Probiotics and Antimicrobial Proteins
·
2025
·
IF 4.4
Chen Fengming,Wu Shu,Wang Xiaoyu,Li Yinghui,He Binsheng,Fu Yafen,Huang Xingguo,Chen Jiayi
Reducing the negative impact of oxidative stress (OS) on weaned piglets is crucial for the further development of the pig industry. Our previous studies found that Lactobacillus delbrueckii (LAB) can alleviate OS and protect intestinal health by activating TLR2 and TLR4 expressions in weaned piglets. This research aimed to verify whether LAB can alleviate OS and intestinal barrier injuries in IPEC-J2 cells by activating TLR2 and TLR4. IPEC-J2 cells were first pretreated with 10 10 CFU/mL LAB for 12 h, and then were induced to OS by 0.8 mmol/L H 2 O 2 for another 12 h. The results showed that LAB significantly alleviated OS induced by H 2 O 2 , indicated by the downregulation of MDA ( P < 0.05), along with upregulation of GSH-Px, CAT, T-SOD, and T-AOC ( P < 0.05). Besides, LAB significantly alleviated intestinal barrier injuries induced by H 2 O 2 , indicated by the upregulation of Claudin-1, Occludin, and ZO-1 expressions. Subsequently, the IPEC-J2 cells were pretreated with inhibitors of TLR2 (TLR2-IN-C29) and TLR4 (MD2-TLR4-IN-1) in the absence of LAB for 12 h, and then treated with 0.8 mmol/L H 2 O 2 for another 12 h. The results showed that both inhibitors significantly prevented the protection effects of LAB on H 2 O 2 -induced OS, indicated by the downregulation of CAT, SOD1, HO-1, and GSH-Px1 expressions ( P < 0.05). Taken together, LAB treatment can alleviate OS and intestinal injuries induced by H 2 O 2 by activating TLR2 and TLR4 expressions in IPEC-J2 cells, thus providing novel theoretical support for LAB in the prevention and treatment of oxidative damage.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
BIOPROCESS AND BIOSYSTEMS ENGINEERING
·
2024
·
IF 3.5
Liu Jiale,Zhao Shufan,Wei Wan,Yu Shupeng,Wang Zhao,Zheng Jianyong
Lipase is one of the most widely studied and applied biocatalysts. Due to the high enzyme leakage rate of the immobilization method of physical adsorption, we propose a new lipase immobilization method, based on the combination of macroporous resin adsorption and organic polymer coating. The immobilized Candida antarctica lipase B (CALB@resin-CAB) was prepared by combining the macroporous resin adsorption with cellulose acetate butyrate coating, and its structure was characterized by various analytic methods. Immobilized lipase was applied for biodiesel production using acidified palm oil as the starting material, the conversion rate achieved as high as 98.5% in two steps. Furthermore, the immobilized lipase displayed satisfactory stability and reusability in biodiesel production. When the aforementioned reaction was carried out in a continuous flow packed bed system, the yield of biodiesel was 94.8% and space–time yield was 2.88 g/(mL∙h). The immobilized lipase CALB@resin-CAB showed high catalytic activity and stability, which has good potential for industrial application in the field of oil processing.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
npj Materials Degradation
·
2024
·Vol. 8
·期 1
·1-11
·
IF 6.6
Xu Changyuan,Li Linyang,Hu Rong,Wu Huihua,Kong Lingnan,Zhong Nianbing,Wan Bo,Wu Lei,Lai Dong,He Yuanyuan,Liu Yang,Peng Xiaoling,Zhao Mingfu,Xie Quanhua
To monitor in situ the temperature, pH, and micro-strain change information of sandstone artifacts in the process of oxalic acid corrosion, the temperature, pH, and micro-strain fiber Bragg grating (FBG) sensors are developed. A theoretical model of the sensors is established. The surface morphology, material composition, pore structure, temperature, pH, and micro-strain of sandstone corroded by oxalic acid solutions of different concentrations are investigated. The experimental results show that the higher the concentration of oxalic acid, the stronger the corrosiveness of the sandstone. Ferrous oxalate and calcium oxalate produced by corrosion continuously precipitate from the inside of the rock, and the dual reaction of crystallization and dissolution occurs, reducing the proportion of fine pores in the rock pore suction and gravity. The oxalic acid solution is transported to the middle of the sandstone (3 cm) and undergoes the strongest chemical reaction with ore particles and debris, resulting in the maximum wavelength drift of the temperature, pH, and micro-strain sensors. The results of this study provide important support for analyzing the acid dissolution mechanism of stone cultural relics and the preventive protection of cultural relics.
