JOURNAL OF SOLUTION CHEMISTRY
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2019
·Vol. 48
·期 2
·125-141
·
IF 1.039
Wei Ying,Zhang Wenbo,Zhang Xinyuan,Yang Huige,Zhang Qingguo
In the present work, a new binary mixture system composed of the ionic liquid 1-ethyl-3-methylimidazolium trifluoromethanesulfonate ([Emim][CF 3 SO 3 ]) and propylene carbonate (PC) was prepared. The densities, dynamic viscosities, and electrical conductivities of ([Emim][CF 3 SO 3 ] + PC) were measured over the whole concentration range (mole fractions of IL from 0 to 1) for temperatures from 288.15 to 353.15 K. The excess molar volumes ( V E ) and viscosity deviations (Δ η ) of the binary systems were calculated to characterize the volume contraction and intermolecular interactions in the mixture system, and both were correlated with the Redlich–Kister polynomial equation. The Vogel–Fulcher–Tamman equation was used to describe the temperature dependences of the dynamic viscosities and the electrical conductivities of the binary system. Further, density functional theory calculations were employed to obtain the structure, energy, and COSMO charge distributions of the cation and anion of the IL and the PC molecule, and the intermolecular interactions in the binary mixture system were evaluated.
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International Journal of Environmental Research and Public Health
·
2016
·Vol. 13
·期 9
·925
·
IF 2.035
Hong-Qin Sun,Yang Du,Zi-Yang Zhang,Wen-Jing Jiang,Yan-Min Guo,Xi-Wu Lu,Yi-Min Zhang,Li-Wei Sun
Benzophenone (BP) andN,N-diethyl-3-methylbenzamide (DEET) are two chemicals often used in personal care products (PCPs). There is a lack of systematic ecotoxicological evaluations about the two chemicals to aquatic organisms. In the present study, the acute toxic effects onChlorella vulgaris,Daphnia Magana, andBrachydanio reriowere tested and the ecotoxicological risks were evaluated. For BP, the 96-h half-maximal effective concentration (EC50) onC. vulgariswas 6.86 mg/L; the 24-h median lethal concentration (LC50) onD. maganawas 7.63 mg/L; the 96-h LC50onB. reriowas 14.73 mg/L. For DEET, those were 270.72 mg/L, 40.74 mg/L, and 109.67 mg/L, respectively. The mixture toxicity of BP and DEET, onC. vulgaris,D. magana, andB. rerioall showed an additive effect. The induced predicted no-effect concentrations (PNECs) for BP and DEET by assessment factor (AF) method are 0.003 mg/L and 0.407 mg/L, respectively. Both are lower than the concentrations detected from environment at present, verifying that BP and DEET are low-risk chemicals to the environment.
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JOURNAL OF HAZARDOUS MATERIALS
·
2010
·
IF 4.144
Lejin Xu,Jianlong Wang
The removal of biocide 4-chloro-3-methyl phenol (CMP) was investigated by heterogeneous Fenton-like system using nanoparticulate zero-valent iron (nZVI) as catalyst. The properties of nZVI before and after reaction were characterized by X-ray diffraction (XRD) and scanning electron microscopy (SEM). The effects of pH value, initial concentration of CMP, nZVI dose and hydrogen peroxide (H 2 O 2 ) concentration were determined. The experimental results showed that lower pH value and CMP concentration brought faster degradation rate. With the initial pH value of 6.1 and initial CMP concentration of 0.7 mM, the optimal dosage of reagents were 0.5 g nZVI/L and 3.0 mM H 2 O 2 . At pH 6.1, the degradation of CMP followed two-stage first-order kinetic that composed of an induction period (first-stage) and a followed rapid degradation stage (second-stage). According to the effects of scavengers n -butanol and KI, hydroxyl radicals ( OH), especially the surface-bounded •OH, had a dominant role in the oxidation of CMP. The degradation intermediates, carboxylic acids and chloride ion produced during the reaction process were monitored by high performance liquid chromatography (HPLC), liquid chromatography/mass spectrometry (LC/MS) and ion chromatography (IC). On the basis of these findings, the possible mechanistic steps of CMP degradation were proposed.
