INORGANIC CHEMISTRY COMMUNICATIONS
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2025
·
IF 5.4
Yan Wang,Jiaqi Lu,Menghui Wan,Yanbao Zhao
Asymmetric structures have many potential advantages when used as drug carriers, but the complex synthesis process is an important factor that limits the application of asymmetric structures. In order to simplify the complex preparation method of asymmetric structures, one-pot method was used to prepare a phenolic resin-silica composite materials with a similar snowman morphology. After calcination in air to remove the resin, asymmetric acorn shell-like mesoporous silica (AMS) carriers with rough surface were obtained, which were expected to improve the efficiency of cellular uptake. Subsequently, selective etching was used to expand its specific surface area to obtain EAMS. After loading chemotherapy drug DOX, hyaluronic acid (HA) molecules were applied to block the loaded drug (DOX@EAMS-HA). The DOX@EAMS-HA system performs pH/enzyme-responsive drug release and good therapeutic effect.
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FOOD RESEARCH INTERNATIONAL
·
2025
·
IF 8
Lang Cai,Yuheng Wang,Jintao Zhang,Tengyang Li,Shixin Song,Lei Yu,Shan Xia
This study aims to utilize the synergistic effect between shellac nanoparticles (SNPs) and chitin nanocrystals (ChNCs) to construct Pickering emulsion (PE) with adjustable structures and properties for loading and delivering astaxanthin. The viscoelastic properties and stability of SNPs-ChNCs co-stabilized PE demonstrated markedly enhanced performance compared to systems stabilized individually by SNPs or ChNCs, particularly at a 5:1 SNPs/ChNCs ratio. Furthermore, the PE demonstrated notable pH responsiveness and salt ion resistance. Encapsulation performance evaluation revealed the SNPs/ChNCs co-stabilized system achieved enhanced payload parameters for astaxanthin. The S5C1 formulation demonstrated optimal encapsulation performance, achieving 92.1 % encapsulation efficiency (EE) with a loading capacity (LC) of 1.05 % under optimized conditions. Furthermore, the retention rate of astaxanthin exceeded 90 % after 21 days of storage and 8 h of UV irradiation. More importantly, the S5C1 PE showed a high free fatty acid (FFA) release rate and bioaccessibility of astaxanthin after simulated gastrointestinal digestion. This study provides a novel strategy for constructing pH-responsive PE and delivery system for functional active substances.
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高影响因子
FOOD RESEARCH INTERNATIONAL
·
2025
·
IF 8
Xinyue Xiang,Zihua Liu,Wenfei Xiong,Yijun Yao,Chao Chen,Lifeng Wang
This study investigates the impact of pH-shift treatment on the properties of rapeseed protein high internal phase emulsions (HIPEs). The results demonstrate that pH-shift treatment significantly enhances the functional characteristics of HIPEs. Morphological and confocal laser scanning microscopy (CLSM) observations reveal that treated HIPEs exhibit superior gel-like semi-solid characteristics with smaller, closely packed droplets and a more compact structure, showing no oil phase separation. Rheological analysis indicates that pH-shift treated HIPEs possess better viscoelasticity and gelation properties, reflected in a higher storage modulus (G'). The pH-shift treatment also increases the centrifugal stability of HIPEs, indicating enhanced oil binding capacity. Furthermore, treated HIPEs demonstrate significantly improved freeze-thaw stability compared to untreated samples and mitigate the destabilizing effects of thermal processing, preventing the decline in viscoelasticity post-heating. These findings underscore the effectiveness of pH-shift treatment in improving the stability, structure, and functional resilience of rapeseed protein HIPEs, making them suitable for applications requiring high stability and consistent performance.
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Small
·
2025
·
IF 12.1
Zedong Zhang,Chunyan An,Jianguo Dong,Xuyu Zhang,Tianyu Shen,Dekun Wang,Xue Mi,Shijing Yue,Xiaoyue Tan,Yuying Zhang
Extracellular pH (pHe) acidification is a hallmark of solid tumors, linked to cancer initiation, progression, and drug resistance. Non-invasive monitoring of pHe spatiotemporal dynamics during cancer growth and in response to drug is crucial for understanding cancer mechanisms and developing novel therapeutic strategies. Here, a micro-sized pH sensor is developed by encapsulating Au@Ag@MBA nanosensors within biocompatible agarose hydrogel microspheres. These Aga microsensors in a size range of 3–10 µm, may avoid cellular endocytosis and stably reside in the extracellular environment. pHe dynamics are monitored via surface-enhanced Raman scattering (SERS) mapping in tumor spheroids and solid tumor tissues over 7 and 25-day periods, respectively. Distinct pH gradients are observed between the outer and core regions of the tumor spheroid, which evolved over time and are disrupted by doxorubicin treatment. In vivo, a decrease of average tumor pHe from ≈6.2 to ≈5.5 is observed with tumor progression, and doxorubicin administration resulted in a pHe elevation of ≈0.6 units. This microsensor-based SERS sensing approach provides a facile method for long-term monitoring of spatiotemporal dynamics within the disease microenvironment.