✓ 已验证
产品关联
DOI
高影响因子
Nano-Micro Letters
·
2024
·Vol. 16
·期 1
·1-14
·
IF 31.6
Li Cuiping,Li Dan,Zhang Shuai,Ma Long,Zhang Lei,Zhang Jingwei,Gong Chunhong
The boosted heterogeneous interfaces in titanium nitride (TiN) nanotube/polydimethylsiloxane (PDMS) composite contributed to strong polarization loss relaxation ability.
The TiN nanotubes/PDMS composite possessed both good impedance matching behavior and strong dielectric loss ability in wide temperature spectrum.
The TiN nanotubes/PDMS composite exhibited excellent EMWA performances (effective absorption bandwidth value of 3.23 GHz and minimum reflection loss value of − 44.15 dB) at the varied temperature from 298 to 573 K.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF MATERIALS SCIENCE-MATERIALS IN ELECTRONICS
·
2024
·Vol. 35
·期 27
·1-12
·
IF 2.8
Zeng Shifan,Zhang Cong,Tian Haiming,Yao Guizhi,Shi Huan,Zhu Yong,Chi Shangpeng,Kan Xucai,Liu Xiansong
The magnetic powder Sm 2 Fe 17 N x has recently garnered considerable interest due to its competitive pricing. In this study, the preparation of Sm 2 Fe 17 N x magnetic powder by melt quenching and nitriding process was successfully completed. In order to obtain a higher coercivity, the particle size of the magnetic powder was reduced to a diameter of less than 2 μm through ball milling. It was observed that as the ball milling time was extended, the coercivity of the magnetic powder exhibited a decline that was premature in comparison to the expected results. Additionally, the presence of minute particles of magnetic powder may appear spontaneous combustion phenomenon. Accordingly, Sm 2 Fe 17 N x magnetic powder with high coercivity ( H cj = 842.8 kA/m) was prepared by phosphoric acid passivation process. Through XRD patterns, it was found that the phosphoric acid passivation process markedly enhanced the antioxidant capacity of the magnetic powder. Through SEM images, it is found that the fine magnetic powder exhibits a sheet structure and has strong shape anisotropy. The research indicate that the phosphoric acid passivation process is effective in enhancing the stability of Sm 2 Fe 17 N x magnetic powder and inhibiting the oxidation reaction of magnetic powder during use. This has a beneficial impact on the service life of permanent magnet devices in industrial production.
✓ 已验证
产品关联
DOI
高影响因子
MICROCHIMICA ACTA
·
2024
·Vol. 191
·期 7
·1-12
·
IF 5.3
Zhou Peipei,Hong Yangluchen,Fan Ru,Wang Huili,Wang Xuedong,Mei He
To realize the reutilization of waste Myrica rubra in the analytical field, we synthesized Myrica rubra –based N-doped carbon dots (MN-CDs) and further anchored them onto the surface of Fe 3 S 4 to fabricate Fe 3 S 4 @MN-CD nanocomposites. The as-fabricated nanocomposites possessed higher peroxidase-mimetic activity than its two precursors, resulting from the synergistic effect between them, and could catalyze colorless 3,3′,5,5′-tetramethylbenzidine (TMB) into deep blue oxTMB with a strong 652-nm absorption. Under optimized conditions (initial solution pH, 3.5; incubation temperature, 35 ℃; Fe 3 S 4 @MN-CD concentration, 50 µg mL −1 , and 652-nm absorption), Fe 3 S 4 @MN-CDs were employed for colorimetric assay of p -aminophenol ( p -AP) with wide linear range (LR, 2.9–100 µM), low detection limit (LOD, 0.87 µM), and satisfactory recoveries (86.3–105%) in environmental waters. Encouragingly, this colorimetric assay provided the relative accuracy of 97.0–99.4% as compared with conventional HPLC-UV detection. A portable smartphone-based colorimetric application was developed by combining the Fe 3 S 4 @MN-CD-based visually chromogenic reaction with a “Thing Identify” APP software. Besides, we engineered an image-capturing device feasible for field use, in which the internal-compact sealing prevented external