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BIOMEDICINE & PHARMACOTHERAPY
·
2024
·
IF 6.9
Junyu Wang,Chaojie Yang,Zhixin Liang,Junping Sun,Mingyue Zhang,Shaofu Qiu,Xinying Du,Xi He,Xiaoying Pang,Xidong Ma,Mei Xie,Xinjie Han,Ru Fan,Enlu Zhou,Hairong Yu,Danyang She,Hongbin Song,Jianxin Wang
Human adenovirus (HAdV) infection is a major cause of respiratory disease, yet no antiviral drugs have been approved for its treatment. Herein, we evaluated the antiviral and anti-inflammatory effects of cyclin-dependent protein kinase (CDK) inhibitor indirubin-3′-monoxime (IM) against HAdV infection in cells and a transgenic mouse model. After evaluating its cytotoxicity, cytopathic effect reduction, antiviral replication kinetics, and viral yield reduction assays were performed to assess the anti-HAdV activity of IM. Quantitative real-time polymerase chain reaction (qPCR), quantitative reverse transcription PCR (qRT-PCR), and western blotting were used to assess the effects of IM on HAdV DNA replication, transcription, and protein expression, respectively. IM significantly inhibited HAdV DNA replication as well as E1A and Hexon transcription, in addition to significantly suppressing the phosphorylation of the RNA polymerase II C-terminal domain (CTD). IM mitigated body weight loss, reduced viral burden, and lung injury, decreasing cytokine and chemokine secretion to a greater extent than cidofovir. Altogether, IM inhibits HAdV replication by downregulating CTD phosphorylation to suppress viral infection and corresponding innate immune reactions as a promising therapeutic agent.
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CERAMICS INTERNATIONAL
·
2017
·
IF 2.986
H.L. Pan,Y.W. Zhang,H.T. Wu
Ultra low-loss Li 2 Mg 3 Ti 0.95 (Mg 1/3 Sb 2/3 ) 0.05 O 6 ceramic with a cubic rock-salt structure was prepared by the conventional solid-state reaction method. The crystal structure, sintering characteristics, microwave dielectric properties , intrinsic parameters and infrared spectrum were investigated systematically. Refined crystal structure was obtained using the Rietveld refinement method. Based on the chemical bond theory, some intrinsic parameters were calculated and Ti–O bonds played an important role in influencing microwave dielectric proprieties. According to the infrared analysis, the major polarization contribution attributed to the absorption of phonon oscillations. A few of (Mg 1/3 Sb 2/3 ) 4+ -substitutions obviously improved the microwave dielectric properties of Li 2 Mg 3 TiO 6 ceramic. Excellent microwave dielectric properties of ε r = 14.40, Q·f = 195,500 GHz and τ f = −4.02 ppm/°C were obtained for Li 2 Mg 3 Ti 0.95 (Mg 1/3 Sb 2/3 ) 0.05 O 6 ceramic sintered at 1575 °C.
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JOURNAL OF MATERIALS SCIENCE-MATERIALS IN ELECTRONICS
·
2025
·Vol. 36
·期 34
·2170
·
IF 2.8
Wang Yan,Su Congxue,Tao Wenlong,Chen Zelong,Fan Jun,Cheng Min,Chen Beiyi,Zhou Huanfu,Sun Yuan
In light of advancements in 5G/6G technologies, current research on microwave dielectric ceramics is focused on the development of materials characterized by low sintering temperatures and low permittivity, in order to satisfy the requirements of high-frequency low-temperature co-fired ceramic (LTCC) applications. Novel monoclinic structure GdBaK(MoO 4 ) 3 and YBaK(MoO 4 ) 3 ceramics, with C2 / c space group, were synthesized using a conventional solid-state method. GdBaK(MoO 4 ) 3 and YBaK(MoO 4 ) 3 ceramics were sintered at 830 °C and 850 °C, exhibited ε r ~ 8.54 and 8.77, τ f ~ − 51.1 ppm/°C and − 45.8 ppm/°C, Q × f ~ 23, 240 GHz and 59, 277 GHz, respectively. The compression from Ba 2+ and K + cations was identified as the main reason for the higher theoretical ε theo compared to the corrected ε corr . The dielectric loss of both ceramics is mainly affected by the density and packing fraction. The full width at half maximum (FWHM) values of the vibrational peak at 932 cm −1 , corresponding to the symmetric stretching modes of MoO 4 2− , exhibits a negative correlation with the Q × f values. Based on the P–V–L theory, the lattice energy and bond energy associated with the Mo–O bond played a substantial role in influencing the Q × f and τ f . Moreover, YBaK(MoO 4 ) 3 showed good chemical compatibility with Ag, indicating its potential for LTCC applications.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2025
