EMBO Molecular Medicine
·
2025
·
IF 8.3
HuangChunling,HuangYuna,HuangBoshui,YaoLei,ZhangZenghui,DongLuoxiao,GuanChang,LiJunping,HuangZhaoqi,ChenSixu,JiangYuan,ZhangYuling,WangJingfeng,ChenYangxin,LiuZhaoyu
Abdominal aortic aneurysm (AAA) is a life-threatening vascular disease without effective medical therapies. Emerging evidence have suggested a crosstalk between adipose tissue and vascular cells. Besides, brown adipose tissue is considered beneficial for cardiovascular health. Nevertheless, whether brown remodeling of white adipose tissue would protect against AAA remains unclear. Here, we showed that patients with AAA had a decreased browning level of adipose tissue, and induction of adipose tissue browning significantly reduced AAA incidence and attenuated AAA development in mice. Using LC-MS/MS and proteomic analysis, we further identified Follistatin-like 1 (FSTL1) as a novel vessel-protective adipokine secreted by browning adipocytes. Mechanistically, FSTL1 inhibited VSMC apoptosis through DIP2A/AKT signaling. Furthermore, we demonstrated that adipocyte-specific deficiency of FSTL1 abrogated the protective effect of browning induction. Moreover, supplementation of FSTL1 either systemically or patched into hydrogel placing around the abdominal aorta markedly limited aortic dilation and AAA progression. Our data suggest a protective role of adipose tissue browning and batokine FSTL1 in the development of AAA, which may represent a novel intervention strategy for AAA.
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Nature Communications
·
2025
·Vol. 16
·期 1
·1-14
·
IF 15.7
Zhou Lingxi,Yang Menghao,Liu Yihong,Kang Feiyu,Lv Ruitao
Electrocatalysis plays a central role in clean energy conversion and sustainable technologies. However, the trade-off between activity and stability of electrocatalysts largely hinders their practical applications, notably in the oxygen evolution reaction for producing hydrogen and solar fuels. Here we report a steam-assisted synthesis armed with machine learning screening of an integrated Ru/TiMnO x electrode, featuring intrinsic metal-support interactions. These atomic-scale interactions with self-healing capabilities radically address the activity-stability dilemma across all pH levels. Consequently, the Ru/TiMnO x electrode demonstrate enhanced mass activities—48.5×, 112.8×, and 74.6× higher than benchmark RuO 2 under acidic, neutral, and alkaline conditions, respectively. Notably, it achieves stable operation for up to 3,000 h, representing a multi-fold stability improvement comparable to other state-of-the-art catalysts. The breakthrough in activity-stability limitations highlights the potential of intrinsic metal-support interactions for enhancing electrocatalysis and heterogeneous catalysis in diverse applications.
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AAPS PHARMSCITECH
·
2025
·Vol. 26
·期 8
·1-12
·
IF 4
Qin Li,Liu Cheng,Bai Ran,Zhao Zhining,Sun Yinghua,Zhang Peng
The objective of the work was to design a novel felbinac transdermal patch to improve its transdermal delivery efficiency by adding chemical penetration enhancers. The adhesion properties and in vitro transdermal release performance were first evaluated. The transdermal stability and skin irritation were then evaluated. Moreover, in vivo tissue distribution was also examined. The novel felbinac transdermal patch with high adhesion was prepared by calendar coating method. Different types of chemical enhancers and their amount on in vitro transdermal delivery efficiency were systematically screened. In vitro transdermal release experiments showed that by adding 1% propylene glycol (PG) as penetration enhancers, the cumulative transdermal amount of the transdermal patch within 12 h was 189.03 μg/cm 2 , which was twice that of commercial product SELTOUCH® (94.44 μg/cm 2 ). In addition, the transdermal patch still maintained stable permeability after being stored at room temperature for 4 months and also had good safety. Further, in vivo experiments confirmed that the concentration of felbinac in plasma, skin, and muscle tissues was significantly increased following administration of the self-made transdermal patch compared to SELTOUCH®. In conclusion, the felbinac transdermal patch developed in this study demonstrated high adhesion, excellent transdermal delivery efficiency and good stability, representing a transdermal drug delivery system with great clinical application potential. Graphical
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Nature Communications
·
2025
·Vol. 16
·期 1
·1-11
·
IF 15.7
Zhou Shenghua,Peng Lu Elfa,Liu Wenyu,Guo Hao,Tang Chuyang Y.
