JOURNAL OF MOLECULAR LIQUIDS
·
2020
·
IF 5.065
Yushu Wu,Min Liu,Wenxin Pei,Yanna Zhao,Danfeng Wang,Tingting Liu,Bin Sun,Qingpeng Wang,Jun Han
DNA nanostructures-based chemotherapy-phototherapy (CTPT) combination therapy can achieve targeted release and effectively overcome multidrug resistance (MDR). The therapeutic effect of CTPT combination drugs loaded in DNA nanostructures is related to the interactions among them. Herein, based on our previous research on AS1411NTrs loading with a single drug of DOX , the interactions between a single drug (toluidine blue O, TBO) or combination drugs (doxorubicin and toluidine blue O, DOX + TBO) and AS1411 aptamer-tethered DNA nanotrains (AS1411NTrs) were investigated. By fluorescence spectroscopy and isothermal titration calorimetry technique, the corresponding thermodynamic parameters were obtained, including the number of binding sites, binding constant , enthalpy change and entropy change. By combining with the differential scanning calorimetry and ferrocyanide ion quenching analysis, the binding mode-thermodynamic parameters were correlated. In addition, the effect of the binding affinity of DOX and TBO to AS1411NTrs on the drugs release rate was studied. Finally, the in vitro cytotoxicity and confocal laser scanning microscopy imaging of AS1411NTrs + TBO + DOX was investigated. The results showed that this drug delivery system could increase its in vitro cytotoxicity and overcome drug resistance in DOX-resistant human breast cancer cells (MCF-7/ADR). The work would provide important information for the combination therapy of DOX and TBO to overcome MDR effectively.
✓ 已验证
DOI
高影响因子
ELECTROCHIMICA ACTA
·
2024
·
IF 5.5
Shulin Li,Qiaoquan Lin,Han Yan,Qiaodong Li,Yu Yang,Xinlin Yan,Zhenyu Wang,Chuang Yu,Long Zhang
Cl-rich Li-argyrodites are one type of sulfide solid electrolytes (SSEs) with a high ionic conductivity and suitable mechanical properties for practical application. However, their tolerance against moisture in air and compatibility with metallic Li need further improvements. Here, we demonstrate that Nb-O dual-doping can be a good strategy for advanced Cl-rich Li-argyrodite SSEs, prepared by high energy ball milling and annealing method. Our results show that the Nb-O co-doping enhances the interface compatibility towards metallic Li and improves the moisture resistance, while maintains a fast ion transport. The Nb-O incorporation improves the Young's modulus and mitigates the side reaction of Li-argyrodite with Li. The doping-optimized sample demonstrates a high critical current density of 2.28 mA cm −2 and a long-term Li plating/stripping stability under a relatively high current density (1 mA cm −2 ) for nearly 3000 cycles. Notably, the corresponding all-solid-state lithium batteries (ASSLBs), using a Li metal electrode, can maintain a superior cycling stability for over 1000 cycles at 1 C.
✓ 已验证
DOI
高影响因子
RSC Advances
·
2018
·Vol. 8
·期 46
·26318-26324
·
IF 2.936
Xianbin Huang,Jinsheng Sun,Kaihe Lv,Jingping Liu,Haokun Shen
This study presents an alternative method to enhance the emulsion stability of oil based drilling fluids (OBMs). Modified dimer acid (MDA) was synthesized with a molecular structure having two hydrophilic heads and two hydrophobic tails. Theoretically, the adsorption of MDA on an oil–water interface makes it possible to increase hydrogen bonding between water droplets and form three dimensional networks which benefit emulsion stability. The influence of MDA on the stability of base emulsions was studied by visual observation. Then the stabilization mechanism of MDA was analyzed from the micro and macro points of view by morphology study using a cryo-scanning electron microscope (cryo-SEM) and rheological measurements including viscosity vs. shear rates, zero-shear viscosity (η0), and creep and recovery tests. Experimental results showed that a substantial improvement in emulsion stability was visually observed when the MDA concentration was 2 g L−1. From cryo-SEM observation, a honeycomb structure was observed in the emulsion containing 2 g L−1 MDA, which can provide a physical barrier to restrain the movement of water droplets. In comparison with the rheological behaviors of the emulsion without MDA, a remarkably larger zero-shear viscosity, a solid-like behavior and a greater elasticity were observed when 2 g L−1 MDA was present. Finally, the application in OBMs shows that MDA can largely enhance electrical stability (ES) and reduce the filtration volume. The method proposed in the paper could be used to enhance the stability of w/o emulsions in a variety of fields.
