CARBOHYDRATE POLYMERS
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2024
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IF 10.7
Zhiyi Liao,Jiayi Li,Wenqiang Ni,Rixing Zhan,Xisheng Xu
Altered skin integrity increases the chance of infection, and bacterial infections often lead to a persistent inflammatory response that prolongs healing time. Functional artificial hydrogels are receiving increasing attention as suitable wound dressing barrier. However, the antimicrobial effect of the new dressing still needs to be explored in depth. In this work, the antimicrobial peptide MSI-1 was covalently attached to chitosan-modified poly (vinyl alcohol) hydrogels mixed with Prussian blue nanoparticles (PBNPs) via a primary amine group coupled to a carboxyl group. The synthesized hydrogel has a long-lasting antimicrobial surface and is able to maintain its bactericidal effect on Staphylococcus aureus and Escherichia coli for 24 h. Due to the presence of PBNPs, the hydrogel was able to rise to 48.3 °C within 10 min under near infrared (NIR) light irradiation at a wavelength of 808 nm and maintain this mild temperature to avoid bacterial biofilms. The hydrogel showed >90 % survival in co-culture with cells for 3 d and did not damage major organs in animal experiments. Thus, the photothermal dual-mode antimicrobial hydrogel synthesized in this study increases the selectivity as a safe and efficient wound dressing for the treatment of infected skin defects.
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JOURNAL OF MOLECULAR STRUCTURE
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2024
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IF 4
Pengfei Liao,Dengjie Zhong,Yunlan Xu,Ran Jiang,Jiayou Zhang,Yuanzhen He
In this work, in order to improve the adsorption capacity of chitosan for Cr(VI), a chitosan-based composite co-modified with lanthanum and polypyrrole (CS-La-PPy) was prepared and its effectiveness in removing Cr(VI) from aqueous solution was investigated. CS-La-PPy was characterized by FT-IR, XRD, BET, SEM, EDS and XPS. The successful synthesis of CS-La-PPy was confirmed by the presence of C=C (pyrrole ring) and La-O in the FT-IR spectrum. The effects of different adsorbent materials, dosage, initial pH, coexisting ions, adsorption time and temperature on the removal of Cr(VI) were investigated by batch experiments. The removal efficiency of 50 mL Cr(VI) with concentration of 150 mg L −1 by CS-La-PPy is 95.28 % at pH=2.0, T = 298 K. The adsorption process is spontaneous, which is consistent with pseudo-second-order kinetic model and Freundlich adsorption isotherm model. The maximum adsorption capacity is 321.96 mg g −1 . XPS analysis showed that the removal mechanism of Cr(VI) by CS-La-PPy was mainly based on the electrostatic adsorption between Cr(VI) and lanthanum, -NH 2 + , and -NH 3 + , the ion exchange between Cr(VI) and Cl − , the reduction of Cr(VI) to Cr(III) by PPy 0 and -OH groups, and the complexation between Cr(III) ions and COO- groups. This work provides a reference for the design and preparation of efficient chitosan-based adsorption materials.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2024
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IF 7.7
Yunquan Liu,Huimei Shan,Shaohong You,Huinan Mo,Hongbin Zhan
Iron decoration has been recognized as one of the most important paths to enhance contaminant adsorption by carbon-based composites. In this study, varying amounts of Fe (II) are used for the modification of graphene oxide chitosan (GOCS) materials to assess the impact of iron oxide (FeOx) morphology on the composites and their efficiency in arsenic (As) removal. Results show that incorporating 0.08 mol Fe(II) into GOCS yields better As removal performance, leading to a remarkable enhancement by 5 times for As(V) and 6 times for As(III). The iron minerals in the material consist of goethite (FeO(OH)) and magnetite (Fe 3 O 4 ), with FeO(OH) playing a predominant role in As removal through the complexation and electrostatic attraction of −OH and Fe − O groups. The adsorption capacity for As ( Q e ) decreases with the increasing pH and the mass and v olume ratio ( m/v ) but increases with the increasing initial concentration ( C 0 ). Besides, the presence of SO 4 2− and HPO 4 2− can significantly reduce As remo v al by the FeOx-modified GOCS. Under the conditions of pH = 3, m/v = 1.0 g/L, and C 0 = 10 mg/L, a maximum Q e value reaches 61.94 mg/g. The adsorption is well-fitted to a pseudo-second-order kinetic model and is an endothermic, spontaneous, and monolayer adsorption process .
