SENSORS
·
2024
·Vol. 24
·期 6
·1789
·
IF 3.4
Fei Hua,Tiancheng Yao,Youzhi Yao
A new, simple, and effective one-step reduction method was applied to prepare a nanocomposite with spherical polycrystalline silver nanoparticles attached to the surface of reduced graphene oxide (Ag@rGO) at room temperature. Equipment such as X-ray diffraction (XRD), scanning electron microscopy (SEM), transmission electron microscopy (TEM), X-ray photoelectron spectroscopy (XPS), and Fourier transform infrared spectroscopy (FTIR) was used to characterize the morphology and composition of the Ag@rGO nanocomposite. A novel electrochemical sensor for detecting L-cysteine was proposed based on fixing Ag@rGO onto a glassy carbon electrode. The electrocatalytic behavior of the sensor was studied via cyclic voltammetry and amperometry. The results indicate that due to the synergistic effect of graphene with a large surface area, abundant active sites, and silver nanoparticles with good conductivity and high catalytic activity, Ag@rGO nanocomposites exhibit significant electrocatalytic activity toward L-cysteine. Under optimal conditions, the constructed Ag@rGO electrochemical sensor has a wide detection range of 0.1–470 μM for L-cysteine, low detection limit of 0.057 μM, and high sensitivity of 215.36 nA M−1cm−2. In addition, the modified electrode exhibits good anti-interference, reproducibility, and stability.
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PubMed
高影响因子
ACS Applied Materials & Interfaces
·
2024
·
IF 8.3
Yanxu Li,Weiben Ji,Chaoying Wang,Lai Chang,Quan Zhang,Jiefeng Gao,Tao Wang,Wei Wu
Electrospun nanocarrier systems, widely employed in the medical field, exhibit the capability to encapsulate multiple drugs and mitigate complications. Doxorubicin hydrochloride (DOX) represents a frequently utilized chemotherapeutic agent for liver cancer patients. Sodium bicarbonate (SB) serves to neutralize the acidic tumor microenvironment, while ibuprofen (IBU) attenuates inflammatory factor production. The combination of these three commonly used drugs facilitates antitumor efficacy and relapse prevention. Composite fibrous membranes were prepared by incorporating the antitumor drug DOX into MSN, which was then codispersed with IBU in a poly l-lactic acid (PLLA) electrospinning solution after acid sensitization using SB. The resulting membrane was characterized using transmission electron microscopy and scanning electron microscopy. The toxic effect of this fibrous membrane and its pro-apoptotic effect on tumor cells were evaluated, along with the expression of cell proliferation-related factors, immune/inflammatory factors, and apoptosis-related factors. Immunohistochemistry and HE staining confirmed its ability to inhibit recurrence of postoperative residual cancer without causing toxicity to vital organs. The PLLA-MSN@DOX-SB-IBU nanofibrous membrane not only mitigates the cardiotoxicity associated with DOX but also inhibits tumor cell proliferation and enhances the tumor microenvironment, demonstrating significant antitumor efficacy. Furthermore, it effectively prevents the recurrence of residual cancer postsurgery while exhibiting excellent biocompatibility. The PLLA-MSN@DOX-SB-IBU nanofibrous membrane demonstrates significant potential in impeding the progression of hepatocellular carcinoma and mitigating the recurrence of residual cancer following surgical intervention for hepatocellular carcinoma.
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高影响因子
Journal of Food Measurement and Characterization
·
2025
·
IF 3.3
Wang Hongji,Li Xiaoyu,Cui Liying,Guo LuLu,Wang Aijiao,Chu Guangru,He Siqi,Liu Shengkai,Fu Yujie,Liu Zhiguo
Vaccinium vitis-idaea L. leaves (VVLL), a renewable forest resource abundant in active compounds, have not been well utilized. This study employed microwave-assisted natural deep eutectic solvents (NADES) to efficiently extract the total flavonoids from VVLL. Among various combinations, the choline chloride-lactic acid solvent exhibited great selectivity for flavonoids, with the highest extraction rate of 269.99 ± 1.42 mg/g, ( n = 3). Six flavonoids in the VVLL extract were further analyzed by UPLC-MS/MS and HPLC. They included two isomers, a triterpenic acid, and Asiatic acid which is firstly reported in VVLL. The total flavonoid content extracted by our method is 3.4 times higher than that of Vaccinium vitis-idaea L. fruit. Fourier-transform infrared spectroscopy results revealed NADES-flavonoid hydrogen bonding as the driving mechanism for enhanced extractability. The extracted flavonoids exhibited superior antioxidant capacity against DPPH and ABTS radicals in comparison to the traditional alcohol extraction methods. Specifically, the scavenging activities were also significantly improved. In conclusion, as a high-quality source of flavonoids, VVLL has substantial promise for the development of novel flavonoid products.
