AQUATIC TOXICOLOGY
·
2024
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IF 4.1
Zhihua Ni,Xinling Tian,Wenbo Zhao,Wenkai Hu,Jinghua Lv,Xiaoli Sun,Yajie Zhang,Yiwen Zhang,Yuming Zhang,Baoku Li,Fengsong Liu
Orlistat (ORL) has been employed as an anti-obesity pharmaceutical for several decades. Given its low absorption rate, the majority of administered ORL is excreted into the environment with feces. It is crucial to collect scientific information regarding the possible ecological risks associated with ORL. Here, the effects of ORL on Daphnia magna were evaluated using a 21-day chronic test at concentrations of 1, 10, 100, and 1000 μg/L. We found the inhibition of feeding and swimming activities in the 100 and 1000 μg/L ORL exposed D. magna , respectively. Their digestive enzyme activities and metabolites were reduced even at 1 μg/L ORL exposure. It is noteworthy that exposure to 100 μg/L ORL induced a decrease in the reproductive capacity of D. magna , although no discernible genotoxicity was observed. To identify the toxicological mechanisms of ORL, a metabolic analysis was conducted on D. magna exposed to 1000 μg/L ORL. A comprehensive reduction in carbohydrates, lipids, and amino acids was observed, which resulted in a blockage of metabolic flux towards the TCA cycle, as evidenced by mitochondrial dysfunction. These findings substantiate the detrimental impact of ORL on D. magna and provide insights into the underlying molecular mechanisms from a metabolic perspective.
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JOURNAL OF COLLOID AND INTERFACE SCIENCE
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2025
·
IF 9.7
Zhi-Jun Zhu,Guanhua Shen,Akbar Bashir,Danqing Liu,Xiaohong Wu,Yikun Huang,Yangjun Zhang,Junxuan Luo,Chen Liu,Da-Zhu Chen
Extreme temperature conditions often accelerate the degradation of supercapacitor materials and elevate electrolyte resistance, reducing device longevity and reliability. Efficient temperature regulation is necessary to ensure that supercapacitors can work stably under harsh environmental conditions. To overcome these challenges, we introduce a phase-change fiber film with a core-sheath structure and dual phase-change temperature range fabricated using advanced layer-by-layer coaxial electrospinning. The film was used as a substrate for the in situ polymerization of polyaniline nano-arrays after vacuum coating with a gold layer to create flexible supercapacitors with a PVA/H 2 SO 4 gel electrolyte. The unique needle-like polyaniline nano-arrays enhance the surface area and ion transport channels, resulting in a device with an areal capacitance of 521.3 mF cm −2 at a scan rate of 5 mV s −1 . Our phase change fibers have a high latent heat of 62.4 J g −1 in the 0–10 °C and 40–50 °C ranges for efficient temperature regulation. The stabilized capacitance and internal resistance over two phase-change regions highlight the robust thermal regulation of the device. This advancement represents a significant leap forward for flexible supercapacitors, offering enhanced thermal management and vast potential for future energy storage applications.
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Cell Reports Medicine
·
2025
·
IF 10.6
Feixiang Wang,Rujuan Bao,Shuiyu Xu,Wenyan Li,Haiyan Huang,Runchang Li,Xinyu Ding,Yuerong Zhang,Xiaoyan Yu,Qiaoqiao Han,Xian Du,Jie Wan,Song Li,Yichuan Xiao,Ren Zhao,Xingang Cui,Youqiong Ye,Jiayuan Sun,Junke Zheng,Guo-Qiang Chen,Qiang Zou
T cell dysfunction with age underlies an increased incidence of cancer in elderly individuals; however, how T cell aging is triggered in the tumor microenvironment is unclear. Here, we show that an age-associated reduction in adipocyte-derived leptin contributes to the accumulation of tumor-infiltrating senescent CD8 + T cells. Single-cell profiling of human and mouse cancer tissues reveals that the frequency of intratumoral senescent CD8 + T cells increases with age, leading to a weak antitumor effect. Moreover, decreased levels of adipocyte-derived leptin are an indispensable factor for CD8 + T cell aging. Leptin signaling prevents p38-dependent CD8 + T cell senescence. Furthermore, plasma leptin levels are negatively related to intratumoral CD8 + T cell senescence in cancer patients. Our findings identify an unappreciated interplay between metabolic perturbation and T cell aging and suggest that modulating adipocyte-derived leptin levels may be a promising therapeutic strategy for older cancer patients.