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FOOD HYDROCOLLOIDS
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2024
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IF 11
Peini Li,Yiqing Deng,Wangcai Zou,Zhenqiao Ma,Xiandi Yang,Qiang Zhao
As living standards improve, the demand for food freshness has gradually increased. Multifunctional packaging materials that monitor food freshness in real-time, delay spoilage, and are environmentally friendly have emerged as ideal solutions. This study synthesized an ammonia-sensitive copper-based metal-organic framework (Cu-MOF) and incorporated it into a matrix composed of chitosan (CS) and gelatin (Gel). The resulting film exhibits ammonia-sensitive color-changing properties, antibacterial activity, and excellent biodegradability. The effects of Cu-MOF incorporation on the structural, physical, and functional properties of the CS/Gel films were systematically evaluated. Results demonstrated that the Cu-MOF was uniformly distributed within the CS/Gel matrix, significantly enhancing the mechanical properties (tensile strength increased by 68.49%), oxygen/water vapor barrier properties, and UV-blocking capability of the films. Notably, the CS/Gel@Cu-MOF films exhibited excellent antibacterial performance, with sterilization rates of 94.2% against Escherichia coli and 99.6% against Staphylococcus aureus . Additionally, the films showed good biocompatibility, biodegradability, and a sensitive color response to ammonia. The films were successfully used to monitor shrimp freshness through color change, transitioning from light green to brown as spoilage occurred. These findings indicate that CS/Gel@Cu-MOF films have significant potential for real-time visual freshness monitoring in food packaging, contributing to reduced food safety risks and waste.
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JOURNAL OF APPLIED POLYMER SCIENCE
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2025
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IF 2.8
Yuying Cui,Lulu Wang,Yang Zhang,Shuang Li,Fan Zhang,Jilin Wang
Developing novel anion-exchange membranes (AEMs) that feature superior hydroxide conductivity and excellent alkaline stability poses a major challenge. Among different kinds, cross-linked AEMs enjoy the highest popularity, thanks to their uncomplicated fabrication procedures and outstanding stability. However, it is noteworthy that in the majority of instances, the employment of covalent cross-linking methods often plunges AEMs into a conductivity-stability conundrum. That is to say, when efforts are made to boost the conductivity, the stability tends to be compromised, and conversely, attempts to enhance stability might adversely affect conductivity. To tackle the conductivity-stability issue faced by conventional covalent cross-linked AEMs, within this research, innovative bifunctional imidazole cross-linking agents that carry imidazole cations were synthesized using N-(3-aminopropyl)-imidazole and 3-chloropropylamine. Following that, these agents were then utilized to manufacture high-performance cross-linked quaternized chitosan (QCS) membranes. The bifunctional cross-linker was able to furnish an ionic 3-D network, further promoting the formation of microphase separation morphology and a densely cross-linked structure, thereby bringing about both excellent conductivity and alkaline stability. The as-prepared QCS-MI 0.3 AEM exhibited a relatively low swelling ratio of 29.7% at 80°C, along with outstanding conductivity reaching 128.83 mS cm −1 at the same temperature. Moreover, it demonstrated remarkable alkaline stability, with 92% of its conductivity retained after being immersed in 6 M KOH at 80°C for 168 h. Meanwhile, the single cell built upon the QCS-MI 0.3 AEM likewise showcased remarkable fuel cell performance, achieving a power output of 518.08 mW cm −2 at 80°C, and exhibited excellent durability as well. This research effort devised a novel approach for synthesizing high-performance cross-linked AEMs, which further augmented the application potential of QCS-based AEMs in the realm of fuel cells.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2025
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IF 8.5
Juan Wang,Junyu Wang,Jun Zhang,Haoran Ye,Dawei Wang,Ling Tao,Yongchao Yao,Ying Chen,Xiangchun Shen
As a notoriously incurable tumor, triple-negative breast cancer (TNBC) exhibits significant sensitivity to ferroptosis and the glutathione (GSH) antioxidant defense system plays a crucial role in its progression. Herein, we report a bimetallic chitosan/hyaluronic acid nanoparticle (5FCN, with a Fe/Cu mass ratio of 5:5) that employs a self-amplified dual mechanism of ferroptosis and cuproptosis for TNBC therapy. Hyaluronic acid in 5FCN specifically binds to the overexpressed CD44 receptor on TNBC cells. This allows 5FCN to enter cells via receptor-mediated endocytosis, then release metal ions in acidic environments. Released Fe 3+ and Cu 2+ react with GSH in tumor cells, weakening the antioxidant system and producing Fe 2+ and Cu + . These ions trigger Fenton/Fenton-like reactions with H 2 O 2 , generating toxic hydroxyl radicals (·OH) to boost ferroptosis. Meanwhile, high-valent Cu 2+ and Fe 3+ are produced, forming a cycle for GSH depletion and ·OH generation. As H 2 O 2 depletes, the rising Cu + level in cells causes lipoylated protein aggregation, amplifying cuproptosis. In vitro and in vivo studies demonstrated that 5FCN exhibited superior cell-killing efficacy against TNBC with few side effects. Collectively, 5FCN represents a potential drug to self-amplify ferroptosis/cuproptosis in TNBC.
