NEW JOURNAL OF CHEMISTRY
·
2026
·
IF 2.6
Xiaoxia Hu,Xin Yang,Chunhua Wang,Tiantian Tan,Xiaojie Liu,Xiaodan Liu
Biothiols, such as glutathione (GSH) and L-cysteine (L-Cys), were essential for maintaining human physiological homeostasis, and their abnormal levels are closely associated with various diseases. Herein, a composite nanoenzyme Co3O4/g-C3N4 with significantly enhanced peroxidase-like activity was successfully synthesized by combining ZIF-67-derived Co3O4 with graphitic carbon nitride (g-C3N4). The 3,3′,5,5′-tetramethylbenzidine (TMB) could be efficiently oxidized to blue TMB (oxTMB) by Co3O4/g-C3N4 in the presence of H2O2, while biothiols (GSH and L-Cys) inhibited this catalytic reaction due to their antioxidant properties, leading to a visible color fading. Based on the mechanism, a colorimetric detection method was established for quantitative analysis of GSH and L-Cys with linear ranges of 0~30 μM for GSH and 1~30 μM for L-Cys, respectively. Moverover, a convenient smartphone-assisted sensing platform was established for detection of GSH and L-Cys benefiting from the Co3O4/g-C3N4 based colorimetric strategy. These established methods had been applied to detect GSH and L-Cys in human urine, which showed great potential for self-health monitoring.
✓ 已验证
DOI
高影响因子
Applied Food Research
·
2026
·Vol. 6
·期 1
·102031
·
IF 5.4
Lexuan Fang,Zhouduan Xu,Feiyan Chen,Zirui Luo,Ziwei Chen,Wenyue Zhang,Ping Wang,Hirokazu Kawagishi,Jing Wu,Peishi Feng
Saffron ( Crocus sativus L.), a traditional Chinese medicine with both medicinal and culinary uses, was examined to establish a comprehensive quality evaluation system integrating morphological, biological, and chemical approaches, based on the "Quality evaluation by appearance characterization" theory, to enable rapid and scientific assessment of its antithrombotic efficacy. A zebrafish thrombosis model was employed to evaluate 50 saffron batches based on bioactivity. Of these, 43 batches demonstrated significant antithrombotic effects (10 batches, including S1, S4, and S41–S48, classified as Grade 1, with the remainder classified as Grade 2). Chemical fingerprinting identified key discriminatory components, such as picrocrocin and crocin-I, while colorimetric analysis provided objective quantification of color parameters. Results revealed significant correlations between color features (L*, a*, b*) and antithrombotic activity/chemical composition ( p < 0.01), with bright-red samples (L* 50–53, a* 25–35, b* 20–30) demonstrating superior efficacy. A quality evaluation card was developed to rapidly assess antithrombotic grade (inhibition rate > 45 % or ≤ 45 %) through color comparison. This study offers a rapid, accurate, and practical strategy for evaluating the quality of medicinal and edible traditional Chinese medicines, advocating a shift from single-component analysis to a holistic, efficacy-focused approach.
