MICROCHIMICA ACTA
·
2019
·Vol. 186
·期 6
·1-8
·
IF 5.479
Liu Xinyan,Deng Keqin,Wang Hao,Li Chunxiang,Zhang Shaowei,Huang Haowen
Gold nanoparticles (AuNPs) with a size of ~3 nm were placed on a thionine-multiwalled carbon nanotube (Thi-CNTs) conjugate to form a novel AuNP-Thi-CNTs nanocomposite. Its morphology and composition were characterized by transmission electron microscopy, atomic force microscopy, X-ray diffraction, and X-ray photoelectron spectroscopy. The nanocomposite was placed on an electrode and used as a redox-active signaling interface to fabricate a ratiometric electrochemical aptasensor for 17β-estradiol (E2). The potentiostatic insertion method was applied to insert an aptamer against E2 into a thin alkane monolayer to warrant an adequate distance between aptamers. The aptamer against E2 acts as both a collector and separator to specifically bind E2. The electrode displays two peak signals (at +0.50 V vs. SCE for E2; and at −0.32 V for Thi) which increase and decrease, respectively, in the 12 pM to 60 nM E2 concentration range. Therefore, the current ratio can be used to reliably, reproducibly, and sensitively quantify the concentration of E2.
Schematic presentation of a novel AuNP-Thi-CNTs nanocomposite. AuNP-Thi-CNTs showed good electrocatalytic oxidation to E2. AuNP-Thi-CNTs was used as self-redox signal interface to fabricate aptasensor. Dual signals of extrinsic E2 and inner Thi was applied to monitor the concentration of E2.
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JOURNAL OF MATERIALS SCIENCE
·
2019
·Vol. 54
·期 15
·10656-10669
·
IF 3.442
Tong Mingxing,Yang Jiaxing,Jin Qiuyang,Zhang Xuan,Gao Jing,Li Guohua
In this work, a simple strategy to fabricate amorphous carbon-coated tungsten oxide with oxygen vacancies (WO 3− x /C, 0 < x < 1) via pyrolysis of hybrid-polyoxometalates (hybrid-POMs) in nitrogen atmosphere is reported. TGA, XRD, Raman, FTIR, SEM, TEM, EDS, XPS and BET have been used to characterize the as-prepared products. The results showed that their compositions, microstructures and concentrations of oxygen vacancies were closely related with the species of organic amines in the hybrid-POMs. When the WO 3− x /C composites were used as catalysts for degradation of dyes such as methylene blue, methyl orange and Rhodamine B under visible light irradiation, they showed much enhanced photocatalytic abilities compared to that of WO 3 and P25, which could be ascribed to the coating of WO 3 by amorphous carbon and the construction of defects (oxygen vacancy) in WO 3 . The synthetic strategy presented in our work is simple and shows a great potential in fabricating efficient transition metal-based composites for photocatalysis applications and so on.
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ANALYTICAL AND BIOANALYTICAL CHEMISTRY
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2019
·Vol. 411
·期 10
·2189-2200
·
IF 3.286
Liu Lu,Du Jie,Liu Wen-e,Guo Yongliang,Wu Guofan,Qi Weinan,Lu Xiaoquan
Enzyme-mimicking (nanozyme)-based biosensors are attractive owing to their unique catalytic efficiency, multifunctionality, and tunable activity, but examples of oxidase-like nanozymes are quite rare. Herein, we demonstrated that histidine-capped gold nanoclusters (His@AuNCs) possessed intrinsic oxidase-like activity, which could directly oxidize 3,3′,5,5′-tetramethylbenzidine (TMB) to blue colored ox-TMB without H 2 O 2 . The assembly of reduced graphene oxide (RGO) with His@AuNCs could further improve its oxidase-like activity and the His@AuNCs/RGO nanocomposites had a lower Michaelis constant ( K m ) and higher catalytic constant ( K cat ) for TMB oxidation. Furthermore, compared to other nanomaterials, the as-prepared His@AuNCs/RGO also exhibited enhanced electrocatalytic activity toward TMB. Interestingly, nitrite inhibited the catalytic (chromogenic) and electrocatalytic processes of His@AuNCs/RGO in the oxidation of TMB. The oxidase-like and electrocatalytic activity of His@AuNCs/RGO was evaluated with nitrite and TMB as substrates, and the results indicated that TMB and nitrite might share the same catalytic active sites. On the basis of these findings, a colorimetric and electrochemical sensor was developed with the His@AuNCs/RGO composite as an oxidase mimic for determination of nitrite with linear ranges of 10–500 μM and 2.5–5700 μM, respectively. The developed method was successfully applied to the detection of nitrites in real samples. The present work suggests that the oxidase-like nanozyme is not only suitable for colorimetric assay but also for development of electrochemical sensors in bioanalysis.