✓ 已验证
DOI
高影响因子
JOURNAL OF CHEMICAL CRYSTALLOGRAPHY
·
2013
·Vol. 44
·期 2
·63-69
·
IF 0.513
Ma De-Yun,Guo Hai-Fu,Qin Liang,Li Yue,Ruan Qiong-Ting,Huang Yue-Wu,Xu Jun
A new 2D Cd(II) coordination polymer, {[Cd(4-cpa) (bpp) 2 H 2 O]·(4-cpa)·(H 2 O)}
n
( 1 ) [4-cpa = 4-chlorophenoxyacetate, bpp = 1,3-bis(4-pyridyl)propane] has been hydrothermally synthesized and characterized by elemental analysis, IR-spectroscopy, thermogravimetric analysis, powder X-ray diffraction and single-crystal X-ray diffraction. Complex 1 consists of discrete 2D cadmium complex, 4-cpa counter ions and free water molecules, which are assembled into a 3D supramolecular structure through hydrogen bonds and π···π stacking interactions. Three-dimensional fluorescence spectra of 1 were detected at room temperature under the excitation and the emission wavelengths in the range of 300–600 nm with the interval of 5 nm. The lifetime of the excited state of 1 upon excitation of 443 nm in solid-state at room temperature is 30.21 ns. The 4-cpa ligand and complex 1 have been screened for their phytogrowth-inhibitory activities against Brassica campestris L. and Echinochloa utilis Ohwi et Yabuno , and the results are compared with the activity of sodium 2,4-dichlorophenoxyacetate. Graphical Hydrothermal synthesis of a new 2D Cd(II) coordination polymer, {[Cd(4-cpa) (bpp) 2 H 2 O]·(4-cpa)·(H 2 O)}
n
( 1 ) [4-cpa = 4-chlorophenoxyacetate, bpp = 1,3-bis(4-pyridyl)propane] leading to a material that displays intense blue 3D luminescence properties and phytogrowth-inhibitory activities.
✓ 已验证
DOI
高影响因子
Inorganic Chemistry Frontiers
·
2022
·Vol. 9
·期 18
·4614-4623
·
IF 7.779
Feixiang Wang,Yun Yang,Congcong Jin,Shilie Pan
A new borate, Li6.58Na7.43Sr4(B9O18)(B12O24)Cl (LNSBOC), was successfully obtained via a spontaneous crystallization method in an open system. LNSBOC crystallizes in a hexagonal crystal system with the centrosymmetric space group of P63/m, with a = 9.3046(2) Å, c = 24.3239(7) Å and Z = 2. According to the statistics, the structure of LNSBOC is extraordinary not only because of the discovery of the novel fan-like fundamental building block B9O18, but also for the unprecedented coexistence of the largest two highly polymerized (number of B atoms more than six) isolated B–O clusters in the structure. A discussion about the cause of the rareness of borates containing two polymerized isolated B–O clusters was carried out by investigating previous research and extant compounds. Even more significantly, a strategy to design compounds/crystal structures containing two polymerized isolated B–O clusters is put forward in this work from the viewpoint of structures and elements. In addition, thermal analysis and infrared and UV–Vis–NIR diffuse reflectance spectroscopy were performed for the title compound.