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npj Science of Food
·
2025
·Vol. 9
·期 1
·1-11
·
IF 7.8
Ma Bo,Miao Yuanxin,Xu Yan,Li Feng,Zhu Deyan,Li Rong,Huang Yechuan
This study evaluated the in vitro and in vivo antioxidant activities of puerarin (PUE) and β-lactoglobulin (β-lg). The results of the in vitro antioxidant assay revealed that the DPPH and ABTS radical scavenging rates of the PUE/β-lg complex were generally superior to those of free PUE within the tested experimental concentration range. The in vivo antioxidant activity assay, using Caenorhabditis elegans ( C. elegans ) as a model organism, showed that the PUE/β-lg complex significantly increased the superoxide dismutase (SOD) activity and reduced glutathione (GSH) content in C. elegans , and also increased the mean lifespan of C. elegans under oxidative and thermal stress conditions. Transcriptomic analysis showed that the PUE/β-lg complex regulated the mRNA expression levels of genes associated with the activation of various signaling pathways, such as the longevity regulation pathway, insulin signaling pathway, and GSH metabolism. Overall, this study demonstrated the potential of the PUE/β-lg complex as an antioxidant, which can lead to its development into food products or pharmaceuticals.
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CHINESE JOURNAL OF CATALYSIS
·
2025
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IF 17.7
Bingjie Zhang,Chunyan Wang,Fulin Yang,Shuli Wang,Ligang Feng
Bifunctional Ir catalysts for proton exchange membrane (PEM) water electrolysis offer transformative potential by streamlining electrolyzer while achieving efficient performance remains challenging due to the distinct conditions required for oxygen and hydrogen evolution reaction (OER and HER). Herein, we propose a theory-directed design of Ir-based bifunctional catalysts, Ir nanoparticles supported on mesoporous carbon spheres embedded with MoSe 2 (Ir/MoSe 2 @MCS), leveraging a work function (WF)-induced spontaneous built-in electric field to enhance catalytic performance. They demonstrate exceptional kinetics for both OER and HER, and potential application in the practical PEM electrolyzer, showcasing the effectiveness of this innovative approach. Low overpotentials of 252 mV for OER and 28 mV for HER to drive 10 mA cm –2 were observed, and the PEM electrolyzer showed the current density of 2 A cm –2 at 1.87 V and maintained stable activity at 1.65 V for over 30 h to deliver 1 A cm –2 . Density functional theory calculations reveal that the WF difference at Ir/MoSe 2 interface induces a spontaneous built-in electric field with asymmetric charge distributions, that modulate the electronic environment and d -band center of Ir promoting bifunctional active phase formation. This significantly lowers reaction barriers for water splitting by balancing intermediate adsorption, endowing the bifunctional activity.
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JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
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2025
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IF 6.2
Xin Ma,Shimin Wu
Parent and oxygenated polycyclic aromatic hydrocarbons (PAHs and OPAHs) have gained increasing attention due to their toxicity. However, their formation mechanisms during baking remain unclear. This study aimed to elucidate their formation pathways from amino acids in baking systems. The effects of five amino acids on PAH24 and OPAH12 levels in bread were investigated. Phenylalanine addition (2%) caused the most significant 15-fold increase in the toxic equivalent quotient of PAH36. Stable isotope tracing technology revealed that both the phenyl ring and C3 atom of phenylalanine were incorporated into benzo[a]anthracene and 9-fluorenone, proving the transformation of phenylalanine into PAHs and OPAHs. By nontarget analysis and chemical reactivity analysis, styrene, (E)-stilbene, and benzophenone were identified as key intermediates in the formation of naphthalene, benzo[a]anthracene, and 9-fluorenone, respectively. Overall, this study first proposed the formation pathways of PAHs and OPAHs from phenylalanine, offering guidance for reducing their health risks during baking.