light source from entering photography chamber, thereby reducing light interference, and also the bottom light source enhanced the intensity of blue imaging. This colorimetric platform exhibited satisfactory LR (1–500 µM), low LOD (0.3 µM), and fortification recoveries (86.6–99.6%). In the chromogenic reaction catalyzed by Fe 3 S 4 @MN-CDs, ·O 2 − played a key role in concomitant with the participation of •OH and h + . Both the colorimetric assay and smartphone-based intelligent sensing show great promising in on-site monitoring of p -AP under field conditions. Graphical Abstract
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Waste and Biomass Valorization
·
2024
·
IF 2.6
Li Yalin,Liu Lei,Zhang Xing,Dong Tingting,Wang Zhaojun,Xiong Manxin,Zhao Jingyi
The increasing amount of food waste and its sustainable management are gradually becoming global issues. The sustainable management of food waste has great potential benefits in terms of emission reduction and economic benefits. This study reports a novel environmentally friendly kitchen waste hydrogel synthesized from kitchen waste prepared from acrylamide, N,N ′-methylene bisacrylamide, Urea, and sodium persulfate by free radical cross-linking polymerization. Further, the effects of single factors on the solubility and mechanical properties of the hydrogel were investigated. Additionally, using a response surface methodology, the combined effects of the three key experimental parameters-cross-linking agent, temperature, and initiator were investigated on the mechanical properties of the hydrogel. The results revealed that at 64.83 ℃, the elastic modulus of the hydrogel reached 277.61 Kpa. The cross-linking agent and modifier amounts were determined to be 0.122 and 4.669 g, respectively. Subsequently, the mechanical properties of the kitchen hydrogels were researched by investigating the experimental mode of interaction between the experiment and molecular dynamics simulation. The simulation results were consistent with the experimental data, acting as a reference for the in-depth study of other properties of the kitchen hydrogel system. Graphical
✓ 已验证
产品关联
DOI
高影响因子
Advanced Composites and Hybrid Materials
·
2025
·Vol. 8
·期 1
·1-20
·
IF 21.8
Ma Yibo,Dong Jiaxing,Zou Xiangqian,Jiang Xiaohua,Liu Linhua,Wang Bing,Mao Xiulin,Gong Liangfeng,Li Guoshu,Chen Changjian
Metabolic reprogramming is fundamental to synovium remodeling with drug delivery for osteoarthritis (OA) therapy. Mitochonic acid 5-MASM7@MnTBAP nanoparticles (MM@MT NPs) with various physicochemical properties and biological activities may be developed as a supramolecular nano-drug delivering to articulus for regulating mitochondrial metabolism of synovium. This study aims to explore the feasibility, efficacy, and mechanism of MM@MT NPs, which possibly excavates a novel perspective for OA therapy. Herein, for feasibility, MM@MT NPs has been indicated to possess excellent photothermal, reactive oxygen species (ROS) response, and oxygen release performances. For efficacy, MM@MT NPs has been confirmed to promote extracellular matrix (ECM) regeneration. For mechanism, MM@MT NPs has been illustrated to restore the mitochondrial membrane potential and recover the mitochondrial dynamics, which is beneficial for maintaining mitochondrial homeostasis. Moreover, MM@MT NPs has been demonstrated to stimulate the tricarboxylic acid (TCA) cycle and oxidative phosphorylation (OXPHOS) in mitochondria as well as enhance antioxidant capacity and eliminate oxidative stress, which is reflected in regulating the adenosine triphosphate (ATP) and ROS metabolism. Therefore, MM@MT NPs can remodel the homeostasis of mitochondria via reprogramming metabolism in synovium, which achieves the symptomatic and etiological treatments of OA.