✓ 已验证
DOI
高影响因子
ULTRASONICS SONOCHEMISTRY
·
2024
·
IF 8.7
Chao Zhang,Yu Zhang,Bin Qiu,Zhenhua Liu,Xueyan Gao,Nan Zhang,Xia Liu,Shasha Qi,Lingfei Li,Wei Liu
This study focuses on developing a water-in-oil-in-water (W 1 /O/W 2 ) double emulsion system using high-intensity ultrasound (HIU)-treated pea protein isolate (HIU-PPI) and pectin to encapsulate Lactobacillus plantarum ( L. plantarum ). The effects of ultrasound treatment on pea protein isolate (PPI) characteristics such as solubility, particle size, emulsification, surface hydrophobicity, and surface free sulfhydryl group were examined, determining optimal HIU processing conditions was 400 W for 10 min. The developed W 1 /O/W 2 double emulsion system based on HIU-PPI demonstrated effective encapsulation and protection of L. plantarum , especially at the HIU-PPI concentration of 4 %, achieving an encapsulation efficiency of 52.65 %. Incorporating both HIU-PPI and pectin as emulsifiers increased the particle size and significantly enhanced the emulsion’s viscosity. The highest bacterial encapsulation efficiency of the emulsion, 59.94 %, was attained at a HIU to pectin concentration ratio of 3:1. These emulsions effectively encapsulate and protect L. plantarum , with the concentration of HIU-PPI being a critical factor in enhancing probiotic survival under simulated gastrointestinal digestion. However, the concurrent utilization of pectin and HIU-PPI as emulsifiers did not provide a notable advantage compared to the exclusive use of HIU-PPI in enhancing probiotic viability during in vitro simulated digestion. This research offers valuable perspectives for the food industry on harnessing environmentally friendly, plant-based proteins as emulsifiers in probiotic delivery systems. It underscores the potential of HIU-modified pea protein and pectin in developing functional food products that promote the health benefits of probiotics.
✓ 已验证
DOI
PubMed
高影响因子
ELECTROCHIMICA ACTA
·
2021
·
IF 6.901
Huihui Zhang,Lushi Tan,Zhejuan Zhang,Guirong Zhang,Jiaxing Lu
In this work, different mass percentage of activated carbon (YBC) doped carbon paste electrodes (YBCPE) were firstly prepared, then electrodeposition of Pt nanoparticles was performed at a constant potential -0.1 V vs. Ag|AgCl|KCl (3 M) to prepare working electrodes Pt/YBCPE. It was shown that Pt/YBCPE(16%) exhibits the highest mass activity for formaldehyde oxidation compared to platinum deposited on pure carbon paste electrode (CPE) and other YBCPE(X%) electrodes. Afterwards, poly-o-anisidine (POA) film was prepared by electro-polymerization onto the CPE and YBCPE(16%) in o-anisidine monomer solution at 0.7 V and then Pt nanoparticles were electro-deposited at the POA film surface for fabrication of the Pt/POA/CPE and Pt/POA/YBCPE composite electrodes. The morphology of the composite electrodes was characterized by SEM, TEM, XRD and XPS which revealed that the presence of YBC and POA in the composite electrodes significantly improves the dispersion of Pt nanoparticles on the electrodes. Electrochemical impedance spectroscopy (EIS), chronoamperometry and cyclic voltammetry were used to verify the conductivity and durability of the composite electrode and its electro-catalytic activity. The obtained results indicated that the Pt/POA(16mC)/YBCPE(16%) exhibits excellent electro-catalytic activity towards the formaldehyde oxidation owing to the synergistic effect of the support-catalyst. Some comparisons for the electrooxidation of formaldehyde and the electrooxidation of methanol and formic acid on the composite electrodes also were conducted.