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高影响因子
ELECTROPHORESIS
·
2019
·Vol. 40
·期 20
·2699-2705
·
IF 2.754
Haochen Qi,Meiqi Zhao,Huaguo Liang,Jayne Wu,Zhengfeng Huang,Anming Hu,Jian Wang,Yingchun Lu,Jian Zhang
Copper is an indispensable trace element for human health. Too much or too little intake of copper ion (Cu 2+ ) can lead to its own adverse health conditions. Therefore, detection of Cu 2+ is always of vital importance. In this work, a simple sensor was developed for rapid detection of trace Cu 2+ in water, in which L-cysteine (Cys) as a molecular probe was self-assembled on a gold interdigital electrode to form a monolayer for specific capture of Cu 2+ . The interfacial capacitance of interdigital electrode was detected to indicate the target adsorption level under an AC signal working as the excitation to induce directed movement and enrichment of Cu 2+ to the electrode surface. This sensor reached a limit of detection of 4.14 fM and a satisfactory selectivity against eight other ions (Zn 2+ , Hg 2+ , Pb 2+ , Cd 2+ , Mg 2+ , Fe 2+ , As 3+ , and As 5+ ). Testing of spiked tap water was also performed, demonstrating the sensor's usability. This sensor as well as the detection method shows a great application potential in fields such as environmental monitoring and medical diagnosis.
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高影响因子
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
·
2016
·
IF 2.653
Man Qiao,Junze Jiang,Jidong Yang,Shaopu Liu,Zhongfang Liu,Xiaoli Hu
Based on l -tryptophan-Pd(II) system, a sensitive and selective fluorimetric assay for the quantification of ceftriaxone (CTRX) had been developed. The experimental results showed that in pH 4.0 Britton–Robinson (BR) buffer medium, the fluorescence of l -tryptophan ( l -Trp) ( λ ex / λ em = 276 nm/352 nm) could be efficiently quenched by Pd(II). When CTRX was added to the mixed solution of the l -tryptophan and Pd(II), the fluorescence of l -Trp recovered. The reaction mechanism and the reasons for the fluorescence recovery were also discussed. Pd(II) reacted with l -Trp to form a 1:1 chelate complex, and then, after CTRX was added in l -Try-Pd(II) system, the ligand exchange reaction occurred between l -Trp and CTRX, which resulted in the fluorescence recovery. Under the optimized experimental conditions, the recovered fluorescence intensities at 352 nm showed excellent linear relationship with the concentration of CTRX over the range of 6.0 × 10 − 8 –2.4 × 10 − 6 mol L − 1 (0.040–1.59 μg mL − 1 ). The correlation coefficient (R) was 0.9997 and the detection limit was 1.8 × 10 − 8 mol L − 1 (11.9 ng mL − 1 ). Furthermore, the assay had been applied to determine trace amount of CTRX human urine samples with satisfactory results.
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高影响因子
POLYMER INTERNATIONAL
·
2018
·Vol. 67
·期 11
·1535-1544
·
IF 2.352
Huang Tan,Hanqing Wang,Yue Tang,Shuyang Zhang,Wei Yang,Zhengying Liu,Mingbo Yang
A rather low crystallization rate has greatly limited the application of poly( l -lactide) (PLLA) in many fields. Thus, functionalized cellulose nanoparticles (CPNs) were prepared based on cellulose aerogel through a novel and simple approach and were then applied as biobased nucleating agents to improve the crystallization rate of PLLA. First, isolated individual CPNs with a mean diameter around 37.2 nm and regular circular shape were obtained. Subsequently, PLLA based nanocomposites with various contents of CPNs were prepared by solution blending. As a result, CPNs promoted the crystallization rate of PLLA significantly. Compared with that of neat PLLA, the crystallinity ( X c ) of the nanocomposites increased dramatically more than 30 times to 36.65% at a CPN loading of 0.5 wt%, and the half-crystal time ( t 1/2 ) at 130 °C decreased by about 91%. Furthermore, due to the presence of CPNs, which provided a large number of nucleation sites in the PLLA matrix, the chain conformational and crystallization kinetics behavior of the PLLA based nanocomposites during isothermal crystallization were changed in the early stages, and based on this result a proposal for the nucleation process for CPNs in a PLLA matrix is presented. © 2018 Society of Chemical Industry
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高影响因子
Journal of Macromolecular Science Part B-Physics
·
2020
·
IF 0.911
Ping Chen,Zhihua Zhou,Wenjuan Liu,Yanmin Zhao,Tianlong Huang,Xiaofei Li,Jianglong Duan,Jianjun Fang
The technique of thermally induced phase separation (TIPS) is favorable for the fabrication of a porous scaffold due to a number of advantages. In this work the poly(L-lactide-co-glycolide-co-ε-caprolactone) (PLLGC) terpolymer was synthesized by melt copolymerization and porous scaffolds thereof from its solution in 1,4-dioxane were fabricated by using the TIPS method. The effects of fabrication parameters, including polymer concentration and freezing temperature, on the morphology, pore size and mechanical properties were studied. The results showed that the average pore size of the PLLGC porous scaffold increased with a decrease in PLLGC concentration and the pore size resulting from freezing at 4 °C (about 20–100 μm) was significantly larger than for other samples (20–50 μm) frozen at lower temperatures. The porosity of the scaffolds decreased with increasing PLLGC concentration or decreasing freezing temperature. On the other hand, the compressive strength of the scaffolds increased with the increase of PLLGC concentration or the decrease of freezing temperature, as would be expected. The present results can be applied in design to control the processing parameters of TIPS for a scaffold with desired pore morphology.
