RSC Advances
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2015
·Vol. 5
·期 97
·79456-79462
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IF 3.84
Zhuo Ma,Yunfeng Qiu,Yanmin Huang,Feng Gao,PingAn Hu
We report the eco-friendly chitosan assisted synthesis of 3D graphene@chitosan@Au nanosheet (3DG@CS@AuNSs) composites without using any toxic reductants or capping agents. The 3D graphene network consists of few-layer graphene sheets. One the one hand, the interfacial energy between graphene and Au nanostructures is significantly weakened due to the existence of chitosan polymers, serving as “glue” for anchoring Au nanosheets on the surface of 3D graphene. On the other hand, chitosan contains abundant hydroxyl and amine groups acting as reducing and stabilizing agents for the formation and even distribution of Au nanosheets. Mild redox reaction between hydrochloroauric ions and hydroxyl and amine groups occurred under thermal conditions due to the matching electrochemical potentials of the oxidants and reductants. The as-prepared 3DG@AuNSs exhibited much higher activities than that of 3DG@Au nanoaggregates towards the reduction of 4-nitrophenol, as well as more convenient recyclability than other supported Au NPs in terms of a robust free-standing foam structure. Furthermore, high performance liquid chromatography was also applied to monitor the emergence of 4-aminophenol during reaction. The present studies not only build a new route for the design of a robust and free-standing foam catalyst based on the integration of graphene and Au nanostructures by the assistance of a natural polymer, but also shed deep insight on the understanding of the synergistic catalytic activity towards nitrophenols.
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MONATSHEFTE FUR CHEMIE
·
2014
·Vol. 146
·期 3
·465-474
·
IF 1.347
Ma Wei,Dai Jiangdong,Dai Xiaohui,Da Zulin,Yan Yongsheng
Abstract Novel magnetic molecularly imprinted polymers (MMIPs) were prepared based on magnetic chitosan microspheres via a simple and effective method; the obtained MMIPs were used for selective recognition and fast separation of chloramphenicol from water. Fe 3 O 4 nanoparticles were uniformly wrapped into the chitosan by emulsion cross-linking method. Imprinted polymerization directly occurred on the surface of microspheres, and core–shell imprinted polymers were developed via in situ precipitation polymerization. The properties of obtained MMIPs were characterized by scanning electron microscopy, transmission electron microscopy, vibrating sample magnetometer, X-ray diffraction, FT-IR, thermogravimetric analysis, and so on. The adsorption equilibrium data were well described by Langmuir isotherm model. Kinetic studies of adsorption showed that the equilibrium was reached within 60 min, and the pseudo-second-order kinetic model was used to fit the adsorption data well. This work can be regarded as a perfect combination of selective adsorption and magnetic separation, and the obtained MMIPs showed specific recognition and selectivity for chloramphenicol in the presence of competitive antibiotics. The obtained MMIPs showed good stability and regeneration property, which could be one of the most promising candidates for environmental pollution application. Graphical abstract
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COLLOIDS AND SURFACES B-BIOINTERFACES
·
2014
·
IF 4.287
Yanjun Chen,Rongyi Yao,Yifeng Wang,Ming Chen,Tong Qiu,Chaocan Zhang
This article describes a straightforward gas–liquid microfluidic approach to generate uniform-sized chitosan microcapsules containing CdS quantum dots (QDs). CdS QDs are encapsulated into the liquid–core of the microcapsules. The sizes of the microcapsules can be conveniently controlled by gas flow rate. QDs-chitosan microcapsules show good fluorescent stability in water, and exhibit fluorescent responses to chemical environmental stimuli. α-Cyclodextrin (α-CD) causes the microcapsules to deform and even collapse. More interestingly, α-CD induces obvious changes on the fluorescent color of the microcapsules. However, β-cyclodextrin (β-CD) has little influence on the shape and fluorescent color of the microcapsules. Based on the results of scanning electron microscopy, the possible mechanism about the effects of α-CD on the chitosan microcapsules is analyzed. These stimuli-responsive microcapsules are low-cost and easy to be prepared by gas–liquid microfluidic technique, and can be applied as a potential micro-detector to chemicals, such as CDs.
