INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
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2026
·Vol. 27
·期 9
·4061
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IF 5.6
Yuelu Lan,Sijia Li,Shuangli Zhu,Can Pan,Kai Fu,Xueping Wang,Liwu Fu,Fang Wang
Chronic liver injury is characterized by sustained activation of transforming growth factor-β (TGF-β) signaling within the fibrotic microenvironment, yet the contribution of TGF-β-associated metabolic remodeling to hepatic stellate cell (HSC) activation remains incompletely understood. Here, we investigated whether TGF-β signaling is associated with lipid metabolic remodeling in HSCs and whether pirfenidone (PFD) interferes with this process. We found that TGF-β1 was spatially associated with lipid accumulation in fibrotic liver tissue and that TGF-β1/2 promoted HSC proliferation. In vitro, TGF-β1/2 coordinately upregulated sterol regulatory element-binding protein 1 (SREBP1) and fatty acid synthase (FASN), accompanied by increased intracellular lipid accumulation and enhanced oleic acid (OA)-associated lipid responses. Low-dose OA further activated AKT/ERK/p70 S6K signaling in HSCs, whereas PFD attenuated these signaling events. In parallel, PFD suppressed TGF-β-associated lipid accumulation in vitro, reduced SREBP1/FASN expression in activated HSC-rich regions in vivo, and alleviated CCl 4 -induced liver fibrosis. Together, these findings support a model in which TGF-β-associated lipogenic remodeling contributes to HSC activation and suggest that interference with this metabolic state may represent one component of the antifibrotic action of pirfenidone.
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FOOD HYDROCOLLOIDS
·
2026
·
IF 13.8
Hui Liao,Dechu Chen,Yee Ying Lee,Chin Ping Tan,Yong Wang,Chaoying Qiu
Sodium alginate (SA) hydrogels have attracted considerable attention due to their excellent biocompatibility and protective effects on bioactive ingredients. However, single−polysaccharide network has insufficient mechanical strength, poor release control, and low efficiency in co−loading of hydrophilic/hydrophobic actives. In this study, β-lactoglobulin nanofibrils (BLGF) with long fibril (LF) or worm−like fibril (WF) morphology were incorporated into the SA network via Ca 2+ crosslinking. The resulting composite hydrogels significantly enhanced water−holding capacity and swelling properties reaching maximum values of 98.52% and 46.84%, respectively. While WF showed a higher binding interaction force with SA, LF demonstrated a more efficient intertwining effect, maintaining a dense gel network. Introducing solid lipid nanoparticles (SLN) resulted in an encapsulation efficiency of 88.19% for β-carotene and a loading rate of 81.57% for folic acid. The composite hydrogel exhibited pH−responsive release reflected by the low release (<5%) of β-carotene in the gastric phase and accelerated release in intestinal fluid. The hydrogel also exhibited a diffusion-controlled release pattern for folic acid and an erosion-controlled release pattern for β-carotene. By varying the SA−LF/WF ratio, coordinated control over the diffusion rates of bioactives was achieved. This study clarifies the structural enhancement provided by BLGF in composite hydrogels and offers insights for designing dual-delivery systems.
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POLYMER ENGINEERING AND SCIENCE
·
2026
·
IF 3.6
Chunmei Gao,Pengfei Zhang,Yiming Bai,Shifeng Ji,Changbing Ye,Yunqing Xing
Conventional polyamide nanofiltration membranes face the dual challenges of chlorine-induced degradation and the permeability–selectivity trade-off. In this study, a thin-film nanocomposite membrane was fabricated by incorporating β-cyclodextrin-functionalized g-C 3 N 4 nanosheets into the polyamide layer via interfacial polymerization. The β-CD@g-C 3 N 4 nanosheets provide additional water transport pathways and reduce mass transfer resistance through their hydrophilic groups, β-CD cavities, and intrinsic triangular nanopores. The optimized PCDN-3 membrane achieved a water permeance of 15.30 L·m −2 ·h −1 ·bar −1 , 2.7 times that of the pristine membrane, while maintaining a Na 2 SO 4 rejection of 98.18% and a NaCl/Na 2 SO 4 separation factor of 47.27. Notably, the N–H groups on g-C 3 N 4 act as sacrificial sites for active chlorine, resulting in only a 0.05% increase in salt rejection after exposure to 12,000 ppm·h active chlorine, demonstrating exceptional chlorine stability. Fouling experiments confirmed the composite membrane's excellent antifouling performance. This “cyclodextrin–carbon nitride” strategy provides a promising approach for developing nanofiltration membranes with high permeability, superior chlorine resistance, and robust antifouling properties. Highlights Membrane shows 2.7× water flux (15.30 L·m −2 ·h −1 ·bar −1 ) and 98.18% Na 2 SO 4 rejection. Hydrophilic –OH/–NH 2 improves antifouling; N–H bonds scavenge Cl radicals via sacrifice. High selectivity for NaCl/Na 2 SO 4 ( α = 47.27) via monovalent/divalent ion separation. PCDN membrane achieves > 90.05% FRR, exhibiting excellent antifouling durability.
