JOURNAL OF NANOBIOTECHNOLOGY
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2024
·Vol. 22
·期 1
·1-16
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IF 10.6
Xiao Rui,Liu Jia,Shi Lin,Zhang Ting,Liu Jie,Qiu Shuyi,Ruiz Matthieu,Dupuis Jocelyn,Zhu Liping,Wang Lin,Wang Zheng,Hu Qinghua
Background Despite recent advances the prognosis of pulmonary hypertension remains poor and warrants novel therapeutic options. Extensive studies, including ours, have revealed that hypoxia-induced pulmonary hypertension is associated with high oxidative stress. Cerium oxide nanozyme or nanoparticles (CeNPs) have displayed catalytic activity mimicking both catalase and superoxide dismutase functions and have been widely used as an anti-oxidative stress approach. However, whether CeNPs can attenuate hypoxia-induced pulmonary vascular oxidative stress and pulmonary hypertension is unknown. Results In this study, we designed a new ceria nanozyme or nanoparticle (AuCeNPs) exhibiting enhanced enzyme activity. The AuCeNPs significantly blunted the increase of reactive oxygen species and intracellular calcium concentration while limiting proliferation of pulmonary artery smooth muscle cells and pulmonary vasoconstriction in a model of hypoxia-induced pulmonary hypertension. In addition, the inhalation of nebulized AuCeNPs, but not CeNPs, not only prevented but also blunted hypoxia-induced pulmonary hypertension in rats. The benefits of AuCeNPs were associated with limited increase of intracellular calcium concentration as well as enhancement of extracellular calcium-sensing receptor (CaSR) activity and expression in rat pulmonary artery smooth muscle cells. Nebulised AuCeNPs showed a favorable safety profile, systemic arterial pressure, liver and kidney function, plasma Ca 2+ level, and blood biochemical parameters were not affected. Conclusion We conclude that AuCeNPs is an improved reactive oxygen species scavenger that effectively prevents and treats hypoxia-induced pulmonary hypertension. Graphical Abstract
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高影响因子
APPLIED SURFACE SCIENCE
·
2026
·
IF 6.6
Lu Han,Xueling Huang,Shilu Zhu,Jing Zheng,Xue-bo Yin
A dual-emission COFs@AuNCs@CDs probe for Al 3 ⁺ detection was developed. • Ratiometric fluorescence improves accuracy and anti-interference ability. • Strong coordination-induced enhancement enables sensitive Al 3 ⁺ sensing. • Low detection limit of 0.47 μM achieved with high selectivity. • Smartphone platform enables rapid visual and on-site Al 3 ⁺ monitoring. Aluminum is a prevalent environmental contaminant with known toxicity to humans. However, despite the existence of various detection methods, a facile and rapid sensor for Al 3+ in aqueous environments has yet to be developed. In this work, a two-dimensional porphyrin COF was employed as a host for the encapsulation of carbon dots (CDs) and the uniform assembly of gold nanoclusters (AuNCs) within its pores. AuNCs were covalently linked to amino-functionalized COF nanospheres, while the incorporated CDs enhanced both the visible absorption and charge-transfer efficiency of the COF matrix. The as-prepared COFs@AuNCs@CDs showed blue emission of CDs at 468 nm and red emission of COFs at 687 nm at excitation of 410 nm. Consequently, a novel ratiometric fluorescence sensor was constructed to detect Al 3+ , owing to the strong complexation-induced fluorescence enhancement to achieve highly selective and accurate analysis with a limit of detection (LOD) of 0.47 µM. Furthermore, a smartphone visual sensing platform integrated with COFs@AuNCs@CDs was developed based on the color transformation and successfully applied to visual smart real-time monitoring of Al 3+ . This study is expected to offer valuable insights into the formation mechanism of fluorescent nanostructures, thereby facilitating their applications in the development of high-performance biosensors for precise monitoring. Here, we successfully constructed a novel ratiometric fluorescent sensor, COFs@AuNCs@CDs, for the sensitive and accurate detection of Al 3 ⁺. A portable smartphone-assisted visual analysis platform was designed for on-site determination of Al 3 ⁺. This work provides new ideas for the future design of intelligent and integrated smartphone-based fluorescent sensing platforms for environmental monitoring and point-of-care testing, and expands the application of COFs composites in fluorescent sensing. Download: Download high-res image (194KB) Download: Download full-size image
