WATER RESEARCH
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2025
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IF 12.4
Zihao Chen,Xingqi Huang,Yanjun Zuo,Haibo Wang,Wenming Chen,Lingce Kong,Xiaoyan Lin
Advanced oxidation processes (AOPs) based on peroxymonosulfate (PMS) enable efficient generation of highly oxidative radicals for eliminating diverse organic pollutants. Developing multi-active, stable catalysts remains challenging. In this study, a composite catalyst integrating high-entropy perovskite oxides (HEPs) with carbon microspheres (CS), denoted as HEPs@CS, was successfully synthesized to activate PMS for generating reactive oxygen species (ROS), enabling efficient degradation of Rhodamine B (RhB, 99.7 % removal in 10 min), tetracycline (TC), and other pollutants via a singlet oxygen ( 1 O 2 )-dominated nonradical pathway, with a high rate constant (0.5815 min -1 ). The HEPs framework, featuring a multi-active-site co-catalytic system and strong metal-support interactions (MSI), exhibited exceptional catalytic activity and stability. Through EPR, FT-IR, and Raman characterization tests, the material's exceptional performance is also attributed to the synergistic participation of oxygen vacancies (O V ), diverse carbon surface functional groups, and defect structures in the reaction system. These factors collectively enhance electron transfer during both PMS activation and pollutant degradation processes. ECOSAR software confirmed the environmental safety of this process. Our findings demonstrate that HEPs@CS exhibits outstanding performance as a PMS activator for wastewater treatment of organic pollutants. This work provides deeper insights into how polymetallic electronic structures in high-entropy perovskites modulate PMS activation mechanisms.
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MICROCHEMICAL JOURNAL
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2025
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IF 5.1
Raj Kumar Parajuli,Jin Liu,Shree Krishna Tamang,Govinda Gurung,Kumar Neupane,Yao Wang,Christopher D. Snow,Matt J. Kipper,Laurence A. Belfiore,Jianguo Tang
Patient urine may provide relatively convenient access to biomarkers, but it is challenging to directly and visibly sense drugs via fluorescence quenching or enhancement. This study reports the synthesis of water-soluble and fluorescence-stable terbium-induced nanoaggregates (TIPAs) of polystyrene-poly(acrylic acid) (PS- b -PAA), containing a novel [Tb( acac )Cl 2 ( phen )Cyclen] complex, to sense doxorubicin ( dox ) in urine. The TIPAs demonstrated remarkable water stability, maintaining high fluorescence intensity in aqueous environments, with a fluorescence lifetime of 55.5 ms and a quantum yield (QY) of 4.60 %, making them ideal for smart sensing applications. The novel aggregate exhibits an orthorhombic structure, with its photophysical properties elucidated through simulated modeling. Fluorescence quenching studies indicate dynamic interactions between TIPAs and dox in urine, achieving a limit of detection (LOD) of 13.77 μM, highlighting the method's sensitivity for real-time dox monitoring. The emission of TIPAs in the visible range (450–600 nm) overlaps with the absorption spectrum of dox , enabling efficient energy transfer and fluorescence quenching. These findings highlight the potential of TIPAs as stable, fluorescence-based sensors for drug monitoring, with promising applications in bioimaging and diagnostics within cancer therapy.
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JOURNAL OF MATERIALS SCIENCE
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2017
·Vol. 52
·期 13
·8311-8320
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IF 2.599
Qu Lu-Lu,Wang Na,Li Yan-Yan,Bao Dan-Dan,Yang Guo-Hai,Li Hai-Tao
A novel ternary nanocomposite consisting of activated carbon (AC) and titanium dioxide (TiO 2 ) decoration in the presence of reduced graphene oxide (TiO 2 –rGO–AC) was fabricated by a facile hydrothermal synthesis method for use as a high-performance photocatalyst. The as-prepared TiO 2 –rGO–AC nanocomposites were characterized by X-ray diffraction (XRD), scanning electron microscopy, transmission electron microscopy, and UV–Vis diffuse reflectance spectroscopy. The results demonstrated that the TiO 2 and activated carbon were well dispersed on the rGO surface. The photocatalytic performance of the TiO 2 –rGO–AC nanocomposite was evaluated as a catalyst for the photodegradation of rhodamine B. The degradation rate was 3.4 times higher than that of pure TiO 2 under simulated solar light irradiation. The enhancement of photocatalytic performance is attributed to the adsorption of AC which significantly increased the organic molecule concentration near the catalytic surface, allowing the effective transfer and separation of photogenerated electrons. TiO 2 –rGO–AC photocatalyst is also effective for the degradation of tetracycline in aqueous solution, suggesting wide application of these nanocomposite materials in various fields including air purification and wastewater treatment.