The colorimetric and electrochemical detection of nitrite using His@AuNCs/RGO.
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高影响因子
CELLULOSE
·
2018
·Vol. 25
·期 12
·7211-7224
·
IF 3.809
Fu Feiya,Zhang Weilan,Zhang Ruihong,Liu Lin,Chen Shichang,Zhang Yupeng,Yang Binbin,Touhid Salvia,Liu Xiangdong,Zhou Jinping,Yao Juming
Abstract Cellulose hybrid fibers embedded with silver nanoparticles (Ag NPs) were prepared from a spinning dope through a bottom-up approach. Instead of using toxic agents or high temperature, an alkaline cellulose dope was directly used as a reducing agent for in situ synthesis of Ag NPs. The regenerated cellulose fibers displayed a dense circular microstructure and Ag NPs with a mean diameter of 40.1 nm were inlaid on its surface and inside. By increasing the spinning drawing ratio, the diameter and Ag content of the nanohybrid fibers decreased while its tensile strength in dry state increased significantly. Because of the embedded structure of NPs, the width of inhibition zone for the nanohybrid fibers against S. aureus and E. coli was small. However, both bacteria could be killed within 5 h in the presence of the nanobybrid fibers. In particular, the nanobybrid fibers showed excellent antibacterial durability and low cell toxicity. Besides, it was demonstrated that the nanobybrid fibers with lower diameter showed better catalytic activity and the catalytic efficiency could reach 99.3% for methyl orange. This biosynthesis approach is expected to offer a sustainable method for scale-up fabrication of functional cellulose fibers. Graphical abstract
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MICROCHIMICA ACTA
·
2018
·Vol. 185
·期 11
·1-9
·
IF 5.705
Li Zehui,Jiang Yuheng,Wang Zhuoya,Wang Wenbo,Yuan Yi,Wu Xiaoxue,Liu Xingchen,Li Mingjie,Dilpazir Sobia,Zhang Guangjin,Wang Dongbin,Liu Chenming,Jiang Jingkun
Core-shell structured particles were prepared from carbonized zeolitic imidazolate frameworks (ZIFs) and reduced graphene oxide (rGO). The particles possess a nitrogen content of up to 10.6%. The loss of nitrogen from the ZIF is avoided by utilizing the reduction and agglomeration of graphene oxide with suitable size (>2 μm) during pyrolysis. The resulting carbonized ZIF@rGO particles were deposited on a glassy carbon electrode to give an amperometric sensor for H 2 O 2 , typically operated at a voltage of −0.4 V (vs. Ag/AgCl). The sensor has a wide detection range (from 5 × 10 −6 to 2 × 10 −2 M), a 3.3 μM (S/ N = 3) detection limit and a 0.272 μA·μM −1 ·cm −2 sensitivity, much higher than that of directly carbonized ZIFs. The sensor material was also deposited on a screen-printed electrode to explore the possibility of application.
Nitrogen doped carbon (NC) derived from carbonized zeolitic imidazolate frameworks is limited because of low nitrogen content. Here, nitrogen-rich NC@reduced graphene oxide (rGO) core-shell structured particles are described. The NC@rGO particles show distinctly better H 2 O 2 detection performance than NC.
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JOURNAL OF MATERIALS SCIENCE
·
2018
·Vol. 54
·期 2
·1692-1702
·
IF 2.993
Pan Jie,Lei Shuaiquan,Chang Lu,Wan Dong
In this study, novel smart pH-sensitive nanoparticles of PLA-mPEG 2000 /TPGS 3350 -PHis-Folate for enhanced effect of chemotherapy are developed. Polyethylene glycol (PEG) is decorated on the surface of nanocarriers in order to prolong the circulation of nanoparticles in blood; the pH-sensitive material of poly( l -histidine) is utilized in nanoparticles for the intelligent purposes: under normal physiological pH, the targeting molecule of folate can be hidden into the layer of PEG in nanoparticles, which closes the active targeting function of nanoparticles; but in weak acid of tumor tissue, poly( l -histidine) is protonated to expose folate on the surface of nanoparticles, opening the active targeting function; next, nanoparticles are internalized by cells via folate receptor-mediated endocytosis; finally, poly( l -histidine) in endosome/lysosome begins to dissociate, leading to quick intracellular drug release. The features of the nanoparticles such as morphology, particle size, drug loading content, in vitro release and in vitro cytotoxicity are further investigated. Nanoparticles designed in this work have multiple functions such as active targeting, long circulation and easy internalization by cells simultaneously, and rapid intracellular drug release, which demonstrates huge potential to apply for the efficient treatment of cancer.
