Journal of Environmental Chemical Engineering
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2024
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IF 7.4
Haofu Liu,Zhiqing Huang,Yingyu Shi,Tingyao Cai,Qi Miao,Zideng Gao,Zhenling Cui
Ensuring efficient iron absorption by crops is crucial in terms of high crop yields and food security . Bio-based materials effectively transport nutrients with minimal environmental impacts. Here, highly efficient lightweight iron fertilizers , CSG@Fe was prepared using chitosan hydrogels (CSG) as the adsorption carrier. Iron release from the various CSG@Fe preparations was slow under neutral conditions but rapid under acidic conditions. The effects of various cross-linking agents were investigated; 1.0 wt% genipin chitosan hydrogels iron fertilizer (GE-CSG@Fe) evidenced an excellent iron adsorption rate and a higher iron loading (326.15 mg/g) than the other two iron fertilizers. Iron release from CSG@Fe materials followed the Korsmeyer-Peppas model. Notably, wheat seed germination and tomato pot experiments revealed that GE-CSG@Fe significantly enhanced germination and growth. GE-CSG@Fe appropriately reduced the soil pH, protected ferrous ions from soil oxidation and rapid fixation, activated the soil microenvironment, and improved nutrient absorption by the roots of crops growing. This work provides a simple and effective strategy for overcoming constraints in the development and application of iron fertilizers and provides insights into the development of green and efficient iron fertilizers with intelligent response properties.
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JOURNAL OF MOLECULAR STRUCTURE
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2024
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IF 4
Shuai Qiang Jiang,Su Ping Dai,Wei Ming Liu,Yin Wang,Zhao Yuan Li,Ya Wei Chen,Hyun Jin Park,Hui Yun Zhou
In this paper, three kinds of cyclodextrin-grafted-chitosan (CD-g-CS) were synthesized from chitosan (CS) and β-cyclodextrin (β-CD) with different ratios. And a series of hydrogel with good temperature sensitivity and injectability were prepared by using sodium glycerophosphate (GP) and ammonium hydrogen phosphate (AHP) as dual gelling agents. The gelation formation time of hydrogel was short, and the shortest time was 0.75 min. The FTIR spectrum and 1 H-NMR spectrum showed the structure of the compounds and intermolecular interactions. The molecular docking technique probed the encapsulation mechanism of the drug with β-CD. The SEM results showed that the hydrogel had a highly interconnected three-dimensional spatial structure. The swelling ratio of hydrogel was not less than 150 % within 1 h and the degradation rate of hydrogel was not less than 75 % within 14 days. The in vitro drug release results showed that the hydrogel had optimal sustained release effect, and the cumulative release ratio was 58.3 % in 34 h. The release kinetics analysis exhibited that the hydrogel conformed to the Riter-Peppas model. The hemocompatibility test and cytotoxicity test proved that the hydrogel had good biocompatibility and biosafety. The antibacterial experiments showed that the hydrogel could inhibit the biological activity of Escherichia coli ( E. coli ) and Staphylococcus aureus ( S. aureus ). Therefore, the CD-g-CS/GP-AHP hydrogel has a broad application prospect in the biological fields of drug delivery and antibacterial materials.
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CARBOHYDRATE POLYMERS
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2024
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IF 10.7
Ting Xie,Fangyan Ou,Chuang Ning,Liang Tuo,Zhichao Zhang,Yi Gao,Wenyu Pan,Zequan Li,Wei Gao
With the development of technology, there is a growing demand for wearable electronics that can fulfill different application scenarios. Hydrogel–based sensors are considered ideal candidates for realizing multifunctional wearable flexible devices. However, there are great challenges in preparing hydrogel–based sensors with both superior mechanical and electrical properties. Herein, we report a composite conductive hydrogel prepared by using a dynamically crosslinked carboxymethyl chitosan network and a covalently crosslinked polymer network, and carboxylated carbon nanotubes as conductive filler. The carboxymethyl chitosan–based hydrogels had excellent mechanical properties and strength (tensile strength of 475.4 kPa, and compressive strength of 1.9 MPa) and ultra–high conductivity (0.19 S·cm −1 ). Based on the above characteristics, the hydrogel could accurately identify the movement signals of the human body and different writing signals, and achieve encrypted transmission of signals, broadening the application scenarios. In addition, a triboelectric nanogenerator (TENG) was fabricated based on the hydrogel, which had an outstanding output performance with open–circuit voltage of 336 V, short–circuit current of 18 μA, transferred charge of 52 nC and maximum power density of 340 mW·m −2 , and could power small devices. This work is expected to provide new ideas for the development of self–powered, multi–functional wearable, and flexible polysaccharide–based devices.
