CHINESE JOURNAL OF CHEMICAL ENGINEERING
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2024
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IF 3.7
Yue Zhou,Wenjun Li,Hongjun Hu,Zhaohui Wang,Zhaoliang Cui
The membrane aeration biofilm reactor (MABR) represents an innovative approach to wastewater treatment, integrating gas separation membranes with biofilm process and demonstrating effectiveness in treating wastewater rich in ammonia nitrogen. In this system, hollow fiber membranes are essential, serving as a substrate for biofilm attachment while facilitating oxygen transfer to microorganisms through aeration, hydrophobic microporous membranes are utilized in MABR applications. This study focuses on the use of poly-4-methyl-1-pentene (PMP) hollow fiber membranes, which exhibit superior oxygen permeation capabilities compared to traditional hydrophobic microporous membranes. To overcome the challenges posed by the hydrophobic nature and low bubble point of PMP microporous membranes, a hydrophilic modification was conducted using dopamine/poly(ethyleneimine) (DOPA/PEI) co-deposition to enhance microbial adhesion on the membrane surface. The composite membrane modified with DOPA/PEI exhibited an approximately 20% higher NH 4 + -N removal efficiency than the unmodified membrane. These findings suggest that the incorporation of DOPA/PEI significantly improves MABR performance, underscoring its potential for further research and development in membrane technology for MABR.
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EUROPEAN JOURNAL OF PAIN
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2024
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IF 3.5
Hao-Nan Zheng,Yu-Ru Zhi,Yang-Shuai Su,Jin-Yan Jiang,Hao-Zhou Zhang,Feng Cao,Yun Wang,Yan Chi,Ying Zhang
Background Visceral hypersensitivity is considered the core pathophysiological mechanism that causes abdominal pain in patients with irritable bowel syndrome (IBS). Fungal dysbiosis has been proved to contribute to visceral hypersensitivity in IBS patients. However, the underlying mechanisms for Dectin-1, a major fungal recognition receptor, in visceral hypersensitivity are poorly understood. This study aimed to explore the role of Dectin-1 in visceral hypersensitivity and elucidate the impact of Dectin-1 activity on the function of transient receptor potential vanilloid type 1 (TRPV1). Methods Visceral hypersensitivity model was established by the intracolonic administration of 0.1 mL TNBS (130 μg/mL in 30% ethanol) in the male mice. Fluconazole and nystatin were used as fungicides. Laminarin, a Dectin-1 antagonist and gene knockout ( Clec7a −/− ) mice were used to interrupt the function of Dectin-1. Colorectal distension-electromyogram recording was performed to assess visceral sensitivity. Immunostaining experiment was performed to determine the localization of Dectin-1 in dorsal root ganglion (DRG) neurons. Calcium imaging study was performed to assay TRPV1-mediated calcium influx in acutely dissociated DRG neurons. Results Pretreatment with fungicides, administration of laminarin or genetic deletion of Clec7a alleviated TNBS-induced visceral hypersensitivity in male mice. The expression of Dectin-1 was upregulated in the DRG and colon of TNBS-treated mice. Colocalization of Dectin-1 and TRPV1 was observed in DRG neurons. Importantly, pretreatment with curdlan, a Dectin-1 agonist, increased TRPV1-mediated calcium influx. Conclusions Dectin-1 contributes to visceral hypersensitivity in IBS or in inflammatory bowel disease in remission and activation of Dectin-1 induces TRPV1 sensitization. Significance Statement This work provides direct evidence for the functional regulation of TRPV1 channel by Dectin-1 activity, proposing a new mechanism underlying TRPV1 sensitization. Control of intestinal fungi might be beneficial for the treatment of refractory abdominal pain in patients with IBS or IBD in remission.