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Artificial Cells Nanomedicine and Biotechnology
·
2014
·
IF 0
Meihao Liang,Xiaoliang Zheng,Linglan Tu,Zhen Ma,Zunyuan Wang,Dongmei Yan,Zhengrong Shen
In order to study the liver targeting of the N-galactosylated chitosan (GC) polymer in liver, we first conjugated the lactobionic acid with chitosan (CS) to obtain the carrier of GC with different degree of substitution of lactosyl group. Western blot was performed to detect the expression levels of the asialoglycoprotein receptors (ASGPR) in the cell lines of HepG2, SMMC-7721, and HL-7702. The protein level of ASGPR was lower in HepG2 compared to HL-7702 and SMMC-7721. Although all treated by CS, viabilities of HL-7702 and HepG2 did not experience any significant drop, while viability of SMMC-7721 decreased 15% on average from control. It was the first data about the inhibitory effect of GC on the liver cells. Fluorescein isothiocyanate (FITC) labeled GC (GC-FITC) was injected intravenously into mice at a dose of 0.02 μmol/mouse. GC-FITC showed maximum liver localization at 5 min and even detectable at 48 h after injection. Further, the accumulation of GC in liver was about 5.4-fold higher than that of CS. In conclusion, GC demonstrated its higher efficacy in drug liver targeting and thus could be a more promising drug or gene carrier in future therapies.
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Soft Matter
·
2014
·Vol. 11
·期 2
·290-296
·
IF 4.151
Shu Peng,Kui Wang,Dong-Sheng Guo,Yu Liu
Supramolecular polymeric vesicles are constructed by the complexation of p-sulfonatocalix[4]arene and chitosan, where the multivalent electrostatic interactions between the anionic sulfonate tetramer and cationic polyammoniums served as the dominant driving force. The supra-amphiphilic assemblies are disassembled upon exposure to a pH stimulus since the partial deprotonation of chitosan accompanied by a pH increase. Adding a competitive guest can also disrupt the assembly, representing the host–guest inclusion response. Interestingly, an abnormal temperature-response is observed, possibly as a result of the temperature-directed fusion process.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2013
·
IF 2.596
Xiaofen Xu,Yanggong Li,Yuanyuan Shen,Shengrong Guo
Norcantharidin-conjugated chitosan conjugates (NCTD-CSs) with different degrees of substitution ( DS , 60.2% and 97.9%) were synthesized and characterized by 1 H NMR, FT-IR, and XRD. In comparison with CS, the NCTD-CSs had lower crystallinity and better water solubility. Less than 6% NCTD was released from the NCTD-CSs through the hydrolysis of ester bonds in phosphate-buffered solution (PBS, pH 5.0 and 7.4) within 16 days, showing sustained drug release characteristic. The result of cytoxicity study showed that the NCTD-CSs were cytotoxic to MGC80-3 cells and their cytotoxicity was lower than that of NCTD. Fluorescence microscope and flow cytometry analysis demonstrated that the amount of the NCTD-CSs uptaken by MGC80-3 cells increased as incubation time. Confocal microscopy study showed that the NCTD-CSs were internalized into cells by endocytosis and mainly localized in lysosomes within 24 h. It was found that the NCTD-CSs arrested MGC80-3 cell cycle at G2/M phase and induced cell death via cell apoptosis similarly to NCTD. These results indicated that the NCTD-CSs might be an efficient NCTD delivery system for cancer therapy.
