ADVANCED FUNCTIONAL MATERIALS
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2024
·
IF 18.5
Jianwen Feng,Jiayi Wang,Qiao Gu,Pingting Li,Hongli Xu,Yonghong Deng,Ping Gao
Gel polymer electrolytes (GPEs) hold great promise for lithium (Li) metal batteries (LMBs). Nevertheless, a critical challenge lies in reducing the thickness of GPEs while maintaining their mechanical integrity to achieve high-energy-density LMBs. Additionally, protecting the Li metal anode via electrolyte engineering in GPEs remains demanding. Herein, an innovative ultrathin (1 µm-thick) yet robust GPE developed using an in situ curing technique, featuring a nanofibrous, exceptionally strong polyethylene separator is presented. The unique microstructure, interfacial conformability, and ultrahigh mechanical robustness of the ultrathin polyethylene separator are thoroughly verified. Enhanced ionic association within the GPE is achieved due to the strong affinity of electrolyte solvent with the fluorinated polymer network, as confirmed by large-scale molecular dynamics simulations. The optimized solvation structure with high contact ion pairs and aggregate fractions contributes to forming an anion-derived inorganic-rich solid electrolyte interphase (SEI), thereby protecting the lithium anode. Benefiting from the ultrahigh robustness of GPE and the excellent interfacial stability, the Li metal full cell with a high mass loading LiNi 0.8 Co 0.1 Mn 0.1 O 2 cathode (≈17.3 mg cm −2 ) and thin Li foil anode (50 µm) demonstrates 91% capacity retention after 200 cycles. This design demonstrates a feasible approach toward the practical quasi-solid-state LMBs.
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JOURNAL OF MEMBRANE SCIENCE
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2025
·
IF 9
Hongjin Li,Yongchao Sun,Jianyu Guan,Lu Bai,Tianyou Li,Fake Sun,Yijun Liu,Gaohong He,Canghai Ma
Mixed matrix membranes (MMMs), composed of polymers and fillers, capitalize on the complementary strengths of both materials, offering a promising approach for developing high-performance membranes for C 3 H 6 /C 3 H 8 separation. However, the effectiveness of MMMs is often hindered by poor interfacial compatibility between the polymer and the filler. To address this challenge, we present an effective strategy that simultaneously enhances both interfacial compatibility and gas separation performance in MMMs. By etching ZIF-8 with cyanuric acid (CA), we successfully synthesized defect-engineered ZIF-8 (DZIF-8), a hollow nanoframe structure that features open metal sites. These sites not only coordinate with the amidoxime groups of amidoxime-functionalized PIM-1 (AO-PIM-1) to improve interfacial compatibility but also significantly enhance the adsorption capacity for propylene. The resulting MMMs exhibited excellent interfacial compatibility with no observable filler agglomeration. Remarkably, the 10 % DZIF-8-based MMM enhances C 3 H 6 permeability to 492 and boosts C 3 H 6 /C 3 H 8 selectivity to 24. The defect-engineered MOF-based MMM (DMMM) surpassed the 2003 upper bound for C 3 H 6 /C 3 H 8 separation and demonstrated outstanding resistance to plasticization. Furthermore, the DMMM exceeded the 2008 Robeson upper bound for H 2 /CH 4 (N 2 ) separation performance, highlighting its exceptional versatility. These results showcase the potential of defect-engineered MMMs in gas separation applications, particularly in high-performance C 3 H 6 /C 3 H 8 separation.
