BIOSENSORS & BIOELECTRONICS
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2021
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IF 10.618
Jiantao Ping,Lubin Qi,Quanbo Wang,Shuhua Liu,Yifei Jiang,Li Yu,Jin-Ming Lin,Qiongzheng Hu
The abnormal levels of trypsin in biological fluids can cause some acute illnesses, such as acute pancreatitis, cystic fibrosis and malnutrition. In this paper, we report the development of an integrated liquid crystal (LC) sensing device for simple, rapid and sensitive detection of trypsin assisted by the surfactant-embedded smart hydrogel. The gelatin hydrogel mixed with CTAB is added into the side channel of the LC sensing device. In the presence of trypsin, the gelatin hydrogel is decomposed, which triggers instant release of CTAB into the aqueous solution. The CTAB molecules are then captured by the LCs and form CTAB monolayers at the aqueous/LC interface, which leads to change of the LC images from the bright to the dark appearance under the crossed polarizers. The integrated LC sensing device has a remarkable detection limit of 3.4 × 10 −5 mg/mL. It is successfully employed to single-step detection of trypsin in human serum within 30 min. The integrated LC sensing device with use of the surfactant-embedded hydrogel takes advantages of single-step detection, high portability, remarkable sensitivity and fast response time, which provides a new perspective to facilitate development of user-friendly LC-based sensors.
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SEPARATION AND PURIFICATION TECHNOLOGY
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2021
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IF 7.312
Xuejiao Zhang,Shijun Deng,Huachang Jin,Yang Yu,Shuai Liao,Xueming Chen
Previously, we invented and investigated membrane-free electrodeionization (MFEDI), a novel deionization technique that uses ion exchange resins as the critical material, for the production of high-purity water. However, the functional materials used in MFEDI are common resins that cannot simultaneously achieve effective adsorption, easy electrical regeneration, and good conductivity. For instance, strong acid resin, a cation exchange resin commonly used in MFEDI, cannot be easily electrically regenerated; weak acid resin can be easily regenerated, but has poor conductivity and adsorption properties. There are currently no available resins that can meet all of the requirements of conductivity, adsorption and regeneration properties. In this study, a novel amphoteric resin was prepared and characterised. This amphoteric resin contained much more cationic functional groups than anionic functional groups, behaving as a medium-strength acid resin due to the introduction of anionic functional groups. The prepared amphoteric resin exhibited better purification property than weak acid resin, and could be electrically regenerated more easily than strong acid resin. When the amphoteric resin was coupled with strong base resin and the conductivity of the purified water was kept below 0.10 µs/cm, the water recovery and energy consumption were 74.60% and 0.84 kWh/m 3 water, respectively. By contrast, the energy consumption and water recovery were 40.74% and 2.65 kWh/m 3 water for strong acid resin, and 64.44% and 1.53 kWh/m 3 water for weak acid resin under similar conditions. Clearly, the developed amphoteric resin significantly improves the MFEDI properties.
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Inorganic Chemistry Frontiers
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2021
·Vol. 8
·期 14
·3473-3481
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IF 6.569
Mili Liu,Hui Liu,Kang Chen,Jiangyong Sun,Hui Wang,Jiangwen Liu,Liuzhang Ouyang
The potential of a multiphase Al–Li alloy with the unreported Al1.08Li1.92 phase for use as a hydrolytic material to produce hydrogen was studied. This alloy enabled rapid hydrogen release in a wide temperature range with robust hydrogen yield. It could produce 1496 ml H2 per g within merely 0.5 min at 299 K and release 1076 ml H2 per g in 0.5 min even at a subzero temperature of 243 K. The hydrogen production kinetics were confirmed with a chemical step and could be well controlled by tailoring the solution components of water/ethanol mixtures. Furthermore, the alloy showed good air-resistance ability, indicating its suitability for safe handling and transport in practical applications. Our results confirmed the excellent hydrogen production achieved using this Al-based generation system. It might shed light on the progress of hydrogen production technologies for commercial use.
