Horticulture Research
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2026
·
IF 9.5
Wang Haotian,He Beixuan,Qi Shuyi,Gao Yue,Dong Xin,Guo Meili
Safflower is featured with time-honored medical and economic values and developing into diverse phenotypic and genetic variations. In this study, to explore the critical genes associated with color phenotypes and flavonoid derivatives biosynthesis of safflower, BSA-seq, conflated with transcriptomic and metabolic methods were performed in two extreme colors (yellow and white) in the population of “ZHH0119” and “XHH007”. After crossing two parent plants reciprocally, the F4 generation of two accessions were used to construct near-isogenic gene pools for the two extreme traits of yellow and white safflower. BSA-seq results located five QTLs regions on chromosomes 2, 8, 9, 10 and 12 including six CtPALs, three CtC4Hs, two Ct4CLs, one CtCHS, thirty-two CtUGTs and seventy CtCYPs which tied to the yellow color phenotype of safflower. Through transcriptome analysis of two accessions and at different flowering stages, 1 CtPAL, 5 CtC4Hs, 4 CtCHSs, 3 CtCHIs, 3 CtFLSs, 48 CtUGTs, 51 CtCYPs and 75 transcription factors were revealed as significantly upregulated in the yellow accession compared to the white. Integrated analysis identified eight CtUGTs (CtUGT50-57) which exhibited significant positive correlations with chalcone glycosides of yellow safflower. Based on functional characterization, CtUGT52 was found to boost Hydroxysafflor yellow A (HSYA) content in yellow safflower which possessing substrate promiscuity (chalones, flavonols and flavonoids) and catalytic promiscuity (flavonols and flavonoids), revealing its vital role in the HSYA biosynthesis through transgenic overexpression. Combining catalytic mechanism verification of CtUGT52 towards phloretin, kaempferol and luteolin, our study to some extent, elucidated the modification function of CtUGTs for flavonoid aglycones in the flavonoid biosynthesis pathway of safflower.
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INTERNATIONAL JOURNAL OF FOOD MICROBIOLOGY
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2026
·
IF 5.7
Hui Jiang,Hui Du,Donglei Jiang,Xinmei Liu,Haijing Wu,Mengjing Huang,Rui Sun,Xiaojie Sun,Siqi Zeng,Yanmin Ju,Jun Yang
Staphylococcus aureus enterotoxin B (SEB) is a leading cause of foodborne illness. In this study, we developed a time-resolved fluorescent immunochromatography test strip (TRFITS) combined with a hydrogel microneedle patch (HMNP) and machine learning (ML) for the rapid detection of SEB in salmon. The developed HMNP, fabricated from methacrylated gelatin, can automatically extract 37 mg of interstitial fluid within 6 min. We then conducted TRFITS analysis on salmon samples to detect SEB and ML algorithms so as to predict its concentration. This method enabled efficient sampling and accurate quantification of SEB within 32 min, with a limit of detection (LOD) of 4.63 ng/mL. In addition, ML-assisted TRFITS applied to salmon demonstrated that the YOLOv11 model achieved a prediction accuracy of 91.3% and a lower LOD of 2 ng/mL. These findings highlight a novel approach toward on-site SEB detection with significant implications for food safety monitoring and point-of-care diagnostic applications.
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NMR IN BIOMEDICINE
·
2026
·Vol. 39
·期 4
·e70249
·
IF 2.8
Xiaomin Duan,Longyang Xiao,Haichen Zhao,Yuanxiang Gao,Lili Wang,Haiyang Yu,Xiaoyuan Zhou,Xiaojuan Shi,Zhiming Li
This study aimed to validate the feasibility of hypoxia-targeted magnetic resonance imaging (MRI) molecular probe (CAIX-Gd) for evaluating hypoxia status in rats with hepatic fibrosis. A macrocyclic ligand compound (Compound 3) was synthesized using the carbonic anhydrase IX (CAIX) inhibitor acetazolamide as the targeting moiety, and its structure was confirmed by 1 H-NMR spectroscopy. CAIX-Gd was then prepared by chelating gadolinium, with free gadolinium content quantified via the xylenol orange assay. In biocompatibility tests, CAIX-Gd administration showed no significant histopathological changes compared with saline controls. For hypoxia detection, rats were divided into three groups: (A) hepatic fibrosis (HF) with CAIX-Gd, (B) HF with DTPA-Gd, and (C) normal controls (NC) with CAIX-Gd. The difference in T1 relaxation time (∆T1) pre- and post-contrast was measured in regions of interest (ROI). HF rats showed increased collagen deposition (Masson staining), α-SMA activation, and elevated hypoxia markers (PIMO/HIF-1α) compared to controls (all p < 0.05). In group C, mild ∆T1 shortening was seen at 10 min post-injection. While ∆T1 continuously decreased in group B, the shortening was significantly greater in group A ( p < 0.05), peaking at 10 min. In conclusion, the CAIX-Gd probe was successfully synthesized and demonstrated potential for the non-invasive MRI detection of hypoxia in hepatic fibrosis.
