CHEMICAL ENGINEERING JOURNAL
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2026
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IF 12.5
Yongseok Jeong,Jeongwoo Han,Sooyoung Lee,Gyeongsoo Kim,Dabin Kim,Jonggeun Sung,Changsik Song
Covalent adaptable networks (CANs) have emerged as promising alternatives to conventional polymer matrices to address the limited service life of carbon fiber-reinforced polymers (CFRPs); however, their mechanical and thermal performance is typically inferior. In this study, we synthesized a CAN matrix by introducing divinyl sulfone (DVS) into an epoxy network, achieving an unusual combination of high performance and malleability. The rigid network of the epoxy resin and the strong polarity of DVS yielded a β -amino sulfone-based CAN-based CFRP (BAS-CP) with an exceptionally high glass transition temperature (170.9 °C) and a tensile strength (876.9 MPa). In addition, the dynamic bond exchange enables crack self-healing, potential fabrication of enduring prepregs, and reshaping of fully cured CFRPs. β -Amino sulfone-based CAN (BAS) can be readily degraded using a mild oxidizing agent such as H 2 O 2 , enabling efficient recovery of carbon fibers from BAS-CP. The combination of these properties, low-cost monomers, and the simplicity of BAS synthesis suggest a new pathway for the development of cost-efficient, sustainable, and high-performance CFRPs.
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JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
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2026
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IF 6.7
Hang Su,Wenjie Han,Hamed I. Hamouda,Huidan Zhang,Ming Lu
β-Xylosidase, crucial for xylan degradation, catalyzes xylose release from xylo-oligosaccharides. However, enzymatic characters of β-xylosidases possess certain limitations, including poor thermal stability, and inhibitors are unclear. This study identified two GH39 family β-xylosidases, CsXyl39A and CsXyl39B, from the thermophilic bacterium Caldicellulosiruptor saccharolyticus. Both enzymes exhibited exceptional thermostability and compatibility with organic solvents, making them promising for industrial applications. CsXyl39A specifically cleaved d-xylopyranosyl groups from substrates such as notoginsenoside R1 and p-nitrophenyl-β-d-xylopyranoside. The catalytic efficiency in organic-solvent/water-miscible (O/Wm) systems was enhanced, and the physical immobilization on macroporous polystyrene strengthened its resistance to organic solvents in high-ratio O/Wm solutions. CsXyl39B demonstrated high specific activity and thermal stability at 70 °C, maintaining a 26 h half-life while producing xylose and glucose, indicating its suitability for lignocellulose biodegradation. Together, these enzymes address key industrial challenges, offering enhanced stability and solvent adaptability for sustainable bioprocessing applications.
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Innovative Food Science & Emerging Technologies
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2026
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IF 6.9
Junli Lv,Zhilong Ren,Jiali Zou,Nan Wang
Ferulic acid (FA) possesses significant therapeutic potential but is severely limited by its poor water solubility and instability. Although β-cyclodextrin (β-CD) inclusion complexation represents a promising strategy to overcome these limitations, the influence of host-guest molar ratios on complex properties remains inadequately understood. This study addresses this knowledge gap through an integrated experimental-computational approach, systematically investigating FA/β-CD complexes at three molar ratios (1:2, 1:1, 2:1) via structural characterization, molecular dynamics (MD) simulation, and comprehensive physicochemical evaluation. Successful complex formation at all ratios was confirmed by X-ray diffraction, Fourier transform infrared spectroscopy, scanning electron microscopy, and 1 H NMR spectroscopy analysis. MD simulations demonstrated that van der Waals forces primarily drive complex formation, while hydrogen bonds significantly contribute to structural stability. The 2:1 complex exhibited the highest loading efficiency of 21.5% and a 5.03-fold water solubility enhancement compared to pure FA, along with superior antioxidant activity as evidenced by IC 50 values of 0.024 mg/mL for DPPH and 0.042 mg/mL for ABTS radical scavenging. The 1:2 complex demonstrated the highest encapsulation efficiency of 93.3% and best light stability with only 8.53% loss after six days of exposure, and remarkably achieved the highest in vitro bioaccessibility of 93.6% after intestinal digestion. Conversely, the 1:1 complex exhibited optimal thermal stability with 95.18% retention after heating and the highest antibacterial activity against Escherichia coli with an inhibition zone diameter of 18.7 mm. These findings provide comprehensive theoretical guidance for selecting appropriate FA/β-CD molar ratios based on specific application requirements in food preservation, packaging materials, and pharmaceutical formulations.
