OPTICAL MATERIALS
·
2022
·
IF 3.754
Fan Yang,Xiaojiao Yu,Zongbin Liu,Kai Wang,Yuduo Liang,Juan Qiu,Ting Zhang,Jinfen Niu,Jie Zhao,Binghua Yao
BiPO 4 with a prismatic morphology is successfully prepared using a hydrothermal method . The phase of the as-prepared BiPO 4 is a monazite monoclinic phase. The pH of the zero point of charge is approximately 5 for the BiPO 4 . The effects of the catalyst dosage, initial concentration of moxifloxacin, and initial pH of the moxifloxacin solution on the photocatalytic degradation of moxifloxacin over the as-prepared BiPO 4 are first studied. In addition, cations such as K + , Zn 2+ , and Al 3+ and anions such as CO 3 2− , HPO 4 2− , SO 4 2− , F − , and Cl − are introduced into the photocatalytic system to investigate their effects. Furthermore, through reactive species trapping, it is proven that ⋅O 2 − can be converted to ⋅OH and N 2 can be reduced to NH 3 in acidic solution. This work provides an essential study of BiPO 4 for its application in photocatalytic fields.
✓ 已验证
DOI
高影响因子
CHEMISTRY-A EUROPEAN JOURNAL
·
2012
·Vol. 18
·期 49
·15676-15682
·
IF 5.925
Xiao-Jiao Kang,Yun-Lu Dai,Ping-An Ma,Dong-Mei Yang,Chun-Xia Li,Zhi-Yao Hou,Zi-Yong Cheng,Jun Lin
Graphical Dual response : Monodisperse poly(acrylic acid)-modified Fe 3 O 4 (PAA@Fe 3 O 4 ) hybrid microspheres with dual responses (magnetic field and pH) were successfully fabricated (see figure). The drug release behavior was strongly dependent on pH value due to the unique properties of PAA. Furthermore, doxorubicin (DOX)-loaded PAA@Fe 3 O 4 composites show an enhanced magnetically guided anticancer effect. Monodisperse poly(acrylic acid)-modified Fe 3 O 4 (PAA@Fe 3 O 4 ) hybrid microspheres with dual responses (magnetic field and pH) were successfully fabricated. The PAA polymer was encapsulated into the inner cavity of Fe 3 O 4 hollow spheres by a vacuum-casting route and photo-initiated polymerization. TEM images show that the samples consist of monodisperse porous spheres with a diameter around 200 nm. The Fe 3 O 4 spheres, after modification with the PAA polymer, still possess enough space to hold guest molecules. We selected doxorubicin (DOX) as a model drug to investigate the drug loading and release behavior of as-prepared composites. The release of DOX molecules was strongly dependent on the pH value due to the unique property of PAA. The HeLa cell-uptake process of DOX-loaded PAA@Fe 3 O 4 was observed by confocal laser scanning microscopy (CLSM). After being incubated with HeLa cells under magnet magnetically guided conditions, the cytotoxtic effects of DOX-loaded PAA@Fe 3 O 4 increased. These results indicate that pH-responsive magnetic PAA@Fe 3 O 4 spheres have the potential to be used as anticancer drug carriers.
✓ 已验证
DOI
高影响因子
Journal of the Taiwan Institute of Chemical Engineers
·
2016
·
IF 2.848
Wenyu Wang,Qinyan Yue,Baoyu Gao,Ruihua Li
In this study, the tendency of coagulation performances, floc characteristics and membrane resistances under different pH conditions in coagulation–ultrafiltration hybrid process was investigated by different Al species and chitosan (CS). Results indicated that CS as coagulation aid was independent of aluminum species. Coagulation efficiencies of three Al species (Al a , Al b and Al c ) combined with CS were enhanced comparing with Al species used alone and shown similar variation tendencies during the pH range. The values of floc size and strength/recovery factor were relatively high at pH 6, and the maximum fractal dimension was achieved under alkaline conditions generally due to adsorption sweeping. Al a /Al b /Al c combined with CS contributed to larger flocs, higher recovery factors and smaller fractal dimension values than those without CS. The results of ultrafiltration experiments shown that membrane resistances during alkaline ranges were higher than those of acidic conditions, which indicated membrane fouling was more serious in alkaline range. In addition, the total membrane resistance was decreased significantly by CS addition.
