was constructed by self-assembly of silver nanoparticles on the gold core, which provided excellent SERS enhancement due to the coupling interaction. Besides, rhodamine B (RhB)-labelled substrate peptides and 4-mercaptobenzonitrile (MBN) were used as the MMP-2 recognizer and internal standard, respectively. MMP-2 specifically cleaved the peptides in half, leaving the RhB molecule free and the Raman signal at 1650 cm −1 weak. Benefitting from the synergistic normalization by MBN at 2223 cm −1 in the cell silent region, this ratio-type readout signal ( I 2223 / I 1650 ) was resistant to the endogenous and exogenous interference, contributing to the reproducibility and stability. The experimental results showed that the nanoprobe was capable of detecting MMP-2 activity at concentrations ranging from 10 to 100 ng/mL, and the limit of detection could be down to 0.715 ng/mL. Importantly, it was successfully used to differentiate the breast cancer cells from the normal cells based on the MMP-2 activity, which could have a great potential in the fields of tumor biology and accurate disease diagnosis. Graphical abstract
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FITOTERAPIA
·
2025
·
IF 2.6
Li Zhang,Hui Wu,Xiaoyuan Li,Xiu Zhang,Hua Li,Huaqiao Tang,Daxuan Tang,Shijing Du,Ya’’ou Liu,Yangfan Tang,Xiaoming Bao,Guoqiang Cheng
Qianghuo (the rhizomes and radixes of Notopterygium incisum Ting ex H.T. chang) is a traditional Chinese medicine, and widely used as an anti-inflammatory, anodyne, antifebrile agent. Qianghuo volatile oil also exhibits the same properties, and the effects are probably related to the inhibition of cyclooxygenase (COX), but its bioactive components are not clear yet. To figure out the bioactive components of Qianghuo volatile oil target to cyclooxygenase-2 (COX-2), a ligand fishing method using immobilized COX-2 magnetic beads (COX-2-MB S ) and gas chromatography–mass spectrometry (GC–MS) were developed to identify the compounds that act on COX-2. Nine ligands, including 3-carene, β-caryophyllene, eucalyptol, α-terpinene, Limonene, δ-terpinene, α-pinene, β-pinene and γ-terpinene, were specifically captured by COX-2-MB S . Among them, 3-carene, β-caryophyllene, and eucalyptol in Qianghuo volatile oil were isolated and confirmed by in vitro inhibition and in vivo anti-inflammatory activity assays as selective inhibitor against COX-2. The IC 50 values were 13.5, 10.1, and 7.6 μM, respectively. Compared with the model, 3-carene, β-caryophyllene, and eucalyptol considerably reduced ear swelling and paw edema. Moreover, 3-carene and eucalyptol significantly decreased the changes of COX-2 expression in RAW264.7 cells activated by LPS. Our study validated that the developed ligand-fishing method using COX-2-MBs coupled with GC–MS can be applied to recognize COX-2 inhibitors in Qianghuo volatile oil. In vitro/vivo assay showed 3-carene and eucalyptol in Qianghuo volatile oil had strong inhibition against COX-2. This study may provide novel methods for discovering active components for volatile oil–based drug development or aromatherapy.
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高影响因子
Cancers
·
2024
·Vol. 16
·期 9
·1614
·
IF 4.5
Tiantian Song,Zheming Yu,Qitao Shen,Yu Xu,Haihong Hu,Junqing Liu,Kui Zeng,Jinxiu Lei,Lushan Yu
Simple SummaryAcute T-lymphoblastic leukemia is a disease with a very low survival rate after relapse, and the search for new therapeutic agents is important for the clinical benefit of patients with acute T-lymphoblastic leukemia. Our study developed YLS010, a small molecule that is more sensitive to acute T-lymphoblastic leukemia cells, based on the structure of the invented small molecule YLS004. This novel small molecule demonstrated good antitumor activity in vivo and in vitro with acceptable toxicity. These findings provide a new avenue for the development of clinical drugs for patients with acute T-lymphoblastic leukemia.Abstract(1) Background: The research group has developed a new small molecule, 6-Isopropyldithio-2′-deoxyguanosine analogs-YLS004, which has been shown to be the most sensitive in acute T-lymphoblastic leukemia cells. Moreover, it was found that the structure of Nelarabine, a drug used to treat acute T-lymphoblastic leukemia, is highly similar to that of YLS004. Consequently, the structure of YLS004 was altered to produce a new small molecule inhibitor for this study, named YLS010. (2) Results: YLS010 has exhibited potent anti-tumor effects by inducing cell apoptosis and ferroptosis. A dose gradient was designed for in vivo experiments based on tentative estimates of the toxicity dose using acute toxicity in mice and long-term toxicity in rats. The study found that YLS010 at a dose of 8 mg/kg prolonged the survival of late-stage acute T-lymphoblastic leukemia mice in the mouse model study. (3) Conclusions: YLS010 has demonstrated specific killing effects against acute T-lymphoblastic leukemia both in vivo and in vitro. Preclinical studies of YLS010 offer a new opportunity for the treatment of patients with acute T-lymphoblastic leukemia in clinical settings.
