Journal of Environmental Chemical Engineering
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2026
·Vol. 14
·期 3
·123101
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IF 7.5
Deyi Han,Lin Ding,Shujuan Yang,Yong Zhang,Haichuan Zhang
This study reports the one-step in-situ assembly of a polydopamine (PDA)@ZIF-8 functional layer on polyethersulfone (PES) ultrafiltration (UF) membranes for high-flux, antifouling dye/salt separation. Leveraging the synergistic effect of dopamine (DA) self-polymerization and the in-situ growth of ZIF-8 during the nonsolvent-induced phase separation (NIPS) process, a highly integrated PDA@ZIF-8 functional layer was successfully constructed on the PES membrane surface. Strong coordination and chelation interactions among Zn 2 + ions, the catechol moieties of PDA, and 2-methylimidazole (2-MIM) increase the casting solution viscosity, triggering delayed demixing and promoting the migration of hydrophilic precursors toward the membrane interface. Structurally, the in-situ assembly of PDA@ZIF-8 significantly increased the selective layer thickness from 4.73 μm to 33.10 μm. The resulting ultrafiltration membrane exhibited exceptional separation efficiency, delivering a Congo Red (CR) rejection rate of over 99.5% while maintaining a salt rejection rate under 5%, enabling the efficient fractionation of dyes and salts. A high pure water flux of 455 L·m −2 ·h −1 at 0.1 MPa is attained, which is attributed to the enhanced surface hydrophilicity and the intrinsic sub-nanometer microporous channels of ZIF-8. Furthermore, the functionalized layer demonstrates remarkable antifouling properties toward anionic dyes, with a stable flux recovery ratio (FRR) exceeding 85% after multiple cycles of CR filtration. This research presents an effective membrane preparation strategy that enhances separation performance while ensuring excellent long-term antifouling stability.
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MICROCHEMICAL JOURNAL
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2026
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IF 5.2
Qianqian Yu,Jingxiao Yu,Qing Yang,Da-Wen Sun,Hongbin Pu
A novel chiral hierarchical porous ZIF-8/Au@Ag bipyramids SERS substrate (HPZA) was constructed. • Developing a dual-chiral synergistic enhancement strategy. • Pioneering the integration of deep learning algorithm with this chiral SERS platform. The widespread use of combined pesticides has led to increasing concerns over mixed pesticide residues in food, posing significant challenges for rapid and reliable detection. Herein, we develop an intelligent surface-enhanced Raman spectroscopy (SERS) platform by integrating a bichiral nanostructured substrate with deep learning for multiplex pesticide analysis. A hierarchical porous chiral ZIF-8 (HPZ) was engineered using L-histidine as a pore-expanding agent and assembled with L-cysteine-directed Au@Ag bipyramids to form the HPZA substrate, enabling synergistic adsorption enrichment and electromagnetic enhancement. The resulting platform exhibits high sensitivity and stability, achieving a detection limit of 9.54 ng/mL for quinalphos in citrus samples. Moreover, when coupled with a fully connected neural network (FCNN), it enables accurate discrimination of multiple pesticides and their mixtures, reaching an identification accuracy of 93.33%. This work presents an integrated material–algorithm strategy for rapid and intelligent detection of pesticide residues, offering a promising approach for food safety monitoring. Download: Download high-res image (105KB) Download: Download full-size image
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Materials Today Chemistry
·
2026
·
IF 7.4
Shuoye Yang,Jinpeng Wang,Qianqian Cheng,Huajian Yuan,Lin Ju,Xin Wang,Suxi Liu,Ruolan Song,Ning Li,Lu Zhang,Peng Li
Chemotherapy drugs are often associated with toxic side effects and low bioavailability, while solid tumors like breast cancer frequently exhibit multidrug resistance, which limits the clinical efficacy of chemotherapy and other monotherapies. To address these challenges, there is a need for the development of efficient delivery systems capable of transporting various therapeutic agents while introducing novel programmed death mechanisms to achieve synergistic antitumor effects. In this study, zeolite imidazole-8 (ZIF-8) was utilized as a core carrier to load doxorubicin (DOX) and photothermal agent CuS, and further coated by folic acid (FA)-functionalized red blood cell membranes (RBCM) to fabricate the FRCZD delivery system. This system possessed the capacity to target breast cancer MCF-7 cells and their drug-resistant strain, MCF-7/ADR cells. Notably, DOX and CuS were rapidly released in response to both the tumor microenvironment (TME) and near-infrared radiation (NIR). Under light stimulation, CuS induced photothermal therapy (PTT), which further enhanced localized drug accumulation while catalyzing H 2 O 2 to produce toxic hydroxyl radicals (⋅OH) that triggered chemodynamic therapy (CDT). Moreover, excessive intake of Cu 2+ led to mitochondrial metabolic dysfunctions that ultimately initiated cuproptosis. The results demonstrated that FRCZD combined with NIR accelerated cell apoptosis while interfering with cell cycle distribution, consequently inhibiting tumor cell proliferation and migration. In vivo experiment results further corroborated that FRCZD + NIR significantly inhibited tumor growth more effectively than other experimental groups while exhibiting favorable biological safety profiles. Overall, the integrated platform FRCZD could substantially enhance treatment outcomes by inducing cuproptosis in conjunction with chemotherapy, PTT, and CDT approaches, thus holding promise for advancing therapies against drug-resistant tumors.