✓ 已验证
DOI
高影响因子
Small
·
2022
·Vol. 18
·期 13
·2106863
·
IF 15.153
Jie Huang,Yeqing Chen,Pengpeng Rao,Zongming Ni,Xueying Chen,Jie Zhu,Chen Li,Gaoyang Xiong,Ping Liang,Xin He,Songnan Qu,Jun Lin
Carbonized polymer dots (CPDs) have received tremendous attention during the last decade due to their excellent fluorescent properties and catalytic performance. Doping CPDs with transition metal atoms accelerates the local electron flow in CPDs and improves the fluorescent properties and catalytic performance of the CPDs. However, the binding sites and the formation mechanisms of the transition-metal-atom-doped CPDs remain inconclusive. In this work, Mn 2+ -ion–doped CPDs (Mn-CPDs) are synthesized by the hydrothermal method. The Mn 2+ ions form Mn O bonds that bridge the sp 2 domains of carbon cores and increases the effective sp 2 domains in the Mn-CPDs, which redshifts the fluorescence emission peak of the Mn-CPDs slightly. The Mn 2+ ions form covalent bonds in the CPDs and remedy the oxygen vacancies of the CPDs, which cuts off the non-radiative–recombination process of the Mn-CPDs and increases the quantum yield of the Mn-CPDs to 70%. Furthermore, the Mn O bonds accelerate the electron flow between adjacent sp 2 domains and enhances the electron transport in the Mn-CPDs. Thus, the Mn-CPDs demonstrate excellent catalytic performance to activate hydrogen peroxide (H 2 O 2 ) and produce hydroxyl radicals (•OH) to degrade methylene blue (MB) and rhodamine B (RhB).
✓ 已验证
DOI
高影响因子
Desalination and Water Treatment
·
2024
·
IF 1
Yiwen Wang,Qinliang Jiang,Hua Fan,Lihe Wang,Jihai Xiong,Jianquan Luo
A novel thin-film nanofiltration (NF) membrane was prepared successfully by interfacial polymerization of piperazine and trimesoyl chloride on a porous molybdenum disulfide oxide (O-MoS 2 ) modified polysulfone (PSf) substrate with greatly enhanced separation performance. In this work, scanning electron microscopy confirmed that the optimized PSf substrate formed elongated finger-like pores during the phase inversion process, significantly different from other membranes and key to improving the water transport and desalination of the membrane. The effects of different dye molecular structures, varieties, and charges, and the feed solution and salt concentrations in the blend solution on salt and dye rejection and water flux of NF membranes were explored. Compared with the control membrane, the optimized membrane’s rejection performance and water permeability were greatly improved when treating simulated dye wastewater. After the introduction of O-MoS 2 (0.06 wt.%), the introduction of O-MoS 2 increased the chromotropic acid 2B and Rose Bengal rejection rates of the membrane compared to the original, from the original of 97.73%, 99.79% to 99.41% and 99.99%, respectively, and the water flux enhanced from the beginning of 32.8, 32.0–43.2 and 43.7 L/m 2 ·h, respectively. Furthermore, in a 120 h simulated dye wastewater treatment stability test, the optimized F6 membrane showed stronger flux stability and excellent rejection performance, providing its vast potential for application in dye wastewater treatment.
✓ 已验证
DOI
高影响因子
Energy Storage Materials
·
2021
·
IF 17.789
Linlin Ma,Li-Juan Yu,Jingchong Liu,Ya-Qiong Su,Shuai Li,Xiaohuan Zang,Tao Meng,Shuaihua Zhang,Jianjun Song,Jiangyan Wang,Xiaoxian Zhao,Zhimin Cui,Nü Wang,Yong Zhao
As the desired sulfur host of lithium-sulfur battery, the strong polarity and fast electron migration capability are indispensable for achieving effective adsorption and conversion of lithium polysulfides (LiPSs), that is, restricting the shuttle effect. Herein a porous microdisk Ti 4 O 7 /TiN/C heterojunction with strong polar N-Ti-O covalent bonds is precisely constructed. Compared with O-Ti-O or N-Ti-N bond in single Ti 4 O 7 or TiN , the N-Ti-O bond with stronger polarity could adsorb and bond with S and Li atoms in LiPSs, which is beneficial for LiPSs adsorption. Beside, the Ti 4 O 7 /TiN heterostructure favors the electron transfer , which could promote the conversion of LiPSs. The design strategy is to construct abundant polar N-Ti-O bonds at Ti 4 O 7 /TiN heterogeneous interface that would realize the associative process of LiPSs adsorption, trapping, and conversion, thereby restraining the shuttle effect efficiently. In the current study, as the host of the sulfur cathode, the porous microdisk TiN/Ti 4 O 7 /C heterojunction exhibits a high specific capacity of 1204.5 mAh g −1 at 0.2 C, and a high specific capacity of 616.5 mAh g −1 at an ultrahigh current density of 4 C. In addition, 86.4% and 116.9% capacity are retained over 1000 cycles at 1 C and 2 C, respectively. This strategy provides an insight into developing lithium-sulfur battery with extraordinary performance, and opens promising routes to design the next-generation electrochemical energy storage devices.