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ENVIRONMENTAL RESEARCH
·
2025
·
IF 7.7
Zhen Li,Xiaoxu Wang,Qing Luo,Ting Sun,Xin Li,Wanzhen Li
In agricultural ecosystems, the coexistence of microplastics (MPs) and polycyclic aromatic hydrocarbons (PAHs) poses a serious environmental challenge. However, a systematic understanding of their migration mechanisms and driving factors remains inadequate. The core innovation of this research was the integration of dynamic soil column leaching with multi-factor control. By employing a multi-factor controlled soil column leaching experiment, we aimed to elucidate the coupled mechanisms underlying the interactive effects of pH and dissolved organic matter (DOM) on the dynamic migration behavior of PAHs in MPs-contaminated soi, thereby establishing a more comprehensive and environmentally relevant mechanistic model. The results indicated that the migration dynamics of PAHs in the soil profile were significantly influenced by pH. Under acidic (pH 3 and 5) and alkaline (pH 9 and 11) leaching conditions, the residue of PAHs was significantly enhanced. When the pH was 11, the residual concentration of PAHs reached their peak at a depth of 30–40 cm (8264.22 ± 167 ng g −1 in polyethylene (PE)-contaminated soil and 4026.17 ± 189 ng g −1 in the control soil (CK)). At all pH levels, the PAHs residual amounts in PE-contaminated soil were consistently (21 ± 2.4)% - (73 ± 5.8)% higher than those in CK. Under acidic and alkaline leaching conditions, the residual concentrations of low-ring (2–3 rings) and medium-ring (4 rings) PAHs in both soils increased initially and then decreased with depth, reaching their peaks at 30–40 cm and 40–50 cm, respectively. pH variations altered the surface charges of PE-MPs and soil particles, establishing electrostatic interactions may be the predominant mechanism governing PAHs-MPs interactions. With the increase in DOM concentration (5–40 mg L −1 ), the residual concentrations of PAHs in each ring were significantly reduced by (19.4 ± 1.5)% - (22.7 ± 2.6)%. Without DOM treatment, the residual amounts continuously decreased with depth, reaching the lowest at 40–50 cm. High-ring PAHs showed strong depth attenuation characteristics in the presence of DOM, with the residual percentages ((32 ± 3.6)% - (56 ± 5.2)%) significantly higher than those of low-ring PAHs ((14 ± 0.9)% - (26 ± 2.3)%). The results shown that the aromatic structures within DOM promoted the adsorption of PAHs throughπ-πinteractions. The residual amounts of each PAH component in PE-contaminated soil were (18.6 ± 1.3)% - (23.8 ± 0.8)% higher than those in CK. The PAHs adsorption phenomenon exhibited by MPs may be governed by the combined effects of electrostatic interactions, π-π interactions and hydrophobic partitioning effect. This study revealed that soil rich in MPs enhanced the environmental residue effect of PAHs through pH and DOM regulation mechanisms, thereby reducing the risk of groundwater pollution.
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Advanced Healthcare Materials
·
2025
·
IF 9.6
Xiangyang Li,Yushuang Wei,Wenwen Li,Rong Xu,Cheng Xu,Beijing Luo,Kai Yang,Bing Yuan
The cryopreservation of human red blood cells (RBCs) is essential for maintaining a stable blood supply, but current glycerol-based methods are hindered by complex and time-consuming post-thaw processing. While trehalose is a promising biocompatible cryoprotectant, its efficient intracellular delivery into non-endocytic RBCs remains a major hurdle. Here, a lyophilized, ionizable lipid nanoparticle (LNP) platform is reported that overcomes this challenge via an acidic pH-triggered membrane fusion mechanism. This approach, inspired by mRNA vaccine technology, enables rapid (<30 min) and efficient intracellular delivery of trehalose. Systematic optimization of the LNP composition and process parameters resulted in a remarkable post-thaw RBC recovery rate of 85%, an efficacy comparable to the clinical glycerol standard but achieved with a simple, single-wash protocol. The efficacy depends on the specific lipid synergy to enable pH-responsive fusion. Critically, the lyophilized LNP powder retains full functionality, ensuring long-term stability and simplifying storage and transportation logistics. This study establishes a clinically relevant, translation-ready cryopreservation strategy that bridges nanotechnology and transfusion medicine, offering a next-generation solution to longstanding challenges in cell preservation.