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Nature Communications
·
2026
·
IF 18.1
Li Min,Hu Longyu,Pi Menghan,Yang Xiayue,He Xiaoyu,Cui Wei,Ran Rong
The properties of polymer gels are governed not only by the crosslinked network but also by the solvent. Conventional small-molecule solvents impose trade-offs among environmental adaptability, cost, and biocompatibility. Here, we employ oligomeric polyethylene glycol as a multifunctional solvent for poly (methacrylic acid) (PMAA), converting the otherwise plastic PMAA network into a transparent, dissipative gel. The oligomeric solvent promotes a hierarchical hydrogen-bonding architecture with broadly distributed strengths, coupling elasticity and viscosity, stabilizing the network, and enabling high energy dissipation for acoustic damping and impact resistance. Meanwhile, thermally reversible hydrogen-bond dissociation provides broad endothermic heat absorption, affording thermal buffering. The gels further exhibit high transparency, robust adhesion, and self-healing. Harnessing the gel as an interlayer, we fabricate laminated glass that integrates light transmission, thermal regulation, sound attenuation, and mechanical protection. This oligomer-solvent strategy offers a practical route to multifunctional, energy-efficient, safer building glazing applications in real-world architecture settings.
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CHEMICAL ENGINEERING JOURNAL
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2026
·
IF 12.5
Jiaxin Zhou,Zitao Lin,Peng Yuan,Hongling Bu,Meiqing Chen,Honghai Wu,Yanfu Wei
The development of cost-effective catalysts for green diesel production from fatty acids is crucial to sustainable energy, yet achieving high efficiency under mild, low-H 2 pressure conditions remains challenging. Natural halloysite nanotubes (HNT), owing to their abundance, low cost, and high metal-loading capability, represent an attractive catalyst support. Herein, RuPt alloy nanoparticles supported on halloysite nanotubes are used for the efficient decarboxylation of stearic acid (SA). Under mild conditions using the in situ H 2 , the optimized Ru 0.7 Pt 1.0 /HNT catalyst exhibits high performance, achieving 87.40% SA conversion, with a C8-C19 alkane selectivity of 90.42%. Meanwhile, the catalyst maintains high catalytic activity over at least three consecutive reaction cycles. Combined experimental results and DFT calculations reveal that the RuPt bimetallic catalyst exhibits a significantly lower activation energy barrier than its monometallic counterparts. This reduction is attributed to electron transfer from Pt to Ru, which lowers the activation energy barrier and accounts for the superior performance. This work establishes a scalable low-noble-metal-loading catalyst design, offering an energy-efficient and sustainable route for green diesel production from waste cooking oils.
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Green Energy & Environment
·
2026
·
IF 16.7
Zhiyang Tang,Xianyuan Wu,Jie Qu,Xinjun He,Fukun Li,Jinxing Long,Qiang Zeng,Haixia Su,Hongyan He,Xuehui Li
Selective hydrogenolysis of cellulose into C 6 -ketones offers a promising route for the production of high-value carbonyl compounds. However, conventional metal-catalyzed hydrogenolysis methods typically rely on externally added acids and require high-purity H 2 . Herein, we report an alternative syngas-promoted hydrogenolysis method that eliminates these dual dependencies while enabling the selective transformation of cellulose into value-added C 6 -ketones. Under optimal conditions, using a commercial Pd/C catalyst at 230 °C and 3.0 MPa total pressure (H 2 /CO = 1.5/1.5 MPa) for 2 h, the yield of C 6 -ketones reached 37.8 C-mol%, representing a 6.8-fold enhancement compared to that obtained under pure H 2 . Mechanistic studies demonstrated a dual promotional effect of CO in directing cellulose to C 6 -ketones. First, competitive adsorption of CO on Pd active sites suppresses excessive hydrogenation and undesired hydrogenolysis of cellulose-derived intermediates. Second, CO participates in the water–gas shift (WGS) reaction (CO + H 2 O ⇌ CO 2 + H 2 ), generating carbonic acid (H 2 CO 3 ) in-situ via CO 2 + H 2 O ⇌ H 2 CO 3 , which provides a controllable acidic environment that promotes key intermediate transformations associated with C 6 -ketone precursor formation.