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JOURNAL OF COLLOID AND INTERFACE SCIENCE
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2024
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IF 9.4
Jingwen Liu,Junfeng Ren,Yongkang Li,Yuchen Wang,Caixia Li,Zexing Wu,Jianping Lai,Yu Yang,Lei Wang
Organic acid treatment can facilitate the in-situ formation of a solid electrolyte interface (SEI) on Zn foil protecting the anode from corrosion. However, the generation of hydrogen (H 2 ) during this process is inevitable, which is often considered detrimental to getting compact SEI. Herein, a H 2 film-assisted method is proposed under concentrated Amino-Trimethylene-Phosphonic-Acid to construct ultrathin and dense SEI within 1 min. Specifically, the (0 0 2) crystal planes survive from the etching process of 1 min due to the adhered H 2 , inducing uniform deposition and enhanced corrosion-resistance. Moreover, the H 2 can effectively regulate the reaction rate, leading to ultrathin SEI and initiating a morphology preservation behavior, which has been neglected by the previous reports. The quick-formed SEI has excellent compatibility, low resistance and effective isolation of electrolyte/anode, whose advantages work together with exposed (0 0 2) planes to get accustomed to high-current surge, leading to the ZAC1@Zn//ZAC1@Zn consistently cycling over 800 h at 15 mA cm −2 and 15 mAh cm −2 , the ZAC1@Zn//Cu preserves high reversibility (CE 99.7 %), and the ZAC1@Zn//MVO exhibits notable capacity retention at 191.7 mAh/g after 1000 cycles.
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SEPARATION AND PURIFICATION TECHNOLOGY
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2024
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IF 8.1
Shuangqi Song,Hong Li,Jingde Li,Yanqin Yang
The trade-off limitation between permeability and selectivity has hindered the widespread applications of polymer membranes. The integration of solid fillers into polymer membranes, namely the development of mixed-matrix membranes (MMMs), can overcome the trade-off effect, serving as an effective method to fabricate high-performance membranes. Porous organic polymer of PP, made from dichloro- p -xylene via Friedel-Crafts alkylation reaction, is excellent candidate for MMMs fabrication. However, tailoring PP for membrane CO 2 separation with desirable performance is still a challenge. Herein, we report the development of a functionalized PP, namely PP@oPIM-1, which is achieved by covalently grafting PIM-1 oligomers (oPIM-1) on the surface of PP. This functionalized product is used as a filler material to construct MMMs. Compared to PP-loaded MMMs, the MMMs containing PP@oPIM-1 filler demonstrate improved interfacial adhesion. Thanks to the excellent interfacial compatibility, the tensile strength of 10 wt% PP@oPIM-1/Matrimid is 59.29 MPa, which is higher than 30.24 MPa and 54.06 MPa for 10 wt% PP/Matrimid and pure Matrimid membrane, respectively. Meanwhile, the interweaving structures between oPIM-1 network on the surface of PP@oPIM-1 and polymer chains of matrix lead to the formation of highly interconnected paths between two phases, which is beneficial to fully demonstrating the advantages of filler in selective permeation of gas molecules. As such, the 10 wt% PP@oPIM-1/Matrimid membrane displays a CO 2 permeability of 17.4 Barrer and CO 2 /N 2 selectivity of 46.7, which are increased by 104.7 % and 51.1 % compared to the bare Matrimid membrane. Additionally, the broad applicability of PP@oPIM-1 in various polymer matrices, such as 6FDA-DAM polyimide and PIM-1, has also been explored.
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Fermentation-Basel
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2025
·Vol. 11
·期 4
·168
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IF 3.3
Yiyan Zhang,Xiongyao Ma,Zhe Xu,Xiangyu Gu,Xiangyang Gu
Lycopene is a natural carotenoid with antioxidation properties. The objective of the present study was to investigate the roles of glutamate and proline in lycopene biosynthesis in a newly isolated purple non-sulfur bacteriumCereibacter sphaeroidesDT.1, under aerobic conditions. This strain contained a distinct CrtI4capable of converting phytoene to lycopene via four-step desaturation. In order to enhance lycopene production, acrtCknockout mutant was constructed via homologous recombination. Supplementation with glutamate or proline to fermentative medium significantly enhanced intracellular lycopene accumulation in wildtype strain by a respective 99.40 ± 0.54% and 101.70 ± 0.49% and in aΔcrtCmutant strain by 38.13 ± 0.15% and 39.83 ± 0.27%, respectively. Differential transcriptomic and metabolomic analyses showed that these promoting effects were associated with downregulation of the expression of the acyclic carotenoid 1,2-hydratase gene, and increased accumulation of lycopene precursors such as pyruvate and acetyl-CoA. The fermentation conditions for lycopene production were optimized through shake flask experiments. Feasibility for lycopene production was confirmed in a fed-batch cultivation process and a high yield of 151.10 ± 0.13 mg/L was achieved. ThisΔcrtCmutant strain exhibited advantages, such as relatively lower oxygen demand and no need for illumination, making it a potentially useful strain for lycopene production under aerobic conditions.