Polyamide reverse osmosis (RO) membranes are widely used in seawater desalination and wastewater reuse, yet often fail to remove small toxic micropollutants. Herein, we develop a thermal-intensified interfacial polymerization (TIP) strategy to fabricate highly selective RO membranes against various micropollutants. Facile heating accelerates amine monomer diffusion, intensifying interfacial polymerization to form a highly crosslinked polyamide membrane. The resultant TIP membrane achieves rejection of 90.8%, 98.0%, and > 99% for boron, arsenite, organic micropollutants at neutral pH, respectively. Meanwhile, high temperature facilitates interfacial degassing and promotes the formation of more extensive nanovoids within the polyamide. These nanovoids increase membrane surface area and optimize water transport pathways, thereby boosting water permeance. The combination of high solute rejection and water permeance enables the membrane to achieve high water-micropollutant selectivity (e.g., water-boron). Our study demonstrates that TIP technique holds a great promise to fabricate ultra-selective polyamide membranes for desalination and wastewater reuse.
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TRANSACTIONS OF TIANJIN UNIVERSITY
·
2025
·
IF 8.5
Song Yanyan,Sun Zhichao,Sun Jiamin,Liu Ying-Ya,Wang Anjie,Peng Chong
The development of efficient photocatalysts for selective organic transformations under visible light remains a major challenge in sustainable chemistry. In this study, we present a straightforward solvothermal strategy for fabricating a defect-engineered ZrO 2 /UiO-66-NH 2 hybrid material with abundant oxygen vacancies, enabling the visible-light-driven oxidation of benzyl alcohol to benzaldehyde. By optimizing the solvothermal treatment duration, the composite (UiO-66-NH 2 -2 h) achieves a 74.1% conversion of benzyl alcohol with > 99% selectivity toward benzaldehyde under mild conditions, substantially outperforming pristine UiO-66-NH 2 . Structural and mechanistic studies reveal that the solvothermal process induces the in situ formation of ultrasmall, uniformly dispersed ZrO 2 nanoparticles (~ 2.3 nm) within the MOF matrix, while simultaneously generating abundant oxygen vacancies, as confirmed by XPS, EPR, and HRTEM analyses. The defect-mediated electronic structure of the ZrO 2 /UiO-66-NH 2 hybrid enhances visible-light absorption, facilitates charge carrier separation, and promotes efficient activation of O 2 into superoxide radicals (·O 2 − ), the primary reactive species. Transient photocurrent measurements and electrochemical impedance spectroscopy further verify the improved charge separation efficiency. The synergistic interplay between oxygen vacancies and the intimate ZrO 2 /UiO-66-NH 2 interface provides a unique defect-mediated charge transfer pathway, distinguishing this system from conventional heterojunctions. This study demonstrates a facile, one-step approach to integrate defect engineering with interfacial hybridization in MOF-based photocatalysts, offering a scalable route for solar-driven organic synthesis. Graphical
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IONICS
·
2025
·
IF 2.6
Liu Dongni,Guo Lichi,Duan Ruochen,Zhang Shengwei,Li Mingying
Microbial fuel cells (MFCs) represent an emerging energy technology that generates electricity through microbial-organic interactions, with the anode serving as a critical component for wastewater-to-electron conversion. This study focuses on developing porous iron-nickel (Fe–Ni) alloys as potential anodes for MFCs, employing electrodeposition to fabricate these anodes with systematically varied Fe/Ni ratios. Through intrinsic electrochemical performance screening, the work aims to achieve composition optimization for high-performance microbial fuel cell anodes. Multi-dimensional analysis integrating linear sweep voltammetry (LSV), cyclic voltammetry (CV), electrochemical