ANALYTICAL AND BIOANALYTICAL CHEMISTRY
·
2022
·Vol. 415
·期 5
·855-865
·
IF 4.478
Lai Haohong,Niu Yuanyuan,Ming Pingtao,Wang Jinhao,Wang Shumei,Xu Yan,Zhai Haiyun
In this paper, a novel electrochemical sensor was constructed for the detection of purine bases. Ultrafine carbide nanocrystals confined within porous nitrogen-doped carbon dodecahedrons (PNCD) were synthesized by adding molybdate to ZIF-8 followed by annealing. With MoC-based PNCDs (MC-PNCDs) as the carrier, gold nanoparticles (AuNPs) were deposited on the electrode surface via potentiostatic deposition as the promoter of electron transfer, forming a AuNPs/MC-PNCDs/activated glassy carbon electrode (AGCE) sensor. MC-PNCDs had a large specific surface area, which combined with the excellent electrocatalytic activity of AuNPs, synergistically improved the electrocatalytic activity. The morphology and structure of the electrode surface modifier were characterized by scanning electron microscopy, transmission electron microscopy, energy-dispersive X-ray photoelectron spectroscopy, infrared spectroscopy, X-ray diffraction, nitrogen adsorption–desorption analysis, and electrochemical characterization. Under the optimal conditions, the linear detection range of guanine (G) and adenine (A) was 0.5–160.0 μM, and the detection limits (S/N=3) were 72.1 and 69.6 nM, respectively. AuNPs/MC-PNCDs/AGCE was successfully constructed, and was used to simultaneously detect G and A with high sensitivity and selectivity. Moreover, the sensor was successfully used to detect G and A in herring sperm DNA samples. Graphical abstract
✓ 已验证
DOI
高影响因子
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
·
2025
·
IF 5.4
Na Li,Shaobai Wen,Chunwei Yu
Sodium alginate (SA) hydrogels have been extensively utilized for pollutant removal from wastewater due to the distinct properties of hydrophilicity, biocompatibility and reusability. However, the limited functional groups and poor adsorption capacity have hindered their applications. In this study, a novel hybrid hydrogel bead, composed of sodium alginate, attapulgite, and zeolitic imidazole framework-8 (SA/ATP/ZIF-8), was synthesized using a one-pot blending and ion cross-linking method for adsorptive removal norfloxacin (NOR) from aqueous solutions. The incorporation of ATP and ZIF-8 significantly enhanced the thermal stability and anti-swelling properties of the SA hydrogel beads. The effects of solution pH, contact time, initial NOR concentration, temperature, and the presence of coexisting substances on NOR uptakes were systematically investigated. The results demonstrated that the NOR uptake on SA/ATP/ZIF-8 hybrid hydrogel beads was significantly higher than that of the pure SA and SA/ATP hydrogel beads, and the maximum theoretical adsorption capacity of SA/ATP/ZIF-8 for NOR was 1360.67 mg/g at pH 5.0. Furthermore, the adsorption kinetic was well-described by a pseudo-second-order model, while the adsorption isotherm was most accurately represented by the Langmuir-Freundlich model. In tests conducted with Nandu River water, the SA/ATP/ZIF-8 exhibited removal efficiencies of 100 % for NOR at an initial concentration of 0.0015 mmol/L and 71 % at 0.015 mmol/L. Spectroscopic characterization and adsorption performance experiments indicated that the adsorption of NOR onto SA/ATP/ZIF-8 involved multiple mechanisms, including hydrogen bonding, electrostatic adsorption, cation exchange, π-π electron donor-acceptor interaction (EDA), and coordination. Consequently, the remarkable features of SA/ATP/ZIF-8 hydrogel beads highlight their great potential and promising practicability for separation and removal of lower-concentration antibiotics from wastewater.