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CHEMICAL ENGINEERING JOURNAL
·
2026
·
IF 12.5
Yixuan Jiang,Yanlin Zhao,Fan Zhao,Xiaowei Cao,Dingding Jing,Haifeng Huang,Qinglei Hang
Chiral D Au NCs capillary SERS for label-free non-invasive saliva D-Glc assay. • Sensor achieves 0.30 nM LOD, covering clinical saliva glucose ranges. • Assay finishes in 10 min with 50 μL sample, high accuracy and anti-interference. • Assay shows correlation with GOD-POD gold std. (R 2 = 0.9313) and 0.947 AUC. • It offers a promising tool for early diabetes screening and clinical translation. Early, non-invasive screening and risk prediction of diabetes are crucial for effective prevention and control, as well as for delaying the onset and progression of complications. In this study, we developed a capillary surface-enhanced Raman scattering (SERS) sensor based on chiral gold nanocubes (D Au NCs) for the non-invasive, label-free, and rapid detection of d -glucose (D-Glc) in saliva. By leveraging the chiral recognition capability and strong SERS activity of D Au NCs, the sensor specifically identifies D-Glc and significantly amplifies its characteristic Raman signals, enabling quantitative analysis in complex saliva matrices without labeling. The sensor demonstrates outstanding analytical performance, covering the clinically relevant range of salivary glucose concentrations with a detection limit as low as 0.30 nM. Based on a capillary detection platform, the assay is simple and rapid, completed within 10 min using only a 50 μL micro-sample, while demonstrating strong anti-interference capability and high detection accuracy. Clinical saliva testing showed strong correlation with the glucose oxidase-peroxidase (GOD-POD) gold standard (R 2 = 0.9313), enabling reliable discrimination between healthy individuals and diabetic patients. Receiver operating characteristic (ROC) analysis yielded an area under the curve (AUC) of 0.947, confirming its high efficacy in diabetes risk screening and strong diagnostic performance. Consequently, the D Au NCs-based capillary SERS sensor provides a promising strategy for early, non-invasive diabetes screening and prevention, possessing broad potential for clinical translation and application.
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Biosensors-Basel
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2026
·Vol. 16
·期 7
·376
·
IF 6.2
Mengli Wang,Yuanyuan Xia,Yulei Li,Lifen Chen,Kunyan Wang,Shuangshuang Wu,Yuelan Zhang
In this work, we developed a novel, ultrasensitive fluorescence sensing platform for determination of organophosphorus pesticides (OPs), using chlorpyrifos as a representative model analyte. The sensing strategy was constructed upon the key inner filter effect (IFE) between graphitic carbon nitride (g-C3N4) nanosheets and silver-coated gold core–shell nanoparticles (Au@Ag NPs). Initially, gold nanoparticles (Au NPs), silver nanoparticles (Ag NPs), and Au@Ag NPs were successfully synthesized, and their fluorescence quenching efficiencies toward g-C3N4were systematically evaluated. Owing to the superior spectral overlap with the fluorescence emission of g-C3N4, Au@Ag NPs exhibited the most obvious quenching effect and were thereby selected as the optimal quencher for sensor fabrication. Then, acetylcholinesterase (AChE) catalyzed the hydrolysis of acetylthiocholine (ATCH) into thiocholine. The generated thiocholine then induced aggregation of Au@Ag NPs via electrostatic and Ag-S interactions, which reduced the IFE efficiency and ultimately restored the fluorescence of g-C3N4. In contrast, the presence of chlorpyrifos effectively inhibits AChE activity, thereby suppressing ATCH hydrolysis and the subsequent aggregation of Au@Ag NPs. The fluorescence intensity of g-C3N4was quenched by Au@Ag NPs and the signal was low. Under optimal experimental conditions, the response signal was found to be proportional to chlorpyrifos (CPF). This work presents a rapid, cost-effective, and highly sensitive approach for CPF residue analysis, holding great potential for applications in food safety monitoring and environmental surveillance.