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF NANOBIOTECHNOLOGY
·
2025
·
IF 12.6
Xinyao Hu,Hua Zhu,Yang Shen,Lang Rao,Jiayi Li,Xiaoqin He,Ximing Xu
Tumor immunotherapy aims to harness the immune system to identify and eliminate cancer cells. However, its full potential is hindered by the immunosuppressive nature of tumors. Radiotherapy remains a key treatment modality for local tumor control and immunomodulation within the tumor microenvironment. Yet, the efficacy of radiotherapy is often limited by tumor radiosensitivity, and traditional radiosensitizers have shown limited effectiveness in hepatocellular carcinoma (HCC). To address these challenges, we developed a novel multifunctional nanoparticle system, ZIF-8@MnCO@DOX (ZMD), designed to enhance drug delivery to tumor tissues. In the tumor microenvironment, Zn²⁺ and Mn²⁺ ions released from ZMD participate in a Fenton-like reaction, generating reactive oxygen species (ROS) that promote tumor cell death and improve radiosensitivity. Additionally, the release of doxorubicin (DOX)-an anthracycline chemotherapeutic agent-induces DNA damage and apoptosis in cancer cells. The combined action of metal ions and double-stranded DNA (dsDNA) from damaged tumor cells synergistically activates the cyclic GMP-AMP synthase (cGAS)–stimulator of interferon genes (STING) pathway, thereby initiating a robust anti-tumor immune response. Both in vitro and in vivo experiments demonstrated that ZMD effectively activates the cGAS-STING pathway, promotes anti-tumor immune responses, and exerts a potent tumor-killing effect in combination with radiotherapy, leading to regression of both primary tumors and distant metastases. Our work provides a straightforward, safe, and effective strategy for combining immunotherapy with radiotherapy to treat advanced cancer.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Microbial Cell Factories
·
2024
·Vol. 23
·期 1
·1-12
·
IF 4.3
Wang Jiajia,Chen Yumeng,Cong Jiawei,Wang Wei
Background Trichoderma reesei is renowned for its cellulase-producing ability and is used for biofuel production from lignocellulose. In plants and fungi, cellulase production is induced by cellulose and suppressed by glucose; however, whether metformin can enhance cellulase production and mitochondrial function in T. reesei remains unclear. Metformin reduces blood glucose levels by inhibiting hepatic gluconeogenesis; therefore, it is worth investigating whether metformin transmission modulates cellulase biosynthesis in T. reesei . Results Metformin increased cellulase production and the transcription of cellulase-related genes. It also enhanced the concentrations of Ca 2+ in the cytosol and mitochondria and regulated the transcription levels of cellulase-related genes by modulating calcium homeostasis in T. reesei QM6a. In addition, metformin was identified as an antioxidant that can enhance cellulase activity by reducing reactive oxygen species (ROS). Our results demonstrated that metformin influences the state of mitochondria by enhancing mitochondrial activity and membrane potential to promote cellulase production. Conclusion Collectively, these results indicate that metformin enhances cellulase production, scavenges ROS, and protects mitochondrial activity in T. reesei . Graphical Abstract
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF SOL-GEL SCIENCE AND TECHNOLOGY
·
2024
·
IF 2.3
Zhao Yuan,Feng Huixia,Shang Qiong,Jiao Linhong
Carbon-based hydrogels have emerged as a promising material for wearable strain and pressure sensors due to their excellent conductive and mechanical flexibility. However, some shortcomings such as limited stretchability and susceptibility to phase separation have led to a narrow range of applications. In this study, a GPEC hydrogel was prepared by incorporating metal ions and oxidized multi-walled carbon nanotubes (oxCNTs) into a double-network (DN) hydrogel consisting of gum arabic (GA) and a copolymer polymerized by acrylamide (AM), acrylic acid (AA) and N-methylolacrylamide (NMAM). The uniformly distributed oxCNTs and metal ions formed a three-dimensional (3D) structure of the hydrogel through a large amount of metal complex bonds and hydrogen bonds. The strong interaction improved the mechanical properties of the hydrogels, with an elongation at break of 1957% and a strength at break of 915 kPa. Furthermore, the hydrogels exhibited excellent self-adhesive and self-healing properties. The hydrogel also exhibits high conductivity due to the embedded metal ions and oxCNTs forming a conductive network. The as-prepared strain sensor revealed ultra-high sensitivity (GF = 3.08) and fast response (72 ms). Moreover, the GPEC hydrogel exhibits high pressure sensitivity (2.27 kPa −1 in the range of 0–10 kPa and 0.08 kPa −1 in the range of 20–80 kPa) when assembled into a pressure sensor. Consequently, the GPEC hydrogel sensor could be used to monitor the full range of human motion and could be incorporated into pressure sensing devices for handwriting recognition. Graphical Abstract
✓ 已验证
产品关联
DOI
高影响因子
CELLULOSE
·
2025
·
IF 4.8
Wu Zhongbo,Shi Zhuqun,Xiong Chuanxi,Yang Quanling
The limited energy storage density which is ascribed to low dielectric constant impedes the more diversified applications of polymer dielectric capacitors, and the environmental pollution problem caused by petroleum-based polymers cannot be ignored. Cellulose has the characteristics of wide source, low cost, and strong polarization generated by the hydroxy groups on the molecular chain giving it a high dielectric constant. In addition, nanocellulose has excellent mechanical properties that enable it to be fabricated into homogeneous films with high tensile strength. In this work, barium titanate nanoparticles (BTNPs) were incorporated into nanocellulose films to obtain enhanced dielectric performance. The composite film has the best comprehensive performance with BTNP content of 0.9 wt.%, resulting in a discharge energy density of 5.21 J cm −3 and charge/discharge efficiency of 77.7% at 350 MV m −1 . Consequently, nanocellulose-based dielectric materials give great promise for applications in biopolymer-based dielectric capacitors. Graphical abstract
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）