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Frontiers in Chemistry
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2021
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IF 5.221
Zhu Wen-Yuan,Niu Kun,Liu Peng,Fan Yu-Hang,Liu Zhi-Qiang,Zheng Yu-Guo
L-methionine is an important natural amino acid with broad application prospects. A novel gene encoding the enzyme with the ability to catalyze O-succinyl-L-homoserine (OSH) to L-methionine was screened and characterized. The recombinant O-succinyl-L-homoserine sulfhydrylase from Thioalkalivibrio sulfidiphilus (tsOSHS) exhibited maximum activity at 35°C and pH 6.5. OSHS displayed an excellent thermostability with a half-life of 21.72 h at 30°C. Furthermore, the activity of OSHS increased 115% after Fe2+ added. L-methionine was obtained with a total yield reaching 42.63 g/L under the concentration of O-succinyl-L-homoserine 400 mM (87.6 g/L). These results indicated that OSHS is a potential candidate for applying in the large-scale bioproduction of L-methionine.
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SOLAR ENERGY
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2021
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IF 5.742
Jixi Wang,Yangbiao Liu,Xiudi Xiao,Zhuoneng Bi,Yuan Lu,Guizhang Sheng,Xuesong Cai,Yanqing Zhu,Xueqing Xu,Gang Xu
All inorganic perovskite solar cells (PSCs) have been demonstrated to get tremendous interest recently owing to their better thermal stability. Nevertheless, some CsPbI 2 Br films prepared at low temperature have lower quality compared to those annealing at high temperature. Herein, to obtain high performance PSCs, a simple post-treatment strategy is presented by spin coating acetylacetone (AA) solution on the CsPbI 2 Br films. The AA treatment can reduce the density traps on the CsPbI 2 Br films surface and enlarge the size of grains, resulting in enhanced performance PSCs. After optimizing surface treatment, the devices based on low-temperature-processed CsPbI 2 Br with AA treatment achieved a power conversion efficiency (PCE) of 14.43%. The better CsPbI 2 Br films quality and interface contact of hole transport layer (HTL)/CsPbI 2 Br result in better device stability. Therefore, it could be a promising post treatment method for enhancing the performance of PSCs by introducing AA on the perovskite surface.
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ANALYTICAL CHEMISTRY
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2021
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IF 6.986
Jian Zhang,Xinming Huo,Chengan Guo,Xiaoxiao Ma,Hanxi Huang,Jiuming He,Xiaohao Wang,Fei Tang
Lipid imaging plays an important role in the research of some diseases, such as cancers. Unsaturated lipids are often present as isomers that can have different functions; however, traditional tandem mass spectrometry imaging (MSI) cannot differentiate between different isomers, which presents difficulties for the pathological study of lipids. Herein, we propose a method for the MSI of the C═C double-bond isomers of unsaturated lipids based on oxidative reactions coupled with air flow-assisted desorption electrospray ionization, which can conveniently achieve rapid MSI of unsaturated lipids at an isomeric level. Using this method, tissue sections can be scanned directly with MSI after only 10 min of accelerated oxidation. This method was used for the imaging of mouse lung cancer tissues, revealing a distributional difference in the unsaturated lipid isomers of normal and pathological regions. Through the MSI of unsaturated lipids at an isomeric level in tissues infected with cancer cells, the regions where the isomers were enriched were exhibited, indicating that these regions were the most concentrated regions of cancer cells. This method provides a convenient platform for studying the functional effects of the isomers of unsaturated lipids in pathological tissues.
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RENEWABLE ENERGY
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2020
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IF 6.274
Hao Chen,Xin Su,Jingjing He,Peng Zhang,Hongming Xu,Chenglong Zhou
Cyclopentanol is a promising alternative biofuel for automobiles. In this study, an optical engine was employed to investigate the effects of cyclopentanol blending ratios on combustion characteristics. Cyclopentanol was blended with diesel by 10% and 20% volume, denoted as CP10 and CP20, respectively. Comparison tests between blends and diesel (denoted as D100) were performed under three injection pressures (100, 120, and 140 MPa) and four injection timings (−6°, −9°, −12° and −15° crank angle after top dead center (°CA ATDC)). The experimental results indicated that the addition of cyclopentanol prolongs the ignition delay , shortens the combustion duration and improves the indicated thermal efficiency . As the injection pressure increases or the injection timing advances, the peak combustion pressures (PCPs) and peak heat release rates (PHRRs) increase. Compared to D100, the PCPs and PHRRs of cyclopentanol/diesel fuel blends are lower and decrease with the increase of cyclopentanol ratio. Blending cyclopentanol in diesel is effective in reducing soot emission, and the reduction effect weakens as the injection pressure increases or the injection timing advances. CP10 is superior to CP20 according to the comprehensive evaluation of combustion and emission, especially at the injection timing of −12°CA ATDC under the injection pressure of 140 MPa.