✓ 已验证
DOI
高影响因子
CERAMICS INTERNATIONAL
·
2018
·
IF 3.057
Jingwei Wang,Yong Kong,Feng Liu,Dan Shou,Yongxin Tao,Yong Qin
Construction of simple and convenient platforms for controlled delivery of anti-cancer drugs is of great importance for medical science and pharmaceutics. Here, chitosan (CS) gels were used to induce the growth of calcium carbonate (CaCO 3 ) microspheres , and the resulting CaCO 3 microspheres were well dispersed within the three-dimensional (3D) network framework of the CS gels. The synthesized CaCO 3 /CS composites were then examined by field emission scanning electron microscopy (FESEM), transmission electron microscopy (TEM), Fourier transform infrared spectrometry (FT-IR) and X-ray diffractometry (XRD). Finally, the designed CaCO 3 /CS composites were used for loading and controlled delivery of methotrexate (MTX), an anti-cancer drug. The encapsulation ratio of MTX calculated by UV–vis spectroscopy was approximately 78.8%. In addition, pH-responsive delivery of MTX from the CaCO 3 /CS composites was successfully achieved due to the pH-sensitive property of CS, and the cumulative release of MTX could reach 93.3%, 86.6% and 77.6% at pH 8.5, 7.4 and 5.8, respectively.
✓ 已验证
DOI
高影响因子
ACS Applied Materials & Interfaces
·
2024
·
IF 8.3
Junxiang Pei,Haofeng Li,Fayi Chen,Zitao Chen,Xiaodong Yuan,Zhaoxia Han,Daqin Chen,Dechao Yu,Dawei Zhang
Carbon quantum dots (CQDs) with fluorescence emission have been widely studied for versatile applications, but facile tunability of the spectral properties of CQDs by doping remains to be further explored. Herein, employing lanthanide ion Eu3+ as a dopant and activator, a simple and efficient synthesis route for pure CQDs and Eu-CQDs was demonstrated using N, N-dimethylformamide, oleic acid, and oleylamine as precursors for carbon sources. In comparison, with the popular citric acid precursor, the as-prepared CQDs and Eu-CQDs exhibited an obviously smaller particle size (1.72 ± 0.29 nm) and a more uniform distribution. Through systematic optimization of Eu3+ doping for the Eu-CQD system, colorful light emissions in the visible range were first realized under excitation of ultraviolet (UV) ∼360 nm for promising application of UV-triggered light-emitting diodes. Most interestingly, this Eu-CQD solution with UV-excited colorful light emissions was utilized as a visual pH sensor, experimentally featuring good repeatabilities and stabilities (pH values switching between 7 and 14). Besides, the Eu-CQD solution exhibited highly sensitive detection characteristics for Co (II) ions. Due to the spectral overlapping, the quenching efficiency is as high as 96.3%, and the detection limit is obtained as 0.139 μM, which is much lower than the maximum concentration of Co (II) in the drinking water permitted by WHO. All of these relevant results significantly demonstrate the great potential of lanthanide doping in the multifunctionalization of CQDs for certain emerging applications like lighting, sensing, and detection.
✓ 已验证
DOI
高影响因子
JOURNAL OF PHYSICAL CHEMISTRY B
·
2011
·
IF 3.603
Panfeng Long,Aixin Song,Dong Wang,Renhao Dong,Jingcheng Hao
The formation of pH-sensitive vesicles and the rheological properties of the mixtures of perfluorolauric acid (PFLA) and its salts (PFL-Na and PFL-Li) neutralized via NaOH or LiOH were investigated in aqueous solution. When the right mixing ratios of the ionized to nonionzed PFLA molecules with a very high Krafft point are established, vesicles can spontaneously form at room temperature. The vesicles spontaneously formed in the PFLA/PFL-Na/H2O system with the rigid fluorocarbon chains were determined by atomic force microscopy images. Compared to those of hydrocarbon amphiphiles, these vesicle samples, which can be kept for 2 years at room temperature, are more stable. The phase transition from the vesicle phase to the lamellar lyotropic liquid crystal phase with the increase of pH was determined by freeze-fracture transmission electron microscopy images in the PFLA/PFL-Li/H2O system. The system of perfluoro fatty acid vesicles exhibits much more interesting rheological properties, compared to hydrocarbon fatty acid vesicles. The perfluoro fatty acid vesicle solutions display a much higher yield stress and viscoelastic properties, which depend on two factors: (i) the fluorinated alkyl chains of PFL–, which are in the crystalline state at room temperature because of their rigid chains compared to analogous hydrocarbon chains, and (ii) the packing of the vesicles, which is very dense. This is the first time that pH-sensitive vesicles exhibiting birefringence were constructed through ionizing perfluoro fatty acid, which may direct primarily toward acquiring an understanding of the mechanism of vesicles depending on the right mixing ratios of the ionized to the nonionzed perfluoro fatty acid molecules with a very high Krafft point and secondarily to expand the development of fluorinated surfactants in both fundamental research and practical applications.