impedance spectroscopy (EIS), and Tafel polarization was conducted to establish structure–activity relationships and synergistic catalytic mechanisms of the alloys. Key findings reveal that compositional optimization profoundly impacts the performance of these potential anodes: the Fe 7 Ni 3 alloy exhibited significantly superior electrochemical activity compared to pure Ni, characterized by dramatically enhanced peak current density, and improved charge storage capacity. Furthermore, Fe 7 Ni 3 demonstrated minimal charge transfer resistance and excellent reaction kinetics. These results validate that bulk composition engineering of porous Fe 7 Ni 3 offers a highly promising strategy for developing potential anode materials for high-performance MFCs, effectively addressing the stability-activity trade-off inherent in conventional surface-modified anodes. This work provides a composition-driven design paradigm for bioelectrochemical systems, paving the way for future scale-up studies focusing on long-term stability and integration into wastewater treatment modules. Graphical abstract
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JOURNAL OF NANOBIOTECHNOLOGY
·
2025
·Vol. 23
·期 1
·1-24
·
IF 12.6
Qiu Qiujing,Yan Xiaoyuan,Zhang Zeying,Zhang Xiyue,Ma Jiawei,Gao Wenqing,An Na,Qiu Lihong,Guo Jiajie
Background Recent studies have implicated periodontitis (PD) as a potential risk factor for osteoporosis; however, the precise mechanisms remain unclear. Porphyromonas gingivalis ( Pg ), a key pathogen associated with PD, can secrete extracellular vesicles (EVs). However, whether Pg EVs can be transported to the bone marrow and influence osteoporosis-related osteoblast differentiation warrants exploration. This study compares Pg EVs with EVs from Porphyromonas endodontalis ( Pe ), which is a less virulent congener but the evidence for its pathogenicity in PD is weak. Results Pg EVs can be translocated into the marrow of mice and be internalized by osteoblasts through clathrin- and lipid raft-mediated endocytosis, thereby exacerbating osteoporosis. Pg EVs promote mitochondrial fission and inhibit mitochondrial fusion, leading to mitochondrial fragmentation, impaired mitochondrial activity and suppressed osteogenic differentiation. Furthermore, Pg EVs downregulate the protein level of carnitine palmitoyl transferase 2 (Cpt2) and inhibit fatty acid oxidation (FAO) by disrupting mitochondrial dynamics, which impairs osteoblast ATP production and exacerbates osteoporosis. The effects of Pe EVs are similar but weaker than those of Pg EVs. Conclusions This study elucidates that Pg EVs exacerbate osteoporosis by disrupting osteoblast mitochondrial dynamics and suppressing Cpt2-regulated FAO. This study contributes to understanding of the etiological mechanisms through which Pg contributes to the progression of osteoporosis and highlights the pivotal role of EVs in the association between periodontal disease and systemic diseases. Graphical
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JOURNAL OF NANOBIOTECHNOLOGY
·
2025
·Vol. 23
·期 1
·1-22
·
IF 12.6
Shang Xiaofei,Shao Wenjie,Dong Wuqi,Ren Wenxia,Du Wei,Li Chuang,Tian Yuxiang,Fang Weijun,Liu Tao,Xu Qinghua,Zhang Zhongping,Zhao Tingting
The main challenge of photosensitizer in image-guided photodynamic therapy (PDT) is the balance between the high singlet oxygen yields and strong fluorescence performance, while simultaneously targeting certain types of cancer to achieve optimal effect in both imaging and therapy. Herein, a novel donor-acceptor system, engineered with silica coated quantum dots as the donor and a typical porphyrin (T790) as the acceptor, has been further integrated with hierarchical targeting strategy, which demonstrated capability of targeting both hepatic tumors and mitochondria. The prepared nanoparticles were found to exhibit high singlet oxygen generation of 0.86, bright red fluorescence, and