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EUROPEAN JOURNAL OF MEDICAL RESEARCH
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2024
·Vol. 29
·期 1
·1-14
·
IF 2.8
Zhao Xun,Yuan WenQiang,Yang LiuChan,Yan Fang,Cui DeJun
Background Worldwide, ulcerative colitis (UC) is becoming increasingly fast growing. Ginsenoside Rh2 has been reported to alleviate UC. However, the latent biological mechanism of Rh2 in the treatment of UC remains uncertain. In this study, the goal was to determine the therapeutic effect of Rh2 on dextran sulfate sodium (DSS)-induced UC. Methods A DSS-induced UC mouse model was established and divided into 7 groups for Rh2 gavage and/or miR-125a-5p lentivirus injection (n = 10 per group). Colonic specimens were collected for phenotypic and pathological analysis. miR-125a-5p and specific protein 1 (SP1) expression, inflammation-related factors IL-6 and IL-10, and apoptosis were detected in mice. Human normal colon epithelial cell line NCM460 was treated with H 2 O 2 and ferric chloride hexahydrate to construct an in vitro cell model of colitis and induce ferroptosis. Independent sample t-test was used to compare cell proliferation, cell entry, apoptosis, and oxidative stress between the two groups. One way analysis of variance combined with the least significant difference t test was used for comparison between groups. Multiple time points were compared by repeated measurement analysis of variance. Results DSS-induced UC mice had significantly decreased body weight, increased disease activity index, decreased colon length, and decreased miR-125a-5p expression (all P < 0.05). In the DSS-induced mouse model, the expression of miR-125a-5p rebounded and ferroptosis was inhibited after Rh2 treatment (all P < 0.05). Inhibition of miR-125a-5p or upregulation of SP1 expression counteracted the protective effects of Rh2 on UC mice and ferroptosis cell models (all P < 0.05). Conclusions Rh2 mitigated DSS-induced colitis in mice and restrained ferroptosis by targeting miR-125a-5p. Downregulating miR-125a-5p or elevating SP1 could counteract the protective impacts of Rh2 on ferroptotic cells. The findings convey that Rh2 has a latent application value in the treatment of UC. Graphical Abstract
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COMBUSTION AND FLAME
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2024
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IF 5.8
Jiuzheng Yin,Xiaoli Zhang,Fangping Bin,Jinzeng Pan,Haikun Lang,Lidong Zhang,Lixia Wei
Olefins are important components in gasoline fuels as well as essential intermediates in the combustion of carbon-based fuels and oxy-fuels. Therefore, it is essential to investigate the oxidation chemistry of olefins, especially of long-chain olefins, to gain a deeper insight into the combustion of these fuels. 1-Decene is an important industrial chemical product and is often regarded as one of the representatives of long-chain olefins. This work investigated the low-temperature oxidation of 1-decene in a jet-stirred reactor with atmospheric pressure, temperature range of 700 – 900 K and equivalence ratio of 1.0. Twelve main oxidation species were detected and measured, by gas chromatography-mass spectrometry, including carbon dioxide, ethylene, ethane, acrolein, 1,3-butadiene, 1-butene, 1-pentene and benzene, etc. Based on previous reports, a detailed low-temperature oxidation kinetic model of 1-decene was developed and validated against the experimental data and literature data. In the model of 1-decene, the rate of production analysis revealed that the majority of 1-decene was consumed by H-abstractions to generate the primary radicals and OH-addition reaction onto C(1) to generate 1-decanol-2-yl radical. Sensitivity analyses show that H 2 O 2 (+ M) = OH + OH (+ M) was the most sensitive reaction to promote 1-decene consumption. The decomposition of hydrogen peroxide was the main source of the hydroxyl radical. Simulation results indicate that ignition delay time of 1-decene is higher than that of n -decane in the low-temperature at equivalence ratios of 0.5 – 2.0 and pressure of 20, 40 bar.