✓ 已验证
DOI
高影响因子
Foods
·
2026
·Vol. 15
·期 5
·895
·
IF 6
Zihao Wei,Xianxian Liu,Qingmin Chen,Wenling Xu,Lichun Chang,Chen Liu,Shufen Wang
Radish leaves are a nutrient-rich yet underutilized byproduct containing abundant fiber, minerals, and phytochemicals; however, their quality is highly affected by drying methods. This study systematically investigated the effects of three drying methods—hot-air drying (HD), microwave drying (MD), and freeze-vacuum drying (FD)—on the nutritional components, bioactive substances, and volatile compounds of radish leaves. A comparative analysis was conducted on their proximate composition, amino acid profiles, mineral contents, antioxidant capacities, glucosinolate profiles, and volatile profiles. Among the three methods, FD exhibited superior preservation of proteins, lipids, minerals (K, Mg, P, Fe, Zn, and Mn), and bioactive components, including polyphenols, flavonoids, glucosinolates, and vitamin C. In contrast, HD and MD led to significant reductions in these nutrients and bioactive compounds. A total of 33 glucosinolates and 779 volatile compounds, including 164 odor-active compounds, were identified collectively across the three treatments. The FD-treated samples exhibited distinct glucosinolate and volatile profiles, whereas HD- and MD-treated samples showed greater similarity. Multivariate analysis further revealed 12 key differential glucosinolates and 27 differential odor-active compounds among the three groups. This study provides a scientific basis for optimizing drying strategies to improve the nutritional quality and flavor characteristics of processed radish leaves.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
·
2026
·
IF 6.7
Guoping Lai,Shan Jiang,Zisheng Han,Mingchun Wen,Jiaping Ke,Wenjuan Chen,Yinbing Cai,Chi-Tang Ho,Liang Zhang
Enzymatic oxidation during black tea processing participates in the formation of aromatic aldehydes from amino acids. The present study investigated the effects of (−)-epigallocatechin (EGC) and (−)-epigallocatechin gallate (EGCG) enzymatic oxidation on phenylacetaldehyde formation from l-phenylalanine. Results showed that the phenylacetaldehyde yield increased over 4-fold with the addition of polyphenol oxidase and EGC/EGCG, while excessive addition of EGC and EGCG inhibited further production. Through liquid chromatography tandem mass spectrometry, six EGC/EGCG–l-phenylalanine adducts, including aminated EGC/EGCG, amino-linked condensation products, and their decarboxylated derivatives, were identified and kinetically characterized. Their structures and temporal variations supported a plausible novel pathway involving reduction, decarboxylation, oxidation, and hydrolysis of Schiff base intermediates to form aminated EGC/EGCG and phenylacetaldehyde. Model fermentation involving tea leaves showed that exogenous addition of l-phenylalanine increased the phenylacetaldehyde content dose-dependently and promoted adduct formation. This research offered new insight into tea aroma formation driven by catechin oxidation.
✓ 已验证
产品关联
DOI
高影响因子
FOOD CHEMISTRY
·
2026
·
IF 10.4
Mengyun Ouyang,Sheng Cao,Yiji Zhou,Mo Mo,Yuanfang Xu,Qiling Zhang,Yong Zhang,Chao Deng,Feng Guo,Hui Song,Yan Wang,Yiqun Huang,Wenge Li
Sun-bleached preserved pepper (SPP) is a low-salt fermented product whose commercial application is often limited by microbial spoilage. This study evaluated the efficacy of gamma irradiation (2–10 kGy) as a preservation method for SPP, focusing on its impact on microbial safety, key phytochemicals (including phenolics and capsaicinoids), and volatile compounds. Irradiation at doses of 2–8 kGy effectively reduced or eliminated total viable counts, yeasts, moulds, coliforms, and Staphylococcus aureus . Total phenolic content was well retained (83–85%), and irradiation promoted the conversion of insoluble phenolics into soluble forms. Capsaicinoid levels increased markedly, with a 221% rise observed at 10 kGy. GC-IMS combined with multivariate analysis revealed a dose-dependent modulation of the volatile profile. Irradiation enhanced the formation of aldehydes and ketones (associated with fatty, green, spicy notes), while leading to the degradation of alcohols, acids, and esters (linked to floral and fruity nuances). A multi-criteria evaluation identified 6 kGy as the optimal dose, ensuring microbial control while preserving desirable quality attributes. These findings support the application of gamma irradiation to improve the safety and stability of low-salt fermented vegetables, thereby facilitating their commercial production.