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CHEMICO-BIOLOGICAL INTERACTIONS
·
2024
·
IF 4.7
Xing Li,Bingtian Xu,Lu Long,Yuting Li,Xuan Xiao,Shuqin Qiu,Jiangping Xu,Li-Wen Tian,Haitao Wang
Mitochondrial dysfunction and endoplasmic reticulum (ER) stress play pivotal roles in the pathology of cerebral ischemia. In this study, we investigated whether phelligridimer A (PA), an active compound isolated from the medicinal and edible fungus Phellinus igniarius , ameliorates ischemic cerebral injury by restoring mitochondrial function and restricting ER stress. An in vitro cellular model of ischemic stroke-induced neuronal damage was established by exposing HT-22 neuronal cells to oxygen-glucose deprivation/reoxygenation (OGD/R). An in vivo animal model was established in rats subjected to middle cerebral artery occlusion/reperfusion (MCAO/R). The results showed that PA (1–10 μM) dose-dependently increased HT-22 cell viability, reduced OGD/R-induced lactate dehydrogenase release, and reversed OGD/R-induced apoptosis. PA reduced OGD/R-induced accumulation of reactive oxygen species, restored mitochondrial membrane potential, and increased ATP levels. Additionally, PA reduced the expression of the 78-kDa glucose-regulated protein (GRP78) and the phosphorylation of inositol-requiring enzyme-1α (p-IRE1α) and eukaryotic translation-initiation factor 2α (p-eIF2α). PA also inhibited the activation of the mitogen-activated protein kinase (MAPK) pathway in the OGD/R model. Moreover, treatment with PA restored the expression of mitofusin 2 (Mfn-2), a protein linking mitochondria and ER. The silencing of Mfn-2 abolished the protective effects of PA. The results from the animal study showed that PA (3–10 mg/kg) significantly reduced the volume of cerebral infarction and neurological deficits, which were accompanied by an increased level of Mfn-2, and decreased activation of the ER stress in the penumbra of the ipsilateral side after MCAO/R in rats. Taken together, these results indicate that PA counteracts cerebral ischemia-induced injury by restoring mitochondrial function and reducing ER stress. Therefore, PA might be a novel protective agent to prevent ischemia stroke-induced neuronal injury.
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NEW JOURNAL OF CHEMISTRY
·
2025
·
IF 2.5
Mengyin Liao,Chao Wang,Xuanhua Zhang,Chao Luan,Wenyuan Xu,Zhongyi He
Novel Pt/Co(OH)2-NiO/C catalysts based on carbon black were successfully synthesized using the hydrazine hydrate reduction method and galvanic replacement strategies. They were subsequently tested for their activity in the electrocatalytic oxidation of methanol. It was observed that the peak current density of Pt/Co(OH)2-NiO/C (8.29 A mg-1Pt) was 22.4 times higher than that of commercial Pt/C-JM (0.37 A mg-1Pt). The electrocatalytic activities and durabilities of the synchronously synthesized Pt/Co(OH)2-NiO/C catalysts were significantly better than those of PtCo/C, PtNi/C, and PtCoNi/C-X (X = 200, 400, 600) catalysts synthesized by calcination in Ar at different temperatures. The reason is that the highly dispersed Pt helps to expose more active sites on the catalyst surface, and the addition of Co(OH)2 and NiO alters the electron density of Pt, which reduces the adsorption of intermediate CO, attenuates the toxic effect, and enables more efficient oxidation of methanol.