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MICROCHEMICAL JOURNAL
·
2026
·
IF 5.2
Chenxuan Ai,Xueli Yang
MOF-derived ZnO and Au-ZnO materials were synthesized via a coprecipitation method. • The response value of 0.5 wt% Au-ZnO to 100 ppm n-butanol is 649.77 at 250 °C. • Response time is just one second, enabling real-time detection of n-butanol. • This sensor has a low detectable concentration, excellent selectivity and stability. N-butanol is a flammable volatile organic compound (VOCs) posing potential threats to human health and environmental quality, making its real-time detection critically important. Although Au-functionalized MOF-derived ZnO has been investigated for gas sensing, the influence of Au loading on surface-defect regulation and n-butanol sensing behavior remains insufficiently understood. Herein, porous ZnO rhombic dodecahedra derived from ZIF-8 were functionalized with controlled Au loadings of 0.25, 0.5, and 0.75 wt%. The optimized 0.5 wt% Au-ZnO sensor exhibited a response of 649.77 and a response time of 1 s towards 100 ppm n-butanol at 250 °C, with the response being approximately 3.6 times that of pristine ZnO. A measurable response of 1.41 was obtained at 50 ppb, representing the lowest experimentally verified concentration in this study. The sensor also demonstrated good selectivity, repeatability, and long-term stability. XPS analysis showed that the 0.5 wt% Au-ZnO sample possessed the highest relative oxygen-vacancy content of 34.8%. DFT calculations further suggested a stronger adsorption tendency of n-butanol on the Au-ZnO surface than on pristine ZnO. These results demonstrate that controlled Au loading provides a favorable balance among interfacial charge modulation, oxygen-vacancy regulation, catalytic activity, and adsorption-desorption kinetics. The dodecahedral structure of the MOF-derived ZnO confers high sensitivity to n-butanol on the sensor, providing uniform anchoring sites for gold nanoparticles (Au NPs). Through Schottky barrier modulation, catalytic effects and oxygen vacancy enhancement, the modification with Au NPs further improves the capture efficiency and signal amplification for n-butanol concentrations in the ppb range. Download: Download high-res image (231KB) Download: Download full-size image
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MICROCHIMICA ACTA
·
2026
·Vol. 193
·期 5
·304
·
IF 5.4
Xiong Nuoxuan,Lin Yue,Luo Fang,Lin Cuiying,Qiu Bin,Lin Zhenyu,Jiang Zhou,Wang Jian
Nucleolin (NCL) is a critical biomarker for early cancer diagnosis and prognostic evaluation. To overcome the limitations of existing detection methods, such as insufficient sensitivity and cumbersome procedures, this study reports an ultrasensitive biosensing platform based on an organic photoelectrochemical transistor (OPECT). The biosensor employs a guanine-rich DNA aptamer, AS1411, immobilized on an n-GaN/Au gate electrode. Specific binding to NCL induces AS1411 to fold into a G-quadruplex (G4) structure, whose intrinsic π-π stacking interactions are proposed to establish an efficient charge transport channel. This effect substantially promotes the separation of photogenerated holes, and combining this with the intrinsic gain of the OPECT transconductance mechanism yields notable signal amplification. As a result, the proposed sensor exhibits ultrahigh sensitivity with a limit of detection (LOD) of 0.28 pM (S/ N = 3) and a wide linear range from 1 pM to 100 nM. The excellent analytical performance originates from the synergistic effect of OPECT amplification, G4-mediated charge transport, efficient photoelectric conversion of the GaN/Au gate, and minimal signal loss. Moreover, the biosensor demonstrates high selectivity against potential interfering proteins and reliable quantitative accuracy in complex biological matrices. In the analysis of breast cancer cell lysates, recoveries range from 96.4% to 97.6%, consistent with the standard ELISA method. This work establishes a label-free detection strategy wherein ultrasensitive signal transduction is achieved exclusively through aptamer conformational switching-without requiring heterojunction engineering enabling point-of-care NCL analysis. Graphical
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Catalysts
·
2026
·Vol. 16
·期 4
·327
·
IF 4.5
Biao Zhang,Liantao Yang,Boyu Chen,Yuanzhe Li,Hao Wang
Defect engineering and metal–support coupling provide an effective route to tune interfacial charge dynamics for selective photocatalytic CO2reduction. Here, Ti-vacancy-rich Bi4Ti3O12(BTvO) nanosheets were prepared and decorated with Au nanoparticles (Au NPs) to build Au-BTvO junctions that favor multi-electron/proton transfer toward deep hydrogenation. The optimized 3%Au-BTvO achieved high hydrocarbon productivity under visible light (λ > 420 nm), delivering CH4and C2H6formation rates of 92.66 and 17.96 μmol g−1h−1, respectively, with stable performance over 25 h. Spectroscopic analyses reveal higher CO2uptake and more effective surface activation, increased water adsorption with a more favorable interfacial hydration environment, and time-dependent formation of key C1and C2intermediates. In situ light-irradiation XPS, PL mapping, and KPFM collectively demonstrate directional electron transfer from Bi4Ti3O12to Au and amplified surface band bending, enabling efficient charge separation and accelerated surface reduction. This work highlights defect–metal synergy as a general strategy to boost activity, selectivity, and durability in visible-light CO2-to-methane conversion.