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Journal of Materials Research and Technology-JMR&T
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2020
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IF 5.289
Deqing Zhu,Yuxiao Xue,Jian Pan,Congcong Yang,Zhengqi Guo,Hongyu Tian,Dingzheng Wang,Yue Shi
The alumina content of iron ores for sintering is gradually increasing with the growing depletion of high-grade iron ores, which is harmful to the sintering process. Therefore, it is essential to reveal the action mechanism of alumina on sinter quality. In this paper, the aluminum occurrence of various iron ores was determined by applying X-ray diffraction (XRD), optical microscopy, scanning electron microscopy and energy dispersive spectrum analysis (SEM-EDS). Then, the effects of iron ore type, aluminum occurrence (free alumina, gibbsite, diaspore, alumogoethite and kaolinite) and alumina content on formation characteristics of SFCA bonding phases as well as sinter matrix strength were investigated based on laboratory compact sintering tests. The results show that the discrepancy of aluminum occurrence contributes to different SFCA formation characteristics and then sinter matrix strength, due to different reactivity of various aluminum-containing minerals with iron oxides and fluxes. Increasing alumina content generally results in an increase in the porosity of sinters and deterioration of sinter matrix strength for all aluminum occurrence. Aluminum in the form of kaolinite is more conducive to form dendritic or acicular SFCA with superior sinter matrix strength compared with other aluminum occurrences. In contrast, aluminum occurring in free alumina presents greatest adverse impacts on sinter matrix strength due to its poor reactivity and high porosity of resultant sinters.
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APPLIED CATALYSIS B-ENVIRONMENTAL
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2020
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IF 16.683
An Zhang,Zhiyong Liu,Bing Xie,Jinshan Lu,Kun Guo,Shanming Ke,Longlong Shu,Huiqing Fan
Excellent vibration-electricity conversion in various piezoelectric materials is frequently restricted, thus hardly generates high mechanochemical potential eliciting by ferroelectric polarization for advanced catalysis processes. Herein, we propose a phase boundary in Li modified Na 0.5 K 0.5 NbO 3 (NKN) materials to improve the piezocatalytic activity, and the relationships among the composition, phase structure, electrochemical and catalytic performances were systematically investigated. An outstanding piezocatalytic performance was exhibited in the LNKN6 (6 mol % Li doped NKN) with coexistence of orthorhombic and tetragonal phases, and the piezocatalytic activity showed a superior repeatability and universal applicability for the degradation of organic pollutants. The reaction rate constant of the LNKN6 was up to 25.16 × 10 −3 min −1 , which was 3.20 times than that of pristine NKN. The enhancement of piezocatalytic activity was confirmed by Landau-Ginsburg-Devonshire phenomenological theory and the transfer efficiency of force-generated electrons and holes, and then an appropriate mechanism of the ultrasonic vibration driven piezocatalysis was speculated. This work provides an alternative strategy to enhance the catalytic efficiency of piezocatalyst and the high activity of the NKN-based piezoelectrics has an important application for environmental remediation.