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ADVANCED MATERIALS
·
2026
·
IF 29.1
Haiming Chen,Xiaoxi Li,Kai Lu,Xiaoyu Niu,Yanzi Gao,Jingling Yan,Zhen Wang
Thermally switchable ion-conductive polymers (TSIPs) show considerable application potential for flexible electronics and information encryption. However, their practical implementation is frequently affected by several inherent limitations, including ion leaching, interfacial instability, and inadequate temperature sensitivity in conductivity switching. To address these issues, a series of ionic polyurethanes featuring covalently grafted ionic groups, rather than small-molecule additives, is reported here. This rational design not only provides ion transport pathways, but also enables precise temperature-switchable conductivity by varying the length of crystalline soft segments. The resulting TSIPs exhibit an ultra-sensitive thermo-electrical response with a record-high temperature coefficient of conductivity of up to 30.2%°C − 1 . Modeling of electrode polarization reveals that ion transport at elevated temperatures operates through a dual mechanism: a “swing-like” segmental motion coupled with dynamic reconstruction of ionic clusters. The dynamic reorganization of ionic clusters promotes efficient charge mobility and provides physical crosslinking networks that ensure mechanical integrity in the melt state. Furthermore, they function as intrinsic fluorophores, producing stable photoluminescence. With the integration of intrinsic fluorescent properties and reversible opaque-to-transparent and insulating-to-conducting transitions, the polyurethanes developed in this work establish a versatile platform for multimodal anti-counterfeiting applications.
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Advanced Science
·
2026
·
IF 14.1
Jiawei Zhao,Jianjun Zou,Chen Zhou,Yingui Wang,Yiman Liu,Yanqing Zhou,Yuxiang Wang,Xinyu Zhang,Huishu Yang,Hongjie Yin,Dongsheng Bai,Yue Zhao,Na Lu
Inflammatory bowel disease (IBD) is a chronic and relapsing inflammatory disorder of the gastrointestinal tract. This disease is characterized by a steadily increasing global incidence. Multiple susceptibility genes are implicated in IBD pathogenesis. However, the molecular mechanisms linking epithelial barrier dysfunction to disease progression remain poorly understood. This study performs an integrative analysis of public bulk RNA-seq and single-cell transcriptomic datasets. Experimental validation is conducted using clinical samples. Analyses reveal that vacuole membrane protein 1 (VMP1) is significantly downregulated in IBD. This reduced expression correlates with disease severity. Functional studies demonstrate that VMP1 deficiency in intestinal epithelial cells disrupts tight junction integrity. This loss increases epithelial permeability and exacerbates intestinal inflammation. Mechanistically, VMP1 facilitates the recruitment of CORO1C to late endosomes. This recruitment promotes Retromer-mediated recycling of the tight junction protein Occludin to the plasma membrane. Impairment of this pathway shifts Occludin trafficking toward ESCRT-dependent microautophagic degradation. This shift results in the sustained loss of tight junctions. These findings identify VMP1 as a previously unrecognized regulator of epithelial tight junction recycling and barrier homeostasis. This discovery provides new mechanistic insights into IBD pathogenesis and highlights a promising therapeutic avenue for restoring intestinal barrier function.
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Materials
·
2026
·Vol. 19
·期 5
·1015
·
IF 3.7
Huaizhang Gu,Yuanxun Li,Yunfei Kai,Xiaojuan Shang
A high-entropy strategy has emerged as a promising approach to enhance the functional properties of piezoelectric ceramics for biomedical applications. For this reason, we have designed two novel high-entropy ceramics, (Bi1/2Na1/2)(Zr1/3Sn1/3Ti1/3)O3(BNZST) and (Bi1/2Na1/2)(Zr1/4Sn1/4Hf1/4Ti1/4)O3(BNZSHT), which were synthesized via a two-step solid-state reaction. The phase structure, surface morphology, biocompatibility, and in vitro bioactivity were assessed. The results showed both ceramics adopted perovskite structures. BNZST and BNZSHT ceramics had relatively even crystallite sizes and element distribution, as well as achieving piezoelectric (d33≥ 78 pC/N) properties. In vitro tests confirmed a high relative cell growth rate (RSG, >80%) after co-culturing BNZST or BNZSHT ceramic with murine fibroblasts L929 for more than 3 days. In particular, the surface with electric charge enhanced L929 with more extensive, widespread, and dense proliferation for the BNZST ceramic compared to ceramics without BNZST or unpolarized BNZST. The above indicated that multi-element doping and entropy stabilization established a novel pathway for developing a high-entropy bio-piezoelectric ceramics with high biocompatibility and bioactivity, providing the possibility for their use in bone repair materials.