✓ 已验证
DOI
高影响因子
Journal of Environmental Chemical Engineering
·
2025
·
IF 7.2
Xuyao Qiao,Shuguang Ning,Hongyao Zhao,Ruiting Ni,Wanyu Zhang,Yangping Zhang,Linzhi Zhai,Danhong Shang,Yanyun Wang,Tongyi Yang,Mengnan Wang,Fu Yang
Addressing the dual challenges of freshwater scarcity and pollution elimination requires innovative technologies that rationally integrate multiple functions. This study developed a representative dual-functional solar evaporator by coupling photothermal Fe₃O₄ nanospheres with oxygen-doped CdS (CdS-O) within a sponge-based hydrogel matrix, achieving concurrent high-efficiency solar-driven water regeneration and pollutant degradation. The design leverages the unique roles of two unique components, wherein, Fe₃O₄ endows the evaporator with broadband solar absorption (300–800 nm) and an superior photothermal conversion efficiency of 80 %, while oxygen doping CdS-O narrows its bandgap (from 2.31 eV to 2.29 eV), enhancing visible-light harvesting and charge separation. Crucially, the synergistic interplay between Fe₃O₄ and CdS-O establishes a self-sustained photo-Fenton-like mechanism. CdS-O generates H₂O₂ via photogenerated electron reduction of O₂, and Fe₃O₄ acts as an electron acceptor to accelerate Fe 3 + /Fe 2+ cycling, Fe²⁺ ions react with H₂O₂ via a Fenton-like process to produce ·OH radicals for pollutant mineralization. Simultaneously, the hydrogel-sponge architecture ensures rapid water transport and localized heat confinement, enabling an evaporation rate of 1.55 kg·m −2 ·h −1 under 1 sun irradiation. The system demonstrates remarkable dual-functionality: 86.9 % tetracycline degradation in lake water within 240 minutes and 89 % photocatalytic activity retention after six cycles. This work overcomes the limitations of conventional single-function systems by unifying photothermal evaporation and photocatalytic oxidation into a scalable platform, offering a sustainable solution for simultaneous water production and purification through material synergy and energy-efficient design.
✓ 已验证
产品关联
DOI
高影响因子
npj Science of Food
·
2025
·Vol. 9
·期 1
·1-9
·
IF 7.8
Ye Xiang,Chen Wen,Yan Fujie,Zheng Xiaodong,Tu Pengcheng
In late-stage type 2 diabetes mellitus (T2DM), impaired islet β cell function leads to absolute insulin deficiency, thereby disrupting blood glucose homeostasis. GLP-1, an incretin hormone, stimulates insulin secretion from islet β cells post-meals. This study investigated the effects of anthocyanin cyanidin-3-O-glucoside (C3G) on GLP-1 secretion using STC-1 (intestinal endocrine L cells) and NIT-1 (islet β cells). In a co-culture system, C3G treatment increased GLP-1 secretion in STC-1 cells, promoting insulin release in NIT-1 cells under high glucose. Mechanistically, C3G activated the PPARβ/δ-β-catenin-TCF-4 pathway in STC-1 cells, enhancing PG precursor transcription and GLP-1 synthesis.Inhibiting PPARβ/δ with GSK0660 blocked this C3G-induced upregulation. Overall, C3G stimulates GLP-1 secretion from intestinal L cells via this pathway, indirectly boosting insulin release from β cells. These findings enhance T2DM mechanism understanding and suggest the potential of C3G in GLP-1-based T2DM therapy.
✓ 已验证
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）