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JOURNAL OF MATERIALS SCIENCE
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2020
·Vol. 56
·期 2
·1643-1657
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IF 3.553
Tian Xuwang,Ge Xiaohui,Guo Mengya,Ma Jinxia,Meng Zhiqian,Lu Peng
Abstract Pickering emulsion templating has become an effective method for preparing polymer foam with precise morphology. The present study reports an antibacterial foam prepared through the polymerisation of acrylated epoxidised soybean oil (AESO) in the external phase of a water-in-oil (w/o) Pickering emulsion. Zinc oxide (ZnO) was used to stabilise water into the AESO and endow the resulting foam with antimicrobial characteristics. The effects of the oil-to-water mass ratio (3:1–1:2) and ZnO concentration (0.1–3.0 wt%) on the stability of the emulsion were studied. The emulsions were characterised in terms of the volume fraction of the emulsion phase, the viscosity of the emulsion, and the interfacial tension. The emulsion prepared with an oil-to-water ratio of 3:2 and ZnO concentration of 1.0 wt% showed strong stability. Absorption of ZnO at the oil–water interface was observed by using graphene oxide quantum dot-doped ZnO as a fluorescent marker. Antibacterial foam was formed by heating the Pickering emulsion at 120 °C for 3 h. Scanning electron microscope images show that the foam has a closed-cell structure with an average pore diameter of approximately 200 μm. The prepared foam showed antibacterial activity with an inhibition rate against E.coli of 99%. The production of a porous polymer from sustainable materials through ZnO-stabilised Pickering emulsion templating provides a facile method for preparing innovative, functional bio-based materials. Graphic abstract
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PHARMACEUTICAL RESEARCH
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2020
·Vol. 37
·期 11
·1-12
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IF 3.242
Shen Bin-Bin,Zhang Zhongwei,Yuan Jun-Jie,Zheng Aiping,Zeng Su,Gao Jian-Qing,Bao Wenhan,Barnard James,Wang Haibin,Fang Wei-Jie
Purposes The main purposes of this article are to describe an unprecedented phenomenon in which significant amount of a shoulder peak impurity was observed during normal non-reducing capillary electrophoresis-sodium dodecyl sulfate (CE-SDS) analysis of a recombinant fusion protein X, and to evaluate the root cause for this phenomenon. Methods A series of experiments were conducted to study the nature of this degradation. Effects of iodoacetamide (IAM), heating temperature, duration, and SDS on the formation of this specific impurity were evaluated using a variety of characterization techniques. Results The formation of the impurity as observed in CE-SDS was actually due to alkylation of lysine and serine residues with IAM, as confirmed by peptide mapping and LC-MS/MS, which increased the molecular weight and therefore decreased the electrophoretic mobility. The amount of impurity was also strongly dependent on sample preparation conditions including the presence or absence of SDS. Conclusions Our study clearly suggested that even though IAM has been used extensively as an alkylation reagent in the traditional non-reducing CE-SDS analysis of monoclonal antibodies and other proteins, alkylation with IAM could potentially lead to additional impurity peak, and therefore complicating analysis. Therefore, before performing CE-SDS and other analyses, the effects of sample preparation procedures on analytical results must be evaluated. For protein X, IAM should be excluded for CE-SDS analysis.
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ACS Applied Bio Materials
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2020
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IF 0
Yao Liu,Daoming Zhu,Jingshan Luo,Xiaojia Chen,Liqian Gao,Wei Liu,Tongkai Chen
Despite the relative severity of Parkinson’s disease (PD), to date, there has been only limited success in preventing or treating this condition owing to the low permeability of the blood–brain barrier (BBB), which makes the cerebral delivery of pharmaceutical agents very challenging. In the present study, we explored an approach to increasing BBB permeability via the use of mesoporous silica-encapsulated gold nanorods (MSNs-AuNRs) that could reliably achieve a robust photothermal effect in response to second near-infrared (NIR-II) irradiation. To test the potential anti-Parkinsonian activity, we loaded MSNs-AuNRs with the frequently utilized anti-PD agent quercetin (QCT) to yield MSNs-AuNRs@QCT. Following NIR-II irradiation, we observed a dramatical increase in QCT transfer through the BBB, indicating that MSNs-AuNRs may enhance BBB permeability via the photothermal effect. These findings were further supported by rat pharmacokinetic studies, which clearly revealed that the combination of MSNs-AuNRs and NIR-II irradiation was associated with significantly improved brain accumulation. In a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced murine model of PD, we also found that intravenous MSNs-AuNRs@QCT delivery and subsequent NIR-II irradiation was sufficient to markedly reduce the neurological abnormalities in these mice. Together, this combination offers promising potential as a nanoplatform for neuroprotective drug delivery and treatment of PD.
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