a large Stokes shift of 285 nm. In vitro assays revealed that they accumulated within the mitochondria of malignant hepatocytes to induce apoptosis due to their high singlet oxygen generation and disrupt the mitochondrial membrane potential, thereby leveling proteins associated with apoptosis. In vivo studies with xenograft tumor model confirmed their excelllent fluorescence imaging capability and remarkable anti-tumor effects. Transcriptomic analysis further revealed the potential molecular mechanisms of donor-acceptor system in the PDT process. This work provides insights for elucidating the transcriptional regulation of image-guided photodynamic therapy and paves the way for the development of more efficient and precise treatment methods.Graphical
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SAUDI PHARMACEUTICAL JOURNAL
·
2025
·Vol. 33
·期 5
·1-17
·
IF 3.4
Wang Ziheng,Xu Yuchen,Liu Manting,Yang Yuchang,Shi Wenjuan,Zhu Qian,Liu Juan,Yi Lisha,Wu Huimin,Yin Xingbin,Dong Xiaoxv,Ni Jian,Qu Changhai
This study aimed to establish a method for quantifying baicalin (BC) in rabbit ocular tissues and plasma, and evaluate the pharmacological efficacy and pharmacokinetic properties of BC and BC@HS15/DSPE-PEG2000-L-Val, a novel ocular formulation for dry eye treatment. BC@HS15/DSPE-PEG2000-L-Val or free BC was administered via eye drops to benzalkonium chloride (BAC)-induced dry eye mice. Corneal and conjunctival tissues were assessed for anti-dry eye efficacy. BC concentrations in cornea, conjunctiva, aqueous humor, and ocular plasma were quantified using LC–MS/MS. Noncompartmental pharmacokinetic parameters (AUC, Tmax) were calculated using DAS 2.0 software. The method demonstrated excellent linearity (0.50–500.00 ng/mL, r > 0.9905), precision (RSD < 10%), and accuracy (± 13%). Compared to free BC, BC@HS15/DSPE-PEG2000-L-Val significantly increased tear secretion, reduced MMP-3/MMP-9 expression, and preserved corneal epithelium integrity. In the micelle group, corneal and conjunctival Cmax values were 2.7- and 3.6-fold higher than the solution group, respectively. A sensitive and validated liquid chromatography-tandem mass spectrometry (LC–MS/MS) method was developed to measure baicalin concentrations in ocular plasma and tissues of rabbits. BC@HS15/DSPE-PEG2000-L-Val for treating dry eye demonstrated significantly superior outcomes. The nano-micelle notably enhanced BC concentration on the ocular surface and effectively prolonged its retention time. Graphical abstract
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JOURNAL OF MATERIALS SCIENCE-MATERIALS IN ELECTRONICS
·
2017
·Vol. 28
·期 13
·9505-9513
·
IF 2.019
Zhang Weiguo,Liu Jing,Guo Zhenyu,Yao Suwei,Wang Hongzhi
CdTe nanoparticle-sensitized TiO 2 nanotube arrays (CdTe/TiO 2 NTAs) were prepared by combining the sol–gel method with the electrodeposition method by the aid of anodic aluminum oxide template. The morphology, structure and composition of the materials were characterized by scanning electron microscopy, transmission electron microscopy, energy dispersive X-ray spectroscopy and X-ray diffraction (XRD). The photo response and photocatalytic activity of the materials were investigated by UV–Vis absorption spectroscopy. The results show that the pore diameter of the TiO 2 nanotubes is about 120 nm and the wall thickness is approximately 30 nm. CdTe nanoparticles are deposited both inside and in the tube-to-tube voids of the TiO 2 nanotubes. XRD analyses identify the anatase structure of TiO 2 nanotubes and cubic sphalerite structure of CdTe. Compared with pure TiO 2 nanotube film, the CdTe/TiO 2 NTAs display a significant increase in absorption coefficient in the visible light and a higher activity for photodegrading Rhodamine B under Xe lamp irradiation with an increase from 34 to 88%. The results also show that CdTe/TiO 2 NTAs exhibit better photoelectrochemical performance than TiO 2 NTAs.