✓ 已验证
DOI
高影响因子
WATER SCIENCE AND TECHNOLOGY
·
2022
·Vol. 85
·期 7
·2051-2064
·
IF 2.43
Jiang Qihui,Qian Ruyi,Shen Tongdong,Tong Shaoping
Graphite felt (GF) supported cerium oxide (CeO 2 ) composite with sulfation pretreatment (H 2 SO 4 -CeO 2 /GF) was prepared by the impregnation method and employed as the catalyst to activate H 2 O 2 for degradation of isoniazid (INH). The obtained samples were characterized by X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM) and X-ray photoelectron spectrum (XPS). The results showed that H 2 SO 4 -CeO 2 /GF had good properties in activating H 2 O 2 for the degradation of INH. The INH removal was about 89.4% in 120 min under the following conditions: H 2 O 2 2.94 mM, H 2 SO 4 -CeO 2 /GF 2.6 g/L, INH 10 mg/L, initial pH at 6.8 and temperature at 25 °C. The effects of some reaction parameters, including initial H 2 O 2 concentration, initial INH concentration, initial pH value, the catalyst dosage and reaction temperature, on INH degradation were investigated. On the basis of mechanism study and intermediate analysis, the possible degradation pathway of INH was proposed. Besides, effective degradation of methyl orange (MO) and norfloxacin (NOF) also confirmed the high activity of H 2 SO 4 -CeO 2 /GF in activation of H 2 O 2 . The H 2 SO 4 -CeO 2 /GF was relatively stable, showing good application prospects. Acidified cerium oxide/GF composite (H 2 SO 4 -CeO 2 /GF) was prepared by impregnation. The activity of H 2 SO 4 -CeO 2 /GF for activation of H 2 O 2 is high even at pH 7.0. The catalyst of H 2 SO 4 -CeO 2 /GF is stable and has great potential for application. The role of acidification of sulfuric acid in the catalyst is explained.
✓ 已验证
DOI
高影响因子
Frontiers in Chemistry
·
2024
·
IF 3.8
Shang Xiujuan,Wang Hongdong,Yu Yongbo,Gu Jin,Zeng Jian,Hou Sinan
Antimicrobial photodynamic therapy (aPDT) has emerged as a highly promising strategy for non-antibiotic treatment of infections due to its unique advantages in efficient bactericidal action and reduction of drug resistance. The natural photosensitizing properties of curcumin (Cur) are widely acknowledged; however, its limited bioavailability has impeded its practical application. In this study, we developed a nanomaterial called Cur@ZIF-8@BA by encapsulating Cur within ZIF-8 and modifying the surface with boric acid (BA). The Cur@ZIF-8@BA exhibits pH-responsive properties and enhances bacterial binding, thereby effectively promoting photodynamic therapy. Moreover, its antibacterial activity against E. coli, Staphylococcus aureus and A. baumannii is significantly increased in the presence of light compared to a dark environment. The mechanism behind this may be that BA increases the affinity of Cur@ZIF-8@BA towards bacteria, and making released Zn2+ and BA from the nanomaterial increase bacterial cell membrane permeability. This facilitates efficient delivery of Cur into bacterial cells, resulting in generation of abundant reactive oxygen species (ROS) and subsequent bactericidal activity. In conclusion, our prepared Cur@ZIF-8@BA holds great promise as a photodynamically mediated antimicrobial strategy.
✓ 已验证
DOI
PubMed
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2022
·
IF 16.744
Ming Zhao,Peiquan Li,Hongjun Zhou,Li Hao,Huayao Chen,Xinhua Zhou
With the increase in global food demand and the destruction of environment, the development of sustainable agriculture has become increasingly more important. Stimuli-responsive controlled-release agrochemicals enhance the bioavailability of active ingredients and reduce the frequency of use and environmental pollution. Herein, 3,3′-dithiodipropionic acid was used as a functional bridge to covalently link the degradable natural polymer zein and chitosan oligosaccharides (CS) to prepare a water-dispersed environmentally friendly pesticide carrier. Subsequently, via hydrophobic and hydrogen bonding interactions photo-decomposable avermectin (AVM) was encapsulated forming a stimuli-responsive intelligent nanopesticide delivery system (AVM@CS-SS-Zein) was developed by encapsulating in the carrier. AVM was released slowly from AVM@CS-SS-Zein particles in a neutral condition and was released rapidly under stimulation of glutathione and alkalinity in simulated insects. The photostability of AVM@CS-SS-Zein was improved by 6-fold compared with that of AVM and the nanoparticles had good adherence to the leaves, slowly releasing AVM and avoiding the light decomposition of active ingredients. When the pests ingest the leaves containing AVM@CS-SS-Zein, the rapid disintegration of the nanoparticles in vivo leads to a good insecticidal effect and the control rate of AVM@CS-SS-Zein on Plutella xylostella was higher than that of AVM. After 120 h of UV irradiation, the pest mortality rate of AVM@CS-SS-Zein was 46.7% while that of AVM and AVM emulsifiable concentrate was only 13.3% and 20.0%, respectively. Therefore, this pH/redox dual stimuli-responsive nanopesticide formulation achieves target control of pests and provides an efficient nanoplatform for green agriculture.