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高影响因子
Materials
·
2025
·Vol. 18
·期 15
·3624
·
IF 3.2
Yanwen Ren,Qianqian Zheng,Cuicui He,Jingjing Nie,Binyang Du
Aqueous organic redox flow batteries (AORFBs) represent an advancing class of electrochemical energy storage systems showing considerable promise for large-scale grid integration due to their unique aqueous organic chemistry. However, the use of small-molecule active materials in AORFBs is significantly limited by the issue of stability and crossover. To address these challenges, we designed a high-water-solubility polymer cathode material, P-T-S, which features a polyvinylimidazole backbone functionalized with 2,2,6,6-tetramethylpiperidine-1-oxyl (TEMPO) and sulfonate groups. P-T-S exhibits a solubility of 34 Ah L−1in water and 31 Ah L−1in 1.0 M NaCl aqueous solution (NaClaq). When paired with methyl viologen to assemble a pH-neutral AORFB with a theoretical capacity of 15 Ah L−1, the system exhibits a material utilization rate of 92.0%, an average capacity retention rate of 99.74% per cycle (99.74% per hour), and an average Coulombic efficiency of 98.69% over 300 consecutive cycles at 30 mA cm−2. This work provides a new design strategy for polymer materials for high-performance AORFBs.
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JOURNAL OF COLLOID AND INTERFACE SCIENCE
·
2025
·
IF 9.7
Jie Meng,Shuang Xie,Zhanlin Zhang,Pan Ran,Xia Lei,Long He,Xiaohong Li
Pyroelectrodynamic therapy (PEDT) of tumors faces challenges due to its low electrocatalytic efficiency at mild temperature and the potential for off-target toxicity to healthy tissue. To overcome these issues, we have engineered pyroelectric nanoparticles (NPs) that feature a pH-triggered heterojunction structure and tumor-selective reactive oxidative species (ROS) production, faclitating synergistic PEDT and mild photothermal therapy (PTT). Herein, molybdenum trioxide (MoO 3 ) was deposited in-situ on the surface of tetragonal BaTiO 3 (tBT) to create tBT@MO. Subsequently, a metal-acid treatment was utrilized to hydrogenate MoO 3 , and the yielded HMO was grafted with poly(ethylene glycol) (PEG) to produce tBT@HMO-PEG. In contrast to vulnerability in normal tissues, hydrogen-doped NPs exhibit stability against H + attacks in the slightly acidic microenvironment of tumors, faclitating efficient near-infrared II (NIR-II) absorption, and the enhanced photothermal conversion enables tumor-selective mild PTT and PEDT. The formation of heterojunctions between tBT and HMO markedly improves electron-hole separations and ROS productions, and the generated pyroelectric field selectively disrupts the membrane potentials of tumor cells, theraby promoting NP internalization. In a tumor-bearing model, NPs exhibit deep tumor penetration and widesperead ROS distribution, overcoming the limitations of the short lifespan and diffusion distance of ROS to achieve potent antitumor efficacy. Moreover, the tumor-selective PEDT and mild hyperthermia ensure treatment safety. Therefore, the innovative design of pH-triggered Schottky heterojunctions effectively mitigate off-target toxicity to normal tissue while improving the precision and efficacy of tumor therapy.
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JOURNAL OF COLLOID AND INTERFACE SCIENCE
·
2024
·
IF 9.4
Tao Zhou,Zhou Liu,Xudong Ma,Chaofeng Cen,Zhangwei Huang,Yi Lu,Tiantian Kong,Cheng Qi
The essence of compartmentalization in cells is the inspiration behind the engineering of synthetic counterparts, which has emerged as a significant engineering theme. Here, we report the formation of ultra-stable water-in-water (W/W) emulsion droplets. These W/W droplets demonstrate previously unattained stability across a broad pH spectrum and exhibit resilience at temperatures up to 80℃, overcoming the challenge of insufficient robustness in dispersed droplets of aqueous two-phase systems (ATPS). The exceptional robustness is attributed to the strong anchoring of micelle-like casein colloidal particles at the PEO/DEX interface, which maintains stability under varying environmental conditions. The increased surface hydrophobicity of these particles at high temperatures contributes to the formation of thermally-stable droplets, enduring temperatures as high as 80℃. Furthermore, our study illustrates the adaptable affinity of micelle-like casein colloidal particles towards the PEO/DEX-rich phase, enabling the formation of stable DEX-in-PEO emulsions at lower pH levels, and PEO-in-DEX emulsions as the pH rises above the isoelectric point. The robust nature of these W/W emulsions unlocks new possibilities for exploring various biochemical reactions within synthetic subcellular modules and lays a solid foundation for the development of novel biomimetic materials.
