Nature Communications
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2022
·Vol. 13
·期 1
·1-9
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IF 17.694
Liao Mochou,Ji Xiao,Cao Yongjie,Xu Jie,Qiu Xuan,Xie Yihua,Wang Fei,Wang Chunsheng,Xia Yongyao
Nowadays, electrolytes for commercial batteries are mostly liquid solutions composed of solvent and salt to migrate the ions. However, solvents of the electrolyte bring several inherent limitations, either the electrochemical window, working temperature, volatility or flammability. Herein, we report polyphosphoric acid as a solvent-free protic liquid electrolyte, which excludes the demerits of solvent and exhibits unprecedented superiorities, including nonflammability, wider electrochemical stability window (>2.5 V) than aqueous electrolyte, low volatility and wide working temperature range (>400 °C). The proton conductive electrolyte enables MoO 3 /LiVPO 4 F rocking-chair battery to operate well in a wide temperature range from 0 °C to 250 °C and deliver a high power density of 4975 W kg −1 at a high temperature of 100 °C. The solvent-free electrolyte could provide a viable route for the stable and safe batteries working under harsh conditions, opening up a route towards designing wide-temperature electrolytes.
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ACS Applied Electronic Materials
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2022
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IF 4.494
Yanting Li,Pengfei Zhao,Jie Lao,Chunli Jiang,Bobo Tian,Chunhua Luo,Hechun Lin,Chang Yang,Hui Peng,Chun-Gang Duan
Fabricating devices with functions of biosynapses is one of attractive highlights in the field of artificial intelligence. Optoelectronic synapses are believed to be an important cornerstone of neuromorphic intelligent systems because they can directly process visual input signals. In this work, a transparent and metal-electrode-free optoelectronic synapse with a structure of CuI/ITO is prepared, in which the CuI layer acts as both an active layer and electrode. Some basic functions of biosynapses are realized by this device, including paired-pulse facilitation (PPF), spike-number-dependent plasticity (SNDP), spike-width-dependent plasticity (SWDP), and ″learning-experience″ behavior. Furthermore, this device exhibits the capability of detecting and processing the integrated optical information, and image recognition and memory. This work illustrates the great application potential of CuI in transparent optoelectronic synapse due to its unique properties.
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JOURNAL OF HAZARDOUS MATERIALS
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2022
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IF 14.224
Zhuo Huang,Qinke Cui,Xin Yang,Feifei Wang,Xinxing Zhang
Microplastics (MPs) have caused global concerns due to their detrimental effects on ecosystems and even humans. Recycling aged plastic products ahead of MPs generation can be an effective approach to mitigate increasingly serious microplastic pollution. However, predicting MPs generation remains a great challenge. In this regard, we report a simulation method through associating plastics aging with mechanical failure on a time scale to predict MPs generation and give an experimental verification. The results indicate that the proposed evaluation method has high accuracy for predicting MPs generation from aged polystyrene foams. Under conditions of ultraviolet (UV) irradiation and heat for 1000 h, the aged polystyrene foam generate significant microplastics (6.78 × 10 6 particles/cm 3 ) by water scouring force after the expected aging time (400 h). Furthermore, the experiment results verify the synergistic effect of UV irradiation and heat on polystyrene MPs generation. This work suggests a new strategy to predict MPs generation from aged plastics in complex environments, which provides meaningful guidance for the use and recycling of plastic products.