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AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
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2025
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IF 3.3
Hong-Yu Li,Wei-Lan Zeng,Yi-Wen Ye,Xin Chen,Ming-Ming Zhang,Yi-Si Chen,Cui-Ting Liu,Zhun-Qiang Zhong,Jing Li,Yan Wang
Glia maturation factor-β (Gmfb), an actin filament debrancher, was initially identified in brain and recently linked to liver diseases. To investigate the role of hepatocyte Gmfb (hep-Gmfb) in liver reparative regeneration, hepatocyte-specific gmfb knockout (HepGKO) and overexpression (HepGOE) zebrafish strains were constructed. Both transgenic and wild-type (WT) zebrafish underwent partial hepatectomy (PHX) or were fed high fat, high cholesterol diets to model metabolism-associated steatotic liver disease (MASLD). Under physiological conditions, the HepGKO, HepGOE, and WT fish displayed similar survival, gross appearance, and liver histology. Following PHX, WT liver gmfb levels positively correlated with cell proliferation and proinflammatory cytokine levels. HepGOE showed enhanced regeneration and reduced liver steatosis compared to WT, while HepGKO exhibited opposite effects. In MASLD, WT liver gmfb increased with disease progression. HepGKO experienced worsening liver enlargement, steatosis, ballooning, inflammation, and endoplasmic reticulum stress, while HepGOE showed improvements. HepGOE liver had the highest cell proliferation, but all three groups showed similar levels of cell apoptosis. Moreover, elevated proinflammatory cytokines were observed across MASLD groups, being the highest in HepGKO and lowest in HepGOE. However, stat3 activation was the lowest in HepGKO and highest in HepGOE, while jnk and mapk/erk activation was consistent across the MASLD groups. In il6-treated primary hepatocytes, gmfb abundance influenced stat3 activation, and hep-gmfb abundance significantly affected actin filaments distribution in hepatocytes both in vivo and vitro. Conclusions: Hep-Gmfb boosts regenerative processes by enhancing hepatocyte proliferation, alleviating fatty liver histological abnormalities, and modulating the Il6/Stat3 signaling, potentially through remodeling of actin-filament network within hepatocytes.
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Stress Biology
·
2025
·Vol. 5
·期 1
·1-15
·
IF 5.8
Hao Xinchang,Li Yiwen,Hang Zhaoyue,Chen Yue,Tang Yidong,Miao Jianqiang,Peng Qin,Liu Xili
Cucumber target spot, a major disease that threatens cucumber production, is caused by Corynespora cassiicola . Cyclobutrifluram, a novel succinate dehydrogenase inhibitor (SDHI) developed by Syngenta, has demonstrated strong inhibitory activity against various plant pathogenic fungi and nematodes. However, its antifungal spectrum, resistance risk as well as underlying mechanisms of resistance in C. cassiicola remain poorly understood. In this study, cyclobutrifluram exhibited potent inhibitory activity against anamorphic fungi and selected ascomycetes, with the mean sensitivity of C. cassiicola isolates to the fungicide being 0.98 ± 1.26 μg/mL. Additionally, five laboratory-derived cyclobutrifluram-resistant mutants showed comparable or lower biological fitness than their respective parental isolates. The resistant mutants and field isolates were also found to possess nine distinct point mutations in the CcSdhB , CcSdhC or CcSdhD genes. Finally, cyclobutrifluram exhibited positive cross-resistance with other SDHIs, with the resistance levels varying depending on the specific mutations present. In conclusion, cyclobutrifluram was found to be effective against anamorphic fungi and selected ascomycetes. C. cassiicola ’s risk of resistance development to cyclobutrifluram was assessed as moderate to high and was primarily associated with mutations in CcSdh genes.
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JOURNAL OF ALLOYS AND COMPOUNDS
·
2025
·
IF 6.3
Yumei Zhang,Yunqi Song,Kemin Xie,Yujie Tang,Yao Yao
A novel chemical sensor featuring an In 2 O 3 -O v /In-nIm heterostructure was facilely fabricated through the in-situ growth of In 2 O 3 -O v on an In 3+ ions-based 2-nitroimidazole metal-organic material (In-nIm MOM). The proposed synthetic strategy effectively enhances the sensing performance. The oxygen vacancies provided by In 2 O 3 -O v can increase the number of reaction centers and active sites, and the abundant porous channels offered by the In-nIm are very beneficial for gas interaction and diffusion. As expected, the In 2 O 3 -O v /In-nIm gas sensor demonstrates outstanding performance, including ultrahigh sensitivity (9853) to 200 ppm ethanol at 230℃, rapid response/recovery speeds (2 s/6 s), an extremely low detection limit (0.003 ppb), superior selectivity, and robust stability. This work provides a potential strategy for fabricating advanced sensing materials by synergistically integrating the merits of metal oxide semiconductors and metal-organic materials, rendering the heterostructure a promising candidate for high-performance chemical sensors.
