Analytical Methods
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2026
·
IF 3
Zhenpeng Chen,Wenqing Zhang,Fuliang Song,Lei Hu,Chun Kan
Copper nanoclusters (CuNCs) are promising fluorophores, yet their practical applications are often limited by low photoluminescence efficiency and poor environmental stability. Herein, we report an acetone-triggered strategy for constructing stable and strongly emissive L-cysteine-capped CuNC submicron assemblies (L-cys-CuNCs/AC) in water. Upon addition of a small amount of acetone, weakly emissive CuNC precursors rapidly evolved into brightly red-emissive assemblies with an emission maximum at 632 nm. Absolute photoluminescence quantum yield measurements revealed a dramatic increase from 0.11% for the precursor dispersion to 19.92% for the assembled state, confirming a substantial assembly-induced enhancement in fluorescence efficiency. Comparative experiments with other water-miscible organic solvents, including methanol, ethanol, acetonitrile, DMF, and DMSO, showed that none of them induced comparable fluorescence enhancement, highlighting the unique role of acetone in triggering the assembly process. The resulting assemblies also exhibited good storage stability in water for over 3 months. Taking advantage of the strong affinity of cyanide (CN⁻) toward copper species, we further developed a turn-off fluorescent sensor based on an assembly-to-disassembly process. CN⁻-induced chemical etching led to structural disintegration of the assemblies and efficient fluorescence quenching, affording a linear response over 10–100 μM with a detection limit of 5.2 μM. The probe was successfully applied to tap water and artificial lake water samples, providing recoveries of 97.6%–110.3%. This work provides a simple route for constructing highly emissive CuNC assemblies in aqueous media and demonstrates their potential for cyanide analysis in environmental water samples.
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LWT-FOOD SCIENCE AND TECHNOLOGY
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2026
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IF 7.1
Guohua Teng,Min Zhou,Initizar Anwar,Yang Liu,Fuyi Li,Yanxu Chang,Yidan Wang,Yuefei Wang,Fei Tian
Flavonoids in Scutellaria Radix ( SR ) exhibit significant pharmacological activities, yet conventional extraction methods often suffer from low efficiency and poor selectivity. Here, a green and effective strategy was developed using deep eutectic solvent (DES)-functionalized magnetic nanoparticles for selective flavonoid enrichment. Forty-eight DESs were screened, and levulinic acid/L-proline (2:1) was identified as the optimal system. The selected DES was employed to synthesize Fe 3 O 4 @SiO 2 @DES, which demonstrated high specificity and adsorption performance in magnetic solid-phase extraction. Under optimized conditions, adsorption efficiencies for four representative flavonoids ranged from 0.770 ± 0.01 to 0.983 ± 0.002, with desorption recoveries of 0.551 ± 0.003 to 0.919 ± 0.019. The method showed excellent linearity (R 2 ≥ 0.9998) and low limits of detection and quantification (0.01-0.35 μg mL −1 and 0.03-0.98 μg mL −1 , respectively). Moreover, the adsorbent retained high adsorption efficiency after six reuse cycles, demonstrating stability and reusability. This work provides a sustainable and selective approach for flavonoid enrichment from SR and highlights the potential of DES-functionalized magnetic nanomaterials as an eco-friendly alternative to conventional organic solvent-based extraction.
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LANGMUIR
·
2026
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IF 3.9
Min Zhao,Mengyue Wang,Hongzhi Zhao,Zhihui Zhao,Yueyao Liang,Kun Zhang,Weichao Chen
Textile inkjet printing has gained significant traction due to its cleanliness, flexibility, and efficiency. However, its application on wool fabrics is hindered by the inherent ultrahydrophobicity and steric hindrance of the surface scale layer, which leads to poor printing quality. Conventional methods often destructively remove the scale layer to improve the inkjet printing quality, which damages the original structure and strength properties of the fabric. Herein, a novel method based on hydroxylamine chloride (HC)/l-cysteine (L-C) and hydroxypropyl methylcellulose (HPMC) was developed to improve the inkjet printing quality while preserving the raw structure and physical properties of wool fibers. Results showed that HC/L-C cleaved disulfide bonds within the keratin, opening the capillary channel for ink to enter the fiber interior. Meanwhile, amphiphilic HPMC significantly enhanced surface wettability. After combined treatment, the apparent color strength (K/S value) of the printed wool fabric greatly increased from 6.9 to 26.3, which was one of the best performances among existing methods. Moreover, the original structure and physical properties of the wool were preserved. The excellent color fastness was maintained due to the unchanged covalent dye-fixation mechanism. Successful application in the textile industry demonstrated the method’s practical viability. This work presents an efficient and nondestructive approach, offering significant promise for advancing sustainable textile digital printing.