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Reaction Chemistry & Engineering
·
2024
·Vol. 9
·期 6
·1521-1531
·
IF 3.4
Yuxing Sun,Zilong Zhang,Juan Yang,Xiang Wang,Huanjun Peng,Jingdong Peng
Generally, a Bi-doped TiO2 nanocomposite was synthesized by a microwave-assisted hydrothermal method to introduce Bi4Ti3O12 and an oxygen vacancy onto the pristine TiO2. The optimized composite 6Bi–TiO2 exhibits a good photocatalytic ability for degradation of rhodamine B (RhB), and the calculated reaction rate constant is about 13.7 times higher than that of pristine TiO2. After 60 minutes of light irradiation, the 6Bi–TiO2 sample achieved a degradation rate of 95% and that of the pristine TiO2 was 21%. Furthermore, the catalyst retains a good photocatalytic ability after recycling five times. The enhanced photocatalytic ability can be credited to the improved charge separation efficiency, caused by the altered band structure after the anchoring of Bi4Ti3O12, and the oxygen vacancy also plays a crucial role in the degradation process. This study offers insights into the application of a microwave-assisted hydrothermal method in the effective synthesis of Bi4Ti3O12 on TiO2 by a Bi-doping strategy.
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SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
·
2011
·Vol. 82
·期 1
·340-344
·
IF 1.77
Yong Xiang Wu,Jing Cao,Hai Yan Deng,Jun Xiang Feng
A novel fluoroionophore 1 based on 3,4-dimethylthieno[2,3-b]thiophene bearing two monoaza-15-crown-5 ethers at 3- and 4-positions was prepared. UV–vis and fluorescence responses of compound 1 upon the addition of alkali and alkaline earth metal cations were evaluated in acetonitrile solution. Receptor 1 showed unique response for Ba 2+ due to the formation of an intramolecular sandwich complex.
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ACS Applied Nano Materials
·
2025
·
IF 5.5
Hao Ren,Yi Cao,Tianjiao Ling,Junli Zhu,Jifang Xu,Minqi Sheng
Even though cobalt monophosphide (CoP) has been recognized as a prospective alternative to noble metal-based electrocatalysts in alkaline water splitting, further enhancement of the catalytic activity and durability of CoP in the hydrogen evolution reaction (HER) and oxygen evolution reaction (OER) requires precise manipulation of its nanoscale spatial architecture and surface electronic structure. Herein, tremella-like Pt, B-codoped CoP nanostructures were successfully anchored on carbon cloth (Pt–B–CoP/CC) through a successive process involving wet chemical deposition, surface Pt impregnation, and phosphorization. The resultant Pt–B–CoP/CC exhibits excellent catalytic activity for both HER and OER, primarily attributed to (i) high-density active sites, (ii) enhanced surface conductivity, and (iii) appropriately modulated electronic structure via Pt, B codoping. In addition, Pt–B–CoP/CC exhibits superaerophobicity, enabling the maintenance of efficient exposure of active sites during electrolysis. In an alkaline medium (1.0 M KOH), the required overpotentials are 52.53 (at −10 mA cm–2) for HER and 224.37 mV (at 10 mA cm–2) for OER, which outperform most of the reported transition metal-based bifunctional catalytic electrode materials. The constructed Pt–B–CoP/CC||Pt–B–CoP/CC cell requires an ultralow cell voltage of 1.51 V (1.74 V) to drive a current density of 10 mA cm–2 (100 mA cm–2). After 100 h of continuous electrolysis, the cell voltage increment is almost negligible at 10 mA cm–2, while at 100 mA cm–2 it increases by only 1.97%, demonstrating the tremendous durability of Pt–B–CoP/CC and its potential applicability in industrial-grade electrolyzers. This study provides inspiration for designing and synthesizing advanced multifunctional catalytic electrodes with high efficiency and long-term stability.