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RSC Advances
·
2013
·Vol. 3
·期 45
·23423-23431
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IF 2.562
Qin Wang,Junping Zhang,Aiqin Wang
A series of magnetic chitosan/Fe3O4/halloysite nanotubes/ofloxacin (CTS/Fe3O4/HNTs/OFL) microspheres was prepared by spray-drying for the sustained release of OFL. CTS was in situ crosslinked by glutaraldehyde in the spray-drying process. The magnetic microspheres were characterized by FT-IR, scanning electron microscopy and thermogravimetric analysis. The magnetic properties, encapsulation efficiency, drug loading and in vitro sustained release properties of the magnetic microspheres for OFL were also evaluated. The CTS/Fe3O4/HNTs/OFL microspheres show superparamagnetic properties and fast magnetic response. The Fe3O4 nanoparticles have a remarkable effect on the surface morphology of the microspheres compared with HNTs. The encapsulation efficiency and the cumulative release are closely related to HNTs and Fe3O4 contents, crosslinking density and CTS concentration. OFL is released from the magnetic CTS/Fe3O4/HNTs/OFL microspheres via anomalous transport.
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JOURNAL OF POWER SOURCES
·
2013
·
IF 4.675
Lu Yue,Lingzhi Zhang,Haoxiang Zhong
Carboxymethyl chitosan (C-chitosan) is investigated as a new water soluble binder for Si anode of Li-ion batteries. The Fourier transformation infrared spectroscopy (FTIR) and X-ray photoelectron spectroscopy (XPS) measurements reveal that the strong hydrogen bonding is formed between the hydroxylated Si surface and the polar groups (–OH, –COOH and –NH 2 ) of C-chitosan. The Si/C-chitosan anode (Si:carbon black:C-chitosan = 62:30:8 in weight ratio) exhibits a high first discharge capacity (4270 mAh g −1 ) with a first coulombic efficiency of 89%, and maintains a capacity of 950 mAh g −1 at the current density of 500 mA g −1 over 50 cycles.
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CARBOHYDRATE POLYMERS
·
2017
·
IF 4.811
Chao Wang,Wenfeng Luo,Puwang Li,Sidong Li,Ziming Yang,Zhang Hu,Yangyang Liu,Ningjian Ao
We prepared a novel hemostatic material using chitosan (CS), alginate , and Bletilla striata , which showed good biocompatibility and hemostatic properties. Alginate-calcium porous microspheres (Alg) were prepared by emulsification/cross-linking methods, and Bletilla striata polysaccharide (Bsp) was extracted from the tubers by water extraction and alcohol precipitation. To improve the water absorption and accelerate the blood coagulation, Alg and Bsp were mixed with chitosan solution to form CS/Alg and CS/Alg/Bsp composite sponges by lyophilization. Based on SEM images, the microspheres exhibited good spherical shape, possessed many pores on the surface, and were well dispersed in the CS/Alg5 and CS/Alg10 composite sponges. The CS/Alg10 composite sponges showed higher water absorption and porosity. In addition, the cytotoxicity assay and hemostatic property of the CS/Alg and CS/Alg/Bsp composite sponges were tested by CCK-8 assay, in vitro blood clotting, red blood cell (RBC) adhesion, and rabbit ear artery bleeding. These ternary composite sponges could be used as potential novel hemostatic materials in surgical treatment.
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JOURNAL OF HAZARDOUS MATERIALS
·
2017
·
IF 6.065
Chaoting Shi,Caizhi Lv,Lan Wu,Xiandeng Hou
The unique characteristics of Chitosan (CS) such as resource abundance, good biocompatibility, film-forming ability and sufficient sites ( NH 2 and OH) for adsorption of heavy metals or organic pollutants make CS-based membranes a promising membrane adsorbent. In this work, a porous Chitosan/Hydroxyapatite (CS/HA) membrane with a sponge-like surface and a three-dimensional interpenetrated porous structure of about mean pore size less than 10 μm was developed. The most striking advantage of the proposed membrane lies on the integration of appreciably high adsorption capacity (as compared with current CS-based membranes, also 2.5 times and 4 times higher than that of non-porous CS/HA membrane and the commercially available activate carbon) and the high-speed dynamic dye removal (98% or even better in less than 15 min). Besides, the synthesis protocol for the proposed membrane is also much simpler, environmental-friendly and economical. Moreover, the proposed membrane also featured repeated dye removal (above 80% after 5 cycles of dynamic adsorption at dye concentration of 150 mg L −1 ). All the above advantages indicated the intriguing potential of the porous membrane in practical wastewater treatment .