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PubMed
高影响因子
LANGMUIR
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2025
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IF 3.9
Shi-Hao Yang,Xue Zhang,Yu-Mei Tan,Rui Xie,Wei Wang,Zhuang Liu,Da-Wei Pan,Xiao-Jie Ju,Liang-Yin Chu
The controllable fabrication and performances of monodisperse genipin-cross-linked gelatin–chitosan composite (GGC) embolic microspheres with both uniform sizes and adjustable characteristics of elasticity and degradation are reported for the first time. Monodisperse emulsion droplets are fabricated as templates by using gelatin and chitosan aqueous solution as the disperse phase in a microfluidic device, and the chemical cross-linking of gelatin and chitosan inside droplet templates is achieved with genipin that transfers from the collection bath into the droplets. The sizes of droplet templates and the resultant GGC microspheres can be flexibly controlled and predicted by adjusting the fluid flow rates and the device dimensions. The elastic property of GGC microspheres can be flexibly regulated by adjusting the molar ratio of gelatin/chitosan in the disperse phase. The in vitro degradation-caused dynamic volume shrinkage of GGC microspheres can be flexibly regulated by adjusting the molar ratio of gelatin/chitosan, the chitosan deacetylation degree, and the enzyme concentration in degradation solution. Based on the Box–Behnken design-response surface method, a second-order equation is developed for the first time to predict the in vitro degradation-caused dynamic volume shrinkage ratios of microspheres prepared with different molar ratios of gelatin/chitosan and different chitosan deacetylation degrees in degradation solutions with different enzyme concentrations. The fabricated GGC microspheres show good repeatable embolization performances in an in vitro embolization chip system. The results of this study provide valuable guidance for controllable fabrication of degradable microspheres with both uniform sizes and on-demand elastic and degradation characteristics for efficient application in embolization therapy.
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JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
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2024
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IF 3.3
Huiyun Zhang,Xinling Li,Ziye Zhang,An Jiang,QiaoQiao Bai
BACKGROUND Previous studies have demonstrated that the addition of chitosan can improve the quality and functional properties of meat products. However, the underlying mechanism remains unclear. In this study, the effect and mechanism of the addition of chitosan on the gel properties of myofibrillar protein (MP) were investigated. RESULTS The results indicated that the gel strength and the water-holding capacity of MP-chitosan gel increased significantly when chitosan was added at 2.5–10 mg mL −1 . Myofibrillar protein samples with 10 mg mL −1 added chitosan exhibited the highest elasticity and viscosity during gel formation and strengthening. The addition of chitosan also caused a modification in both the secondary and tertiary structure of MP, resulting in an enhanced exposure of hydrophobic and sulfhydryl groups in comparison with the control. Chitosan inhibited the conversion of immobilized water into free water and the formation of water channels during the thermal gelation process of MP. The denaturation enthalpy ( Δ H) of myosin decreased as the concentration of chitosan exceeded 5 mg mL −1 . The microstructure showed that the incorporation of chitosan (5–10 mg mL −1 ) facilitated the formation of compact and well organized MP gel networks. CONCLUSION The addition of chitosan can enhance the functional properties of meat protein and facilitate heat-induced gelation, making it a promising ingredient for improving the quality of processed meat products. © 2024 Society of Chemical Industry.
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Polymer-Plastics Technology and Materials
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2024
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IF 2.6
Lu Guo,Shiwei Wang,Weizhen Xie,Xuan Wu,Bo Zhao,Man Liu,Chaolu Yin,Qian Li
In order to improve the thermal insulation and smoking properties of expanded vermiculite matrix composites, a kind of expanded vermiculite (EV)/chitosan (CS) composites was prepared by hot pressing. The effects of CS on smoke density, fire-resistance, insulation, and mechanical properties of the EV/CS composites were studied. The results show that with the increase of CS content, the smoke absorption performance and energy storage modulus of the composites is improved. Thermogravimetric (TG) analysis shows that the thermal stability of the EV/CS composite is improved by the presence of chitosan. The pores appear on the surface of the composites after the single-side fire-resistance test. After that, the thermal conductivity of the composites gradually decreases and the insulation performance is improved as the CS content increases. The CS carbonized during the preparation of the composites and thermal decomposition during the test. The morphology results show phase separation of the composites, and the porosity of the composites increases after the test. The reticular structure formed between the EV particles, sodium silicate, and CS molecules reduces the strength loss of the composites.