✓ 已验证
产品关联
DOI
高影响因子
Small
·
2025
·
IF 12.1
Yan Gao,Xiayu Lia,Shuai Huang,Na Zhao,Jianshe Zhao
Three-dimensionally ordered macro-microporous 3DOM-ZIF-8-based peroxophosphotungstate (DIL-PW 4 ) is constructed to break the limitation of micropores inherent in traditional supported catalysts. The presence of ordered macropores expose more active sites and significantly enhance mass diffusion, thereby boosting catalytic activity, especially in reactions involving larger molecules. The prepared composite DIL-PW 4 @3DOM-ZIF-8 is verified by various characterization techniques and used as a catalyst for the extraction oxidation desulfurization of multi-component simulated fuel. The results showed that heterogeneous catalyst DIL-PW 4 @3DOM-ZIF-8 has a remarkable catalytic effect, with 97.03% total sulfides removal in 120 min. In addition, the stability and reusability of the catalyst DIL-PW 4 @3DOM-ZIF-8 are evaluated as important parameters for industrial applications. In addition, a possible mechanism based on experimental studies are proposed.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
FOOD CHEMISTRY
·
2025
·
IF 9.8
Qing Yang,Hongbin Pu,Da-Wen Sun
The sensitive detection of quinalphos in food is crucial due to its improper use and the potential for serious harm. Surface-enhanced Raman spectroscopy (SERS) technology, provides a new way for rapid and ultra-sensitive detection. To exploit the molecular sieving effect of metal-organic frameworks (MOFs) in mitigating interference from food matrix components during pesticide residue detection, a novel chiral spiny L-Au@Ag@ZIF-8 (L-AAZ) three-layer core-shell composite was developed as an effective SERS substrate, with chiral L-AABPs providing abundant “hot spots” and spiny ZIF-8 shell provides excellent absorption properties, causing a five-fold increase in SERS intensity compared to traditional Au@Ag NPs. The experimental results revealed that L-AAZ achieved a high enhancement factor (EF) of 3.15 × 10 5 , a low limit of detection (LOD) of 6.56 × 10 −10 M, and a relative standard deviation (RSD) of 14.6 % for malachite green (MG), indicating its superior SERS sensitivity and consistency. Moreover, it demonstrated stable performance, maintaining good storage stability for up to 55 days. The substrate's suitability for the actual fruit sample (tangerine) was confirmed, showing an LOD of 10 ng/mL, demonstrating its capability for rapid and sensitive detection of trace amounts of pesticide residues in food.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Small
·
2025
·
IF 12.1
Qi Jing,Tao Gong,He-Qing Shao,Yu-Jie Wu,Jia-Xing Guo,Kai Ke,Lei Gong,Yong Cao,Zheng-Ying Liu,Wei Yang
Elastomer-based resistive super-thin film strain sensors show great application potentials in electronic skins, human–machine interaction systems, wearable devices for healthcare, and machine learning algorithms. However, it is challenging to accurately monitor the deformation of human body joints and organs with curved surfaces (e.g., knees, throats, finger joints) by only taking advantage of material thickness and elasticity of conventional 2D film strain sensors. Herein, a simple strategy is developed to fabricate conformal elastomeric thin film sensors with periodic 3D microstructure inspired by the ridges and valleys of human skin for accurate signal acquisition. Specifically, an 8-micrometer-thick elastic film strain sensor with 3D microstructure is fabricated via thermoforming followed by in situ chemical growth of silver nanoparticles. The 3D film strain sensors exhibit excellent signal linearity (R 2 = 0.99) and relatively high sensitivity (gauge factor = 14) over a relatively wide strain range (≈43%), with an ultra-low strain detection limit of 0.025%, enabling potential applications in human healthcare monitoring and air leakage detection. Thus, this study unveils a simple methodology to process microstructure-enabled conformable 3D film strain sensors, which show good conformability and multiple mechanical sensing functions for advancing the development of next-generation flexible strain sensors.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
SEPARATION AND PURIFICATION TECHNOLOGY
·
2025
·
IF 9
Zhibo Huang,Tiandi Pan,Ning Tang,Fei Sun,Peijian Du,Ni Li
Nanofibrous membranes are considered ideal candidates for water purification. However, the membrane fouling results in an irreversible decline in separation flux, while the slippage of nanofibers leads to an increase in pore size under driving pressure, subsequently inducing a decline in separation efficiency. Rational structure design and material selection are crucial for separation performance improvement. In this study, we report double-layer hierarchical structured nanofibrous membranes that demonstrate simultaneous superhydrophilicity and underwater superoleophobicity for oil-water separation via a combination of electrospinning and seed-mediated solvothermal strategy. The double-layered hierarchical structure comprises an upper layer of ZIF-8@PMIA composite nanofibers and a bottom layer of PMIA nanofibers. Notably, the incorporation of ZIF-8 species confers several advantages, such as increased surface roughness, reduced pore size, and enhanced superhydrophilicity, collectively contributing to superior anti-fouling performance and high separation efficiency. Meanwhile, the bottom PMIA nanofibers, with larger diameters, ensure robust mechanical integrity for the entire membrane. Due to the rational structural design, the membrane achieves outstanding separation performance, including a 99.91 % separation efficiency for diesel-in-water emulsions and an ultrahigh flux of 3821.7 L m − 2 h −1 for dichloromethane-in-water emulsions. Therefore, this membrane has broad application prospects in the oil–water separation field.