✓ 已验证
产品关联
DOI
高影响因子
Biomedical Materials
·
2026
·Vol. 21
·期 3
·035002
·
IF 3.9
Shanchun Zhang,Xiangyu Cheng,Jingtong Wu,Yunuo Song,Liping Ren
To address the challenge of preventing peri-implantitis, the present study developed a pH-responsive drug delivery coating on titanium (Ti) implants for controlled aspirin release. A hierarchical metal-organic framework coating was constructed on alkali- and heat-treated titanium by sequentially synthesizing Zeolitic imidazolate framework-L (ZIF-L) and ZIF-8 (denoted AHTL8). Material characterization confirmed the successful fabrication of a hierarchical micro–nano structure, which significantly enhanced surface hydrophilicity. The AHTL8 system exhibited a remarkably high aspirin-loading capacity (0.227 mg) and intelligent release kinetics, with sustained delivery (77.36% over 72 h) at physiological pH (7.4) and rapid, extensive release (97.39% over 72 h) under acidic conditions pH (6.5). Furthermore, the coating demonstrated excellent cytocompatibility, and the aspirin-loaded AHTL8 significantly promoted the proliferation of mouse osteoblastic MC3T3-E1 cells. These findings indicate that the ZIF-L/ZIF-8 composite coating serves as a highly efficient pH-triggered platform with high drug-loading and responsive release capacity, and its excellent cytocompatibility and MC3T3-E1 proliferation-promoting effect provide a preliminary basis for its potential application in promoting osseointegration.
✓ 已验证
DOI
高影响因子
Applied Materials Today
·
2026
·
IF 7
Siqi Zhan,Chihao Gao,Junyi Yan,Xiaoli Lin,Xu Yan,Yaohui Fan,Zongrui Zhang,Xinyu Wang
Improve the sterile inflammation caused by soft tissue fillers. • Reduce inflammatory mediators and ROS levels. • Promoted cell migration and orderly collagen deposition. The increasing prevalence of soft tissue fillers has given rise to a concern regarding the occurrence of local sterile inflammation induced by the filler material. This study proposes the use of Poly(D,L-lactic acid) (PDLLA) microspheres composite with D-α-Tocopherol acetate (α-TA) and Hydroxyapatite (HAp) to eliminate aseptic inflammation caused by PDLLA degradation. The reduction of aseptic inflammation is achieved by prolonging degradation time, modulating the local microenvironment, and suppressing inflammatory mediators. HAp and α-TA were evenly distributed in PDLLA/HAp(α-TA) microspheres, and those microspheres have a particle size suitable for soft tissue filling (30–70 µm). Utilizing a conventional commercial formulation, PDLLA/HAp(α-TA) is uniformly amalgamated with carboxymethyl cellulose (CMC) to formulate CMC@PDLLA/HAp(α-TA) gel. CMC@PDLLA/HAp(α-TA) exhibits sustained release properties for at least 6 weeks and possesses excellent injectability. Meanwhile, CMC@PDLLA/HAp(α-TA) exhibits excellent biocompatibility and the ability to promote cell migration. Specifically, CMC@PDLLA/HAp(α-TA) significantly reduces inflammatory mediators and reactive ROS levels, while exhibiting prolonged and orderly collagen deposition. In summary, as an injectable soft tissue filler, CMC@PDLLA/HAp(α-TA) offers a novel strategy for the long-term suppression of sterile inflammation. Download: Download high-res image (287KB) Download: Download full-size image
✓ 已验证
DOI
高影响因子
MICROCHIMICA ACTA
·
2026
·Vol. 193
·期 8
·563
·
IF 5.4
Liu Huan,Chen Yuhan,Sun Han,Wang Boyan,Liu Aihua
The sensitive monitoring of bisphenol A (BPA) concentration remains a critical challenge in environmental analysis and public healthcare. In this study, Mn 3 O 4 nanorods were facilely prepared in an aqueous solution at room temperature using Mn 2+ as the precursor, NaOH as the basic source and L-histidine as the mediator. The as-prepared Mn 3 O 4 nanorods exhibit excellent laccase-mimicking activity with a catalytic efficiency of 3.85 × 10 − 3 min − 1 . The catalytic mechanism was confirmed to be oxygen vacancies by electron paramagnetic resonance spectrum and enzymatic inhibition experiment. Taking advantage of the excellent laccase-mimetic properties of the Mn 3 O 4 nanozyme, a sensitive and selective colorimetric sensing platform for BPA detection was constructed. The colorimetric sensing platform achieved a linear detection range of 1–60 µM BPA and a detection limit of 0.23 µM for BPA (3σ/S). The proposed method was applicable to the determination of BPA in plastic-packaged white vinegar, bottled water and milk with good recoveries and reproducibility. This work not only provides a novel and efficient analytical tool for the rapid detection of BPA but also offers a new insight into the design and synthesis of other amino acid-mediated nanozymes for environmental monitoring applications. Graphical