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Polymer Chemistry
·
2024
·
IF 4.1
Huangbing Xu,Teng Qiu,Haotian Shi,Xiaoqian Tian,Xiaoyu Li,Longhai Guo
RAFT-mediated polymerization-induced self-assembly (RAFT-PISA) has been undergoing fast development currently, promoting research toward more diverse morphologies and more cutting-edge applications. Herein, we demonstrate a polymerization-pH tailored RAFT-PISA (pH-PISA) process, which can conveniently harvest abundant nano/micro-scale morphologies using popular monomers N,N-dimethylacrylamide (DMAA) and diacetone acrylamide (DAAM). The process proceeded through ordinary RAFT dispersion polymerization in an aqueous medium but under different pH conditions. With the use of pH-sensitive bi-carboxylic acid-capped trithiocarbonate as the chain transfer agent (CTA), it was found that the PISA of propagating amphiphilic ABA triblock copolymers was highly affected by the different ionization of the CTA. When the polymerization pH was adjusted to 2.5, an especially wide spectrum of morphologies was detected, including spheres, worms, lamellae, single or double-head tadpoles, vesicle strings and large spheres with surface protrusions. However, the diversity in morphology gradually declined when the polymerization pH was increased to 6 or 8. Diverse structures with same monomer compositions provide an ideal model to explore the influence of particle morphology on ice recrystallization inhibition (IRI) activities. The variations in mean largest grain sizes (MLGS) and growth rates of a single ice crystal were related to packing parameters (P), bridging the interface geometry of the packing of amphiphilic molecules and ice-controlling activities.
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LANGMUIR
·
2024
·
IF 3.7
Jinyu Wang,Dongsheng Ran,Hongsheng Lu,Jiaping Zhang,Yang Wu
The increasing exploitation of fossil resources needs to shift people’s attention to developing unconventional reservoir resources. Polyacrylamide-based emulsion drag reducers can effectively reduce the turbulence of fracturing fluid and improve oil recovery, but their release effect is poor, which limits their practical application. Here, we constructed a pH-responsive inverse polymer emulsion of poly(acrylamide–2-acrylamido-2-methylpropanesulfonic acid). Interestingly, HOA/Tween 80 exhibits remarkable pH-responsive behavior, which enables the monomer emulsion to change the type of emulsion under pH stimulation. Our results propose that the P(AM-AMPS) polymer emulsion is eluted with the same aqueous phase as the W/O P(AM-AMPS) polymer emulsion, thereby achieving the effect of drag reduction. P(AM-AMPS) can be rapidly released from the inverse polymer emulsion within 70 s upon pH stimulation, the drag reduction rate of which was 60.4%. Obviously, the inverse polymer emulsion prepared by a pH-responsive surfactant not only has good stability but also can achieve rapid release of the polymer upon pH stimulation, which supplies an interesting indication to explain why a balance exists between the stability of the emulsion and release of P(AM-AMPS).
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CHEMICAL ENGINEERING JOURNAL
·
2024
·
IF 13.3
Jinhua Liu,Lan Guan,Zhe Li,Li Huang,Dan Li,Zhe Li,Xiaohui Wang,Yingqun Zhu,Yuanan Liu
Real-time blood gas analysis is of great significance in disease diagnosis and treatment. Here we have developed a pH, PO 2 and PCO 2 multifunctional fluorescent capillary sensing system. The pH, O 2 and CO 2 fluorescent indicators with same excitation wavelength are fixed into a single capillary tube. The sensing system possesses sensitive fluorescence response to pH, O 2 and CO 2 , and the changes of pH, O 2 and CO 2 in buffer, in vitro, and in vivo can be detected simultaneously by measuring the fluorescence signals of sensor probe. The PO 2 , PCO 2 and pH of rabbits in four disease models were assessed efficiently by the sensing system, exhibiting similar variation trend with the results by blood gas analyzer. Studies in living rabbit display the reasonable and favorable feasibility of capillary sensing system in real-time arterial blood gas analysis. Overall, the multifunctional fluorescent capillary sensing system exhibits significant potential in real-time arterial blood gas analysis and clinical application of disease diagnosis.
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