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ACS Omega
·
2026
·
IF 5.2
Tao Yang,Tao Wang,Tao Shen,Mingrong Dong,Jinkun Liu,Ming Ni,Yan Zhu
Targeting tumor-specific characteristics of acidic microenvironment, elevated H2O2 levels, and thermosensitivity, this study proposed and developed a copper-doped ZIF-8 nanoplatform coloaded with indocyanine green (ICG) and doxorubicin hydrochloride (DOX), designated as Cu-ZIF-8@ICG&DOX (CZID), to establish a multimodal therapeutic system integrating chemodynamic therapy, photothermal therapy, and chemotherapy. Results showed that the 25% copper doping level optimized the structure, achieving 7.46% actual doping content while limiting the average nanoparticle size to 99.6 nm. Dual loading of ICG and DOX induced morphological transition to spherical core–shell architectures, as confirmed by zeta potential reversal, with maximum drug loading capacities of 23.01 μg/mg for ICG and 122.43 μg/mg for DOX. The ZIF-8 framework exhibited pH-responsive degradation under acidic conditions. Released Cu2+ ions mediated continuous hydroxyl radical generation through glutathione-depletion redox cycling, confirming chemodynamic efficacy. Under 808 nm laser irradiation, ICG enabled enhanced photothermal conversion, showing concentration- and power-dependent temperature elevation. Cellular assays revealed efficient CZID internalization by MCF-7 cells, generating significantly higher intracellular reactive oxygen species levels under irradiation and more intense dead cell staining compared to CZI and CZD groups. Such an enhancement was attributed to photothermally accelerated ZIF-8 degradation, promoting Cu2+ ions and DOX release, thereby strengthening chemodynamic–chemotherapy synergy. At the working concentration of 50 μg/mL, CZID induced 95.36% apoptosis in MCF-7 cells while maintaining over 70% viability in MCF-10A normal cells, validating its precise antitumor potential.
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PubMed
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SEPARATION AND PURIFICATION TECHNOLOGY
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2026
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IF 9.1
Ying Jiang,Wanting Wang,Guichun Luo,Yungui Li,Yapeng Dong,Xiuyuan Zuo,Hai Liang
ZIF-8-decorated biochar hold great potential for heavy metal contaminated wastewater remediation due to the superior adsorption performance of ZIF-8. However, the inevitable blockage of nature pore during preparation restricted the enhancement of adsorption performance and further practical applications. Herein, a novel Zn(NO 3 ) 2 activation-combined in-situ growth strategy was established for porous ZIF-8-decorated biochar (AI-BC@ZIF-8) preparation, this strategy enables the synergistic promotion of porous structure and distribution of ZIF-8 for adsorbent. The AI-BC@ZIF-8 exhibited an excellent adsorption capacity of 249.63 mg/g for Pb, achieving removal efficiency of 99.8% for conventional 50 mg/L Pb-containing wastewater. The adsorption process conforms to the pseudo-second-order kinetic model and the Langmuir isothermal model, indicating the monolayer chemical adsorption mechanism. The results of FTIR, BET and XPS analyses indicate that the adsorption mechanism of AI-BC@ZIF-8 is electrostatic interaction, N-coordination, precipitation, ion-exchange and pore-filling. Overall, this adsorbent demonstrates outstanding adsorption performance, showing its great potential in efficient and low-cost water purification. This work provides a viable strategy for the synthesis of highly porous and efficient ZIF-8-decorated biochar for heavy metal removal from wastewater.