✓ 已验证
产品关联
DOI
PubMed
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2026
·
IF 12.5
Xin Shi,Qiuyan Bi,Zizhen Peng,Zhicheng Wang,Fangbo Zhu,Yakai Lin,Wenzhong Ma,Chuanjie Fang,Shiai Xu
RIP microenvironment regulation and amino acid functionalization synergize NF design. • BDM scavenges H + to suppress PEI protonation and preserve reactivity. • L-Arginine functionalization enhances membrane hydration and positive charge. • P-B-0.8/A-0.1 membrane achieves 99.5% Mg 2+ rejection and an SF of 131.7. • After 80 h, MgCl 2 rejection >98%, showing stable and antifouling performance. Thin-film composite (TFC) nanofiltration (NF) membranes show great potential for Mg 2+ /Li + separation. However, during conventional interfacial polymerization, excessively rapid amine diffusion and local acidification at the reaction interface can lead to nonuniform interfacial reactions. This study proposes a synergistic construction strategy of membrane forming microenvironment regulation and amino acid interface empowerment. Bis (2-dimethylaminoethyl) ether moderated the apparent migration and protonation behavior of polyethylenimine and alleviated local acidification at the reaction front. Subsequent L-arginine post modification enhanced surface hydration and modified the acid–base/charge characteristics of the polyamide layer interface. P-B-0.8/A-0.1 membrane with high positive surface charge (IEP pH = 8.5), excellent antifouling properties, and a uniform pore-size distribution were constructed for Mg 2+ /Li + separation. In the MgCl 2 /LiCl mixed salt system, the membrane achieved an Mg 2+ rejection rate of 99.5% and a separation factor of 131.7. During 80 h of continuous operation, the Mg 2+ rejection rate remained above 98%. Moreover, the P-B-0.8/A-0.1 membrane exhibited excellent flux recovery and anti-scaling stability during BSA and lysozyme fouling cycles, as well as in CaSO 4 and CaCO 3 inorganic scaling systems.
✓ 已验证
产品关联
DOI
高影响因子
Agronomy-Basel
·
2026
·Vol. 16
·期 13
·1271
·
IF 4.1
Qian Qiu,Zhiwu Huang,Aisheng Xiong,Guofei Tan,Sucheng Ren,Daguo Gu,Hengyu Meng,Luzhao Pan,Weimin Zhu,Jun Yan
The Cytochrome P450 (CYP) superfamily plays an important role in the regulation of plant growth and development. However, the composition, evolutionary characteristics, and potential functions of CYPs in celery remain largely unexplored. Therefore, the objective of this study was to perform a genome-wide characterization of theApium graveolensCytochrome P450 (AgCYP) gene family and investigate its potential roles in seed development. In this study, a total of 227AgCYPswere identified, and phylogenetic analysis classified them into six clades. Conserved motif and domain evaluations indicated that most AgCYP proteins possess conserved P450 domains. Chromosomal localization revealed an unequal distribution ofAgCYPsacross the 11 celery chromosomes. DuplicatedAgCYPgene pairs were identified by synteny and Ka/Ks analyses, indicating that the duplicatedAgCYPshave undergone strong purifying selection. Inter-genomic synteny analysis further reflects the closer relationship within Apiaceae. Analysis ofcis-acting elements in the promoter regions identified an abundance of elements associated with light, hormone, and environmental stress. Moreover,AgCYPsshowed stage-specific expression patterns and were correlated with monoterpene and phthalide accumulation during celery seed development, suggesting their potential functions in secondary metabolism in seed development. Treatment with exogenous auxin and its transport and biosynthesis inhibitors differentially induced distinct expression responses amongAgCYPs, indicating their possible participation in auxin-related regulatory pathways. Moreover, candidate genes were selected. They exhibited diverse tissue-specific expression patterns and were potentially localized to the endoplasmic reticulum and interacted with some auxin-related proteins. In conclusion, this study provides the first comprehensive framework for understanding the functional diversification of AgCYPs in celery seeds, providing new insights into the evolutionary features and biological functions of theAgCYPgene family and establishing a foundation for future functional studies and molecular breeding applications.