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MACROMOLECULAR RAPID COMMUNICATIONS
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2024
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IF 4.2
Hao Huang,Zexin Liu,Hanxin Jian,Yuan Yao,Wenjuan Tan,Shuguang Yang
Living tissues span a remarkable spectrum of modulus ranging from the level of Pa to GPa in a water-rich environment. Constructing soft and hard materials that match the mechanics of tissues and researching mechanical transition in water, are beneficial for their biological applications. Here, using polyelectrolyte complex fiber as a model system and reinforcing the fiber by stepwisely introducing additional coordination and covalent bonds, this investigated that the water effect on mechanical transition behaviors. Alginate/chitosan fiber (AC fiber) has a single electrostatic bond and shows continuous mechanical transition containing a glassy state, rubbery state, and terminal relaxation (initial modulus lower than 10 MPa) in aqueous solution. Alginate/chitosan/calcium fiber (ACC fiber) has both electrostatic and coordination bonds, which shows the behavior of hard rubber (initial modulus 100 MPa) when water reaches equilibrium. Alginate/chitosan/calcium/polydopamine fiber (ACCP fiber) with triple bonds, including electrostatic, coordination, and covalent bonds, exhibits the behavior like ductile plastics in aqueous solution (initial modulus 1000 MPa). This work not only provides important insight into the toughening mechanism of polyelectrolyte complexes in water but also contributes to the preparation of tissue adaptive implantations.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2024
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IF 7.7
Haoyang Xu,Yage Zheng,Yue Shen,Chaoqun Mu,Zhiqiang Zhang,Zhixian He,Yao Wang,Juanqin Xue,Liang Zhang
In this work, the photocatalyst BiOCOOH/BiYO 3 /Chitosan (CS) was prepared by using CS as the carrier and adsorbent. The performance of the material was studied through the photocatalytic degradation of tetracycline (TC) in water. Theoretical calculations and experiments demonstrate that the formation of BiOCOOH/BiYO 3 heterojunctions improves the separation of photogenerated carriers and the absorption of visible light by the material. The introduction of CS improves the difficulties in material recovery, demonstrating exceptional degradation ability for TC under the action of adsorption and photocatalysis. Adsorption kinetics studies indicate that the adsorption of TC by BiOCOOH/BiYO 3 /CS fits the pseudo-second-order model better, while the adsorption at different concentrations of TC is more suitably described by the Freundlich isotherm model. The synthesis of BiOCOOH/BiYO 3 /CS was confirmed by the analysis of XRD, XPS, and FTIR. UV–vis DRS showed that the synthesis of BiOCOOH/BiYO 3 /CS broadened the range of light absorbed by the material. The testing results of PL and transient photocurrent density indicate that BiOCOOH/BiYO 3 exhibits a higher efficiency in separating photogenerated charge carriers. After 5 cycles of reuse, the degradation efficiency can still reach 90 % of the initial efficiency, indicating that CS-based photocatalytic composite catalysts have practical application potential in the field of water pollution treatment.
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COLLOIDS AND SURFACES B-BIOINTERFACES
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2012
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IF 3.456
Rui Chen,Qi Chen,Da Huo,Yin Ding,Yong Hu,Xiqun Jiang
A novel chitosan–gold (CS–Au) hybrid hydrogel was developed from chitosan and chloroauric acid in aqueous solution. Its physiochemical characteristics, including UV absorption, structure, morphology, swelling properties were studied. The CS–Au hybrid hydrogel exhibited an excellent water-absorbing property and could be applied as a drug delivery system for anticancer drug: doxorubicin (DOX) due to its high equilibrium water swelling content. The drug loading and release experiments elicited an efficient drug loading content and sustained drug release pattern. Moreover, DOX released from hydrogel which itself had no cytotoxicity was biological active similar as the free DOX, but lower cytotoxicity due to its controllable release. All proved it an ideal local drug delivery system indicating a promising potential future in medical or pharmaceutical area.