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AMERICAN JOURNAL OF PATHOLOGY
·
2024
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IF 4.7
Mingxiang Zou,Wenkang Chen,Jing Li,Xin Qi,Xiaobin Wang,Fubing Liu,Jiarui Hu,Qianshi Zhang
This study investigated the role of apoptosis signal-regulated kinase-1 ( ASK1 ) in intervertebral disc degeneration (IDD). The nucleus pulposus (NP) tissues of non-IDD and IDD patients were subjected to hematoxylin and eosin, Safranin O–fast green, and immunohistochemical staining. Quantitative real-time PCR was used to assess the ASK1 mRNA level within NP tissue samples and cells. The Cell Counting Kit-8 assay, senescence-associated β-galactosidase staining, and then flow cytometry were conducted, respectively, to assess the viability, senescence, and apoptosis of NP cells. The extracellular matrix–related factors were detected using Western blot analysis. Furthermore, the effect of ASK1 on the IDD rat model was evaluated through nuclear magnetic resonance imaging analysis, hematoxylin and eosin, Safranin O–fast green staining, and immunohistochemical staining. Finally, c-Jun N-terminal kinase (JNK) inhibitors were used to verify the effect of the JNK/p38 signaling on IDD. ASK1 mRNA and protein were up-regulated within NP tissue samples from the IDD group, IL-1β–stimulated NP cells, and IDD rats. ASK1 inhibition promoted cell viability and repressed the senescence and apoptosis of NP cells; promoted collagen II and aggrecan; inhibited matrix metalloproteinase 3, matrix metalloproteinase 9, a disintegrin and metalloproteinase with thrombospondin motifs 4, and a disintegrin and metalloproteinase with thrombospondin motifs 5 protein levels; and increased NP cells in rat intervertebral disc tissues. ASK1 overexpression exerted the opposite effects of ASK1 inhibition on NP cells. Additionally, JNK/p38 signaling suppression could reverse the ASK1 up-regulation–induced dysfunction. In conclusion, ASK1 facilitated the senescence and apoptosis of NP cells in promoting IDD progression, which may be mediated by the JNK/p38 pathway.
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ANALYTICA CHIMICA ACTA
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2024
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IF 5.7
Shaojie Ma,Yuchen Zhu,Boxin Chen,Bin Zhao,Fei Feng
Background The micro gas chromatography column (μGCC) is one of the key components of the miniaturized gas chromatography system. However, light alkanes are difficult to be separated by a micro gas chromatography column , especially for methane and ethane, because the length of μGCC is limited by the area of a silicon substrate. More importantly, the heterogeneous microchannel surface formed by silicon glass bonding causes uneven stationary phase coating and the forces between the untreated microchannel surfaces and the stationary phase materials are weak, which will prevent the improvement of separation performance. Results In this paper, a micro gas chromatography column (μGCC) with uniform HKUST-1 stationary phase is reported. Significantly, an alumina film prepared by the atomic layer deposition (ALD) technique is used to homogenize the heterogeneous microchannels. The alumina is a hydrophilic material and the alumina made by the ALD technique is uniform. The forces between hydrophilic alumina film and HKUST-1 are strong, which can greatly improve the coating uniformity of the hydrophilic stationary phase HKUST-1. The test results show that the μGCC could baseline separate the light alkane mixtures (CH 4 , C 2 H 6 , C 3 H 8 , and C 4 H 10 ) at the high testing temperature of 120 °C. The maximum resolution of the difficult-separated methane and ethane reached 19.2, which is 108 % higher than the μGCC using the same stationary phase without homogenizing the microchannel inner surface. Significance The μGCC uses ALD alumina film to homogenize the microchannel inner surface; meanwhile, hydrophilic ALD alumina has a strong electrostatic attraction with the hydrophilic stationary phase HKUST-1. Homogeneous microchannel surface and strong electrostatic attraction are favorable to obtain uniform stationary phase which greatly improves the separation performance, resulting in a large resolution for methane and ethane. The μGCC has broad application prospects in light alkane separation.
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ChemSusChem
·
2019
·Vol. 12
·期 10
·2231-2239
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IF 7.804
Ying Pan,Xiaofei Zhai,Jian Yin,Tianqi Zhang,Liujia Ma,Yi Zhou,Yufeng Zhang,Jianqiang Meng
Graphical A metal-ion-crosslinked PIM-1 framework as heterogeneous catalyst is reported for promoting the CO 2 cycloaddition with epoxides. The new catalyst PIM-COONa-Zn demonstrates both high catalytic efficiency and good recyclability. CO 2 cycloaddition to epoxides is an effective and economical utilization method to alleviate the current excessive CO 2 emission situation. The development of catalysts with both high catalytic efficiency and high recyclability is necessary but challenging. In this context, a heterogeneous catalyst was synthesized based on a zinc-ion-crosslinked polymer with intrinsic microporosity (PIM-1). The high microporosity of PIM-1 promoted a high Zn 2+ loading rate. Additionally, the relatively stable ionic bond formed between Zn 2+ and the PIM-1 framework through electrostatic interaction ensured high loading stability. In the process of CO 2 cycloaddition with propylene epoxide, an optimized conversion of 90 % with a turnover frequency as high as 9533 h −1 could be achieved within 0.5 h at 100 °C and 2 MPa. After 15 cycles, the catalytic efficiency did not demonstrate a significant decline, and the catalyst was able to recover most of its activity after Zn 2+ reloading. This work thereby provides a strategically designed CO 2 conversion catalyst based on an ionic crosslinked polymer with intrinsic microporosity.