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JOURNAL OF MEMBRANE SCIENCE
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2026
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IF 8.8
Haojie Ren,Zongkai Liu,Bingquan Hua,Nan Yang,Zhengqi Chen,Xiuxiu Ren,Meng Guo,Guanying Dong,Jing Zhong,Yatao Zhang
Seamless integration at the interphase is the foremost issue delaying the development of high-performance mixed matrix membranes (MMMs). Here we report an in-situ crosslinking strategy to effectively integrate the solvent-assisted linker exchange (SALE)-derived ZIF-8 with amidoxime-modified PIM-1 (AOPIM-1) for the challenging propylene/propane separation. In this crosslinking system, the AOPIM-1 polymer matrix can chemically anchor to the surrounding ZIF-8 fillers, promoting the formation of core-shell-like structures, thereby improving interfacial compatibility and filler dispersion. As a result, both high propylene permeability and high selectivity are readily achieved at a low filler loading (10 wt%), significantly surpassing the single- and mixed-gas upper bounds. Additionally, we demonstrate a contraction behavior in ZIF-8 unit cells that correlates with filler loading. Despite the persistence of excellent filler dispersion in highly loaded MMMs, excessive unit cell contraction leads to undesirable interfacial debonding and blocked transport through filler, ultimately deteriorating separation performance. Thus, the in-situ crosslinking imparts a ‘double-edged sword’ effect―simultaneously ensuring superior interfacial compatibility while inducing controllable ZIF-8 lattice contraction. These insights are expected to provide valuable guidance for the rational design and performance optimization of MOF-based MMMs via in-situ crosslinking.
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Food Analytical Methods
·
2026
·Vol. 19
·期 9
·248
·
IF 3
Qin Shili,Zhao Dongsheng,Jin Fenglong,Qin Yuting,Liang Xinyu,Liu Jingwen,Chu Hongtao,Gao Lidi,Zhao Ming
In this study, the octahedral core–shell ZIF-8@UiO-66-NH 2 composite, exhibiting high crystallinity, microporous structural properties and multifunctional groups, was synthesized, characterized, and applied for the first time as stationary phase in capillary electrochromatography. The baseline separation of four groups containing 14 analytes was achieved within 11.6 min, with resolution of at least 1.51. Compared to the individual components of ZIF-8 and UiO-66-NH 2 used as chromatographic stationary phase, the bonded capillary column based on ZIF-8@UiO-66-NH 2 exhibited the improvement in resolution and column efficiency (theoretical plate numbers) ranging from 68.14 to 918.75% and from 3.92 to 398.31%, respectively, and sample loading capacity increased by ≥ 26.8%. Furthermore, an accurate, rapid, and reliable electrochromatography method was developed for the qualitative and quantitative analysis of thiamphenicol and florfenicol in pork meat. The limits of detection and quantification for thiamphenicol were 0.34 μg/mL and 1.75 μg/mL, and for florfenicol, 1.00 μg/mL and 5.82 μg/mL, with sample recoveries in the range of 96.00 to 108.00% and the standard deviations less than 4.59%. This work not only confirmed the potential of MOF@MOF composite as high-performance stationary phases but also broadened the electrochromatography application in food inspection. Graphical
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Food and Bioprocess Technology
·
2026
·Vol. 19
·期 7
·346
·
IF 5.6
Li Changhao,Liu Ruiqi,Li Na,Yang Lingfan,An Guangying,Tian Tian,Li Huina,Wang Guangxian,Wang Songlei
Wolfberry, a medicinal and edible plant rich in nicotinamide adenine dinucleotide (NADH), is noted for its antiaging and antioxidant properties. However, the trace levels and instability of NADH present significant detection challenges. To overcome the inherent limitations of traditional electrochemical linear peak fitting, three machine learning algorithms were introduced: random forest, support vector machine regression (SVR), and long short-term memory neural networks. This pioneering approach established a complex nonlinear relationship model between concentration and response current, effectively mitigating high-concentration linear distortion and interference constraints within the detection system. The Shapley additive prediction method (SHAP) was ultimately employed to quantify the contribution of each electrode potential to the prediction of response currents. This study developed an electrochemical biosensor based on a NbC@NC-ZIF-8/ADH heterojunction substrate, combined with a machine learning–based nonlinear modeling approach, achieving precise quantitative detection of NADH concentration in wolfberry. It exhibits a broad detection range from 1 μM to 1.5 mM, with a detection limit as low as 0.075 μM. The linear prediction model achieved R 2 = 0.976. After constructing a nonlinear model using the SVR machine learning algorithm, the NADH concentration detection accuracy improved to R 2 = 0.996, significantly enhancing detection precision. SHAP analysis indicated that the 0.264 V potential contributed most significantly to the model output. This study established a trace detection research framework encompassing “heterojunction material preparation–density functional theory analysis–nonlinear model construction–SHAP interpretability analysis,” providing a reliable solution for the rapid and accurate detection of NADH in wolfberry. It demonstrates broad application prospects in the field of bioanalysis.