·
IF 8.5
Xiaofang Liu,Jiaxin Yi,Wenya Ma,Min Fan,Qingfeng Dong,Kunpeng Qian,Li Li
The gas permeability of packaging films significantly impacts the micro-environment and postharvest quality of fruits and vegetables. By regulating gas permeability to regulate the internal atmospheric composition of packaging, this method modulates the respiratory intensity and physiological metabolism of fruits and vegetables, thereby extending their postharvest shelf life. In this study, different proportions of Poly(lactic acid) (PLA)/Poly(3-hydroxybutyrate- co -4-hydroxybutyrate) (P34HB) composite films were prepared using the melt blending method, aiming to optimize the packaging microenvironment by adjusting the gas permeability of the films. The results indicate that the oxygen transmission rate of the composite film at a PLA/P34HB ratio of 20:80 was measured at 628.65 ± 7.2 cm 3 ·m −2 ·24 h −1 ·0.1 MPa, which was 90.98 % higher than that of the PLA film. The Pearson heatmap further confirmed that the permeability of the composite film had a significant impact on the preservation effect of peaches, while the influence on mechanical properties was not significant. This finding was corroborated by preservation experiments using films of different compositions, which demonstrated that the PLA20:80P34HB composite film performed the best. Specifically, it effectively slowed the loss of free water, thereby maintaining moisture content, total soluble solids content, and weight, ultimately extending the shelf life by 66.67 %.
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CHEMICAL ENGINEERING JOURNAL
·
2025
·
IF 13.2
Baiwei Ma,Xuanyu Lin,Wenxin Liu,Pengjing Chen,Yanjie Wang,Ping Li,Xiaobin Lin,Lipeng Zhai,Mengyang Li
The development of efficient photocatalytic covalent organic frameworks (COFs) remains challenged by rapid charge recombination and insufficient carrier utilization. Herein, we report BC-TAPE-COF, a covalent organic framework engineered with synergistic functional compartmentalization for photocatalytic indole thiocyanation. Its tetraphenylethylene (TPE) π-bridge served dual roles: activating oxygen and enhancing interlayer charge separation, while bicarbazole as localized asymmetric electron distribution (LAED) units drove exciton dissociation through intrinsic electron density gradients. This cooperative design strategy yielded a photocatalyst with unprecedented catalytic efficiency. BC-TAPE-COF can drive the photocatalytic indole C-3 thiocyanation with ultra-low loading and maintain structural integrity over multiple catalytic cycles.
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JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY
·
2025
·
IF 5.4
Wen Xu,Yujing Zhang,Qianqian Xu,Haibo Zhao,Qun Gao,Xinyu Zhao,Hongfei Jiang,Chao Wang
Microtubules, composed of tubulin subunits, represent a critical target in anticancer drug discovery. The design and evaluation of small-molecule inhibitors targeting tubulin polymerisation continue to hold significant promise for advancing cancer therapeutics. Based on structural insights into tubulin polymerisation inhibitors and tubulin interaction models, a novel series of 3-aryl-4-(3,4,5-trimethoxyphenyl)selenophene derivatives were designed as potential tubulin polymerisation inhibitors. Among the synthesised analogs, compound 7i, featuring a selenophene linker, demonstrated superior antiproliferative activity against Huh7, MCF-7, and SGC-7901 cancer cell lines, with IC50 values slightly lower than those of combretastatin A-4 (CA-4). Structure-activity relationship studies revealed that electron-donating substituents at the para-position of the B-ring significantly enhanced cytotoxic potency. Mechanistic studies revealed that compound 7i effectively inhibited tubulin polymerisation, disrupted microtubule networks, induced G2/M cell cycle arrest, and triggered apoptosis in cancer cells. These results underscore the potential of incorporating selenophene into the CA-4 scaffold as a promising strategy for developing potent tubulin polymerisation inhibitors, offering new avenues for cancer therapy.