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Redox Biology
·
2024
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IF 10.7
Mengfei Chen,Zhenjun Zhu,Shujian Wu,Aohuan Huang,Zhiqing Xie,Jie Cai,Rong Huang,Shubo Yu,Ming Liu,Jumei Zhang,Yuchung Tse,Qingping Wu,Juan Wang,Yu Ding
Oxidative stress (OS) and disruption of proteostasis caused by aggregated proteins are the primary causes of cell death in various diseases. Selenopeptides have shown the potential to control OS and alleviate inflammatory damage, suggesting promising therapeutic applications. However, their potential function in inhibiting proteotoxicity is not yet fully understood. To address this gap in knowledge, this study aimed to investigate the effects and underlying mechanisms of the selenopeptide VPRKL(Se)M on amyloid β protein (Aβ) toxicity in transgenic Caenorhabditis elegans . The results revealed that supplementation with VPRKL(Se)M can alleviate Aβ-induced toxic effects in the transgenic C. elegans model. Moreover, the addition of VPRKL(Se)M inhibited the Aβ aggregates formation, reduced the reactive oxygen species (ROS) levels, and ameliorated the overall proteostasis. Importantly, we found that the inhibitory effects of VPRKL(Se)M on Aβ toxicity and activation of the unfolded protein are dependent on skinhead-1 (SKN-1). These findings suggested that VPRKL(Se)M is a potential bioactive agent for modulating SKN-1, which subsequently improves proteostasis and reduces OS. Collectively, the findings from the current study suggests VPRKL(Se)M may play a critical role in preventing protein disorder and related diseases.
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MICROPOROUS AND MESOPOROUS MATERIALS
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2025
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IF 4.7
Beining Luo,Yan Wang,Yingqi Zhang,Caifeng Qiu,Guoqiang Yu,Liang Li,Xianzai Yan,Guoqiang Wu
Catalytic epoxidation limitations of conventional ellipsoid titanosilicate-1 (TS-1) remains owing to the narrow microporous channels and low efficiency of the Ti species. Herein, two-dimensional planer TS-1 zeolite (TS-1-P) was synthesized by adding crystal growth regulator in the hydrothermal synthesis process, and then TS-1-P supported molybdenum (Mo/TS-1-P) and mesoporous Mo/TS-1-P (Mo/MTS-1-P) were prepared and applied in epoxidation of olefins. The TS-1-P and the modified TS-1-P catalysts show a similar MFI framework and grain morphology but the different pore structure and coordination environment of Ti or Mo species. Especially, the Mo/MTS-1-P possesses many mesoporous pore and highly dispersed Mo species, which can improve the coordination environment of Ti species and weaken the Ti-O bond, the results are beneficial for the framework Ti species to combine more easily with H 2 O 2 to C=C band of the olefin molecules. Therefore, compared with TS-1-P, Mo/MTS-1-P exhibits the highest conversion of ACH (91.78 %) and 1-hexene (47.44 %) in the epoxidation of ACH and 1-hexene, respectively, the selectivity of epoxidized products simultaneous is above 96.42 % and 94.04 %, respectively. Moreover, the deactivation behavior of carbon deposit on the catalyst surface and regeneration method were also proposed. The successful preparation of Mo/MTS-1-P not only results in an efficient catalyst for epoxidation process but also provides a possible approach for surface and pore structure modification of TS-1 zeolite.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2024
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IF 7.7
Guodong Chai,Ning Wang,Meiling Xu,Lina Ma,Xinglong Liu,Qiteng Ding,Shuai Zhang,Anning Li,Guofeng Xia,Yingchun Zhao,Wencong Liu,Dadong Liang,Chuanbo Ding
Bacterial infection, hyperinflammation and hypoxia, which can lead to amputation in severe cases, are frequently observed in diabetic wounds, and this has been a critical issue facing the repair of chronic skin injuries. In this study, a copper-based MOF (TAX@HKUST-1) highly loaded with taxifolin (TAX) with a drug loading of 41.94 ± 2.60 % was prepared. In addition, it has excellent catalase activity, and by constructing an oxygen-releasing hydrogel (PTH) system with calcium peroxide (CaO 2 ), it can be used as a nano-enzyme to promote the generation of oxygen from hydrogen peroxide (H 2 O 2 ) to provide sufficient oxygen to the wound, and at the same time, solve the problem of the oxidative stress damage caused by excess H 2 O 2 to the cells during the oxygen-releasing process. On the other hand, TAX and HKUST-1 in PTH synergistically promoted antimicrobial and anti-oxidative stress properties, and the bacterial inhibition rate against Staphylococcus aureus and Escherichia coli reached 90 %. In vivo experiments have shown that PTH hydrogel is able to treat diabetic skin repair by inhibiting the expression of inflammation-related proteins and promoting epidermal neogenesis, angiogenesis and collagen deposition.