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DYES AND PIGMENTS
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2026
·
IF 3.9
Daoxin Wu,Shuyao Li,Jingkun Sun,Yang Qiu,Zhaoyang Wu,Wenzhao Liu
A novel ZIF-8/carboxylated polyurethane 3D photonic crystal sensor is developed for putrescine and cadaverine detection. • Dual sensing mechanism: ZIF-8 enables size-selective adsorption and refractive index modulation, while PU provides carboxyl-amine acid-base swelling. • The optimal sensor (n BDO :n DMBA = 3:7) achieves a low detection limit of 0.86 ppm for putrescine and high selectivity over common VOCs. • Synergistic signal amplification yields a maximum reflection peak shift of 27.02 nm at 100 ppm. Rapid on-site detection of biogenic amines (e.g., putrescine and cadaverine) is critical for food freshness monitoring. Herein, we report a three-dimensional photonic crystal (3DPC) sensor composed of ZIF-8 nanoparticles and carboxyl-functionalized polyurethane (PU). The PU matrix, with tunable carboxyl content via DMBA/BDO ratio, enables acid-base induced swelling upon exposure to amine vapors, while ZIF-8 provides size-selective enrichment and refractive index modulation. The sensor with an optimal n BDO :n DMBA molar ratio of 3:7 exhibits a low detection limit of 0.86 ppm for putrescine, a sensitivity of 0.2384 nm/ppm, and excellent selectivity over common VOCs. The synergistic dual-mechanism (swelling + refractive index change) yields a maximum reflection peak shift of 27.02 nm at 100 ppm. Moreover, the sensor shows moderate response time (2.5 min) and good long-term stability (35 days). This work provides a new strategy for integrating MOF adsorption and polymer swelling into a visual sensing platform for biogenic amines.
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Catalysis Science & Technology
·
2025
·
IF 4.2
Bin Guan,Junyan Chen,Lei Zhu,Zhongqi Zhuang,Xuehan Hu,Chenyu Zhu,Sikai Zhao,Kaiyou Shu,Hongtao Dang,Junjie Gao,Luyang Zhang,Tiankui Zhu,Wenbo Zeng,Minfan Qian,Zhangtong Li,Yang Lu,Shuai Chen,Zhen Huang
Herein, Co–Zn bimetallic center-modulated ZIF-67@ZIF-8 composites were prepared by ultrasonic synthesis, and the effects of the metal ratio on the photothermal coupling catalytic CO2 reduction performance and product selectivity were systematically investigated. The experiments showed that catalysts with higher Zn content (e.g., Co0.1Zn0.9) exhibited higher CH4 selectivity (29.32%), while the high Co ratio (e.g., Co0.9Zn0.1) significantly enhanced the CO generation rate (3.13 μmol g−1 h−1). Characterization by N2 adsorption, XRD, XPS, UV-vis DRS, and in situ DRIFTS revealed that the metal ratio affected the CO2 adsorption and electron transport efficiency by modulating the catalyst specific surface area (1213 → 555 m2 g−1), the band gap width (3.53 → 3.39 eV), and the distribution of the surface-active sites. The DFT calculations further revealed the synergistic effect of Co/Zn: high Zn content lowers the *CHO generation barrier (3.45 eV) and promotes the CH4 pathway, while the Co center enhances CO2 activation. This study provides a theoretical and experimental basis for the optimization of CO2 reduction product selectivity through precise regulation of metal centers.