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高影响因子
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
·
2014
·
IF 2.129
Lei Chen,Bing Yan
Several kinds of host–guest hybrid materials have been synthesized employing a ship in a bottle method by loading 9-hydroxy-2-methylphenalenone (MHPO) or 9-hydroxyphenalen (HPNP) from gas phase into the nanochannels of Ln 3+ -exchanged zeolite L (ZL) crystals (Ln = Gd or Eu). The resulting hybrids without lanthanide ions, MHPO–ZL, HPNP–ZL and the hybrids with lanthanide ions Ln–MHPO–ZL and Ln–HPNP–ZL are characterized with FT-IR, UV–vis DRS and photoluminescence spectroscopy. The photoluminescence properties of these hybrid materials have been analyzed and discussed, exhibiting the luminescence of Eu 3+ and ligands under the excitation at ultraviolet–visible region. These results provide useful data and can be expected to have potential application in the practical fields.
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高影响因子
Plants-Basel
·
2026
·Vol. 15
·期 15
·2370
·
IF 4.7
Qian Shen,Tian-Tian Xia,Liang-Yuan Tong,Bin-Bin Lan,Wei-Lin Huang,Ti Wu,Xin Ye,Ning-Wei Lai,Li-Song Chen
MostCitrusspp. trees in China are cultivated in acidic soils with low soil organic matter and high Al3+. The mechanisms of humic acid (HA) to alleviate Al3+stress in plants remain unclear. ‘Sour pummelo’ (Citrus grandis(L.) Osbeck) seedlings were exposed to 0.5 (HA0.5), 0.1 (HA0.1), or 0 (HA0) mM sodium humate and 1.2 (Al1.2) or 0 (Al0) mM AlCl3·6H2O for 128 days. Thereafter, the research examined biomass; Al and mineral nutrients; leaf photosynthetic performance; and leaf and root nonstructural carbohydrates, reactive oxygen species metabolism, and related physiological parameters. Al1.2 significantly reduced whole plant dry weight (DW), root DW, leaf CO2assimilation (ACO2), and chlorophylla + bconcentration by 61%, 45%, 61%, and 35%, respectively, at HA0, but only 48%, 17%, 44%, and 11%, respectively, at HA0.5. Further analysis suggested that the addition of HA endowedCitruswith Al resilience by the following several aspects: (a) lessened tissue (leaf, stem, and root) concentrations of Al and enhanced capacity to maintain macronutrient (S, K, Mg, Ca, N, and P) homeostasis at Al1.2; (b) improved capacity to combat oxidative stress at Al1.2; and (c) enhanced ACO2and growth at Al1.2. Further analysis indicated that HA-mediated alleviation of growth decline caused by Al1.2 involved (a) reduced ability to absorb Al and less root-to-shoot Al transport and (b) increased ability to maintain macronutrient homeostasis and to combat oxidative stress; and that HA-mediated alleviation of leaf chlorophyll and ACO2decline and photosynthetic electron transport chain impairment involved less leaf Al concentration and improved leaf macronutrient homeostasis. To conclude, the addition of HA lowered roots’ ability to absorb Al and tissue Al concentration and subsequently mitigated Al-toxic impairment to root growth and function, thereby enhancing the ability of plants to maintain macronutrient homeostasis, and hence alleviating Al1.2-stimulated oxidative damage and inhibition of ACO2and growth.