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Oncogenesis
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2026
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IF 6
Shen Tao,Ma Yuejiang,Wu Tingting,Cao Zhu,Yi Peng,Huang Xiufeng,Yang Shizhou
High-risk human papillomavirus (HPV) is a causal factor in cervical cancer, driving the cancer’s initiation and progression. Although cancer stem cells (CSCs) have been implicated in maintaining the stemness and malignancy of cervical cancer cells, the underlying mechanisms are not yet fully understood. In this study, we modulated gene expression in Caski and SiHa cervical cancer cells using siRNA and overexpression approaches. Functional assays, including MTT, transwell, RT-qPCR, western blotting, immunohistochemistry, luciferase reporter, immunofluorescence, and sphere formation, were performed to evaluate target gene expression. Additionally, transcriptome sequencing was used to analyze the impact of silencing HPV16 E7 on SiHa cells, and a xenograft model was assessed for in vivo effects. Our transcriptome sequencing reveals substantial changes in gene expression profiles upon HPV16 E7 silencing in cervical cancer. Notably, we identified APC2 as a key downstream target transcriptionally activated by HPV16 E7 through the transcription factor E2F1, and its elevated expression is associated with poor prognosis in cervical cancer. Surprisingly, APC2 exhibits oncogeneic properties in cervical cancer by activating the Wnt/β-catenin pathway, and its overexpression reverses the inhibitory effects of HPV16 E7 silencing on malignancy and CSC properties. Additionally, SPIN4 is identified as a pivotal downstream target of the HPV16 E7/APC2 axis, positively modulating cervical cancer progression. Our study reveals a novel HPV16 E7-APC2-SPIN4 axis as a key driver of cervical cancer. In this pathway, APC2 unexpectedly functions as an oncogene by activating the Wnt/β-catenin signaling to promote tumorigenesis and CSC properties.
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Journal of Food Measurement and Characterization
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2026
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IF 3.6
Luo Jia-wei,Xiao Shan,Chen Xuan,Zeng Pu-sheng,Gao Ning,Wang Ji-hui
In this study, a composite deodorization method combining β-cyclodextrin (β-CD) and Hanseniaspora opuntiae was developed to eliminate the fishy odor in shrimp meat. The deodorization process was optimized using one-way and response surface methodologies, with optimal conditions of 8.3% β-CD, 7.27% Hanseniaspora opuntiae , 82.75 min of deodorization time, and a temperature of 29.42 °C. Under these conditions, trimethylamine, the primary contributor to the fishy odor, was reduced to 11.22 mg/kg. Comparative analysis of physical deodorization (PT), microbial deodorization (MT), and combined deodorization (MxT) showed that MxT was the most effective. The MxT method reduced the relative signals of several fishy odor-related volatiles, including aldehydes, ketones, and sulfur-containing compounds, while enhancing fruity and floral aroma-related volatiles. Furthermore, sensory analysis revealed improvements in umami, richness, and freshness, along with reductions in bitterness and astringency. Electronic tongue, partial least squares discriminant analysis, and correlation analysis confirmed significant relationships between free amino acids, volatile compounds, and sensory attributes, further validating the effectiveness of MxT. Overall, the β-CD– Hanseniaspora opuntiae method not only reduced fishy odors but also improved the overall quality and sensory characteristics of shrimp meat, offering potential for high-quality shrimp product development and seafood processing. Graphical The alternative text for this image may have been generated using AI.