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF NANOBIOTECHNOLOGY
·
2022
·Vol. 20
·期 1
·1-18
·
IF 9.429
Chen Xuehua,Huang Yongquan,Chen Hui,Chen Ziman,Chen Jiaxin,Wang Hao,Li Dan,Su Zhongzhen
Background Insufficient radiofrequency ablation (IRFA) can promote the local recurrence and distal metastasis of residual hepatocellular carcinoma (HCC), which makes clinical treatment extremely challenging. In this study, the malignant transition of residual tumors after IRFA was explored. Then, arsenic-loaded zeolitic imidazolate framework-8 nanoparticles (As@ZIF-8 NPs) were constructed, and their therapeutic effect on residual tumors was studied. Results Our data showed that IRFA can dramatically promote the proliferation, induce the metastasis, activate the epithelial–mesenchymal transition (EMT) and accelerate the angiogenesis of residual tumors. Interestingly, we found, for the first time, that extensive angiogenesis after IRFA can augment the enhanced permeability and retention (EPR) effect and enhance the enrichment of ZIF-8 nanocarriers in residual tumors. Encouraged by this unique finding, we successfully prepared As@ZIF-8 NPs with good biocompatibility and confirmed that they were more effective than free arsenic trioxide (ATO) in sublethal heat-induced cell proliferation suppression, apoptosis induction, cell migration and invasion inhibition, and EMT reversal in vitro. Furthermore, compared with free ATO, As@ZIF-8 NPs exhibited remarkably increased therapeutic effects by repressing residual tumor growth and metastasis in vivo. Conclusions This work provides a new paradigm for the treatment of residual HCC after IRFA. Graphical Abstract
✓ 已验证
DOI
PubMed
高影响因子
CARBON
·
2025
·
IF 11.6
Hao Lu,Xianchu Wang,Chenyu Wang,Qihang Wang,Jingjing Xie,Weiming Wang,Zhengyi Fu,Zhaoyong Zou
Zeolitic Imidazolate Frameworks (ZIF-8) has emerged as promising candidate for alleviating the aggregation of Fe 3 N-catalysts, exhibiting significantly improved oxygen reduction reaction (ORR) and oxygen evolution reaction (OER) for rechargeable zinc-air batteries. To further improve the catalytic performance, it is crucial to fabricate ZIF-8 with hierarchically porous structures, which remains challenging due to the rapid crystallization kinetics and the weak interactions. Inspired by biological porous materials, we developed a novel method using 1,3,5-trimethylbenzene TMB as a mediating molecule to dynamically regulate the organic-inorganic interface between templates and ZIF-8 precursors, achieving the micro-meso-macropores of ZIF-8, which synergistically enhances mass transport and active site accessibility. Additionally, TMB preserves the weakly alkaline environment required for ZIFs’ structural integrity by leveraging its hydrophobic co-solvent effect. The as-synthesized Fe 3 N-HPZIF-8 catalyst integrates Fe 3 N active sites, hierarchically porous structures, and pyrrolic-N dopants, resulting in the exceptional bifunctional activity in alkaline media (ΔE = 0.619 V), exceeding most benchmark catalysts. When integrated into zinc-air batteries, a peak power density of 205.2 mW cm -2 is achieved. This work presents a generalizable synthetic approach for high-performance metal-air battery catalysts.
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY
·
2022
·Vol. 78
·期 4
·777-791
·
IF 5.08
Li Ling,Bai Yu,Du Runyu,Tang Lei,Li Ling
Gestational diabetes mellitus (GDM) is a common pregnancy complication with a high incidence in women. Orphan nuclear receptor NUR77 is involved in regulating glucose metabolism. However, its role in GDM has not been fully elucidated yet. In this study, an animal model of GDM was established by feeding mice with a high-fat diet (HFD) before and during pregnancy. NUR77 expression was abnormally upregulated in placenta tissues of GDM mice. We performed gain- and loss-of-function studies of NUR77 in HTR-8/SVneo cells. Cells were incubated with 1 × 10 −6 M insulin for 48 h to induce insulin resistance (IR). The expression of NUR77 was downregulated in HTR-8/SVneo cells following IR induction. Overexpression of NUR77 promoted cell proliferation, migration, and invasion. Notably, NUR77 promoted glucose uptake and enhanced insulin sensitivity in vitro. NUR77 increased the ratio of p-insulin receptor β (IRβ) Tyr1361 /IRβ, p-insulin receptor substrate (IRS)-1 Tyr612 /IRS-1, p-Akt/Akt and decreased p-IRS-1 Ser307 /IRS-1, as well as lowered the expression of glucose transport protein type 1 (GLUT1) and elevated GLUT4. These results suggest the involvement of IRβ/IRS/Akt/GLUT4 signaling activation in the regulatory effects of NUR77 on IR in HTR-8/SVneo cells. Silencing of NUR77 displayed opposite effects. Besides, NUR77 enhanced the expression of autophagy-related protein Beclin 1 and the ratio of LC3II/LC3I. Further study demonstrated that the inhibitory effect of NUR77 on IR was partially attributed to the activation of autophagy. Therefore, we demonstrate that NUR77 enhances insulin sensitivity in HTR-8/SVneo cells likely through activating IRβ/IRS/Akt/GLUT4 pathway and regulating autophagy.