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Biomaterials Advances
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2025
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IF 6
Pu Hou,Kun Lei,Zhishen Zhang,Pengchao Zhao,Jinghua Li,Guangda Li,Jianfeng Bao,Xin Li,Yun Xue,Chunshan Quan,Fangfang Fu
Hydrogels possessing appropriate adhesion and antibacterial properties have emerged as promising dressings for expediting wound healing, while also providing the convenience of visualizing the wound site to accurately monitor the healing process. In this study, we incorporated oxidized and degraded polydopamine nanoparticles into quaternized chitosan/oxidized dextran hydrogel QOP series, resulting in enhanced transmittance exceeding 95 % and adhesion strengths reaching up to 19.4 kPa. Moreover, these hydrogels exhibit a well-defined porous structure, rapid gelling ability (<50 s), exceptional self-healing capacity, and a swelling rate surpassing 760 %. Furthermore, the QOP hydrogels demonstrate outstanding hemocompatibility (hemolysis rate < 3 %) and cytocompatibility (cell viability >100 %). In addition, they display potent inhibition against Staphylococcus aureus , methicillin-resistant S. aureus (MRSA), Staphylococcus pasteuri and Escherichia coli , with bactericidal rates exceeded 90 %. The closure of MRSA-infected wounds along with H&E and Masson staining analysis revealed that QOP hydrogels can expedite wound healing by stimulating collagen deposition and facilitating angiogenesis.
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JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY
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2025
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IF 4.7
Jinzhao Shu,Zhiguo Hou,Yuqi Zhang,Xueyi Dong,Yue Zhang,Qiangwei Liu,Shijun Kang,Mingliang Liu,Sen Wang,Bin Yang,Jiasheng Qian
In this paper, PVA/CS/CuS-based antibacterial hydrogel was prepared by a simple method. The CuS-based particles were characterized using zeta potentiometers, X-ray diffraction, X-ray photoelectron spectroscopy, transmission electron microscopy, and scanning electron microscopy. These analyses verified the successful synthesis of CuS@PDA and CuS@PDA@Ag particles. The composite hydrogel exhibited good photothermal effect and antibacterial activity, with silver doping significantly improving its photocatalytic performance. Under 808 nm near-infrared light irradiation, the hydrogel exhibited excellent photothermal conversion ability, with the maximum temperatures of the three hydrogels being 59.2 °C, 61.5 °C, and 64.8 °C, respectively. After 10-minute irradiation, the composite hydrogel exhibited obvious antibacterial activity due to the synergistic effect of hyperthermia and reactive oxygen species, resulting in a bactericidal efficiency of 96.2 % against E. coli and 98.4 % against S. aureus.
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MACROMOLECULAR RAPID COMMUNICATIONS
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2024
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IF 4.2
Hao Huang,Zexin Liu,Hanxin Jian,Yuan Yao,Wenjuan Tan,Shuguang Yang
Living tissues span a remarkable spectrum of modulus ranging from the level of Pa to GPa in a water-rich environment. Constructing soft and hard materials that match the mechanics of tissues and researching mechanical transition in water, are beneficial for their biological applications. Here, using polyelectrolyte complex fiber as a model system and reinforcing the fiber by stepwisely introducing additional coordination and covalent bonds, this investigated that the water effect on mechanical transition behaviors. Alginate/chitosan fiber (AC fiber) has a single electrostatic bond and shows continuous mechanical transition containing a glassy state, rubbery state, and terminal relaxation (initial modulus lower than 10 MPa) in aqueous solution. Alginate/chitosan/calcium fiber (ACC fiber) has both electrostatic and coordination bonds, which shows the behavior of hard rubber (initial modulus 100 MPa) when water reaches equilibrium. Alginate/chitosan/calcium/polydopamine fiber (ACCP fiber) with triple bonds, including electrostatic, coordination, and covalent bonds, exhibits the behavior like ductile plastics in aqueous solution (initial modulus 1000 MPa). This work not only provides important insight into the toughening mechanism of polyelectrolyte complexes in water but also contributes to the preparation of tissue adaptive implantations.