✓ 已验证
DOI
高影响因子
Biomaterials Science
·
2025
·
IF 5.7
Jia-Qi Luo,Yong-Cong Huang,Jing-Yang Zhang,Qi-Song Tong,Areesha Batool,Jinzhi Du,Yuyou Duan
Antigen-presenting cells (APCs), such as macrophages and dendritic cells (DCs) are key players in modulating the immune responses of cytotoxic T lymphocytes (CTLs). Resiquimod (R848), a toll-like receptor (TLR) agonist, has demonstrated the capacity to enhance APC function and reprogram the phenotype of macrophages; however, the unfavorable in vivo performance constrains its therapeutic potential. Here, we developed R848-loaded mesoporous silica nanoparticles (denoted as R848@MSN-bi-PEG) with pH-responsive surface PEG detachment to effectively modulate APCs. The acidic tumor pH triggered PEG detachment when R848@MSN-bi-PEG accumulated at the tumor site, thereby promoting APC uptake and R848 release, which facilitated DCs maturation and macrophage repolarization to a pro-inflammatory phenotype. The in vivo antitumor study indicated that R848@MSN-bi-PEG led to potent anti-tumor immunity by modulating the immunosuppressive tumor microenvironment. This approach offers a novel strategy to improve the effectiveness of cancer immunotherapy.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
International Journal of Pharmaceutics-X
·
2025
·
IF 6.4
Yang Yu,Yili Zhao,Yujiao Zou,Chanyi Lu,Ni Li,Zhiyuan Shi,Xin Li,Xixi Lai
Ultra-sensitive pH-responsive drug delivery system designed to operate within the slightly acidic microenvironment of tumors are highly desired for hydrogel applications in cancer therapy. In this study, 4-Formylbenzoic acid modified polyvinyl alcohol (PVA-FBA, PF) was synthesized and utilized as a carrier for encapsulating the anticancer drug Doxorubicin (Dox). This was subsequently crosslinked with polyethylenimine (PEI) via benzoic-imine bond to form drug-loaded PVA-FBA/PEI hydrogel (D-PFP). The D-PFP hydrogel was characterized using various techniques. The results indicated that the optimal conditions for hydrogel preparation involved using PF-0.25 polymer, which had an aldehyde group content of 0.82 mmol/g, as the precursor, along with a 12 wt% precursor solution for crosslinking with a 5 wt% PEI solution. The resulting hydrogel exhibited good structural stability and favorable morphology. Drug release studies indicated that the hydrogel demonstrated minimal drug leakage under physiological conditions (pH 7.4), while exhibiting a significantly higher drug release rate at pH 6.8, thereby underscoring its superior pH sensitivity. Rheological evaluations further confirmed its injectability and self-healing properties. Moreover, the hydrogel displayed excellent cytocompatibility and significantly inhibited cancer cell activity at pH 6.8. These characteristics suggest the potential of this hydrogel as a drug delivery system with ultra-sensitive drug release properties, particularly for future applications in chemotherapy for cancer.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Advanced Healthcare Materials
·
2025
·
IF 9.6
Yifan Zhou,Fanjia Dai,Sifang Zhao,Zelong Li,Hongze Liang,Xiao Wang,Lingling Zhao,Hui Tan
The microenvironment of diabetic wounds is complicated and characterized by hyperglycemia, hyperinflammation, persistent infection, hypoxia, and ischemia, making wound restoration and healing extremely challenging. Therefore, functional hydrogel dressings with the ability to regulate the microenvironment of diabetic wounds are a promising strategy for the treatment of diabetic wounds. In this study, a pH/glucose dual-responsive hydrogel based on phenylboric acid-modified carboxymethyl chitosan (CMCSPBA), aldehyde-terminated polyethylene glycol (PEGCHO), and polyvinyl alcohol (PVA) has been developed for diabetic wound treatment via Schiff base and phenylboric ester interactions. Glucose oxidase (GOX), catalase (CAT), and deferoxamine mesylate (DFO) are incorporated into the hydrogel to endow it with multi-functionality. In the hyperglycemic environment of diabetic wounds, a benign feedback loop is formed through the synergistic action of each component of the hydrogel, which enables the reshaping of the microenvironment of diabetic wounds by adjusting the pH and glucose, alleviating oxidative stress and hypoxia, regulating the inflammatory response, inhibiting bacterial infection, and promoting angiogenesis, thus accelerating diabetic wound healing in streptozotocin (STZ)-induced diabetic mice.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）