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INDUSTRIAL CROPS AND PRODUCTS
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2026
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IF 6.4
Xue-mei Wang,Hui-dan Shi,Ting-ting Liu,Jia-jia Li,Hai-bo Wu
Root-knot nematodes ( Meloidogyne incognita ) pose a serious threat to global agriculture, necessitating eco-friendly alternatives to synthetic nematicides. This study explores the innovative use of deep eutectic solvents (DES) to extract bioactive compounds from Artemisia rupestris , offering a sustainable approach to nematode management. Six choline chloride (ChCl)-based DES systems were evaluated, revealing extraction efficiency dependent on the hydrogen-bond donor. ChCl–1,4-butanediol (But) yielded the highest thiophene content (143.65 μg/g), which was 2.9 fold greater than that obtained with ethanol. ChCl–urea (U) and ChCl–citric acid (CA) achieved the highest extraction efficiency for phenolics (267.78 mg/g) and flavonoids (175.32 mg/g), respectively. In vitro assays demonstrated that ChCl–But extracts showed the highest nematode mortality at 86.50 %. Thiophene content showed a strong correlation with bioactivity (r = 0.925), identifying it as the principal bioactive driver. Pot trials confirmed a dose-dependent efficacy, with ChCl–But extracts reducing root galling by 79.59 % and nematode populations by 81.65 %. Moreover, the extracts considerably enhanced tomato plant growth, outperforming the commercial nematicide abamectin. Field trials demonstrated that ChCl–But extracts reduced root galling by 68.37 % and second-stage juvenile nematode densities by 66.30 % while increasing tomato shoot biomass by 59.53 %. Five thiophene derivatives were isolated, exhibiting potent nematicidal activity, with xanthopappin A (compound 3 ) showing 4.8 fold greater efficacy (LD 50 = 2.00 mg/L) than abamectin. This study highlights DES as a sustainable platform for valorizing underutilized plant resources, integrating efficient extraction of bioactive thiophenes with the dual benefits of nematode suppression and crop growth promotion. The findings offer scalable solution for sustainable agriculture, addressing environmental and resistance challenges in nematode management.
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EUROPEAN JOURNAL OF NUTRITION
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2026
·Vol. 65
·期 2
·52
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IF 4.5
Liu Kaiyue,Li Na,Fan Jiayi,He Siliang,Tang Weixiang,Cao Yaxin,Shen Liang,Sun Shuyang,Du Chengcheng,Du Chao
Purpose This study investigated the basic composition, in vitro digestibility, biological activities, and potential bioactive peptides of Pacific oyster (PO), Mytilus edulis (ME), Argopecten irradians (AIS), and Meretrix meretri x L. (MML) after simulated gastrointestinal digestion (SGD). Methods SGD products were prepared using the INFOGEST 2.0 model, and their nutritional properties and biological activities were analyzed. A comprehensive peptidomic profiling of the digested samples was conducted using nano-liquid chromatography-tandem mass spectrometry (nano-LC MS/MS) analysis. Results All four shellfish exhibited a nutritional profile characterized by high protein and low-fat content. The digestibility of shellfish increased progressively, while the average molecular weight (MW) of the hydrolysates gradually decreased during SGD, with the intestinal hydrolysates showing the highest overall digestibility. Biological activity analysis demonstrated that intestinal digestion products from all four species exhibited notable ABTS radical scavenging activity and α-glucosidase inhibition activity, with PO and ME exhibiting the strongest effects. A total of 349, 99, 314 and 105peptides were identified from the digestion products of PO, ME, AIS, and MML, respectively. Among these, PO and AIS showed the highest sequence similarity, sharing 69 identical peptides. By contrast, MML displayed distinct peptidomic characteristics, including a higher proportion of large MW peptides. Conclusion This study provides a comprehensive peptide catalog of shellfish digestion products and offers new insights into the biological activities of shellfish-derived peptides, supporting their potential as functional food resources.