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CHEMICAL ENGINEERING JOURNAL
·
2026
·
IF 12.5
Zhen Zhang,Chongyang Wang,Shun Liu,Shuo Yang,Mengchao Kuang,Longqing Wang,Yaming Wang,Chuntai Liu,Zhen Wang
Melt stretching and ZnO nanofillers induce highly oriented β-phase with an 81.7% fraction. • Flow-driven ZnO interconnection constructs acid-etching channels for anisotropic pore formation. • Oriented β-phase and porous architecture synergistically boost piezoelectric output. • Piezoelectric film devices enable wearable sensing and CNN-assisted information transmission. Oriented β-phase crystallites and well-defined porous structures are two well-established routes to boost PVDF piezoelectricity, yet integrating both in a single material remains an unsolved challenge. Here, we report a film processing strategy by combining ZnO incorporation, irradiation crosslinking, melt stretching, and acid etching to address this issue. ZnO nanoparticles play a dual role, serving as both a promoter to enhance flow-induced β-phase formation and a sacrificial template for pore generation. The synergistic effects of high ZnO loading (60 wt%), slight chain crosslinking, and strong melt stretching (20×) yield highly oriented β-phase with a fraction as high as 81.7%. Meanwhile, flow-induced redispersion of ZnO aggregates forms an interconnected nanofiller network, enabling complete ZnO removal upon acid etching to generate anisotropic pores. The resulting porous architecture, together with the oriented β-phase, enhances piezoelectric performance through three synergistic mechanisms: the intrinsic piezoelectricity of the β-phase, reduced dielectric permittivity, and the piezoelectret effect of the pores. The optimized film achieves a high piezoelectric coefficient ( d 33 ) of 69.6 pC/N and a figure of merit of 4.6 × 10 −11 m 2 /N, with robust mechanical properties. The corresponding piezoelectric device exhibits a broad force-response range, high sensitivity to weak stimuli, and excellent cyclic stability. Flexible sensors based on these films can monitor human motion and physiological signals, and integration with a two-dimensional convolutional neural network enables Morse-code-based transmission with 98.4% accuracy. This work offers a scalable melt-processing route for high-performance porous PVDF piezoelectric films toward flexible wearable electronics and self-powered sensing systems. Download: Download high-res image (241KB) Download: Download full-size image
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Current Research in Food Science
·
2026
·
IF 7.7
Yuyuan Hu,Xueyao Zhang,Yuanlan Zhou,Heng Du,Shangde Sun
Liposomes stabilized by adipate-bridged β -sitosterol glycosyl derivatives (hereafter, β -sitosterol glycosyl adipates) were characterized to elaborate their structure-activity relationship (SAR) as effective cholesterol alternatives. Compared with liposomes stabilized by cholesterol or β -sitosterol, those stabilized by β -sitosterol glycosyl adipates exhibited improved bilayer structural properties. Among all formulations, liposomes stabilized by β -sitosterol sucrose adipate possessed the most compact lipid packing and the smallest particle size (<80 nm). After curcumin (Cur) loading, the optimized liposomes reached an encapsulation efficiency of 78.67% ± 2.13%, maintained an apparent Cur retention rate above 97% over 28-day storage at 25 °C, and achieved in vitro bioaccessibility exceeding 44%. SAR analysis revealed that hydrogen-bonding interactions and glycosyl steric hindrance worked synergistically to regulate the physicochemical and functional properties of the liposomes. This study facilitates the development of amphiphilic phytosterol derivatives and supports the design of efficient cholesterol-free liposomal carrier systems for food applications.