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ANALYST
·
2025
·
IF 3.3
Jingwen Li,Yifei Li,Kai Zhang,Xiaomei Liu,Yuguo Tang,Kun Han
We developed a novel fluorescence detection method utilizing graphene quantum dots (GQDs) and manganese dioxide (MnO2) nanocomposites to enhance the sensitivity and specificity of in vitro monitoring of Bcl-2 gene expression, a key factor in tumor survival and treatment resistance. This method leverages the interplay between reduced glutathione (GSH) and hairpin DNA structures (H1 and H2) to simulate a cellular environment, enabling the redox-mediated disintegration of MnO2 nanosheets and the release of GQDs, restoring fluorescence. The presence of the Bcl-2 gene triggers a catalytic hairpin assembly (CHA) reaction, amplifying the Cy3 fluorescence signal and achieving a detection limit of 20.7 pM. The system demonstrated high specificity and stability, validated through control experiments with various DNA sequences. Optimization of key parameters, including MnO2 nanosheet concentration, GSH levels, and the ratio of hairpins H1 and H2, was critical for maximizing assay performance. The MnO2 nanosheets quench GQDs fluorescence and act as carriers for DNA probes, which are released upon reduction by GSH, mimicking intracellular redox conditions. The CHA reaction further amplifies the signal, allowing sensitive detection of low target gene levels. This biosensing platform integrates the unique properties of GQDs and MnO2 nanosheets, offering a real-time, sensitive, and selective method for monitoring Bcl-2 gene expression. This approach holds significant promise for early cancer diagnosis and personalized treatment strategies.
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高影响因子
NATURE MATERIALS
·
2025
·Vol. 24
·期 8
·1186-1194
·
IF 38.5
Shi Zude,Qin Wen,Hu Zhili,Ma Mingyu,Liu Hong,Shu Zhiwen,Jiang Yubing,Xia Hang,Shi Wenyan,Zhang Chao Yue,Sang Xiaoru,Guo Cui,Li Yunxin,Liu Chengzhi,Gong Chengshi,Wang Hong,Liu Song,Tapasztó Levente,Gao Caitian,Liu Fucai,Tang Pengyi,Liu Yuan,Duan Huigao,Xie Erqing,Zhang Zhuhua,Liu Zheng,He Yongmin
Atom-thin amorphous materials (for example, amorphous monolayer carbon) offer a designable material platform for fundamental studies of the disorder system, as well as the development of various applications. However, their growth at a single layer remains challenging since their thermodynamically favourable grains are neither two dimensional nor layered. Here we demonstrate the growth of 1-nm-thick, amorphous metal chalcogenides at a wafer scale using a nanodroplet-driven nanoribbon-to-film strategy. Metal clusters are initially liquified into 1–2 nm droplets at 120 °C, and they then orchestrate the growth of amorphous single-layer nanoribbons, which eventually merge into a continuous centimetre-scale film. Phase-field simulations, combined with our characterizations, suggest a non-equilibrium kinetic growth mechanism, which can be applicable to various films, for example, PtSe x , IrSe x , PdSe x and RhSe x . The synthesized films exhibit a range of unique properties, including tunable conductivity through disorder modulation, high work functions and remarkable catalytic activity, making them promising candidates for hole-injection contacts in p-type transistors and hydrogen production applications. This work opens a pathway for the synthesis of non-layered materials approaching the single-layer limit.
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高影响因子
ADVANCED FUNCTIONAL MATERIALS
·
2023
·Vol. 34
·期 8
·2310124
·
IF 19
Xinyu Li,Chengfeng Ma,Naiyun Liu,Chunxu Xiang,Shuxia Wei,Weibo Yan,Wei Huang,Hao Xin
Solution-processed chalcopyrite thin film solar cells have made great progress but still lag behind the vacuum-based ones due to inferior absorber quality and non-ideal interfaces. Here, plasma treatment of the molybdenum (Mo) substrate is reported to modify the back interface and improve the efficiency of solution-processed copper indium sulfoselenide (CuIn(S,Se) 2 , CISSe) solar cells. The results show plasma treatment oxides the surface Mo/MoO 2 to high oxidation oxides MoO 3-x (0 ≤ x < 1). The higher surface polarity greatly improves the wettability of the substrate to the precursor solution and results in formation of more compact and uniform precursor film, which grows to void-free larger grains absorber film with better adhesion to the substrate. In addition, the much higher chemical stability of MoO 3-x than Mo significantly reduces the thickness of high resistive MoSe 2 layer. The improved absorber quality and back interface property decreases charge carrier recombination in the absorber and back contact interface, resulting in 14.53% efficiency solution-processed CISSe solar cell, which is improved by 13% compared to device without plasma treatment.
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