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FOOD CHEMISTRY
·
2026
·
IF 10.4
Rui Wang,Ziqian Meng,Han Yan,Meiqi Yin,Jinfeng Huang,Hao Zheng,Jingtao Sun,Jiyun Nie,Wei Wu,Qinzhi Wang
Flexible CP-MXene@Au chip fabricated via layer assembly and electrodeposition. • MXene prevented Au NPs aggregation while preconcentrating analytes. • Electrodeposition enabled facile optimization of uniformity and reproducibility. • Thiophanate-methyl in fruits detected with good recovery and practical applicability. For the common fruit contaminant thiophanate-methyl (TPM) residue monitoring, a portable ultra-sensitive flexible surface-enhanced Raman scattering (SERS) chip was developed using carbon paper and electrochemical deposition technology for the rapid and efficient trace detection of TPM in fruits. The flexible chip was constructed using MXene (CP-MXene) through layer-by-layer assembly and plasmonic metal (CP-MXene@Au) by the chronopotentiometry method, which dramatically improved the intrinsic electrical conductivity contributing to forming SERS-active “hot spot” with superior stability and reproducibility. Based on prepared SERS chip, the TPM was rapidly detected as the lowest detection limit as 0.00923 μM and a wide detection linear range of 0.1–100 μM. Furthermore, TPM in fruits can be collected and recognized with excellent reusability and satisfactory recovery of 90.5–109.5%, demonstrating its good practical applicability. This flexible SERS chip is also highly sensitive and low-cost, providing a new idea for efficient food safety monitoring.
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JOURNAL OF COLLOID AND INTERFACE SCIENCE
·
2026
·
IF 9.6
Junyao Zheng,Zhen Xiao,Yong Xu,Weili Dai,Kunxian Hu,Man Zhang,Wanzhen Chang,Jianping Zou,Xubiao Luo
Efficient dissociation of excitons is induced through the combination of O v and plasma effect. • The disruption of electronic structure uniformity in BiOCl leads to a decrease in exciton binding energy. • Photo-induced electrons efficiently migrate to Bi sites adjacent to O v , facilitating subsequent CO 2 reduction. • The introduction of Au and O v help to reduce the energy barrier of rate-determining step, improving reduction rate. Photogenerated carriers are one of the cores of photocatalysis, however, layered structural materials mainly form excitons after being excited by light due to lack of one dimension, while the utilization of excitons is crucial for low-dimensional photocatalysts. Herein, the strong excitonic effect in BiOCl (BOC) can be reduced via photodeposition of Au, accompanied by formation of additional oxygen vacancies (O v ). It can break the uniformity of electronic structure, lower exciton binding energy (E b ) and promote efficient dissociation of excitons into free carriers. Besides, the loading of Au with plasma resonance can dramatically improve light absorption capacity and generate additional electrons. Based on above advantages, as well as analysis through electrochemical testing, fluorescence and Bader charge, it is known that photo-induced electrons efficiently migrate to Bi sites adjacent to O v , increasing electron density and facilitating subsequent CO 2 activation and hydrogenation reduction. Resultly, 0.8%Au/BOC possesses the highest catalytic performance, delivering a CO production rate of 18.7 μmol g −1 , which is 6.2 times the catalytic activity of BOC. By combining advanced characterization and computational modeling, we reveal the introduction of Au and more O v helps to reduce the energy barrier of rate-determining step, and thus improving the reduction rate. Download: Download high-res image (125KB) Download: Download full-size image
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高影响因子
Science China-Technological Sciences
·
2026
·Vol. 69
·期 5
·1520202
·
IF 5.1
Niu Jiaxin,Ling Hangyang,Sun Xu,Sun Gongxian,Wang Shengyan,Li Feiyan,Zhang Na,Chen Tianshuang,Zhuo Xiaolu,Zhu Jinjin,Zhang Han,Kong Xiangdong
Bacterial infections pose persistent threats to global public health, while the antimicrobial resistance caused by the overuse of antibiotics further exacerbates this problem. The development of novel disinfectants that are efficient, durable, broad-spectrum, and deploy non-antibiotic mechanisms is therefore highly desired. Multifunctional nanocomposites with multi-effect antibacterial properties can meet the above demands. Herein, we developed a core-shell nanocomposite of Au-Ag nano-urchins coated with room-temperature synthesized covalent organic frameworks for efficient morin loading and multi-scenario antibacterial applications. This material achieves exceptional bactericidal efficacy at ultralow doses by combining photothermal therapy, tip-mediated physical puncture, and the action of released antibacterial components. It achieves over 99.99% in-activation of both Escherichia coli and Staphylococcus aureus at a low concentration of 8 µg mL −1 under weak xenon lamp illumination of 0.3 W cm −2 . The nanocomposites can be readily spray-coated onto various surfaces, forming a durable and stable antibacterial layer. Furthermore, in the in vivo infected wound healing model, the nanocomposite demonstrated excellent antibacterial efficacy and promoted nearly complete wound closure within 7 days. By integrating physical puncture, photothermal effect, and controlled drug/ion release, this nanocomposite offers an effective strategy for daily antibacterial applications.