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JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY
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2022
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IF 10.319
Weishu Ni,Ke Jiang,Qiaomei Ke,Jia Su,Xianying Cao,Ling Zhang,Chunxia Li
Chemodynamic therapy (CDT) as an emerging modality in cancer treatment, its implementation remains a daunting challenge by the lack of smart Fenton catalyst under acidic tumor microenvironments. Herein, we have successfully constructed a Fe 3 O 4 @MIL-100 heterojunction by growing Fe-based metal-organic framework (MIL-100) onto the surface of Fe 3 O 4 nanoparticles. The as-made heterojunction after encapsulating glucose oxidase (termed FMG) is demonstrated as a pH-responsive intelligent Fenton nanosystem with the synergistic effect of starvation therapy (ST). Density functional theory (DFT) calculations reveal that such heterojunction could greatly reduce the energy barrier of the Fenton reaction, which better explains the mechanism of Fenton performance improvement. Moreover, the encapsulated glucose oxidase has successfully activated the ST process, in which its generated H 2 O 2 and gluconic acid further improve the CDT efficiency. More O 2 from the enhanced CDT in turn promotes the enzymatic reaction of glucose oxidase. The Fenton/cascade enzymatic reaction operates in a self-feedback manner as proposed. In vitro and in vivo experiments demonstrate that such intelligent Fenton nanoreactors provide a powerful anticancer mechanism for effective tumor ablation with enough safety. This work provides insights into the developments of MOF-based heterojunctions as powerful anticancer treatment nanoreactors.
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FOOD AND AGRICULTURAL IMMUNOLOGY
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2019
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IF 2.398
Lipeng Yuan,Bo Liu,Kaidan Yin,Zhen-Lin Xu
In this study, a heterologous competitive indirect enzyme-linked immunosorbent assay (ciELISA) for the determination of estriol (E3) in milk was developed. Rabbit polyclonal antibody specific for E3 was raised by introducing a carboxyl spacer arm from bromoacetic acid of E3 as immunizing hapten. A heterologous ciELISA using a coating hapten containing a carboxyl spacer arm from 6-ketoestriol of E3. The assay exhibited the required sensitivity for detection of E3 with limit of detection of 0.07 ng mL−1 and a working range from 0.41 ng mL−1 to 15.78 ng mL−1. Good recoveries were obtained ranging from 83.2% to 125.8% for E3 spiked milk samples. A satisfactory correlation (R2 = 0.994) between the results of ciELISA analysis and that of LC–MS/MS analysis indicated good accuracy and reproducibility of the proposed method, which was ideally suited as a rapid screening tool for routine E3 monitoring.
研究领域:
生物化学
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分析化学
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食品科学
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Developments in the Built Environment
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2023
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IF 8.2
Yanchen Oinam,Prabhat Vashishtha,Mandip Dahal,Sukhoon Pyo
This study investigates the potential use of calcined lime mud as an activator in the development of a sustainable, ground granulated blast furnace slag (GGBFS)-based cementless UHPC. The effects of the calcination temperature (550 °C to 850 °C) of lime mud and its weight percentage in the UHPC mixture were evaluated with various tests, such as compressive strength, isothermal calorimeter, and thermogravimetric analysis. Microstructural changes and pore size distribution were also analyzed using XRD, FTIR, and MIP. The results showed that calcined lime mud can be an effective activator in the UHPC mix, and its mechanical properties are influenced by the calcination temperature and weight percentage. The addition of 10% calcined lime mud enhanced the compressive strength of the UHPC up to 150 MPa without negatively affecting its microstructural and hydration characteristics, suggesting that calcined lime mud has the potential to be used as a sustainable alternative to CaO in GGBFS-based cementless UHPC.
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INTERNATIONAL JOURNAL OF HYDROGEN ENERGY
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2023
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IF 7.2
Yu-Ying Li,Ting-Ting Yao,Xiao-Fang Zhang,Yu-Ting Liu,Xinyuan Wang,Gang-Ping Wu
The gas diffusion layer (GDL) is a key component responsible for mass transfer in the proton exchange membrane fuel cell (PEMFC); however, the conventional commercial GDLs exist with series of disadvantages of the long mass transfer routine, high cost of the substrate layer, and complex preparation processes. To address these problems, we develop a novel substrate-free gas diffusion layer (sfGDL) composed of the whisker carbon nanotubes and Ketjen blacks as a crack-free micrometer network structure. Such a unique sfGDL exhibits a competitively high power density of 1.37 W cm −2 at 100 % relative humidity and 3.77 A cm −2 current density at 0.2 V. Besides, compared with the conventional GDLs, the thickness of sfGDL in this work is significantly reduced by 40 %, indicating great potential for practical applications. This work paves a new way to boost the high performance of PEMFCs.
