CRYSTENGCOMM
·
2025
·
IF 2.6
Jiangwen Bai,Jiamin Li,Jinmeng Xiang,Chongfeng Guo
The built-in electric field (IEF) between two components of heterojunction has been proven to be capable of efficiently separating photogenerated carriers in photocatalysis. However, the rapid charge accumulation near the interface of heterojunction tends to neutralize this electric field, resulting in the deterioration of the heterojunction performance. Herein, the ferroelectric-based BiFeO3/BiOI-n heterojunctions (BFO/BiOI-n) were prepared utilizing epitaxy growth. The BFO not only endows the heterojunctions with stronger ferroelectric polarization, which was confirmed by the hysteresis loop, but also induces a significant redistribution of carriers, which maintains a stronger IEF in BFO/BiOI-n. Furthermore, the ferroelectric polarization of BFO was further regulated via corona poling and the enlarged ferroelectric polarization was also favorable to improve the photocatalytic performance. The optimal PBFO/BiOI-4 sample delivers a complete degradation of RhB within 30 minutes and a hydrogen evolution rate of 150 µmol·g−1·h−1. The significantly improved photocatalytic performance is attributed to the efficient photogenerated carriers separation synergistically promoted by the IEF in the heterojunction and the polarized electric field (PEF) in BFO. This work provides a feasible scheme for designing ferroelectric-based heterojunction photocatalyst.
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EUROPEAN POLYMER JOURNAL
·
2024
·
IF 5.8
Xiangjun Gong,Wei Guo,Zhiping Zhao,Changmei Sun,Ying Zhang,Rongjun Qu,Yunxia Shen,Ying Wang
Traditionally, aramid fibers or nanofibers (ANFs) consist of poly- p -phenylene terephthanlamide (PPTA) molecules, which can be used to reinforce polar polymers containing the same polar groups (e.g., C = O and –NH-). In this paper, aramid nanomaterials (ANM) were synthesized directly from polyvinyl chloride (PVC) matrix solution using “bottom-up” in-situ method to improve the poor toughness of PVC. Transmission electron microscopy (TEM) showed that ANM was uniformly dispersed in PVC matrix, and the morphology of ANM synthesized in different solvents was different, with slightly different modification effects. ANM shows two characteristic peaks of 1536 cm −1 and 1339 cm −1 in Fourier transform infrared spectroscopy (FTIR), which are characteristic of PPTA, and shows the same 2θ angles of 18°, 22°, and 27° as PPTA in X-ray diffraction (XRD). In terms of the mechanical properties of the composites, the addition of ANM can significantly increase the toughness and strength of PVC and improve the corrosion resistance of the material, in which the toughness increase rate of ANM/PVC/DMF-4 is 861.7 %.
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AQUATIC TOXICOLOGY
·
2024
·
IF 4.1
Zhihua Ni,Xinling Tian,Wenbo Zhao,Wenkai Hu,Jinghua Lv,Xiaoli Sun,Yajie Zhang,Yiwen Zhang,Yuming Zhang,Baoku Li,Fengsong Liu
Orlistat (ORL) has been employed as an anti-obesity pharmaceutical for several decades. Given its low absorption rate, the majority of administered ORL is excreted into the environment with feces. It is crucial to collect scientific information regarding the possible ecological risks associated with ORL. Here, the effects of ORL on Daphnia magna were evaluated using a 21-day chronic test at concentrations of 1, 10, 100, and 1000 μg/L. We found the inhibition of feeding and swimming activities in the 100 and 1000 μg/L ORL exposed D. magna , respectively. Their digestive enzyme activities and metabolites were reduced even at 1 μg/L ORL exposure. It is noteworthy that exposure to 100 μg/L ORL induced a decrease in the reproductive capacity of D. magna , although no discernible genotoxicity was observed. To identify the toxicological mechanisms of ORL, a metabolic analysis was conducted on D. magna exposed to 1000 μg/L ORL. A comprehensive reduction in carbohydrates, lipids, and amino acids was observed, which resulted in a blockage of metabolic flux towards the TCA cycle, as evidenced by mitochondrial dysfunction. These findings substantiate the detrimental impact of ORL on D. magna and provide insights into the underlying molecular mechanisms from a metabolic perspective.