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INTERNATIONAL DAIRY JOURNAL
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2024
·
IF 3.1
Zhiwen Ge,Dan Wang,Mingsheng Dong,Wenting Zhao,Pan Wang,Peiyou Qin,Xiaoyan Zhao
The functional properties of foods are closely related with its matrix. This study examined the impact of curcumin-fortified Lactobacillus helveticus MB2-1 fermented milk gel on the intestinal lipid digestion and bioaccessibility of curcumin through dynamic digestion method. The gel properties, microstructure, oil droplets stability, free fatty acid (FFA) release and curcumin bioaccessibility during digestion of the curcumin-fortified milk gels fermented by L. helveticus MB2-1 or tradition commercial starters ( Streptococcus thermophilus and Lactobacillus bulgaricus ) were investigated and compared. The curcumin-fortified L. helveticus MB2-1 fermented milk gel was found to present higher apparent viscosity, more thicker properties, and firmer texture, which affect the gastrointestinal digesta status together with the release of oil droplets and solubilized curcumin, promote lipid digestion as well as enhance the bioaccessibility of curcumin during digestion. These results may provide valuable references for the design of therapeutic dairy products beneficial to health in terms of food matrix.
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FUEL
·
2024
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IF 6.7
Xin Guo,Zhiyuan Wang,Siqi Jiang,Mengwei Li,Jianing Guo,Yu Cui,Xueyang Wei,Baohui Qi,Qizhong Huang,Yanduo Liu,Hongquan Jiang,Yufeng Hu
Photocatalytic technology for converting CO 2 into useful chemicals or clean energy is an effective strategy to solve today's energy and environmental problems. In this study, we present a direct photocatalytic pathway for the conversion of CO 2 -to-CO involving the formation and activation of carboxyl intermediates over amino-functionalized ionic liquid (3-aminopiperidine hydrochloride, [3APip]Cl)-modified titanium silicalite-1 (TS-1) molecular sieve nanosheets . Various in-situ characterizations reveal that the key to activating this pathway lies in the CO 2 adsorption capacity and the efficiency of photoexcited charge migration induced by [3APip]Cl in the hybrid catalyst. In the above catalytic pathway, CO 2 molecules are first adsorbed on the surface of the [3APip]Cl/TS-1 hybrid catalyst under the induction of amino groups in the ionic liquid. Then, these adsorbed CO 2 are activated and transformed into carboxyl intermediate, which can be further converted into CO and CH 4 through photoexcited electrons captured by [3APip]Cl. Based on the results of CO 2 reduction performance, the optimized [3APip]Cl/TS-1 hybrid catalyst achieves a 6-fold increase, and the CO selectivity is 83.0%. This research provides new insights into the CO 2 reduction pathway in mild conditions and emphasizes the importance of the adsorption–activation tandem process for enhancing photoactivity and selectivity.
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FREE RADICAL BIOLOGY AND MEDICINE
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2024
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IF 7.1
Deshan Yao,Liuxiang Bao,Sichuan Wang,Meng Tan,Yuanyuan Xu,Tianxu Wu,Zhengang Zhang,Kaizheng Gong
Ischemia-reperfusion (I/R) injury, a multifaceted pathological process, occurs when the prolongation of reperfusion duration triggers ferroptosis-mediated myocardial damage. Isoliquiritigenin (ISL), a single flavonoid from licorice, exhibits a wide range of pharmacological impacts, but its function in ferroptosis caused by myocardial I/R injury remains unclear. This study delved into the protective effect of ISL on myocardial I/R injury-induced ferroptosis and its mechanism. Neonatal mouse cardiomyocytes (NMCM) underwent hypoxia/reoxygenation (H/R) to simulate the pathological process of myocardial I/R. ISL significantly attenuated H/R-triggered production of reactive oxygen species in NMCM, reduced the expression of malondialdehyde and the activity of lactate dehydrogenase, enhanced superoxide dismutase and catalase activity, and increased the expression of nuclear factor E2-related factor 2 (Nrf2) and its downstream heme oxygenase 1 (HO-1), thereby mitigating oxidative stress damage. CCK8 experiment revealed that the ferroptosis inhibitor Ferrostatin-1 significantly improved myocardial cell viability after 24 h of reoxygenation, and ISL treatment showed a similar effect. ISL reduced intracellular free iron accumulation, up-regulated glutathione peroxidase 4 (GPX4) and solute carrier family 7 member 11 (SLC7A11) expression, and inhibited lipid peroxidation accumulation, thereby alleviating ferroptosis. The Nrf2-specific inhibitor ML385 counteracted ISL's defensive role against H/R-triggered oxidative stress damage and ferroptosis. In vivo experiments further confirmed that by regulating the translocation of Nrf2 into the nucleus, ISL treatment increased the levels of HO-1, GPX4, and SLC7A11, inhibited the expression of ACSL4, Drp1 to exert the antioxidant role, alleviated mitochondrial damage, and ferroptosis, ultimately reducing myocardial infarction area and injury induced by I/R. ML385 nearly abolished ISL's protective impact on the I/R model by inhibiting Nrf2 function. In summary, ISL is capable of mitigating oxidative stress, mitochondrial damage, and cardiomyocyte ferroptosis caused by I/R, thereby reducing myocardial injury. A key mechanism includes triggering the Nrf2/HO-1/SLC7A11/GPX4 pathway to prevent oxidative stress damage and cardiomyocyte ferroptosis caused by I/R.