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INTERNATIONAL IMMUNOPHARMACOLOGY
·
2025
·
IF 4.7
Xiaolin Ma,Xuan Zhao,Yulong Yang,Jinjin Yan,Xiaoyan Shi,Hongfei Wu,Yarong Liu,Min Dai
Atherosclerosis is a chronic inflammatory disease characterized by lipid streaks, which are produced by aggregates of lipid-rich foam cells. Foam cells intensify atherosclerosis by secreting a range of inflammatory mediators. Neutrophil extracellular traps produced by activated neutrophils, which are abundantly present in lipid-accumulating plaques. However, the relationship between neutrophil extracellular traps and foam cells inflammation is still unclear. Paeonol is well known for its anti-inflammatory effects in atherosclerosis. Nevertheless, the exact pharmacological mechanisms by which paeonol affects atherosclerosis are not fully understood which require further investigation. The purpose of this study is to investigate the effects of paeonol on the neutrophil extracellular traps' formation and foam cell inflammation caused by neutrophil extracellular traps, and to explore the potential mechanisms. A high-fat diet was administered to ApoE −/− mice for a period of 12 weeks to induce an atherosclerosis model. Our findings demonstrated that paeonol notably suppressed the advancement of atherosclerosis in ApoE −/− mice, curtailed the formation of neutrophil extracellular traps, and lowered inflammatory factor levels within the plaque. In vitro studies have shown that neutrophil extracellular traps could enhance the inflammation in foam cells. CitH3 played a role in the cellular communication between neutrophil extracellular traps and foam cells. Concurrently, NLRP3 acted as a key receptor in the inflammation mediated by this interaction. Paeonol is capable of regulating NE, thereby affecting the formation of neutrophil extracellular traps. Most notably, the foam cell inflammation caused by neutrophil extracellular traps was significantly mitigated by the inclusion of paeonol. Our findings suggested that paeonol inhibited foam cell inflammation which induced by neutrophil extracellular traps through the CitH3/NLRP3/caspase-1 signaling pathway, shedding new lights on its anti-atherosclerotic pharmacological mechanism.
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Greenhouse Gases-Science and Technology
·
2024
·Vol. 14
·期 6
·954-976
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IF 2.7
Xianglian Wu,Aisha Nulahong,Conghui Miao,Qinghua Liu,Jiangyuan Li,Changmin Tuo
In this work, an alkali melting-pickling assisted solid phase synthesis method of S-1 zeolite molecular sieve with excellent adsorption properties for CO 2 was successfully developed by using solid waste fly ash. SiO 2 with a purity of up to 97.84% was successfully extracted by using alkaline fusion activation, high temperature calcination and pickling. The CO 2 adsorption capacity of the prepared SiO 2 was 0.51 mmol/g at 298 K and 1 bar. Silicalite-1 molecular sieve was prepared by solid phase synthesis method using SiO 2 extracted from fly ash as silicon source. The results showed that the prepared Silicalite-1 had good morphology and relatively high crystallinity. The specific surface area is 623.30 m 2 /g, and the total pore volume is 0.31 cm 3 /g. In addition, the adsorption capacity of CO 2 was 2.05 mmol/g at 298 K and 1 bar. Compared with the prepared SiO 2 , the adsorption capacity of CO 2 by Silicalite-1 molecular sieve increased by four times. Moreover, under the test condition of 298 K, it has a high selectivity coefficient for CO 2 /N 2 mixed gas, and after 10 times of adsorption-desorption cycle tests, the adsorption capacity of Silicalite-1 molecular sieve for CO 2 does not change significantly, and its adsorption rate can still be as high as 89.31%. The results indicate that Silicalite-1 molecular sieve prepared by solid phase synthesis method has good adsorption selectivity and adsorption–desorption cycle regeneration stability, and can be used in the field of CO 2 adsorption, separation and purification. © 2024 Society of Chemical Industry and John Wiley & Sons, Ltd.