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PLANT FOODS FOR HUMAN NUTRITION
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2026
·Vol. 81
·期 1
·22
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IF 3.6
Xu Yazhou,Xiong Tao,Kang Xinyi,Ma Fang,Zhang Linli,Zhao Mingwei,Xue Lu,Xie Mingyong,Yu Qiang
The development of natural anti-hyperglycemic agents with minimal side effects is a critical objective in functional food research. This study comprehensively investigated the anti-diabetic potential and bioactive substances in guava juice fermented with Lacticaseibacillus paracasei NCUH012072 (FM). Using an integrated in vitro and metabolomic approach, the anti-hyperglycemic activity was systematically assessed through a series of bioassays (enzyme inhibition, antioxidant capacity, and insulin-resistant cell models), untargeted metabolomics, and bioinformatic and affinity-based validation. The results demonstrated that FM significantly inhibited key carbohydrate-metabolizing enzymes ( α -amylase, α -glucosidase) as well as the insulin signaling regulator protein tyrosine phosphatase 1B (PTP1B) ( P < 0.05). Additionally, FM exhibited enhanced antioxidant capacity and improved glucose uptake in insulin-resistant HepG2 cells ( P < 0.05). Untargeted metabolomics revealed that fermentation modulated 13 pivotal metabolic pathways. Integrated analysis using Spearman correlation and random forest modeling identified key anti-hyperglycemic metabolites, including flavonoids ( e.g ., liquiritigenin), phenolic acids ( e.g ., cis-caffeic acid), and redox-active compounds such as (R)-lipoic acid. Affinity ultrafiltration combined with liquid chromatography-mass spectrometry (AF-LC-MS) further characterized quercetin 3-galactoside and resveratrol as potent inhibitors of the target enzymes. This study not only systematically demonstrates the anti-hyperglycemic properties of probiotic-fermented guava juice but also proposes a comprehensive strategy for identifying bioactive compounds in complex food matrices. The findings offer a theoretical basis for developing fermented fruit-based functional foods as dietary strategies in hyperglycemia management.
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Polymers
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2026
·Vol. 18
·期 3
·378
·
IF 4.9
Lin Sun,Zihao Zhang,Bingxin Sun,Zhiheng Yu,Guoyong Wang
Vanadium carbide (V 2 C) MXene shows great potential for addressing challenging implant-associated infections in bone regeneration due to its strong photothermal conversion efficiency. However, its photothermal efficacy is restricted to the near-infrared I (NIR-I) region due to a limited absorption range. To address this, we designed platinum nanoparticle-decorated V 2 C heterostructures (Pt@V 2 C) via an in situ growth method, leveraging Pt’s plasmonic and catalytic properties to extend the photoresponse to the NIR-II window. Subsequently, Pt@V 2 C was integrated into poly-L-lactic acid (PLLA) to fabricate PLLA-Pt@V 2 C scaffolds with photothermal antibacterial function by selective laser sintering. The optimized PLLA-Pt@V 2 C scaffold achieves a record photothermal conversion efficiency (56.03% at 1064 nm), triggering simultaneous hyperthermia (>52 °C) and catalytic ·OH radical generation. In vitro studies demonstrate exceptional antibacterial efficacy against Staphylococcus aureus and Escherichia coli, achieving over 99% killing rates upon 1064 nm near-infrared irradiation. Furthermore, the scaffold demonstrated significant inhibition of biofilm formation, achieving over 90% reduction in biofilm biomass. Moreover, the scaffold demonstrated high cell viability, confirming its dual functionality of potent bactericidal activity and biocompatibility that supports tissue regeneration. This work provides a feasible strategy for combating implant-associated infections.