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CARBOHYDRATE POLYMERS
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2011
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IF 3.463
Hongyan Zhu,Fei Liu,Jing Guo,Jianpeng Xue,Zhiyu Qian,Yueqing Gu
Folate modified chitosan micelles were synthesized for cancer-specific targeting and drug delivery. Receptor-mediated uptake and drug delivery were characterized in vitro and in a small animal model of cancer after loading with hydrophobic fluorescent dyes as drug models. Hydrophilic succinic anhydride and hydrophobic octaldehyde were reacted with chitosan respectively to form amphipathic N-succinyl-N′-octyl chitosan (SO-chitosan). SO-chitosan was covalently modified with folate to form folate-modified N-succinyl-N′-octyl chitosan (folate-SO-chitosan). The folate-SO-chitosan micelles were obtained through self-assembling and maintained a stable core-shell structure with average diameter of about 136 nm up to 15 days. The prepared folate-SO-chitosan micelles displayed a good drug loading content (12.17%), entrapment efficiency (69.32%) and sustained release behavior for the model drug fluorescein. The in vitro cellular uptake and in vivo tumor targeting ability of the folate-SO-chitosan micelles were evaluated by fluorescence microscopy and near infrared imaging, respectively. In vitro and in vivo results demonstrated enhanced targeting behaviors in a folate receptor positive tumor model (Bel-7402), which suggests that the folate-SO-chitosan micelles are promising tumor targeting carriers for hydrophobic diagnostic agents as well as anti-tumor agents.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2024
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IF 7.7
Tingting Zhao,Jianyu Zhou,Wanting Wu,Kunpeng Qian,Yan Zhu,Miao Miao,Xin Feng
The utilization of biomass-based conductive polymer hydrogels in wearable electronics holds great promise for advancing performance and sustainability. An interpenetrating network of polyacrylamide/2-hydroxypropyltrimethyl ammonium chloride chitosan (PAM/HACC) was firstly obtained through thermal-initiation polymerization of AM monomers in the presence of HACC. The positively charged groups on HACC provide strong electrostatic interactions and hydrogen bonding with the PAM polymer chains, leading to improved mechanical strength and stability of the hydrogel network. Subsequently, the PAM/HACC networks served as the skeletons for the in-situ polymerization of polypyrrole (PPy), and then the resulting conductive hydrogel demonstrated stable electromagnetic shielding performance (40 dB), high sensitivity for strain sensing (gauge factor = 2.56). Moreover, the incorporation of quaternary ammonium chitosan into PAM hydrogels enhances their antimicrobial activity, making them more suitable for applications in bacterial contamination or low-temperature environments. This conductive hydrogel, with its versatility and excellent mechanical properties, shows great potential in applications such as electronic skin and flexible/wearable electronics.
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ACS Applied Materials & Interfaces
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2024
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IF 8.3
Shuo Xu,Shaorong Yan,Jun You,Xiaochen Wu
Antibacterial hydrogels have emerged as a promising approach for effective wound treatment. However, despite extensive research on the fabrication of antibacterial hydrogels, it remains challenging to develop injectable, biocompatible, transparent, and mass-producible hydrogels with antibacterial properties. In this study, we successfully fabricated an antibacterial drug-loaded composite hydrogel, named CC45/OKG40/HS, through a Schiff base reaction between carboxymethyl chitosan (CC) and oxidized konjac glucomannan (OKG), followed by the encapsulation of stevioside-stabilized honokiol (HS) micelles. The CC45/OKG40/HS hydrogel exhibited several favorable properties, including a short gel time (<10 min), high water content (>92%), injectability, good adhesiveness, self-healing ability, and high transparency. In vitro experiments confirmed its excellent antibacterial properties, antioxidant activities, and high biocompatibility (no cytotoxicity, hemolysis ratio <5%). Furthermore, in vivo evaluation demonstrated that the CC45/OKG40/HS0.5 hydrogel accelerated wound healing by relieving inflammatory responses and enhancing re-epithelization. Given its feasibility for mass production, the findings showed that the CC45/OKG40/HS hydrogel has the potential as an advanced antibacterial wound dressing for commercial use.
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