✓ 已验证
DOI
PubMed
高影响因子
PROGRESS IN ORGANIC COATINGS
·
2025
·
IF 7.3
Chao Wang,Xin Yu,Qinghe Gao,Mingliang Zhu,Huijuan Qian,Lixin Wei
To enhance the long-term protective efficacy of epoxy resin (EP) coatings, this study prepared naringin (Nar)-functionalized thiourea (TU)@ZIF-8/graphene oxide (NTZG) nanoparticles via in situ growth coupled with self-assembly and used these nanoparticles to prepare a pH-responsive modified EP coating. The uniformly dispersed particles considerably improved the protective efficacy of the coating, reducing the water absorption rate to 1/56 that of pure EP coating. After 90 d of coating corrosion resistance testing, the impedance modulus of the NTZG/EP coating at 0.01 Hz remained above 10 8 Ω·cm 2 , whereas the pure EP coating lost its protective capability. The release of TU and Nar from damaged sites on the coating effectively suppressed corrosion. Simultaneously, the released agents exhibited a synergistic effect with Zn 2+ generated through ZIF-8 degradation, producing potent antibacterial effects by disrupting the membrane structures of bacteria and inhibiting the activity of enzymes. Experimental studies combined with quantum chemical calculations showed that strong molecular interactions between TU and Nar effectively inhibited the penetration of media into the damaged coating area. Thus, the proposed strategy shows promise for the design of multifunctional smart protective coatings suitable for harsh energy production environments.
✓ 已验证
产品关联
DOI
高影响因子
FUEL
·
2025
·
IF 7.5
Jui-Yeh Rau,Yulin Xie,Zhujian Mao,Youyi Wang,Jiayi Hao,Shihan Cai,Jian Huang
The development of high-performance hydrogen separation membranes is a crucial step in the advancement of sustainable energy technologies and the achievement of carbon neutrality. In this study, zeolitic imidazolate framework-8 (ZIF-8) membranes with an ultra-high selectivity for hydrogen over carbon dioxide were successfully synthesised on polydopamine/3-aminopropyltriethoxysilane (PDA/APTES) modified Al 2 O 3 supports. The interfacial layer exhibited excellent adhesion and a high density of functional groups, which served as nucleation sites for the growth of ZIF-8 crystals. The resulting membranes exhibited a dense and defect-free structure, achieved through an optimised 12 h in-situ growth process. The membranes exhibited excellent gas separation performance, with hydrogen(H 2 ) permeance reaching 14 × 10 −7 mol·Pa −1 ·m −2 ·s −1 and ideal selectivities of 20.3, 22.1, and 26.8 for H 2 /CO 2 , H 2 /N 2, and H 2 /CH 4 , respectively, at 25 °C and 0.2 MPa. In comparison with the ZIF-8 membrane that was synthesised on a pure PDA modified layer, the H 2 permeance increased by 14.8 %. Notably, the selectivity for H 2 /CO 2 increased by almost threefold. Moreover, long-term stability tests demonstrated the durability and robustness of the ZIF-8 membranes under operational conditions.
✓ 已验证
产品关联
DOI
高影响因子
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
·
2025
·
IF 5.4
Liangliang Zhao,Mingyang Lin,Hongyan Pan,Zheng Chen,Mingrui Liao,Qian Lin,Song Li
Membrane separation technology encounters significant challenges in achieving simultaneous separation and purification of oily wastewater contaminated with heavy metal ions. Herein, ZIF-8 derived mesoporous carbon etched by oxygen plasma (DMC-OP X ) was used as a functional component for adsorbing heavy metal ions and blended with hydrophilic copolymers PVDF- g -PHEMA into the PVDF casting solution, enabled the fabrication of an advanced nanocomposite membrane (M-H-DMC-OP X ) with separation-adsorption functionality through NIPS method. The characterization results indicate that oxygen plasma etching significantly increases the oxygen-containing groups on DMC-OP X surfaces enhancing hydrophilicity, heavy metal adsorption capacity, and mitigating flux reduction caused by unmodified DMC incorporation. Calculation analyses demonstrate that the oxygen-containing groups on DMC-OP X surface can form hydrogen bonding networks with PVDF- g -PHEMA chains, thereby improving the tensile strength of M-H-DMC-OP X membrane. The one-step separation experiments on oil-water emulsions containing Cu 2 + , Pb 2+ , Cr 3+ , Fe 3+ , and Co 2+ demonstrate that the M-H-DMC-OP 6 membrane exhibits outstanding oil-water separation efficiency and heavy metal removal efficiency, reaching over 99.2 % and 82.4 %, respectively. This work developed a multifunctional separation membrane for complex oily wastewater and established a feasible strategy for improving the water flux of nanocomposite membranes.
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）