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CARBOHYDRATE POLYMERS
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2011
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IF 3.463
Hongyan Zhu,Fei Liu,Jing Guo,Jianpeng Xue,Zhiyu Qian,Yueqing Gu
Folate modified chitosan micelles were synthesized for cancer-specific targeting and drug delivery. Receptor-mediated uptake and drug delivery were characterized in vitro and in a small animal model of cancer after loading with hydrophobic fluorescent dyes as drug models. Hydrophilic succinic anhydride and hydrophobic octaldehyde were reacted with chitosan respectively to form amphipathic N-succinyl-N′-octyl chitosan (SO-chitosan). SO-chitosan was covalently modified with folate to form folate-modified N-succinyl-N′-octyl chitosan (folate-SO-chitosan). The folate-SO-chitosan micelles were obtained through self-assembling and maintained a stable core-shell structure with average diameter of about 136 nm up to 15 days. The prepared folate-SO-chitosan micelles displayed a good drug loading content (12.17%), entrapment efficiency (69.32%) and sustained release behavior for the model drug fluorescein. The in vitro cellular uptake and in vivo tumor targeting ability of the folate-SO-chitosan micelles were evaluated by fluorescence microscopy and near infrared imaging, respectively. In vitro and in vivo results demonstrated enhanced targeting behaviors in a folate receptor positive tumor model (Bel-7402), which suggests that the folate-SO-chitosan micelles are promising tumor targeting carriers for hydrophobic diagnostic agents as well as anti-tumor agents.
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FOOD CHEMISTRY
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2024
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IF 8.5
Linlin Li,Li Xia,Feng Xiao,Yewen Xiao,Wei Ji,Baocai Xu,Hualin Wang
Using novel active food packaging has gradually become a daily necessity in terms of impeding microbial contamination. Here, an antimicrobial photodynamic inactivation (PDI) pH-responsive film is developed by incorporating aloe-emodin (AE) into a vehicle of gelatin/chitosan (GC). Besides enhancement in hydrophobicity, the well-dispersed crystals of AE in the GC matrix by hydrogen bonding can upgrade the film's mechanical strength and barrier. The matrix is capable of regulating the release of AE in response to acidic stimuli by a combination mechanism of diffusion and polymer relaxation. Being benefitted from the inherent bioactivity of AE and the PDI activity under visible light irradiation (i.e., 456 nm), the target film of GC-AE2 has excellent antibacterial effect towards Staphylococcus aureus and Escherichia coli , showing bacterial viability of 9.93 ± 1.33 % and 14.85 ± 1.16 %, respectively. Furthermore, the film can effectively thwart Botrytis cinerea infection in cherry tomatoes, demonstrating its potential in preventing the microbial spoilage of postharvest fruits.
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JOURNAL OF APPLIED POLYMER SCIENCE
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2025
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IF 2.8
Yuying Cui,Lulu Wang,Yang Zhang,Shuang Li,Fan Zhang,Jilin Wang
Developing novel anion-exchange membranes (AEMs) that feature superior hydroxide conductivity and excellent alkaline stability poses a major challenge. Among different kinds, cross-linked AEMs enjoy the highest popularity, thanks to their uncomplicated fabrication procedures and outstanding stability. However, it is noteworthy that in the majority of instances, the employment of covalent cross-linking methods often plunges AEMs into a conductivity-stability conundrum. That is to say, when efforts are made to boost the conductivity, the stability tends to be compromised, and conversely, attempts to enhance stability might adversely affect conductivity. To tackle the conductivity-stability issue faced by conventional covalent cross-linked AEMs, within this research, innovative bifunctional imidazole cross-linking agents that carry imidazole cations were synthesized using N-(3-aminopropyl)-imidazole and 3-chloropropylamine. Following that, these agents were then utilized to manufacture high-performance cross-linked quaternized chitosan (QCS) membranes. The bifunctional cross-linker was able to furnish an ionic 3-D network, further promoting the formation of microphase separation morphology and a densely cross-linked structure, thereby bringing about both excellent conductivity and alkaline stability. The as-prepared QCS-MI 0.3 AEM exhibited a relatively low swelling ratio of 29.7% at 80°C, along with outstanding conductivity reaching 128.83 mS cm −1 at the same temperature. Moreover, it demonstrated remarkable alkaline stability, with 92% of its conductivity retained after being immersed in 6 M KOH at 80°C for 168 h. Meanwhile, the single cell built upon the QCS-MI 0.3 AEM likewise showcased remarkable fuel cell performance, achieving a power output of 518.08 mW cm −2 at 80°C, and exhibited excellent durability as well. This research effort devised a novel approach for synthesizing high-performance cross-linked AEMs, which further augmented the application potential of QCS-based AEMs in the realm of fuel cells.
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