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高影响因子
FOOD RESEARCH INTERNATIONAL
·
2026
·
IF 8.8
Tian Du,Qing-Ping Zheng,Ye-Ting Wang,Meng Li,Yan-Zhen Zheng
Green NADES extracted propolis bioactives integrated into PVA/ZIF-L films. • Leaf-like ZIF-L nanocarriers enhanced UV shielding and film flexibility. • PVAD/ZIF0.5 exhibited 70.2% DPPH scavenging and strong antibacterial activity. • Composite films effectively inhibited oyster spoilage during 10 d refrigeration. • Synergistic DES–ZIF-L system enabled safe and sustainable active packaging. Active packaging materials with integrated antioxidant and antimicrobial functions offer an effective strategy for extending the shelf life of highly perishable aquatic foods. In this study, a multifunctional composite film was fabricated by incorporating natural deep eutectic solvent (NADES)-extracted propolis bioactives and two-dimensional ZIF-L nanocarriers into a poly(vinyl alcohol) (PVA) matrix. The synthesized ZIF-L exhibited a characteristic leaf-like morphology with an average particle size of 140 nm, facilitating its uniform dispersion within the polymer network. Structural analyses confirmed that ZIF-L and propolis extracts were successfully integrated into the PVA matrix through hydrogen bonding and physical interactions. The resulting PVAD/ZIF composite films displayed enhanced flexibility and improved UV-shielding properties while maintaining good transparency. The optimized PVAD/ZIF0.5 film exhibited the highest antioxidant activity with a DPPH radical scavenging rate of 70.2%, and showed strong antimicrobial activity against Staphylococcus aureus and Escherichia coli . Application tests demonstrated that oysters packaged with PVAD/ZIF0.5 maintained TVB-N values below 30 mg/100 g and a TVC of 5.80 log CFU/g after 10 days of refrigerated storage, whereas control samples exceeded spoilage limits. Furthermore, the PVAD/ZIF0.5 retained good mechanical integrity under high-humidity conditions, while Zn 2+ migration remained well below the regulatory limit for food-contact materials. In addition, cytocompatibility assays showed high cell viability (96.28%) after 24 h incubation. These findings demonstrate that the PVAD/ZIF composite film is a promising biodegradable active packaging material for aquatic food preservation. Download: Download high-res image (113KB) Download: Download full-size image
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高影响因子
Advanced Industrial and Engineering Polymer Research
·
2026
·
IF 18.4
Feng Yang,Jiye Jia,Yingang Xiao,Pei Feng,Cijun Shuai
Mechanism by which process parameters affect the shape memory properties of 4D-printed objects remains unclear. In this study, laser powder bed fusion (LPBF) was employed as the printing technique to systematically investigate the relationship from poly(L-lactic acid) (PLLA) raw material preparation to process-properties mapping. It was found that increasing the laser energy density led to a lower shape recovery ratio of PLLA scaffold with a lower crystallization, wherein the crystalline phase acted as netpoints remembering the permanent shape. And the phenomenon that crystalline phases were breaking down into fewer and smaller crystalline phases under a high laser energy density was intuitively observed. The mechanism was proposed that the laser broke the crystalline phase of PLLA powder during printing and enabling control over the netpoints and thereby influencing the shape memory properties of PLLA scaffold. Furthermore, based on the above mechanism, multi-phase composite scaffolds with pixel-level distribution of amorphous and semi-crystalline phases were fabricated using a single semi-crystalline PLLA as the raw material by tailoring LPBF process parameters. In conclusion, this study revealed that laser-induced breaking of PLLA crystalline phase governed the shape memory properties and provided a new paradigm for multi- phase printing via LPBF.
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高影响因子
Advanced Science
·
2026
·
IF 14.1
Kaiyuan Jiang,Fen Xiong,Yiwen Peng,Lingfei Meng,Xinran Wang,Yingruo Xu,Tian Tang,Hongchang Gao
Diabetic cardiomyopathy (DCM) is a major cardiovascular complication of diabetes with limited effective interventions. Using a streptozotocin-induced insulin-deficient, type 1 diabetes-like DCM mouse model, we show that intermittent fasting (IF) improves cardiac function and attenuates myocardial remodeling. Antibiotic-mediated microbiota depletion largely abolished these benefits, whereas fecal microbiota transplantation from IF-treated donors recapitulated cardioprotection, supporting a causal role of the gut microbiota. Metagenomic profiling identified Akkermansia muciniphila ( A. muciniphila ) as a prominent IF-responsive taxon, and A. muciniphila supplementation alleviated cardiac injury without obvious improvement in glycaemia. Integrated serum and heart metabolomics identified 1-methyl-L-histidine as a microbiota-associated metabolite reduced in diabetes but restored by IF and A. muciniphila . In vitro and ex vivo assays further supported an L-anserine-linked microbial route for 1-methyl-L-histidine generation. Importantly, oral 1-methyl-L-histidine supplementation recapitulated key cardioprotective effects, remodeled cardiac lipid homeostasis, and reduced lipid peroxidation and oxidative injury. Together, these findings support a gut microbiota–metabolite–lipid axis associated with IF-related cardioprotection in DCM and highlight microbial metabolites as tractable targets to complement dietary intervention.
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高影响因子
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