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PubMed
高影响因子
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
·
2024
·Vol. 38
·期 11
·e70023
·
IF 3.2
Jin Wu,Yingmao Jia,Ya Liao,Denghui Yang,Honglin Ren,Zhihui Xie,Jie Hu,Yuanlan Lu
Coenzyme Q10 (CoQ10) plays an important role in improving mitochondrial function and has many beneficial effects on the kidney. However, whether CoQ10 protects against diquat (DQ)-induced acute kidney injury (AKI) remains unclear. In this study, we investigated the protective effects and mechanism of action of CoQ10 against DQ-induced AKI. Institute of Cancer Research (ICR) mice were intraperitoneally injected with DQ to induce AKI. The expression levels of serum creatinine (Cr), urea, and kidney injury molecule-1 (KIM-1) increased, those of aquaporin 1 (AQP-1) decreased, and those of mitochondrial reactive oxygen species (ROS) increased with increased depolarization of mitochondrial membranes and mitochondrial rupture. In contrast, treatment with CoQ10 significantly improved DQ-induced AKI. CoQ10 treatment reduced serum Cr, urea, and KIM-1 contents, increased the AQP-1 expression, and reduced ROS contents in mice with DQ poisoning. Our results suggest that AKI caused by DQ poisoning may be related to the disruption of mitochondrial homeostasis and that CoQ10 treatment protects against AKI caused by DQ poisoning by improving mitochondrial kinetic homeostasis. Thus, CoQ10 represents a new therapeutic option for the prevention and treatment of AKI caused by DQ poisoning.
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JOURNAL OF ANALYTICAL AND APPLIED PYROLYSIS
·
2024
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IF 5.8
Xiao Cheng,Yuchen Jiang,Kai Sun,Chao Li,Shu Zhang,Yi Wang,Hengda Han,Xun Hu
Mixing feedstocks of varied aromatic/aliphatic content is a simple method for tailoring pore structures of activated carbon (AC) in activation. Herein, willow wood and homogenous biochar produced at 300 or 500°C, which have distinct content of aliphatic component, were co-activated with K 2 C 2 O 4 , at 800°C for changing pore characteristics of resulting AC. The results indicated that co-activation of willow and biochar diminished production of AC and impacted evolution of organics and gases through intensive volatiles-char interactions. The AC from the co-activation of willow with either biochar-300 or biochar-500 exhibited higher specific surface area than that from direct activation of willow (1409.7 or 1297.0 m 2 g −1 versus 1243.6 m 2 g −1 ), which was also higher than calculated average of that from feedstock (ca. 1160 m 2 g −1 ). This resulted from intensified gasification of the biochar with H 2 O/CO 2 derived from willow, creating additional macropores and micropores of enlarged pore sizes. The enhanced gasification also reduced crystallinity of graphitic carbon, lowered O content via accelerated deoxygenation and diminished C O on nascent AC. Volatiles-char interactions also minimized pore filling from carbonaceous deposit generated from secondary condensation of primary volatiles. Additionally, direct activation of aliphatic-rich willow tended to form more micropores, while more mesopores were formed from aromatic-rich biochar.
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CHINESE JOURNAL OF CATALYSIS
·
2025
·
IF 17.7
Bingjie Zhang,Chunyan Wang,Fulin Yang,Shuli Wang,Ligang Feng
Bifunctional Ir catalysts for proton exchange membrane (PEM) water electrolysis offer transformative potential by streamlining electrolyzer while achieving efficient performance remains challenging due to the distinct conditions required for oxygen and hydrogen evolution reaction (OER and HER). Herein, we propose a theory-directed design of Ir-based bifunctional catalysts, Ir nanoparticles supported on mesoporous carbon spheres embedded with MoSe 2 (Ir/MoSe 2 @MCS), leveraging a work function (WF)-induced spontaneous built-in electric field to enhance catalytic performance. They demonstrate exceptional kinetics for both OER and HER, and potential application in the practical PEM electrolyzer, showcasing the effectiveness of this innovative approach. Low overpotentials of 252 mV for OER and 28 mV for HER to drive 10 mA cm –2 were observed, and the PEM electrolyzer showed the current density of 2 A cm –2 at 1.87 V and maintained stable activity at 1.65 V for over 30 h to deliver 1 A cm –2 . Density functional theory calculations reveal that the WF difference at Ir/MoSe 2 interface induces a spontaneous built-in electric field with asymmetric charge distributions, that modulate the electronic environment and d -band center of Ir promoting bifunctional active phase formation. This significantly lowers reaction barriers for water splitting by balancing intermediate adsorption, endowing the bifunctional activity.