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Scientific Reports
·
2026
·
IF 4.9
Pei Shuchen,Yan Kangli,Cai Shaoyu,Hou Yinjun,Luo Kang,Xiang Pu,Peng Yang
This study demonstrates a one-step hydrothermal synthesis of bright yellow phosphorus-doped carbon quantum dots (P-CQDs) using Caesalpinia sappan L. as carbon source. Comprehensive characterization through TEM, XPS, UV-Vis and FTIRspectroscopy confirmed the successful formation of P-CQDs. The obtained P-CQDs exhibited exceptional selectivity and was capable of detecting ciprofloxacin across a wide linear range of 0.01–0.1 µM, with a LOD determined to be 2.06 nM. Antimicrobial assays revealed MIC values of 7.14 µg/mL and 8.33 µg/mL against S. aureus and E. coli , respectively. Practical application studies confirmed their efficacy for rapid CIP detection in milk samples, establishing a novel sensing platform for food safety monitoring. This work provides valuable insights into the multifunctional applications of carbon dots in food chemistry and biomedical fields.
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POLYMER ENGINEERING AND SCIENCE
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2026
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IF 3.6
Lei Gong,Yuesheng Zhang,Enyang Xu,Hongtao Lu,Junrui Duan,Jianna Bao
In this work, poly(L-lactide-co-ε-caprolactone) (PLCL) copolymers with varying ε-caprolactone (ε-CL) contents that ranged from 0% to 10% were synthesized via ring-opening polymerization of L-lactide and ε-CL at 170°C for 1 h. Fully biodegradable PLCL/poly(D-lactide) (PDLA) blends with stereocomplex (SC) crystallites were fabricated through a solution blending approach. The effects of ε-CL content in PLCL on the crystallization behavior, thermal properties, mechanical performance, and degradation behavior of PLCL/PDLA blends were systematically investigated. The successful synthesis of PLCL was confirmed by 1 H NMR and FTIR analyses. The melting peaks observed in the high-temperature region and the characteristic diffractions in WAXD patterns provided evidence for the formation of SC crystallites in PLCL/PDLA blends. Compared with PLCL, the incorporation of PDLA significantly enhanced the crystallization rate, due to the nucleation function of SC crystallites. With increasing ε-CL content in the copolymer system, the T g and crystallinity of PLCL gradually reduced, and the melting peaks of HC and SC crystals shifted toward lower temperatures due to the reduced sequence regularity. A pronounced improvement in deformability was achieved by the presence of ε-CL segments. As the ε-CL content increased from 1.5% to 10%, the elongation at break rose from 12% to 192%, with the morphology of elongated fibrils. Higher ε-CL contents accelerated enzymatic degradation, with mass loss exceeding 75% after 7 days at 10% ε-CL, because the increased chain mobility may facilitate the penetration of water and Proteinase K into the blend, thereby promoting enzymatic erosion. Overall, high-performance PLA-based composites with excellent biodegradability were achieved via SC crystallization and modulation of ε-CL comonomer content. Summary PLCL copolymers with tunable ε-CL content were prepared and characterized. SC crystallization regulated the crystallization and thermal behavior. ε-CL segments enhance chain mobility and improve blend deformability. Enzymatic degradation kinetics were accelerated as ε-CL content increased.
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JOURNAL OF CONTROLLED RELEASE
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2026
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IF 12.4
Yue Hu,Tiancong Liu,Yahan Zhang,Mengmeng Ding,Guang Shi,Haiying Su,Jian Guan,Xinyu Fan
L-type amino acid transporter 1 (LAT1) is essential for the transport of large neutral amino acids (AA) across the blood–brain barrier (BBB), which plays a crucial role and is widely employed in brain drug delivery. Thus, in this study, tryptophan (Trp), leucine (Leu) and tyrosine (Tyr) were selected and various amino acid grafted chitosan (CTS) was first synthesized and characterized by Fourier transform infrared spectroscopy (FTIR) and 1 H nuclear magnetic resonance ( 1 H NMR) spectrum. Furthermore, oxytocin (OT) loaded polyelectrolyte complex (PEC) based on various amino acid grafted chitosan and chondroitin sulfate (CS) as well as OT loaded chitosan-chondroitin sulfate PEC was fabricated and optimized by particle size, zeta potential and encapsulation efficiency (EE%). The morphologies and OT conformation stability of different PEC formulations were investigated by transmission electron microscopy (TEM) and circular dichroism (CD) spectroscopy respectively. Moreover, to further reveal the superiority of amino acid grafted chitosan PECs on mucosal permeation and brain targeting via LAT1 transporter, the ex vivo permeation study, in vivo pharmacokinetics behavior as well as brain distribution of OT in different PECs were also carried out by intranasal administration. It was found that both chitosan-chondroitin sulfate and amino acid grafted chitosan-chondroitin sulfate PECs exhibited comparable particle size ranging from 180 to 210 nm with a positive charge. The PEC formulation presented a sustained release behavior compared to the OT solution and better nasal mucosal permeation was observed for amino acid grafted chitosan-chondroitin sulfate PECs. Both pharmacokinetics behavior and brain distribution results demonstrated that amino acid grafted chitsaon could significantly improve the OT absorption and brain accumulation in the order of Trp > Tyr > Leu, compared to naked chitosan-chondroitin sulfate PECs and OT solution. The behavioral and immunofluorescence results also revealed that amino acid grafted chitosan-chondroitin sulfate PECs exhibited a superior inhibitory effect on oxycodone (Oxy) addiction. In conclusion, amino acid grafted chitosan-chondroitin sulfate PECs could significantly promote brain drug transportation and could be a potential vehicle for protein or peptide delivery via nasal to brain pathway.