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RSC Advances
·
2026
·Vol. 16
·期 14
·12639-12650
·
IF 6.1
Runnan Wang,Kang Chen,Yilong Yu,Guiwen Qu,Qining He,Helei Lu,Rui Wang,Yun Zhao,Jinjian Huang,Tao Zheng
Open abdomen (OA) therapy is crucial for managing severe abdominal infections, intra-abdominal hypertension, and trauma but often faces complications like infections and enteric fistulas. To address this, a novel multilayer drug-loaded hydrogel dressing was designed to promote wound healing. The dressing comprises a bottom layer of a carboxymethyl chitosan/aldehyde-modified hyaluronic acid (CC/HA-CHO) hydrogel loaded with Ag nanoparticles (AgNPs) for rapid gelation and broad-spectrum antibacterial action; a middle polyacrylamide (PAAm) gel layer loaded with interleukin-4 (IL-4) to polarize macrophages toward the M2 phenotype for tissue repair; and a top polydimethylsiloxane (PDMS) antifouling layer treated with oxygen plasma for enhanced adhesion and hydrophilicity. Characterization via FTIR, SEM, swelling tests, and drug release assays confirmed the hydrogel's structure, stability, and sequential release of AgNPs and IL-4. In vivo experimental results show that the percentage of wound closure in the drug-loaded hydrogel group reached approximately 30% on day 7, while that in the control group was only about 10%. Thus, the drug-loaded hydrogel can significantly accelerate wound healing of open abdominal wounds. This multifunctional hydrogel combines antibacterial, anti-inflammatory, and tissue-regenerative properties, offering a promising strategy for OA wound management.
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ADVANCED FUNCTIONAL MATERIALS
·
2026
·
IF 19.9
Mingwei Cai,Fuhui Liang,Huahui Liang,Congcong Wu,Luxin Sun,Xiaohua Ma,Shiyang Zhang,Yonggang Min
Achieving precise customization and structural regulation of sub-Ångström pores of Carbon molecular sieve membranes (CMSMs) remains challenging. In this study, CMSMs with ultra-high H 2 /CH 4 separation performance were developed by a UV induced super-crosslinking network polyimide precursor, which was formed by click reaction through an imide intermediate that contains C≡CH and the SH as functional end groups. The as-formed polyimide contains C═C─S in each repeat unit of the polyimide which can be crosslinked using UV light via the [2+2] reaction and form molecular “stitches” with a super-crosslinking network. The cross-linking node density can be easily adjusted by the UV irradiation time (0–30 min). During pyrolysis, the dimensions of the connecting interior pore necks for sub-Ångström pores can be fine-tuned (4.0±0.3 Å), promoting the formation of a higher concentrated (4%–8%) sub-4 Å pores. The optimized CMS-30 membrane demonstrates outstanding gas separation performance, with H 2 permeability of 2930 Barrer and remarkable selectivity for H 2 /CH 4 (4651), surpassing the Robeson upper bounds and outperforming most reported CMSMs. This photo-induced super-crosslinking network precursor method provides a versatile strategy for high-performance CMSM by sub-nanometer precision engineering of CMSMs.
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ACS Applied Materials & Interfaces
·
2026
·
IF 7.8
Honglin Zhou,Wenxiu Yuan,Jie Dong,Xiang Shao,Jinyun Chen,Fei Chang,Xinyi Cheng,Haoran Bai,Yujie Cheng,Qincheng Ma,Ying Wang,Jun Tang,Qingping Ke,Jianli Wang
The selective oxidation of cyclohexene to high-value cyclohex–2–enone using singlet oxygen holds significant importance in chemical production. However, conventional methods for generating singlet oxygen are often constrained by harsh conditions, typically requiring high-energy input. This study develops a new methodology that leverages the Pickering emulsion droplet interfaces to facilitate the generation of singlet oxygen for the efficient oxidation of cyclohexene. First, an amphiphilic catalyst SiO2/CNx was synthesized by growing hydrophobic nitrogen-doped carbon on the surface of hydrophilic sheet-like silica through a combined surface-polymerization and carbonization process. Such amphiphilic catalyst can then self-assemble at the interfaces of the oil phase (cyclohexene in ethyl acetate) and water phase (tert-butyl hydroperoxide aqueous solution), thereby stabilizing a water–in–oil Pickering emulsion. The graphitic nitrogen sites on the nitrogen-doped carbon promote the cleavage of tert-butyl hydroperoxide to form superoxide radicals, while the pyridinic nitrogen sites can adsorb and enrich the resulting radicals. In addition, the unique proton-rich microenvironment at the Pickering emulsion droplet interfaces promotes the disproportionation of adsorbed superoxide radicals, generating the desired singlet oxygen for the selective oxidation of cyclohexene. As a result, this Pickering emulsion system achieved a cyclohexene conversion of >99.0% with a 95.0% selectivity toward cyclohex–2–enone, significantly outperforming the results reported in prior studies. This strategy of harnessing the Pickering emulsion droplet interfaces to regulate the generation of highly reactive singlet oxygen opens up a promising route for the efficient synthesis of oxygenated fine chemicals.
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