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Journal of Energy Chemistry
·
2025
·
IF 14.9
Zhan Zhao,Tao Shi,Jia Liang,Kelei Huang,Xiangchao Meng
Acceleration of hydrogen spillover on electrocatalysts is effective for improving the hydrogen evolution reaction. However, it is still challenging to design rational proton migration pathway. Herein, we propose an in-situ reconstruction strategy to provide MoO 4 2− -modified micro-environment, which prominently promotes the hydrogen spillover effect. The Mo species is introduced to be in situ oxidized and transformed to MoO 4 2− . Experimental and theoretical studies indicate that the generation and re-adsorption of MoO 4 2− not only suppress the interfacial electron accumulation, but also optimize the electronic structure to facilitate thermo-neutral adsorption of H*, thus forming the effective hydrogen spillover channel. Finally, the reconstructed catalyst exhibits excellent HER performance (overpotential of 183 mV at 1000 mA cm −2 in alkaline solution) and sustained high stability for 1000 h at 1000 mA cm −2 , which also shows great promising prospects for practical applications ( E W : 4.09 kW h m −3 ; η ETH : 86%@60 ℃) in anion exchange membrane alkaline water electrolyzer.
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npj Science of Food
·
2025
·Vol. 9
·期 1
·1-11
·
IF 7.8
Ma Bo,Miao Yuanxin,Xu Yan,Li Feng,Zhu Deyan,Li Rong,Huang Yechuan
This study evaluated the in vitro and in vivo antioxidant activities of puerarin (PUE) and β-lactoglobulin (β-lg). The results of the in vitro antioxidant assay revealed that the DPPH and ABTS radical scavenging rates of the PUE/β-lg complex were generally superior to those of free PUE within the tested experimental concentration range. The in vivo antioxidant activity assay, using Caenorhabditis elegans ( C. elegans ) as a model organism, showed that the PUE/β-lg complex significantly increased the superoxide dismutase (SOD) activity and reduced glutathione (GSH) content in C. elegans , and also increased the mean lifespan of C. elegans under oxidative and thermal stress conditions. Transcriptomic analysis showed that the PUE/β-lg complex regulated the mRNA expression levels of genes associated with the activation of various signaling pathways, such as the longevity regulation pathway, insulin signaling pathway, and GSH metabolism. Overall, this study demonstrated the potential of the PUE/β-lg complex as an antioxidant, which can lead to its development into food products or pharmaceuticals.
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AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
·
2025
·
IF 3.3
Hong-Yu Li,Wei-Lan Zeng,Yi-Wen Ye,Xin Chen,Ming-Ming Zhang,Yi-Si Chen,Cui-Ting Liu,Zhun-Qiang Zhong,Jing Li,Yan Wang
Glia maturation factor-β (Gmfb), an actin filament debrancher, was initially identified in brain and recently linked to liver diseases. To investigate the role of hepatocyte Gmfb (hep-Gmfb) in liver reparative regeneration, hepatocyte-specific gmfb knockout (HepGKO) and overexpression (HepGOE) zebrafish strains were constructed. Both transgenic and wild-type (WT) zebrafish underwent partial hepatectomy (PHX) or were fed high fat, high cholesterol diets to model metabolism-associated steatotic liver disease (MASLD). Under physiological conditions, the HepGKO, HepGOE, and WT fish displayed similar survival, gross appearance, and liver histology. Following PHX, WT liver gmfb levels positively correlated with cell proliferation and proinflammatory cytokine levels. HepGOE showed enhanced regeneration and reduced liver steatosis compared to WT, while HepGKO exhibited opposite effects. In MASLD, WT liver gmfb increased with disease progression. HepGKO experienced worsening liver enlargement, steatosis, ballooning, inflammation, and endoplasmic reticulum stress, while HepGOE showed improvements. HepGOE liver had the highest cell proliferation, but all three groups showed similar levels of cell apoptosis. Moreover, elevated proinflammatory cytokines were observed across MASLD groups, being the highest in HepGKO and lowest in HepGOE. However, stat3 activation was the lowest in HepGKO and highest in HepGOE, while jnk and mapk/erk activation was consistent across the MASLD groups. In il6-treated primary hepatocytes, gmfb abundance influenced stat3 activation, and hep-gmfb abundance significantly affected actin filaments distribution in hepatocytes both in vivo and vitro. Conclusions: Hep-Gmfb boosts regenerative processes by enhancing hepatocyte proliferation, alleviating fatty liver histological abnormalities, and modulating the Il6/Stat3 signaling, potentially through remodeling of actin-filament network within hepatocytes.