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ACS Applied Materials & Interfaces
·
2025
·
IF 8.2
Dan Zu,Jun Yao,Xiao Li,Yixing Huang,Can Hu,Mingcong Deng,Qimei Bao,Yin Shi,Zu Ye,Xiangdong Cheng
Gastric cancer (GC) is one of the most common malignant tumors in the world, which is resistant to conventional chemotherapy drugs. Although polyphyllin B (PB) exhibits antitumor activity against GC, its clinical application is limited by systemic toxicity and poor target specificity. Here, we developed a dual-targeting nanoparticle (Ma/HA@NP) coated with a gastric cancer cell membrane (Ma) and hyaluronic acid (HA) to enhance biocompatibility, immune evasion, and homologous targeting. Ma/HA@NPs preserve the immune evasion and homologous targeting properties of both components. Upon endocytosis, Ma/HA@NPs react with cysteine to release PB, deplete glutathione (GSH), and reduce the enzymatic activity of glutathione peroxidase 4 (GPX4), leading to ferroptosis activation. Compared to single PB, Ma/HA@NPs not only enhance PB release but also trigger immunogenic cell death, promoting dendritic cell maturation and cytotoxic T lymphocyte activation. Moreover, interferon-γ release further suppresses cysteine uptake, synergistically amplifying ferroptosis. In vivo, intravenous administration of Ma/HA@NPs-PB in an orthotopic GC model achieved an 85.4% tumor inhibition rate with reduced systemic toxicity compared to free PB. Together, this dual-targeting platform enhances PB delivery and synergizes ferroptosis with immunogenic cell death (ICD) activation, offering a promising strategy for the treatment of gastric cancer.
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SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
·
2025
·
IF 4.6
Xiaoya Kou,Shiyi Yang,Jing Zou,Siying Chen,Jianying Wu,Bo Sun,Zhongda Yan,Dezhao Liu,Haoqiang Tan
Recently, increasing attention had been paid for using peracetic acid (PAA) as an efficient disinfectant or a strong oxidant in wastewater treatment. In this study, a rapid and simple spectrophotometric method for the selective determination of PAA in aqueous solution was established, based on the oxidative decolorization of rhodamine B (RhB) by reactive species generated from the combination of PAA and Co(II). Under the optimized conditions (20 μmol L −1 RhB, 1.0 mmol L −1 Co(II), pH = 5.0 buffered with 10 mM acetate acid buffer, and reaction time = 40 s), the extent of RhB decolorization at the characteristic wavelength of 552 nm was found to be proportional to the concentration of PAA in the aqueous solution. A strong linear correlation was observed between the consumption of RhB and the concentration of PAA in the range of 0.25–25 μmol L −1 (R 2 = 0.9991), and the sensitivity for PAA was as high as 2.99 × 10 4 M −1 cm −1 . The RhB spectrophotometric method is effectively tolerant to interference the coexistent H 2 O 2 in PAA solution, the common coexisting species in practical water samples (KCl, MgSO 4 , NaNO 3 , NaHCO 3 , DCF and humic acid) and even the added reducing substances such as hydroxylamine and ascorbic acid. As a selective colorimetric agent, RhB is resistant to interference from reducing substances and water bodies, enabling accurate determination of PAA concentration in actual water environments. Overall, the RhB spectrophotometric method could be used as an alternative method for the cheap, rapid and selective determination of PAA in water samples.
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JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY
·
2026
·
IF 5.3
Wei Li,Yan Guo,Xiaoli Wang,Chunyan Yang,Jiang Zhu,Zhongcheng Cao
Alzheimer’s disease (AD) still lacks therapies that definitively halt its progression. Dual AChE/MAO-B inhibitors offer a promising strategy to address both symptoms and pathology. Here, we designed and synthesised a series of donepezil-safinamide hybrids. The optimised compound 28c was identified as a potent inhibitor of AChE (IC50 = 1.70 μM) and MAO-B (IC50 = 0.18 μM). Mechanistic studies indicated that 28c acts as a reversible mixed-type inhibitor of AChE and a competitive reversible inhibitor of MAO-B. Molecular docking and molecular dynamic simulations revealed that 28c could strongly and stably bind to MAO-B and AChE mainly through van der Waals interactions. Moreover, compound 28c demonstrated effective blood-brain barrier penetration, exhibited suitable stability in mouse plasma and brain homogenate, and showed a favourable safety profile both in vitro and in vivo. Furthermore, 28c could attenuate AD-related symptoms and exert hippocampal neuroprotection effect in vivo, highlighting its promise as an anti-AD candidate.