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Scientific Reports
·
2024
·Vol. 14
·期 1
·1-12
·
IF 3.8
Gao Kexin,Liu Yancui,Sun Cheng,Wang Ying,Bao Hongrong,Liu Guoyang,Ou Jinrui,Sun Ping
Pyroptosis is a gasdermin-mediated pro-inflammatory form of programmed cell death (PCD). Tumor necrosis factor-ɑ (TNF-ɑ) is an inflammatory cytokine, and some studies have shown that TNF-ɑ can cause pyroptosis of cells and exert anti-tumor effects. However, whether TNF-ɑ exerts anti-tumor effects on breast cancer cells by inducing pyroptosis has not been reported. In this study, to explore the impact of TNF-ɑ on pyroptosis in breast cancer cells, we treated MCF-7 cells with TNF-ɑ and found that TNF-ɑ induced cell death. Moreover, we observed that the dead cells were swollen with obvious balloon-like bubbles, which was a typical sign of pyroptosis. Further studies have found that the anti-tumor effect of TNF-ɑ on breast cancer cells in vitro was achieved through the canonical pyroptosis pathway. In addition, TNF-ɑ-induced pyroptosis in MCF-7 cells was associated with mitochondrial dysfunction, in which mitochondrial membrane potential was decreased and mitochondrial ROS production was increased. After inhibiting ROS production, the activation effect of TNF-ɑ on NLRP3/Caspase-1/GSDMD pathway was weakened, and the inhibitory effect of TNF-ɑ on the growth of MCF-7 cells in vitro was also decreased, further confirming the involvement of ROS in TNF-ɑ-induced pyroptosis. Overall, our study revealed a new mechanism by which TNF-ɑ exerts an anti-tumor effect by inducing pyroptosis in MCF-7 cells through the ROS/NLRP3/Caspase-1/GSDMD pathway, which may provide new therapeutic ideas for the treatment of breast cancer.
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Nature Energy
·
2024
·
IF 49.7
Jie Yulin,Wang Shiyang,Weng Suting,Liu Yue,Yang Ming,Tang Chao,Li Xinpeng,Zhang Zhengfeng,Zhang Yuchen,Chen Yawei,Huang Fanyang,Xu Yaolin,Li Wanxia,Guo Youzhang,He Zixu,Ren Xiaodi,Lu Yuhao,Yang Ke,Cao Saichao,Lin He,Cao Ruiguo,Yan Pengfei,Cheng Tao,Wang Xuefeng,Jiao Shuhong,Xu Dongsheng
The development of practical lithium metal cells is plagued by their limited lifespan, primarily due to the poor interfacial stability of the electrolytes. Here we present a compact ion-pair aggregate (CIPA) electrolyte that enables high-performance Li metal pouch cells under lean electrolyte conditions. The electrolyte features a unique nanometre-scale solvation structure in which ion pairs are densely packed to form large CIPAs, in contrast to conventional electrolytes that comprise small aggregates. Notably, the CIPAs facilitate fast interfacial reduction kinetics on the Li metal anode via a collective electron-transfer process, leading to the formation of a stable interface. A 505.9 Wh kg −1 Li metal pouch cell with a high-nickel-content cathode (LiNi 0.905 Co 0.06 Mn 0.035 O 2 ) exhibited a 91% energy retention after 130 cycles. This work demonstrates nanostructured electrolyte design for realizing high-performance Li metal batteries. It also showcases the importance of understanding interfacial reaction mechanisms in the design and development of electrolytes.
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