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TALANTA
·
2026
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IF 6.7
Ruyu Li,Tingting Zhang,Lijie Zhou,Jingjing Feng,Longgang Wang,Haiyan Xiao
Pd 3 Au-LCLP NPs-DOX with anti-protein adsorption properties was prepared. • Pd 3 Au-LCLP NPs-DOX exhibit good enzyme-like activity and photothermal performance. • More DOX was released under the irradiation of 808 nm laser. • Pd 3 Au-LCLP NPs-DOX shows significant anti-tumor effects by multi-therapy. Traditional cancer therapies are limited by severe side effects and therapeutic challenges, while noble metal nanozymes offer promising enzyme-like therapeutic potential but remain constrained by poor aqueous stability. In this work, palladium-gold bimetallic nanoparticles (Pd 3 Au-LCLP NPs) with peroxidase-like activity were constructed using Leonurus cardiaca L. polysaccharide as both a reducing agent and stabilizing template, and further loaded with doxorubicin (DOX) to form Pd 3 Au-LCLP NPs-DOX. The resulting nanoplatform exhibited excellent water dispersibility, structural stability, anti-protein adsorption capability, and enhanced photothermal conversion performance. Under 808 nm laser irradiation, Pd 3 Au-LCLP NPs-DOX achieved a cumulative DOX release of 81% at pH 5.5. In vitro , it showed significant cytotoxicity against A549 and HeLa cells. In vivo , the tumor inhibition rate reached 82.6%. Overall, this combined therapeutic strategy integrating chemodynamic therapy (CDT), photothermal therapy (PTT), and chemotherapy (CT) demonstrated strong synergistic anti-tumor efficacy. Download: Download high-res image (393KB) Download: Download full-size image
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Frontiers of Materials Science
·
2026
·Vol. 20
·期 2
·260766
·
IF 2.3
Zhou Tao,Song Liying,Ding Hongmeng,Wang Jing,Sui Lina,Song Na,Yu Liyan,Wei Qingli,Dong Lifeng
Lead is a highly toxic and persistent heavy metal that poses serious risks to human health. The detection of lead ions in water is therefore essential not only for balancing economic and environmental priorities, improving public services, and ensuring agricultural safety, but also for preventing lead poisoning, promoting health equity, and safeguarding international trade in the context of global health. Conventional detection methods are often limited by expensive instrumentation and complex procedures, whereas surface-enhanced Raman scattering (SERS) has emerged as a promising alternative due to its high sensitivity and operational simplicity. In this study, we developed an ultrasensitive SERS-based method for the Pb 2+ detection using L-cysteine-functionalized bismuth nanoparticles as probes. L-cysteine binds Pb 2+ through its −COOH and −NH 2 groups, inducing nanoparticle aggregations and generating Raman hotspots that enhance the signal of 4-aminothiophenol (4-ATP). Additionally, an electrodeposited bismuth substrate further amplifies the SERS response. This method achieves a detection limit as low as 0.005 nmol·L −1 (1.04 · 10 −3 µg·L −1 ), demonstrating 2–5 orders of magnitude greater sensitivity compared to conventional lead ion detection techniques.
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危险品化学品经营许可证（带存储）