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JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
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2026
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IF 6.7
Fang Ruiqi,Chen JiaJia,Xu Yan,Yan Lishi,Ju Xin,Li Liangzhi
Biomass polysaccharides are explored
as inexpensive raw materials
for preparing value-added products, such as mannan oligosaccharides
(MOS). However, the varied composition of MOS and the underlying mechanism
have not been studied thoroughly yet. Here a β-mannanase from Paenibacillus sp. was engineered for hydrolyzing
biomass polysaccharides and producing prebiotic MOS. Structural analysis
and alanine scanning revealed two hot spots, Q66 and T88, in the carbohydrate
binding module (CBM). The mutant T88Y demonstrated a 65% activity
improvement and a 5-fold thermal stability enhancement at 70 ° C,
and Q66F produced 2.2 g/L of mannobiose and mannotriose from locust
bean gum, with a 46% activity increase. Moreover, Q66F generated a
2.0 molar ratio of mannobiose/mannotriose, and a reverse ratio of
0.4 was found in Q66R. The application of Q66R was further validated
in the fermentation of citrus peel waste. The results provided efficient
biocatalysts for producing prebiotic MOS from biomass polysaccharides
and deeper comprehension of altering product chain length of β-mannanases
from CBM.
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JOURNAL OF MOLECULAR STRUCTURE
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2026
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IF 4.9
Jinglin Tan,Wei Zhang
CB[7] and β-CD bind Si-4Ph-2Am guest in contrasting modes. • CB[7] binds cationic trimethylanilinium, forming nanorods with green emission. • β-CD encapsulates hydrophobic core, forming irregular aggregates with blue emission. In this work, the contrasting recognition behavior between a symmetric dicationic guest, 4,4′-(diphenylsilanediyl)bis(N,N,N-trimethylanilinium)diiodide (Si-4Ph-2Am) and two macrocycles (cucurbit[7]uril (CB[7]) and β-cyclodextrin (β-CD)) were investigated employing 1 H NMR, 13 C NMR, 29 Si NMR, 2D NOESY, and FT-IR, fluorescence spectroscopy, transmission electron microscopy, dynamic light scattering, and thermogravimetric analysis. The results of 1 H NMR and 2D NOESY revealed that CB[7] encapsulates the two cationic trimethylanilinium groups via ion-dipole interactions, while, β-CD accommodates the central diphenylsilane unit through hydrophobic inclusion. The results of Job plot analyses indicate an host: guest stoichiometry of 1:2 for the CB[7] system and 2:1 for the β-CD system. The CB[7] directed complex assembles into uniform nanorods accompanied by a bathochromic emission shift from 460 nm to 512 nm. In contrast, the β-CD-directed complex remains as irregular aggregates with enhanced emission at 460 nm. This study establishes a powerful principle of host directed programming, wherein the choice of macrocycle influence the binding modes, stoichiometry, photophysical properties, and nanoscale assembly of multifunctional guest.