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CERAMICS INTERNATIONAL
·
2025
·
IF 5.6
Yuanyuan Fan,Shun Li,Daobin Zhu,Keyu Guo,Rangrang Fan,Chunfeng Dong,Yongtao Liu,Yong Li,Junshan Hu
The thermal quenching effect of photoluminescent materials greatly limits their practical applications in bioimaging, sensing, radiation detection, and photovoltaic devices. In this paper, the upconversion luminescence (UCL) of Sc 2 W 3 O 12 :Er 3+ /Yb 3+ was significantly improved by doping Ba 2+ ions. The study identifies that the optimal doping concentration of Ba 2+ ions within the negative thermal expansion (NTE) phosphors Sc 2 W 3 O 12 : Er 3+ /Yb 3+ is 0.03 mol, the green and red light intensities of Sc 2 W 3 O 12 : Er 3+ /Yb 3+ /Ba 2+ phosphor were increased by 32.76 times and 23.06 times. When the temperature rises from 298 K to 523 K, the NTE effect causes an abnormally increased luminous intensity. Utilizing fluorescence intensity ratio (FIR) technology, the temperature sensing characteristics of the Sc 2 W 3 O 12 : 0.30 Yb 3+ , 0.02 Er 3+ , 0.03 Ba 2+ phosphor were further examined, achieving maximum relative and absolute sensitivities of 1.24 % K −1 and 1.97 % K −1 , respectively.
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COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
·
2025
·
IF 5.4
Thao Pham Manh,Dinh Son Le,Ky Nguyen Van,Lan Ngo Thi,Tien Phat Doan,Dinh Thao Vu,Tuan Nguyen Van,Thu Hoa Nguyen Thi,Nguyen Vo Anh Duy,Minh Triet Dang,Nguyen To Van
s The present study demonstrates a successful synthesis of manganese-doped nickel cobalt sulfides (Mn-NiCo 2 S 4 ), which deliver marked improvements in electrochemical properties compared to pristine NiCo 2 S 4 . Comprehensive structural, morphological, compositional, surface, and electronic characterizations provide clear insights into the enhanced performance. Specifically, we identify three primary factors contributing to the superior electrochemical behaviors of Mn-NiCo 2 S 4 : ( i ) the appearance of hollow nanorods, which facilitates electrolyte access and improves ionic transport; ( ii ) the synergistic effects arising from the Faradaic reactions, which play a crucial role in boosting the electrochemical performance of Mn-NiCo 2 S 4 compared to the unmodified NiCo 2 S 4 ; and ( iii ) the enhances electronic conductivity from increased electron density and effective charge redistribution due to Mn doping confirmed by density functional theory simulations and experimental observations, leading to reduced internal resistance and improved electrochemical kinetics. Remarkably, Mn-NiCo 2 S 4 achieves an exceptional specific capacity of 470 C g -1 at a current density of 1 A g -1 . Additionally, the Mn-NiCo 2 S 4 //AC asymmetric supercapacitor delivers impressive energy densities ranging from 37.09 to 84.85 Wh kg -1 , corresponding to power densities decreasing from 7.09 to 0.79 kW kg -1 ; maintaining 50.52% capacity retention after 10,000 cycles at 2 mA cm -2 . These results underscore the potential of Mn-NiCo 2 S 4 and related doped materials as next-generation electrodes for advanced, high-performance supercapacitors, paving the way for significant advancements in energy storage technology.
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JOURNAL OF COLLOID AND INTERFACE SCIENCE
·
2025
·
IF 9.7
Shengqiang Zhang,Tengdiao Zhang,Miao Huang,Razium Ali Soomro,Xiaojie Liu
Microporous carbons are promising sulfur hosts for room temperature sodium–sulfur (RT Na–S) batteries. Yet, most designs primarily focus on confining small S 2 – 4 molecules and overlook the sluggish redox of short-chain polysulfides (Na 2 S ₙ , n ≤ 4), which accumulate as insulating Na 2 S/Na 2 S 2 . Herein, we report a Cu-MOF-derived microporous carbon bearing both carboxyl ( COOH) and amide ( CONH 2 ) groups (denoted MPC-Cu). The unique 0.5–0.8 nm uniform pores effectively physically lock S 2 – 4 molecules, eliminating long-chain polysulfides (Na 2 S ₙ , 4 < n ≤ 8) shuttling. Density functional theory (DFT) calculations and electrochemical analysis confirm that COOH groups enhances Na 2 S ₙ adsorption (binding energy −1.51 eV for Na 2 S 4 ) and promotes Na + diffusion (ranging from 10 −9 –10 −11 cm 2 s −1 ), whereas CONH 2 groups lower the Na 2 S oxidation barrier from 1.16 eV to 0.70 eV. Consequently, S/MPC-Cu cathode delivers long-term cycle performance (571.5 mAh g −1 at 2 A g −1 with a capacity retention of 83 % over 1000 cycles) and outstanding rate performance (504.1 mAh g −1 at 5 A g −1 ). This work provides a novel strategy in designing microporous carbon catalysts for cathodes of high-capacity, long-life RT Na S batteries.
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