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JOURNAL OF COLLOID AND INTERFACE SCIENCE
·
2017
·
IF 4.233
Peng Xu,Xuguang Liang,Nannan Chen,Jingen Tang,Wei Shao,Qinwei Gao,Zhaogang Teng
In the work, we have synthesized silver (Ag) nanoparticles deposited chitosan (CS) microcapsules with magnetic multiple Fe 3 O 4 cores (denoted as Fe 3 O 4 /CS-Ag) as efficient catalysts for the reduction of 4-nitrophenol. The Fe 3 O 4 /CS-Ag catalysts are prepared by coating hydrophobic Fe 3 O 4 nanoparticles with chitosan via a multiple emulsion-chemical crosslinking method and following in situ deposition of Ag nanoparticles onto the surfaces. The morphology and composition of the Fe 3 O 4 /CS-Ag microcapsules are characterized by Fourier transform infrared (FT-IR) spectra, scanning electron microscopy (SEM), energy dispersive X-ray spectroscopy (EDX), and X-ray photoelectron spectroscopy. Moreover, the catalytic activity of the Fe 3 O 4 /CS-Ag catalyst was investigated, which shows a conversion efficiency as high as 98% within 15 min for the reduction of p-nitrophenol to p-aminophenol. At the same time, the recovered Fe 3 O 4 /CS-Ag catalyst with an external magnet can retain good activity after 10 cycles. These results indicate that the multiple emulsion-chemical crosslinking method is an efficient and simple way for the preparation of magnetic separable chitosan microcapsules, and the fabricated Fe 3 O 4 /CS-Ag is a promising catalytic material with excellent catalytic activity and convenient recovery ability.
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JOURNAL OF APPLIED POLYMER SCIENCE
·
2025
·
IF 2.8
Xiaowei Tan,Ziyi Liu,Cuiling Ouyang,Minxin Deng,Jingyi Xiao,Shufen Xiao,Tuo Huang,Siyu Yu,Hezhang Chen,Hui Chu,Jian Chen
Chitosan (CS)-based drug delivery systems often face challenges in obtaining clinical approval. Enhancing the binding affinity of CS-based carriers to target cells, such as tumor cells, is crucial for their translation from bench to bedside. Strategies like crosslinking (NHS-disulfide-NHS) and utilizing materials like albumin have proven effective in strengthening interactions between CS-based nanoparticles and tumor cells, thereby enhancing cellular uptake (cellular avidity). This study presents a novel approach using crosslinked CS nanoparticles loaded with doxorubicin, featuring reduction-responsive drug release and albumin coating. The albumin-coated crosslinked chitosan (ACCC) was assembled via reaction between amino of CS/albumin and NHS-disulfide-NHS. The resulting ACCC nanoparticle micelles demonstrate enhanced stability of the micelles. The hybrid crosslinked network ensures stability while providing ample space for drug loading and achieves reduction-responsive drug release through disulfide bond crosslinking. Moreover, the proposed system possesses excellent biocompatibility. Compared to uncoated crosslinked chitosan nanoparticle micelles, ACCC nanoparticle micelles exhibit potent cytotoxicity against tumor cells, particularly in reducing environment. Fluorescence imaging and flow cytometry analyses confirm the enhanced cellular affinity conferred by albumin coating. These findings underscore the potential of ACCC nanoparticles in improving tumor cell adhesion and anti-tumor efficacy, thus offering promising prospects for translational medicine in CS-based drug delivery.
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