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CATALYSIS LETTERS
·
2018
·Vol. 148
·期 10
·3112-3118
·
IF 2.911
Han Yan,Yang Yawei,Zhao Jianqiu,Yin Xingtian,Que Wenxiu
Abstract Ternary Cu 2 SnS 3 (CTS) and Cu 2 SnSe 3 (CTSe) quantum dots were grown in-situ on reduced graphene oxide (rGO) nanosheets by a facile one-pot colloidal synthesis. Possessing abundant active sites and having the ability to harvest solar energy and to facilitate charge separation, the CTS(e)/rGO 0D/2D nanocomposites showed remarkably enhanced photocatalytic activities for degradation of rhodamine B and methyl orange aqueous solutions upon visible light irradiation. The nanocomposites of rGO supported monodispersed quantum dots were proved to be a suitable platform for photocatalytic applications due to the well-maintained 0D/2D nanostructure. Graphical Abstract
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Nanoscale Research Letters
·
2018
·Vol. 13
·期 1
·1-8
·
IF 3.125
Yue Tian-Tian,Li Xiao,Wang Xiao-Xiong,Yan Xu,Yu Miao,Ma Jian-Wei,Zhou Yu,Ramakrishna Seeram,Long Yun-Ze
Electrospinning provides an effective method for generating nanofibers from solution of carboxymethyl chitosan/polyoxyethylene oxide (CMCS/PEO). The goal of this work is to explore the potential application of electrospun CMCS/PEO nanofiber membrane in fruit fresh-keeping. The microstructure, antibacterial activity, hydrophilia, and air permeability of the nanofiber membrane have been tested. For comparison, the fresh-keeping effects of commercial cling wrap and CMCS/PEO nanofiber membranes on strawberries’ rotting rate and weight loss rate have been studied. The results indicate that the electrospun CMCS/PEO membrane could effectively avoid water loss in strawberries and has a remarkable effect to prolong strawberries’ shelf life due to its breathability and antibacterial activity. In addition, the composite CMCS/PEO, nanofiber membrane is non-poisonous and edible, which can be used in food industry.
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MICROCHIMICA ACTA
·
2018
·Vol. 185
·期 7
·1-9
·
IF 5.705
Wang Jiasheng,Hui Ni
A non-fouling electrochemical immunosensor is described for determination of the tumor biomarker carcinoembryonic antigen (CEA). It is based on the use of composite wires made by chemical grafting of hyaluronic acid onto polyaniline nanowires. The modified nanowires possess excellent antifouling property both in single protein solutions and in dilute serum samples. The current of immunoelectrode exhibits a linear response in the 0.01 pg mL −1 to 10,000 pg mL −1 CEA concentration range and 0.0075 pg mL −1 detection limit. This work demonstrates that coating an electrode with hyaluronic acid can largely reduce unspecific adsorption of proteins on the electrode surface.
Schematic of a nonfouling electrochemical immunosensor for the carcinoembryonic antigen. It is based on novel composite wires made through the chemical grafting of easily available hyaluronic acid (HA) onto polyaniline (PANI) nanowires. The HA/PANI demonstrated excellent antifouling property both in single protein solutions and human serum samples.