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Biomaterials Advances
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2026
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IF 6.7
Liu Xuanhao,Zhang Jing,Xu Biying,Xu Yang,Wang Yuxin,Huang Zhi,Liu Bin,Fuxiang Song
Multimodal optimization improved scaffold structure, mechanics, and bioactivity. • Low-dose BT generated a detectable but mild local piezoelectric response. • PTB4 achieved the best overall balance of printability and biological performance. • PTB4 enhanced osteogenic differentiation and VEGF-related endothelial responses. • PTB4 promoted osteogenesis–angiogenesis coupling and calvarial bone regeneration. Critical-size bone defects (CSDs) remain a major clinical challenge. Although three-dimensional (3D) printing enables precise structural control and defect-specific scaffold fabrication, conventional polymer-based scaffolds often exhibit insufficient mechanical strength and limited osteogenic activity. In this study, poly(ε-caprolactone)/β-tricalcium phosphate (PCL/β-TCP) scaffolds containing 0, 1, 2, 4, or 8 wt% barium titanate (BaTiO 3 , BT) were fabricated by direct ink writing. Their rheology, microstructure, mechanical properties, local electromechanical response, cytocompatibility, angiogenesis-related activity, osteogenic differentiation, and bone regeneration in vivo were evaluated. All formulations exhibited suitable printability and regular porous structures. Moderate BT incorporation increased surface roughness and mechanical strength, with compressive strength remaining within the range of human cancellous bone. Piezoresponse force microscopy confirmed a detectable but mild local piezoelectric response. However, its direct osteogenic contribution was not isolated from other BT-related material effects and requires further verification. All scaffolds exhibited good cytocompatibility. PTB4 showed the most favorable biological performance, including enhanced MC3T3-E1 cell proliferation, increased ALP-positive area, greater mineralized deposition, and more pronounced VEGF-related fluorescence in HUVECs. After 12 weeks in a rat calvarial critical-size defect model, PTB4 exhibited significantly higher bone volume fraction and bone mineral density than the blank and PT groups. Histological and immunohistochemical analyses showed more extensive new bone formation, collagen deposition, and stronger osteogenesis–angiogenesis coupling. Overall, PTB4 achieved the best balance among printability, mechanical compatibility, cytocompatibility, angiogenesis-related activity, and osteogenic performance, supporting low-dose BT modification as a promising strategy for safe, printable scaffolds for critical-size craniofacial and oral bone defect repair. Download: Download high-res image (217KB) Download: Download full-size image
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COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
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2026
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IF 5.4
Mengyao Sun,Yaqi Liu,Bo Cui,Chao Yuan
Regular morphology of BCDMOFs enhanced their adsorption at the oil-water interface. • Apigenin embedded in BCDMOFs improved the antioxidant properties of emulsions. • Both emulsions degraded in small intestine with Fickian diffusion of FFA release. Cyclodextrin metal-organic frameworks (CDMOFs), a promising class of sustainable porous materials, have emerged as biocompatible carriers for active compounds. In the present study, the potential of CDMOFs composites on stabilization of Pickering emulsions and control digestion of active components was investigated. Two target Pickering emulsions were successfully fabricated employing β -cyclodextrin metal-organic frameworks (BCDMOFs) and apigenin/BCDMOFs composites, respectively. The emulsions stabilized by 3% (w/v) BCDMOFs or 4% (w/v) apigenin/BCDMOFs composites exhibited the smallest droplet size and optimal centrifugal stability. The regular lamellar crystal structure of BCDMOFs provided excellent contact to enhance adsorption and arrangement at the oil-water interface. The irregular shape of apigenin/BCDMOFs composites led to higher consumption to stabilize the emulsions. However, the incorporation of apigenin provided apigenin/BCDMOFs emulsions additional oxidative protection for the oil phase. In vitro digestion kinetics demonstrated that both emulsions were extensively broken down in the intestinal phase, with free fatty acid (FFA) release following Fickian diffusion. The study could extend the application of BCDMOFs complexes in antioxidative Pickering emulsions systems and pave the way for the food with the function of rapid nutrient absorption. Download: Download high-res image (253KB) Download: Download full-size image
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FOOD CHEMISTRY
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2026
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IF 10.4
Jialing Long,Jin Liu,Bowen Qin,Rui Shi,Mingming Zheng,Yibin Zhou,Shiyi Li