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Food Bioscience
·
2026
·
IF 6.2
Qiaoqiao Shi,Li Lu,Tao Liu,Qian Chen,Dezhao Kong,Hua Ye
Kanamycin (KAN) residues in food pose a serious risk to human health, necessitating the development of rapid and sensitive detection methods. Herein, a novel surface-enhanced Raman scattering (SERS) aptasensor for ultrasensitive detection of kanamycin, which integrates hollow Au/Ag alloy nanourchins (HAAA-NUs) tags with high-density “hot spots” and exonuclease III (Exo III)-assisted cyclic amplification. In the presence of KAN, its specific binding with the KAN aptamer (KAN-Apt) triggers the release of complementary DNA (cDNA), followed by hybridization with hairpin DNA (HAP) and Exo III-mediated digestion, resulting in cyclic amplification of target DNA. The amplified target DNA serves as a bridging mediator that specifically hybridizes with the DNA1 immobilized on Fe 3 O 4 @Au nanoparticles (NPs) and the DNA2 anchored on PATP-loaded HAAA-NUs, leading to the formation of a Fe 3 O 4 @Au NPs-DNA1/target DNA/DNA2-HAAA-NUsPATP complex, which subsequently produces a strong SERS signal. In addition, the background signal can be effectively reduced through magnetic separation. Under optimal conditions, the SERS aptasensor exhibited a wide detection range for KAN from 1 to 10 5 fg/mL with a good linear correlation (R 2 = 0.9913), and a limit of detection (LOD) as low as 0.12 fg/mL. It also performed satisfactorily in the analysis of real samples (milk and honey), achieving good recoveries ranging from 89.72% to 112.54%. Moreover, the method demonstrated excellent specificity and stability.
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高影响因子
JOURNAL OF CHROMATOGRAPHY A
·
2026
·
IF 4
Mingyi Du,Xiran Chen,Yaming Sun,Jiadu Hu,Wenlin Wen,Hanhong Xu,Zhibin Yin,Xinzhou Wu
MBSA-SiO2@Au nanoshells enabled selective enrichment and SALDI-MS of QACs. • The bifunctional platform served as both adsorbent and ionization matrix. • The method achieved 0.5–1.5 ng/mL LODs with 20–40-fold sensitivity enhancement. • Recoveries of 87.0–108.8% were achieved in white radish, carrot, and potato matrices. The widespread use and persistence of quaternary ammonium compounds (QACs) in food environments raise concerns about their detection at trace levels in complex matrices. In this study, we developed a negatively charged 4-mercaptobenzenesulfonic acid functionalized SiO 2 @Au core-shell nanocomposite (MBSA-SiO 2 @Au) that serves as both a selective adsorbent and an efficient surface-assisted laser desorption/ionization (SALDI) matrix. The sulfonate modified gold shell provides a stable negative surface potential to promote electrostatic interactions with cationic QACs, and their plasmonic properties synergistically enhance laser energy absorption and ionization efficiency. Critical enrichment parameters, including adsorbent amount, solution pH, adsorption time, and redispersion volume, were optimized. The optimized method achieved limits of detection of 0.5 ng/mL for paraquat (PQ), dodecyltrimethylammonium chloride (DTAC), and didodecyldimethylammonium chloride (DDAC), and 1.5 ng/mL for dodecyldimethylbenzylammonium chloride (DBAC), with excellent linearity (R 2 ≥ 0.9843), achieving an enrichment factor of approximately 33.3, and a 20- to 40-fold sensitivity enhancement after enrichment. Application to real food samples, including white radish, carrot, and potato, revealed no detectable QAC residues and satisfactory recoveries ranging from 87.0 to 108.8%. The bifunctional MBSA-SiO 2 @Au-based SALDI platform minimizes organic solvent consumption and offers a rapid, green, and sensitive approach for monitoring QACs in food safety applications.
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