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JOURNAL OF MATERIALS SCIENCE-MATERIALS IN ELECTRONICS
·
2019
·Vol. 30
·期 16
·14954-14966
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IF 2.195
Fang Hongjun,Pan Yusong,Yin Minyuan,Pan Chengling
Active co-catalysts have been extensively used for improving photocatalytic activity in semiconductor-based photocatalytic systems. Herein, 2D alkalized Ti 3 C 2 (Ti 3 C 2 -OH) nano-sheets were coupled with CdS via a facile electrostatic self-assembly strategy and combined with hydrothermal method to prepare Ti 3 C 2 -OH/CdS photocatalyst. The morphologies, crystal phases, optical and photoelectrical properties of the prepared photocatalysts were characterized by XRD, SEM, TEM, FTIR, PL, and EIS analysis, respectively. The photocatalytic degradation results verified that the photo-degradation performance of Ti 3 C 2 -OH/CdS photocatalyst (degradation of 97% RhB in 100 min) was obviously superior to that of pure CdS (degradation of 70% RhB in 100 min) and Ti 3 C 2 /CdS (degradation of 82% RhB in 100 min). The active species trapping experiments for Ti 3 C 2 -OH/CdS photocatalyst revealed that the superoxide radical ( · O 2 − ) and holes (h + ) were the predominant species for degradation of RhB. Furthermore, the Ti 3 C 2 -OH co-catalyst in the Ti 3 C 2 -OH/CdS composite not only played the role of promoting the effective separation of photo-generated electron–hole pairs, but also constructing strong connections with CdS semiconductor to establish heterostructure, ultimately enhancing the photocatalytic performance of the Ti 3 C 2 -OH/CdS photocatalyst.
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JOURNAL OF MATERIALS SCIENCE
·
2019
·Vol. 54
·期 20
·13298-13313
·
IF 3.442
Zhang Liuwei,Qian Ming,Wang Jingyun,Xia Jing,Cui Hongyan,Chen Qixian
Photo-responsive nitrophenyl moieties were proposed to conjugate as pendants of the pullulan backbone through labile carbamate linkage to yield amphiphilic pullulan derivatives. Note that the hydrophobicity of the conjugated nitrophenyl components in the amphiphiles enable facile their self-assembly with the hydrophobic chemotherapeutic drug (doxorubicin) as the internal drug reservoirs, whereas the hydrophilic pullulan segments existed as the biocompatible surroundings. Upon photo-illumination, the carbamate linkage was susceptible to cleavage for departure of the nitrophenyl components from the pullulan backbone owing to the photo-responsive nitrophenyl moieties. Simultaneously, the nitrophenyl components transformed into water-soluble aldehyde-terminalized nitrosophenyl derivatives, leadingly accounting for structural disassembly and liberation of the cytotoxic doxorubicin payloads. Therefore, our proposed photo-responsive strategy could address the reluctant intracellular drug release drawbacks of the conventional amphiphile-based drug delivery systems. Notably, markedly lower IC 50 (half maximal inhibitory concentration) index of our constructed doxorubicin delivery systems was determined to be approximately 1.0 μg/mL upon photo-illumination, in contrast to IC 50 index of 5.6 μg/mL in the absence of photo-illumination (approximate fivefold), thereby representing as a facile spatiotemporal artifice to execute on-demand drug release to the photo-imposed cells.
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AAPS PHARMSCITECH
·
2019
·Vol. 20
·期 7
·1-10
·
IF 2.608
Xu Yingxin,Fang Tianxu,Yang Yifan,Sun Li’ang,Shen Qi
Docetaxel (DTX) was effective in the treatment of neoplasm but could only be administered intravenously with the poor oral bioavailability owing to its undesirable solubility, remarkably metabolic conversion, and other factors. Cimetidine (CMD), a classic CYP3A4 isozyme inhibitor, had exhibited a wide range of inhibition on the metabolism of many drugs. The aim of this study was to construct the novel docetaxel-cimetidine (DTX-CMD) complex and the chitosan-deoxycholate nanoparticles based on it to confirm whether this formulation could show advantages in terms of solubility, dissolution rate, small intestinal absorption, and oral bioavailability in comparison with the pure drug. The solid-state characterization was carried out by powder X-ray diffraction (PXRD), Fourier transform infrared spectroscopy (FT-IR), and simultaneous DSC-TGA (SDT). Dissolution rate and kinetic solubility study were determined by evaluating the amount of DTX in distilled water and phosphate buffer solution (pH = 7.4), respectively. And small intestinal absorption and pharmacokinetics study were conducted in rats. The results of this study demonstrated that we successfully constructed DTX-CMD complex and its chitosan-deoxycholate nanoparticles. Furthermore, the DTX-CMD complex increased the solubility of DTX by 2.3-fold and 2.1-fold in distilled water and phosphate buffer solution, respectively. The ultimate accumulative amount of DTX-CMD complex nanoparticles through rat small intestinal in 2 h was approximately 4.9-fold and the oral bioavailability of the novel nanoparticles was enhanced 2.8-fold, compared with the pure DTX. The superior properties of the complex nanoparticles could both improve oral bioavailability and provide much more feasibility for other formulations of DTX.
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