Binary oleogels were developed using β-sitosterol (Sit) and propyl gallate (PG). • The 5:5 M ratio (Sit:PG) showed the densest and most ordered crystal network. • Hydrogen bonding between Sit and PG drove the self-assembly of oleogels. • The oleogels showed excellent thermal and freeze-thaw stability. In this study, binary oleogels based on β-sitosterol (Sit) and natural phenolics bearing aromatic hydroxyl groups were developed. Among five screened phenolics (eugenol, propyl gallate (PG), thymol, carvacrol, and resveratrol), only PG formed stable binary oleogels with Sit, specifically at Sit:PG molar ratios ranging from 2:8 to 6:4. All resulting Sit-PG binary oleogels exhibited short needle-like crystals, with hydrogen bonding identified as the primary molecular interaction driving self-assembly. Among these, the 5:5 M ratio (S5P5) showed the highest fractal dimension (D b = 1.7672), the smallest intermolecular spacing and subcell dimensions, and the strongest gel network. Consequently, this formulation also showed the highest storage modulus (7.71 × 10 5 Pa), viscosity, and thixotropic recovery rate (49.47%), along with excellent oil binding capacity (98.21%) and hardness (8.62 N). These findings identify PG as an effective co-gelator for Sit and provide insights into the design of binary oleogels. Download: Download high-res image (231KB) Download: Download full-size image
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2026
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IF 8.7
Deyi Peng,Wenchang Zhang,Chengfeng Tan,Xia Zhang,Yan Zhao,Yide Han,Mi Wu
β-Chitin nanofibers enable freeze–thaw reinforcement of hemostatic cryogels. • Freeze–thaw cycling improves structural integrity and rapid blood absorption. • β-Chitin nanofibers mainly enhance coagulation through the intrinsic pathway. • The sponges show low hemolysis and high cytocompatibility in vitro. • An optimized sponge achieves 3.5 s hemostasis in a rat liver injury model. Non-compressible hemorrhage remains a major clinical challenge, requiring hemostatic materials with rapid blood absorption and sufficient mechanical robustness. Conventional carboxymethyl chitosan (CMCS)/sodium alginate (SA) polyelectrolyte complex (PEC) sponges exhibit high swelling capacity but limited uptake kinetics and mechanical strength. Here, β-chitin nanofibers (β-ChNFs) were incorporated into the CMCS/SA system to establish a freeze–thaw reinforcement strategy depended on β-ChNFs. Repeated freeze–thaw cycles had little effect on the storage modulus (G′) of CMCS/SA alone, whereas G′ progressively increased with the number of cycles in β-ChNF-containing systems. After six freeze–thaw cycles and electrostatic complexation, the resulting double-network sponges featured layered, stacked pore walls that conferred excellent shape recovery and fatigue resistance, together with rapid blood absorption and enhanced platelet–red blood cell adhesion, thereby accelerating blood clotting. The β-ChNF-dependent procoagulant enhancement was mainly associated with activation of the intrinsic coagulation pathway, and the sponges also exhibited favorable hemocompatibility and cytocompatibility. In a rat liver perforation model, the optimized sponge demonstrated significantly superior hemostatic performance compared with a commercial gelatin sponge, achieving a hemostasis time of 3.5 s and blood loss of 80 mg, underscoring its strong potential for controlling non-compressible hemorrhage. Download: Download high-res image (144KB) Download: Download full-size image
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PHYTOMEDICINE
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2026
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IF 11.3
Ningyue Liu,Xuan Li,Xiaojuan Xu
Lentinus β-glucan (LBG) could directly interact with the human colon cancer cells. • PRSS3 was identified as the potential target of LBG. • LBG inhibits colon cancer cell proliferation and promotes apoptosis by targeting PRSS3. Lentinus β-glucan (LBG), an edible dietary fiber, has promising anticancer potential. However, the anticancer mechanism remains poorly understood. Herein, we focus on the anti-colon cancer mechanism of four LBGs with different molecular weights. As a result, LBGs could directly interact with the human colon cancer cells and were even ingested into cells. Mass spectrometry results reveal that the protein interacting with LBGs was most likely PRSS3. Molecular docking simulation further confirmed LBGs interacted with PRSS3 through hydrogen bonding, van der Waals forces, and hydrophobic interactions. In vitro results demonstrate that LBGs down-regulated PRSS3 expression in colon carcinoma cells, as well as decreased cell viability. Meanwhile, in vivo studies reveal that LBGs targeted the carcinogenic promoter of PRSS3, leading to cancer cell proliferation inhibition and apoptosis promotion. This study provides new insights that LBG can be used for clinical colon cancer treatment as a PRSS3 inhibitor without system toxicity. Download: Download high-res image (245KB) Download: Download full-size image
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