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Cell Reports Medicine
·
2025
·
IF 10.6
Feixiang Wang,Rujuan Bao,Shuiyu Xu,Wenyan Li,Haiyan Huang,Runchang Li,Xinyu Ding,Yuerong Zhang,Xiaoyan Yu,Qiaoqiao Han,Xian Du,Jie Wan,Song Li,Yichuan Xiao,Ren Zhao,Xingang Cui,Youqiong Ye,Jiayuan Sun,Junke Zheng,Guo-Qiang Chen,Qiang Zou
T cell dysfunction with age underlies an increased incidence of cancer in elderly individuals; however, how T cell aging is triggered in the tumor microenvironment is unclear. Here, we show that an age-associated reduction in adipocyte-derived leptin contributes to the accumulation of tumor-infiltrating senescent CD8 + T cells. Single-cell profiling of human and mouse cancer tissues reveals that the frequency of intratumoral senescent CD8 + T cells increases with age, leading to a weak antitumor effect. Moreover, decreased levels of adipocyte-derived leptin are an indispensable factor for CD8 + T cell aging. Leptin signaling prevents p38-dependent CD8 + T cell senescence. Furthermore, plasma leptin levels are negatively related to intratumoral CD8 + T cell senescence in cancer patients. Our findings identify an unappreciated interplay between metabolic perturbation and T cell aging and suggest that modulating adipocyte-derived leptin levels may be a promising therapeutic strategy for older cancer patients.
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ADVANCED FUNCTIONAL MATERIALS
·
2024
·Vol. 35
·期 16
·2420014
·
IF 18.5
Dongrong Yang,Qiye Guan,Baowen Wang,Da Zhang,Kun Ren,Huangkai Zhou,Xiaoyu Li,Yingjie Zhou,Yongqing Cai,Pan Liu,Lanqing Zhao,Minjie Hou,Bin Yang,Dongfeng Xue,Feng Liang
Solid-state sodium-metal batteries (SSSBs) have emerged as a potential next-generation energy storage technology due to their abundant resource, high energy density, and safety. However, the uncontrolled Na dendrite growth and low charging/discharging rate pose a severe constraint on their practical applications. Herein, high interfacial sodium-ion diffusion performance and interface stability of Na anode are achieved in SSSBs by designing an interfacial built-in electric field (IBEF) driven by a laminated hybrid solid electrolyte with a mixed-ion/electron-conducting layer. The electrochemical characterizations and density functional theory (DFT) calculations reveal that IBEF effectively improves interfacial sodium-ion diffusion by reinforcing electron delocalization and decreasing Na + transfer energy barrier. Furthermore, finite element simulation and experiments indicate that the IBEF endows a uniform interfacial charge distribution and Na deposition during plating/stripping. The IBEF boosts the cyclability of solid-state symmetric cells, enabling ultralong cycle life over 26 400 cycles at 0.1 mA cm −2 , the Na/Na 3 V 2 (PO 4 ) 3 (NVP) full cells display a remarkable capacity retention of 97.4% after 1500 cycles at 2.0 C and stable charging/discharging even at −20 °C. Na/NVP pouch cells exhibit a capacity of 65.7 mAh g −1 after 50 cycles under 0.19 mA g −1 .
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RENEWABLE ENERGY
·
2025
·
IF 9.1
Dandan Zhou,Zhiheng Zhang,Shiyu Zhang,Di Meng,Qiulu Chu,Jing Wang,Shufang Wu,Jinguang Hu
The recalcitrance of softwood towards enzymatic hydrolysis is one of the major bottlenecks hindering its profitable use as feedstock for lignocellulosic biorefinery. This study presents double in-situ lignin modification in an acid-alkaline combinational pretreatment. Results indicated that complete delignification was not essential to achieve theoretical hydrolysis of cellulose. Alternatively, partial lignin removal accompanied by selective modification of the lignin gave rise to significantly inproved ease of enzymatic hydrolysis. Several analyses, including (GPC, 31 P NMR, 2D HSQC NMR, QCM and DLS) were performed to reveal the underlying mechanism of the double in-situ lignin modification in enhancing ease of cellulose hydrolysis. Moreover, detaching behavior of lignin during enzymatic hydrolysis was also elucidated, which provided new insights into understanding the role lignin repolymerization inhibitors and combinational pretreatments played in improving enzymatic digestibility of lignocellulosic biomass.
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