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Frontiers of Chemical Science and Engineering
·
2025
·Vol. 19
·期 8
·1-13
·
IF 4.5
Han Meng,Guo Dan,Zhang Xuening,Yao Yitong,Zhang Haozhe,Lu Yifei,Fu Zelong,Lv Jing,Wang Yong,Cheah Joe Yeang,Wang Shengping,Ma Xinbin
The upgrading of underutilized methane in shale gas with anthropogenic CO 2 can produce the value-added syngas via dry reforming. Nickel-based catalysts, due to their efficiency and cost-effectiveness, have received widespread attention. However, Ni-catalyzed dry reforming of methane is usually subjected to sintering or coking-induced instability. To address these issues, a series of Al 2 O 3 -supported nickel nanoparticle catalysts with uniform sizes are synthesized by varying the calcination temperatures and applied in methane dry reforming (DRM). Ni/Al 2 O 3 -700 °C catalyst behaves better catalytic performance compared to the other catalysts, which can be attributed to its higher metal dispersion and stronger metal-support interaction. In addition, the abundant moderate-strength basic sites and optimal Al IV /Al VI ratio can promote the adsorption and activation of CO 2 and suppress the deep cracking of CH 4 for Ni/Al 2 O 3 -700 °C catalyst, respectively, causing the enhancement of anti-coking performance. Furthermore, combining CH 4 -temperature programmed surface reaction and in situ Fourier transform infrared spectroscopy demonstrates that the presence of CO 2 can promote the activation of CH 4 for Ni/Al 2 O 3 -700 °C catalyst, which is rate-determining step for DRM system. These findings provide valuable theoretical guidance for the rational design of Ni-based catalysts with enhanced catalytic performance.
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POLYMER BULLETIN
·
2016
·Vol. 74
·期 1
·75-90
·
IF 1.371
Chen Xiuqiong,Yan Huiqiong,Shi Zaifeng,Feng Yuhong,Li Jiacheng,Lin Qiang,Wang Xianghui,Sun Wei
A novel biosensor based on electro-co-deposition of myoglobin (Mb), sodium alginate (SA), Fe 3 O 4 -graphene (Fe 3 O 4 -GR) composite on the carbon ionic liquid electrode (CILE) was fabricated using Nafion as the film forming material to improve the stability of protein immobilized on the electrode surface, and the modified electrode was abbreviated as Nafion/Mb-SA-Fe 3 O 4 -GR/CILE. FT-IR and UV–vis absorption spectra suggested that Mb could retain its native structure after being immobilized in the SA-Fe 3 O 4 -GR composite film. The electrochemical behavior of the modified electrode was studied by cyclic voltammetry, and a pair of symmetric redox peaks appeared in the cyclic voltammograms, indicating that direct electron transfer of Mb was realized on the modified electrode, which was ascribed to the good electrocatalytic capability of Fe 3 O 4 -GR composite, the good biocompatibility of SA and the synergistic effects of SA and Fe 3 O 4 -GR composite. The electrochemical parameters of the electron transfer number ( n ), the charge transfer coefficient ( α ) and the electron transfer rate constant ( k
s ) were calculated as 0.982, 0.357 and 0.234 s −1 , respectively. The modified electrode exhibited good electrocatalytic ability to the reduction of trichloroacetic acid (TCA) with wide linear range from 1.4 to 119.4 mmol/L, low detection limit as 0.174 mmol/L (3 σ ), good stability and reproducibility.
研究领域:
生物传感器
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电化学
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蛋白质电化学
·
纳米材料
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生物相容性材料
·
分子诊断
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转化医学
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危险品化学品经营许可证（带存储）