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CHEMICAL ENGINEERING JOURNAL
·
2025
·
IF 13.2
Jieqiong Wang,Boxin Yu,Fengshuo Wang,Zhe Wang,Ming Xu,Yanping Wu,Hongyuan Zhang
Heavy metal ions (HMIs) pollution has become a significant threat to the global environment and agricultural safety. The accumulation of these metals in soil and crops may have a serious impact on human health. Therefore, it is of utmost importance to develop a rapid, reliable and highly sensitive detection platform. A self-supporting electrochemical sensor based on an interpenetrating twin ZIF-8/carbon nanofiber aerogel (ZIF-8(IT)/CNT-NFCA) was developed for the sensitive and simultaneous detection of Cd 2+ and Pb 2+ in soil and crop samples. Unlike traditional electrodes, this independent architecture eliminated the need for rigid conductive substrates and complex surface modifications. The freestanding 3D nanofiber network, reinforced by carbon nanotubes and embedded with twin-structured ZIF-8, provided a mechanically stable and highly conductive matrix with abundant accessible active sites. Under optimized differential pulse anodic stripping voltammetry conditions, the sensor exhibited wide linear ranges of 0.10–100 μg·L −1 for both Cd 2+ and Pb 2+ , with low limit of detection (LOD) 0.09 μg·L −1 and 0.05 μg·L −1 , respectively. Benefiting from the integrated structure, the sensor showed enhanced signal stability and resistance to electrode delamination under real sample testing. Applications in actual rice, wheat, soil, and water samples demonstrated high recovery rates and validated the sensor's reliability. This study provides a robust and portable sensing platform, offering promising prospects for field-deployable heavy metal ion monitoring in environmental and agricultural safety.
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Journal of Environmental Chemical Engineering
·
2025
·
IF 7.2
Xinyue Liang,Weihong Zhang,Xiaolong Yao,Zhengyang Feng,Qingwei Bu,Wenwen Gong,Wei Wang,Chun Wang,Yingxue Sun
Adsorption-electrocatalytic oxidation is a promising technology for organochlorine removal; however, its practical application is hindered by electrode limitations in activity, stability, and mechanistic understanding. In this study, a copper-doped ZIF-8/multi-walled carbon nanotube composite electrode (Cu-ZIF-8/MWCNTs/CC) was innovatively designed. Adsorption-electrochemical batch experiments were conducted to systematically investigate the degradation behaviors of three typical organochlorine contaminants: 2,4-dichlorophenol (2,4-DCP), triclosan (TCS), and chloramphenicol (CAP), using MOF-based electrodes. The results demonstrate that compared to the undoped ZIF-8/MWCNTs/CC, the incorporation of Cu introduced additional mesoporous structures and Cu-N coordination bonds, which effectively enhanced adsorption performance based on the size-matching effect and d-band center theory. Furthermore, the highly reversible and kinetically rapid Cu 2 + /Cu + redox couple served as an efficient mediator for charge transfer, thus promoting the synergistic adsorption and electrochemical degradation of organochlorine contaminants. Notably, the material maintained considerable removal efficiency even under competitive conditions in multicomponent systems. Mechanistic investigation demonstrated that hydroxyl radicals (·OH) preferentially attacked critical chemical bonds (including C-Cl, ether, and amino groups) in accordance with density functional theory (DFT) predictions. This reaction pathway resulted in the generation of less toxic intermediates that were eventually mineralized into CO 2 and H 2 O. The ecological structure-activity relationships (ECOSAR) model further confirmed the low acute and chronic toxicity of the major degradation products. Moreover, the electrode maintained high removal efficiency across multiple consecutive cycles, demonstrating excellent stability and reusability. Collectively, this work proposes a novel strategy for the synergistic adsorption and electrocatalytic removal of organochlorine contaminants; thereby highlighting its significant potential for practical application.
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