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AICHE JOURNAL
·
2025
·
IF 4
Lizhi Wu,Ying Zhang,Caixin Zou,Qin Sun,Baozhen Li,Wenchun Zheng,Jiamin Liu,Juncheng He,Yu Tang,Li Tan
Ethane dehydrogenation to aromatics (EDA) is one of the most promising routes to produce aromatics. Herein, the tandem of dehydrogenation component and acidic zeolite are prepared and investigated for EDA. Pt/Fe-S-1 coupled with ZSM-5 of Si/Al of 14 via mixing homogeneously shows excellent EDA performance with 54.0% ethane conversion, 61.5% aromatics selectivity as well as a deactivation rate constant of 0.00010 h −1 . According to catalysts characterizations and controlled experiments, it is confirmed the highly dispersed positive Pt δ + species around Fe species over Pt/Fe-S-1 is the active sites for ethane dehydrogenation to ethylene and subsequent naphthenes dehydrogenation to aromatics, Brønsted acid sites of ZSM-5 and MFI pore are responsible for ethylene oligomerization and cyclization to naphthenes and further naphthenes dehydrogenation to aromatics. The short spatial space between dehydrogenation active sites and acid sites is beneficial for EDA. And the ethylene generation rate is the rate-determining step of EDA.
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MICROPOROUS AND MESOPOROUS MATERIALS
·
2025
·
IF 4.7
Beining Luo,Yan Wang,Yingqi Zhang,Caifeng Qiu,Guoqiang Yu,Liang Li,Xianzai Yan,Guoqiang Wu
Catalytic epoxidation limitations of conventional ellipsoid titanosilicate-1 (TS-1) remains owing to the narrow microporous channels and low efficiency of the Ti species. Herein, two-dimensional planer TS-1 zeolite (TS-1-P) was synthesized by adding crystal growth regulator in the hydrothermal synthesis process, and then TS-1-P supported molybdenum (Mo/TS-1-P) and mesoporous Mo/TS-1-P (Mo/MTS-1-P) were prepared and applied in epoxidation of olefins. The TS-1-P and the modified TS-1-P catalysts show a similar MFI framework and grain morphology but the different pore structure and coordination environment of Ti or Mo species. Especially, the Mo/MTS-1-P possesses many mesoporous pore and highly dispersed Mo species, which can improve the coordination environment of Ti species and weaken the Ti-O bond, the results are beneficial for the framework Ti species to combine more easily with H 2 O 2 to C=C band of the olefin molecules. Therefore, compared with TS-1-P, Mo/MTS-1-P exhibits the highest conversion of ACH (91.78 %) and 1-hexene (47.44 %) in the epoxidation of ACH and 1-hexene, respectively, the selectivity of epoxidized products simultaneous is above 96.42 % and 94.04 %, respectively. Moreover, the deactivation behavior of carbon deposit on the catalyst surface and regeneration method were also proposed. The successful preparation of Mo/MTS-1-P not only results in an efficient catalyst for epoxidation process but also provides a possible approach for surface and pore structure modification of TS-1 zeolite.
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