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LAB ON A CHIP
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2023
·Vol. 24
·期 1
·8-19
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IF 6.1
Jingsong Xu,Xingcheng Wang,Qingyuan Huang,Xiaodong He
The closed-open digital microfluidic (DMF) system offers a versatile and powerful platform for various applications by combining the advantages of both closed and open structures. The current closed-open DMF system faces challenges in scaling up due to electrode structural differences between closed and open regions. Here we developed an adjustable closed-open DMF platform by utilizing the modified slippery liquid-infused porous surfaces (SLIPS) with asymmetric electrowetting on dielectric (AEWOD) as a hydrophobic dielectric layer. The consistent electrode structures of the bottom printed circuit board (PCB) electrode array on both the closed and open regions, and the utilization of a transparent acrylic with floating potential as the top plate allow a low-cost and easily scalable closed-open DMF system to be achieved. The impacts of applied voltage, parallel plate spacing, electrode switching interval, and electrode driving strategies on various droplet manipulations were investigated. The results show that the optimal plate spacings range from 340–510 μm within the closed region. Meanwhile, we also studied the influence of the thickness, geometry, and position of the top plate on the droplet movement at the closed-open boundary. Through force analysis and experimentation, it is found that a thin top plate and a bevel of ∼4° can effectively facilitate the movement of droplets at the boundary. Finally, we successfully achieved protein staining experiments on this platform and developed a customized smartphone application for the accurate detection of protein concentration. This innovative closed-open DMF system provides new possibilities for future applications in real-time biological sample processing and detection.
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Journal of Energy Storage
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2023
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IF 9.4
Mingyue Yu,Xiaozhong Yu,Jiahui Hu,Chengbin Tang,Cong Fan
An organic polymer cathode called poly(anthraquinone- alt -benzene) (PAQB) is in-situ synthesized between the monomers of 2,6-dibromoanthraquinone and 1,4-benzenediboronic acid bis(pinacol) ester based on the matrix of carbon nanotube (CNT), leading to the growth of a polymer on CNT (PAQB@C) and the better formation of electron transportation network. After optimization, the sample (PAQB@C) of PAQB grown on 2 wt% CNT shows the best results in Li-ion batteries. In half cells, PAQB@C shows the average discharge potential around 2.2 V (vs. Li + /Li) and peak discharge capacity of 184 mAh g −1 , stably running for 1000 cycles. In full cells with the Li-intercalated graphite (LiC 6 ) as the anode, PAQB@C can deliver the peak discharge capacity of 187 mAh g −1 cathode and peak energy density of 374 Wh kg −1 cathode . And the full cells can show the long lifespan for over 2500 cycles. To the best of our knowledge, the comprehensive performance of PAQB@C is one of the best organic cathodes reported in Li-ion batteries.
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Advanced Healthcare Materials
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2023
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IF 10
Wen Zheng,Wenyue Yang,Wenlong Wei,Ziru Liu,Pier-Luc Tremblay,Tian Zhang
Multifunctional hydrogel adhesives inhibiting infections and enabling the electrical stimulation (ES) of tissue reparation are highly desirable for the healing of surgical wounds and other skin injuries. Herein, a therapeutic nanocomposite hydrogel is designed by integrating β-cyclodextrin-embedded Ag nanoparticles ( CD AgNPs) in a polyvinyl alcohol (PVA) matrix enhanced with free β-cyclodextrin (CD) and an atypical macromolecule made of β-glucan grafted with hyaluronic acid (HAG). The main objective is to develop a biocompatible dressing combining the electroconductivity and antibacterial activity of CD AgNPs with the cohesiveness and porosity of PVA and the anti-inflammatory, moisturizing, and cell proliferation-promoting properties of HAG. The last component, CD, is added to strengthen the network structure of the hydrogel. PVA/CD/HAG/ CD AgNP exhibited excellent adhesion strength, biocompatibility, electroconductivity, and antimicrobial activity against a wide range of bacteria. In addition, the nanocomposite hydrogel has a swelling ratio and water retention capacity suitable to serve as a wound dressing. PVA/CD/HAG/ CD AgNP promoted the proliferation of fibroblast in vitro, accelerated the healing of skin wounds in an animal model, and is hemostatic. Upon ES, the PVA/CD/HAG/ CD AgNP nanocomposite hydrogel became more efficient both in vitro and in vivo further speeding up the skin healing process thus demonstrating its potential as a next-generation electroconductive wound dressing.