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CARBOHYDRATE POLYMERS
·
2026
·
IF 13.2
Yunhe Qu,Ziyan Sun,Xiushi Jia,Yuanning Wang,Xing Yang,Yunmei Ma,Kevin H. Mayo,Lin Sun,Dongfang Shi,Yifa Zhou
A ∼ 20 kDa heteroglucan composed of glucose (Glc) and glucuronic acid (GlcA) was isolated from Hypsizygus marmoreus . Preliminary analysis through methylation analysis and nuclear magnetic resonance (NMR) showed the backbone consisted of β-1,6-linked d -glucopyranosyl (Glc p ) residues, with branches at O-3 positions containing t-β-D-Glc p residues. The linkages of GlcA was carried out using partial acid and glycosidase hydrolysis. HILIC-FLR/ESI-MS n , methylation and NMR of the partial acid and glycosidase hydrolysis products revealed Glc p A was in the forms of t-β-D-Glc p A and β-1,4-D-Glc p A attached to the C-3 position of part of the Glc in the main chain. Furthermore, the β-glucan exhibited structural heterogeneity, comprising three distinct domains: (a) unsubstituted β-1,6-glucan; (b) β-1,6-heteroglucan substituted with GlcA (1–2 sugar residues); and (c) β-1,6-heteroglucan substituted with Glc (single sugar residue). The proposed heteropolysaccharide structure provides critical insights into the structural diversity of mushroom-derived β-1,6-glucans, thereby facilitating future investigations into their structure-activity relationships.
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INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
·
2023
·
IF 4.2
Xuejuan Wei,Xiaopeng Chen,Linlin Wang,Xiaojie Wei,Yang Yang,Jiaqi Liang,Jiezhen Liang
Isothermal vapor–liquid equilibrium data of the binary system (−)-α-pinene + (−)-β-pinene and the quaternary system (−)-α-pinene + (−)-β-pinene + water + phenoxyacetic acid were measured at 313.2, 323.2, and 333.2 K using headspace gas chromatography. The experimental data showed that the addition of phenoxyacetic acid and water promoted the separation of (−)-α-pinene and (−)-β-pinene. The experimental data were correlated using the UNIQUAC and NRTL models. The two models showed good correlation for the binary system, whereas the UNIQUAC model gave more accuracy for the quaternary system. Moreover, the COSMO-RS model can be an efficacious method for predicting VLE data of the determined binary and quaternary systems. In addition, the optimal spatial configuration and binding energy between the molecules were obtained by DFT, and the effects on (−)-α-pinene and (−)-β-pinene with the addition of phenoxyacetic acid and water were discussed on the molecular scale.
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INDUSTRIAL CROPS AND PRODUCTS
·
2023
·
IF 5.9
Qiufeng Deng,Rui Zhai,Baohua Chen,Xiaoxiao Jiang,Haixiang Li,Chen Li,Mingjie Jin
Developing value-added lignin-based biomaterials for enzyme immobilization has drawn great attention. This study developed a cost-effective and eco-friendly one-pot strategy to synthesize the rod-like lignin@zeolitic imidazolate framework-8 (ZIF-8) hybrid nanomaterial by using lignin derived from lignocellulosic biofuel production. The incorporation of lignin into the ZIF-8 network not only altered the morphology, but also modified the surface properties of the material, making it an ideal support for enzyme immobilization. The synthesized nanoscale hybrid materials were used to immobilize beta-glucosidase (BG) with high immobilization capacity and about 92–166 mg/g of BG was immobilized through physical adsorption. The immobilized BG exhibited good stability, catalytic activity and recycling properties, and was reused under acidic conditions for more than 8 cycles with more than 60% activity kept. The as-prepared hybrid material can serve as a great carrier for immobilizing various biomolecules.
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Nanomaterials
·
2023
·Vol. 13
·期 5
·915
·
IF 5.3
Jing-Jing Yang,Ying-Zhuo Shen,Zheng Wang,Bo Zhou,Xiao-Ya Hu,Qin Xu
In this study, β-Bi2O3nanosheets functionalized with bisphenol A (BPA) synthetic receptors were developed by a simple molecular imprinting technology and applied as the photoelectric active material for the construction of a BPA photoelectrochemical (PEC) sensor. BPA was anchored on the surface of β-Bi2O3nanosheets via the self-polymerization of dopamine monomer in the presence of a BPA template. After the elution of BPA, the BPA molecular imprinted polymer (BPA synthetic receptors)-functionalized β-Bi2O3nanosheets (MIP/β-Bi2O3) were obtained. Scanning electron microscopy (SEM) of MIP/β-Bi2O3revealed that the surface of β-Bi2O3nanosheets was covered with spherical particles, indicating the successful polymerization of the BPA imprinted layer. Under the best experimental conditions, the PEC sensor response was linearly proportional to the logarithm of BPA concentration in the range of 1.0 nM to 1.0 μM, and the detection limit was 0.179 nM. The method had high stability and good repeatability, and could be applied to the determination of BPA in standard water samples.Keywords:β-Bi2O3;nanosheet;PEC sensor;bisphenol A;molecularly imprinted
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Small
·
2023
·Vol. 19
·期 30
·2300154
·
IF 13.3
Rong Tu,Xinyu Li,Qingfang Xu,Tenghua Gao,Xian Zhang,Bao-Wen Li,Song Zhang,Takashi Goto,Lianmeng Zhang
The oriented growth of β-Ga 2 O 3 films has triggered extensive interest due to the remarkable and complex anisotropy found in the β-Ga 2 O 3 bulks. Remarkable properties, including stronger solar-blind ultraviolet (SBUV) absorption, better mobility, and higher thermal conductivity, are usually observed along <010> direction as compared to other low-index axes. So far, <010>-oriented β-Ga 2 O 3 film growth has been hindered by the lack of suitable substrates and higher surface energy of the (010) crystal plane. Herein, the first growth of uniquely <010>-oriented β-Ga 2 O 3 films on quartz substrates by laser chemical vapor deposition (LCVD) are reported. By investigating the effects of deposition temperature ( T dep ) and O 2 flow rate ( R O2 ) on the growth of β-Ga 2 O 3 films, it is found that the formation of <010> orientation is closely related to the higher stability of oxygen close-packed planes under O-rich condition. As a result, a grain size of up to ≈2 µm and a deposition rate of up to ≈ 40 µm h −1 are obtained. Metal-semiconductor-metal (MSM) type detector based on <010>-oriented β-Ga 2 O 3 film exhibits ultra-fast response speed, 1–2 orders of magnitude higher than those of most detectors based on β-Ga 2 O 3 films with other orientations.