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COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
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2025
·
IF 5.4
Meng Ge,Yuanye Zhuang,Shiyang Bai,Jingjing Sun,Yingying Cheng,Xufeng Gong,Jihong Sun,Yanmin Yu
Metal-organic frameworks (MOFs) exhibit excellent structural properties, but their application in catalysis is limited due to their saturated coordination structures. Herein, catalysts containing unsaturated coordination MOF structural units loaded onto 3-aminophenol-formaldehyde resin (APF) were prepared using a stepwise assembly method. The amino groups in APF serve as anchoring groups, enabling the optimal dispersion of zinc on the surface of the carrier. The coordination saturation and the dominant surface groups can be controlled by the stepwise assembly. SEM, FT-IR, UV spectroscopy, XPS, zeta potential, and SAXS were employed to demonstrate the stepwise assembly process. The characterization results revealed that the binding strength between zinc and ligands on the APF spheres, as well as the coordination saturation state of zinc, progressively increased during the stepwise assembly process. Additionally, comprehensive evaluation of the catalytic performance was conducted via the cycloaddition reaction of CO₂ with epoxides to elucidate the feasibility and superiority of the synergistic catalysis between metal ions and functional ligands in the dual-active-center catalyst. The hybrid catalyst Zn-BDC/A-1 with the highest surface roughness but lowest Zn coordination exhibited the most efficient catalytic performance. Furthermore, the density functional theory (DFT) calculations substantiated that zinc centers on the APF surface exhibit a preferential coordination geometry involving no more than two ligand groups, and a ligand-dominated chemical environment. These findings demonstrate that the stepwise assembly maintains the coordinative unsaturation of metal centers and also optimizes the spatial availability of ligand functionalities.
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TALANTA
·
2024
·
IF 5.6
Min Fang,Zhaojie Wang,Qing Fu,Qing Yang,Lin Xu,Yuepeng Lu,Yong Yang,Xiaoming Jiang,Yongning Wu,Zhiyong Gong,Xin Liu
The aim of this work was to develop a fluorescence method based on the polydopamine-polyethyleneimine (PDA-PEI) copolymerization, which was subsequently applied for the determination of 3-monochloropropane-1,2-diol (3-MCPD) in food contact papers (FCMs). PEI could provide an alkaline environment and then react with dopamine (DA) to produce copolymers by Michael addition and Schiff-base reactions. This copolymer has a strong fluorescence emission at 527 nm. We found that amino groups of DA and PEI could also react with 3-MCPD in an alkaline medium, which improved the morphology and fluorescence intensity of PDA-PEI copolymers. The fluorescence intensity of the polymers was linear but inversely proportional to the concentration of 3-MCPD in the range of 10.0–500.0 μg kg −1 and the detection limit was 2 μg kg −1 . The standard addition method was used in FCMs to demonstrate the practical applicability and the spiked recoveries ranged from 99.8 to 110.3 %. Finally, the levels of 3-MCPD in different FCMs (n = 70) were determined by the proposed method. The detection frequencies ranged from 25 % to 100 % and both the highest detection frequency and levels were observed in kitchen papers. More than half of the samples did not comply with the limits recommended by the German Federal Institute for Risk Assessment, suggesting that 3-MCPD released from FCMs is a major route of human exposure.
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SENSORS AND ACTUATORS B-CHEMICAL
·
2025
·
IF 7.7
Huai Wang,Zhenyu Yuan,Jingfeng Li,Renze Zhang,Fanli Meng
Xylene is not only a carcinogenic gas, but also one of indoor pollution gases. Therefore, it is indispensable to develop a xylene gas sensor with fast response and high sensitivity. In this paper, 5 wt%rGO-Fe 2 (MoO 4 ) 3 -1 wt%Pt gas sensitive material was prepared by integrating the excellent properties of reduced graphene oxide (rGO) and noble metal Pt. In addition, the microstructure, elemental composition, phase and crystal structure of 5 wt%rGO-Fe 2 (MoO 4 ) 3 -1 wt%Pt nanocomposites were characterized. The nanostructure of Pt-modified Fe 2 (MoO 4 ) 3 nano-hollow spheres compounded on rGO was successfully prepared. The gas sensitive experiment results showed that 5 wt%rGO-Fe 2 (MoO 4 ) 3 -1 wt%Pt had better gas sensitive performance than Fe 2 (MoO 4 ) 3 (FMO), FMO-1 wt%Pt and 5 wt%rGO-FMO. At the optimum working temperature (175℃), the 5 wt%rGO-FMO-1 wt%Pt sensor had a maximum response value to xylene, and could detect 500 ppb xylene. In addition, the 5 wt%rGO-FMO-1 wt%Pt nanocomposite showed a rapid response and recovery process to xylene. Moreover, the gas sensitivity mechanism and enhancement of gas sensitivity of 5 wt%rGO-FMO-1 wt%Pt to xylene were systematically analyzed. The 5 wt%rGO-FMO-1 wt%Pt gas sensor prepared provided a new reference for the detection of xylene.
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