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Frontiers in Pharmacology
·
2026
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IF 5.4
Shan Luo,Yake Lan,Ruoqi Zhang,Zhongqiu Luan
Introduction Diabetic nephropathy (DN), as a complication of diabetes, is one of the major causes of end-stage renal disease. Licochalcone B (LCB), a flavonoid active component derived from licorice, is well known for its anti-inflammatory and antioxidant properties. However, the influence of LCB on DN remains unclear. This research investigated the effect of LCB on DN and elucidated the regulatory mechanism. Methods We employed male C57BL/6 mice to construct a DN mouse model induced by a high-fat diet (HFD)/streptozotocin (STZ). In vitro , a high glucose (HG)-induced injury model in HK-2 (human renal tubular epithelial) cells was used to further confirm the protective effects of LCB. Results LCB treatment (20 mg/kg and 40 mg/kg) decreased blood glucose levels, kidney injury, glycogen deposition, and collagen accumulation in the DN mice. Moreover, LCB at a dosage of 40 mg/kg reduced albumin, creatinine, and blood urea nitrogen levels by about 70.7%, 33.4%, and 45.6%, respectively, indicating an improvement in kidney function. In renal tissues, LCB suppressed oxidative stress and apoptosis in HFD/STZ-induced mice. Consistent with in vivo findings, LCB alleviated HG-induced oxidative stress and apoptosis in HK-2 cells. Transcriptome analysis revealed that LCB affects oxidative stress and renal function-related pathways to alleviate DN. Further mechanistic studies demonstrated that LCB treatment upregulates the expressions of heme oxygenase-1 (HO-1) and nuclear factor (erythroid-derived 2)-like 2 (Nrf2), suggesting activation of the Nrf2/HO-1 signaling pathway. Conclusion Taken together, this research demonstrates that LCB suppresses oxidative stress and apoptosis accompanied by modulating the Nrf2/HO-1 pathway to ameliorate DN, which provides a promising strategy for DN treatment.
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POLYHEDRON
·
2026
·
IF 2.8
Innocent Tayari Mwizerwa,Jiayi Tang,Tianlei Huang,Li Zelong,Zhuyu Sun,Xiaoxiang Zhao
Graphitic carbon nitride photocatalytic efficiency is hindered by limited active sites and fast electron-hole recombination. A facile two-step calcination strategy was used to fabricate iron and nickel co-doped g-C 3 N 4 (Fe/Ni-g-C 3 N 4 ) for enhanced photocatalytic degradation of Rhodamine B (RhB) under visible light irradiation. This increased specific surface area (11.2 m 2 /g for Fe 3 /Ni 1 -g-C 3 N 4 compared to 10.3 m 2 /g for pure g-C 3 N 4 ), improved visible light harvesting, and triggered a prolonged charge carrier lifetime. The Fe 3 /Ni 1 -g-C 3 N 4 catalyst showed superior performance, with a kinetic rate constant of 0.04481 min −1 , which is three times greater than that of its other counterpart photocatalysts. It also exhibited excellent stability, degrading over 90% of RhB for three consecutive cycles. Meanwhile, mechanistic study of radical quenching tests and DFT calculations showed degradation via h + radicals, initiating deethylation and hydroxylation reactions that mineralized RhB into CO 2 and H 2 O. Finally, this report provides the synergy of Fe/Ni and an avenue for efficient and stable metal-doped graphitic carbon nitride photocatalysts.
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ANTIVIRAL RESEARCH
·
2026
·
IF 4
Yarong Song,Yitong Zeng,Han Zheng,Shu Shi,Zhongqing Li,Mingchen Liu,Sijin Shao,Ziheng Luo,Yurong Li,Jie Li,Kuanhui Xiang,Jie Wang
Chronic hepatitis B virus (HBV) infection is a major global health problem. Currently, existing antiviral drugs are difficult to achieve a functional cure for chronic hepatitis B (CHB). Therefore, it is necessary to develop new antiviral targets, especially those that can directly target HBV covalently closed circular DNA (cccDNA) in hepatocytes. Here, we identified a conserved SOX6 binding site in the enhancer I (ENI) region of the HBV genome, and found that SOX6 promotes the replication of multiple genotypes HBV through its HMG domain. Mechanistically, SOX6 binds to the conserved binding site located in the HBV ENI region through its HMG domain, thereby promoting HBV replication by enhancing the transcriptional activity of ENI. Moreover, cisplatin and doxorubicin not only promote HBV replication but also promote SOX6 expression. Knocking down the expression of endogenous SOX6 or mutating the SOX6 binding site in the HBV ENI region significantly weakens the direct promoting effect of cisplatin and doxorubicin on HBV replication. In summary, SOX6 promotes HBV replication by enhancing the transcriptional activity of HBV ENI through its HMG domain, suggesting that it can serve as a potential target for regulating HBV cccDNA transcription. In addition, SOX6 participates in the direct promotion of HBV replication by cisplatin and doxorubicin, providing new insights into the molecular mechanisms of tumor chemotherapy related HBV reactivation (HBVr) and potential targets for the prevention of HBVr during tumor chemotherapy.
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