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JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION
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2023
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IF 3.6
Jie Yang,Xiao-Jie Wang,Si-Mei Li,Dong-Xue Jiang,Yu-Xin Liu,Yan Huang,Di-Di Dong,Wei Hu,Bo Liu
Nowadays, chemotherapy is a common clinical treatment for cancer, but it still faces many limitations and challenges. Therefore, the combination of chemotherapy and other treatments often enhances the effectiveness of treatments. Herein, an injectable hydrogel of PC10ARGD/Cu2+/DOX based on Cu2+, hydrophilic doxorubicin (DOX), and genetically engineered polypeptide PC10ARGD was prepared. First, Cu2+ was attached to the histidines in the PC10ARGD polypeptide by the coordination reaction to form PC10ARGD/Cu2+ hydrogel, then the PC10ARGD/Cu2+/DOX hydrogel was prepared by encapsulating the DOX into the PC10ARGD/Cu2+ hydrogel. The results of scanning electron microscopy showed that the PC10ARGD/Cu2+/DOX hydrogel displayed loose porous morphology. In vitro, reactive oxygen species production results showed that the PC10ARGD/Cu2+/DOX hydrogel could continuously produce ·OH in the presence of H2O2. In vitro MTT results showed that the PC10ARGD/Cu2+/DOX hydrogel had a good inhibitory effect on cell activity. Flow cytometry further confirmed the antitumor effect of the PC10ARGD/Cu2+/DOX hydrogel. In vivo experiment results showed that the tumor volume of mice treated with the PC10ARGD/Cu2+/DOX hydrogel was significantly inhibited compared with control groups, which was due to the combination of chemodynamic and chemotherapy. The results of body weight and blood analysis of mice showed that the PC10ARGD/Cu2+/DOX hydrogel possessed good biocompatibility.
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Biomedical Optics Express
·
2023
·Vol. 14
·期 11
·5921-5931
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IF 3.4
Hang Qu,Linyao Tan,Fang-Cai Wu,Weiyuan Huang,Kaiwei Li,Xiaoyong Chen,Xiaoyong Chen,Yi-Wei Xu,Yi-Wei Xu,Xuehao Hu
Autoantibodies against New York esophageal squamous cell cancer 1 (NY-ESO-1) play a crucial role in the diagnosis of esophageal cancer. In this work, a surface plasmonic tilted fiber Bragg grating (TFBG) biosensor is proposed for the detection of NY-ESO-1 antibody, as well as the investigation of the hook effect (which refers to the false negative result in some immunoassays when the concentration of antibodies in the sample is very high) during biomolecular binding between NY-ESO-1 antigen and antibody. The biosensor is made by an 18° TFBG coated with a 50-nm-thick gold film over the fiber surface together with NY-ESO-1 antigens attached to the metallic surface serving as bio-receptors. This biosensor can provide a limit of detection at a concentration of 2 × 10−7 µg/ml with a good linearity in the range from 2 × 10−7 to 2 × 10−5 µg/ml. For a concentration higher than 2 × 10−3 µg/ml, the performance of the sensor probe is reduced owing to the hook effect. Furthermore, experimental results have also demonstrated the repeatability of the proposed biosensor. This proposed biosensor features label-free, compactness, and fast response, which could be potentially applied in the diagnosis of esophageal cancer.
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