✓ 已验证
DOI
高影响因子
POLYMER ENGINEERING AND SCIENCE
·
2025
·
IF 3.2
Xiaofeng Wang,Hongyan Jin,Shuya Zhang,Zifan Zou,Tao Zhang,Yingzheng Lv,Zichen Yuan,Wenjuan Han,Qian Li
In tissue engineering and regenerative medicine, biodegradable PLCL polymers are highly valued. This is because their mechanical properties can be finely adjusted, and they are compatible with biological tissues. However, precise control over their degradation rate remains a challenge for biomedical applications. In this study, magnesium oxide (MgO) nanoparticles were incorporated into PLCL matrices to systematically modulate both mechanical properties and degradation behavior. To determine the microstructure and thermal robustness of the PLCL/MgO composites, a battery of tests was conducted. These tests included scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FTIR), differential scanning calorimetry (DSC), rheometry, and thermogravimetric analysis (TGA). The results revealed that MgO nanoparticles significantly enhanced the ultimate tensile strength and modulus of elasticity of PLCL while simultaneously accelerating its hydrolytic degradation. This was attributed to MgO's dual role: (1) stabilizing the local pH by neutralizing acidic degradation byproducts, thereby mitigating autocatalytic degradation of the PLCL matrix, and (2) acting as an alkaline catalyst to facilitate ester bond hydrolysis. Notably, the degradation rate increased in a MgO concentration-dependent manner, with minimal impact on the polymer's biocompatibility. This study demonstrates that MgO can effectively modulate the degradation process, thereby enabling the creation of bioresorbable PLCL-based materials with tailored lifespans. This advancement holds great promise for advanced biomedical applications.
✓ 已验证
产品关联
DOI
高影响因子
APPLIED SURFACE SCIENCE
·
2025
·
IF 6.9
Yuanjiang Li,Haobo Yuan,Feng Gao,Yu Shi,Haiqin Wei,Xiaodong Wang,Wei Huang
This work focused on improving the pervaporation performance of Pebax® 2533 membranes cast on polytetrafluoroethylene substrates, by incorporating home-made bifunctionalized ZIF-L with amino groups and aromatic rings, to prepare MMMs for dephenolization from the aqueous solution. Amino groups in ZIF-L-NH 2 led to the enhanced interaction between the fillers and the matrix by forming hydrogen bonds, thus aminated fillers dispersed more homogeneously in MMMs than the non-aminated fillers and the MMMs possessed a better interface structure. Aromatic rings in ZIF-L-NH 2 made the membranes more organophilic and brought them a stronger affinity towards phenol. The separation performance of the MMM with 15 wt% fillers and 20 μm thickness surpassed most of the other phenol-selective membranes with the separation factor of 59.79 and the total flux of 1.93 kg/m 2 ·h for 1000 ppm phenol solution at 80 ℃. Notably, the MMMs maintained a good separation performance even when the phenol concentration of the feed solution extended to 18,000 ppm. In a 60 h long-term pervaporation, the MMM was stable. We believe that such MMMs design based on fillers with a ligand rich in aromatic rings and amino groups is a promising approach for high-performance dephenolization membranes.
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）