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JOURNAL OF RARE EARTHS
·
2022
·
IF 4.632
Junlian Wang,Guodong Xu,Wen Xu,Jianguo Cui,Yufu Chen,Ziyong Chang
The relationship between dialkylphosphinic acid structure and their loading capacity for HREEs and emulsification phenomena has rarely been studied. In this paper, we took Lu extraction as an example to study the effect of β , γ , δ -substituents of dialkylphosphinic acids on their loading capacity and anti-emulsification performance for HREEs. To discuss conveniently, the dialkylphosphinic acids were classified into two groups: β -substituent group (P208, INET-1, P218, USTB-1 and P227) and γ , δ -substituent group (P218, P2132 and Cyanex 272). For β -substituent group extractants, their loading capacities are in the order P208 (299.7 mg/L) ≈ INET-1 (299.5 mg/L) > P218 (270.8 mg/L) >> USTB-1 (163.1 mg/L) > P227 (151.4 mg/L), while their anti-emulsification/gelation performances are just in the opposite order P227 > USTB-1 > P218 > P208 ≈ INET-1 under the studied conditions. For γ , δ -substituent group extractants, their loading capacities are in the order P218 (270.8 mg/L) > P2132 (192.3 mg/L) > Cyanex 272 (131.7 mg/L), while the anti-emulsification performance of P218 is better than those of P2132 and Cyanex 272. The loading capacity data given in the parentheses are obtained through repeatedly extracting Lu from ∼4 × 10 −4 mol/L of Lu aqueous feed solution with initial pH of 2.40 by 0.01 mol/L extractant at phase ratio A/O of 1:1.
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BIOLOGICAL & PHARMACEUTICAL BULLETIN
·
2023
·Vol. 46
·期 1
·74-85
·
IF 2
Jianchao He,Yuhui Bu,Xiaolong Li,Xiaojun Zhang,Li Ma
Breast cancer (BC) is the most generally diagnosed cancer and the driving cause of cancer-related death. Transmembrane (TMEM) proteins have been reported to serve as prognostic indicators in a variety of cancers, and it can offer therapeutic targets for carcinoma. However, the function of TMEM in BC remains unclear. In this study, TMEM9A, a member of TMEM family, was screened as the candidate gene after analyzing the profiles of GSE42568 and GEPIA-BRCA database via bioinformatic method. The upregulated expression of TMEM9A was confirmed in BC samples compared with the paired normal tissues. Hence, we speculated that TMEM9A might promote BC progression. To test the hypothesis, we performed a series of loss/gain-of-function experiments and found that BC cells with TMEM9A deletion inhibited cell proliferation, migration, and invasion along with induced apoptosis. Conversely, TMEM9A overexpression reversed the trend. Mechanically, TMEM9A knockdown blocked the Wnt/β-catenin signaling pathway as evidenced by the increased adenomatous polyposis coli (APC) expression and decreased β-catenin, cyclin D1, and axis inhibition protein 2 (AXIN2) expression. Furthermore, over-activation of the Wnt/β-catenin pathway by transfecting BC cells with β-Catenin-S33Y (β-Catenin tyrosine for serine at codon 33) plasmids reversed the effects caused by TMEM9A knockdown. In conclusion, TMEM9A may play a tumor-promoting role in BC progression via activating the Wnt/β-catenin signaling pathway. Therefore, TMEM9A may be an effective therapeutic option for BC.
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