INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2025
·
IF 8.5
Ning Li,Chang Liu,Li Niu,Xu Li,Jacko Feng,Zhiming Liu
In this study, we examined the plasticizing effects of 1-butyl-3-Methylimidazolium Chloride (BmimCl), glycerol, and their combination on chitosan (CS) films. Additionally, we examined the effect of plasticizers for chitosan films structure and physicochemical properties of CS films by FTIR, XRD, SEM and mechanism of action of plasticizers on the structure of CS films. The results indicated that the interaction between BmimCl and chitosan is mainly ionic interaction and hydrogen bonding, while the interaction between glycerol and CS is mainly hydrogen bonding. The utilization of a 1:1 mixture of BmimCl and glycerol as a plasticizer exhibits a synergistic impact on the film samples. In dry conditions, the elongation at break of the CS/BmimCl 0.5 /Gly 0.5 film reached 17.47 %, representing a 33 % and 78 % increase compared to the CS/BmimCl and CS/Gly films, respectively. In moist environments, the mechanical strength of CS/BmimCl 0.5 /Gly 0.5 film was significantly enhanced to 35.09 MPa compared to the CS/BmimCl and CS/Gly films. Notably, the elongation at break of the films remained at 37.05 %, without compromising their flexibility properties.
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高影响因子
Molecular Medicine Reports
·
2024
·Vol. 29
·期 5
·1-14
·
IF 3.4
Xinya Yu,Xiaoxi Li,Yunchun Xu,Yuwei Li,Ye Zhou,Junhua Zhang,Le Guo
Ulcerative colitis (UC) is a chronic idiopathic inflammatory condition affecting the rectum and colon. Inflammation and compromisation of the intestinal mucosal barrier are key in UC pathogenesis. Resveratrol (Res) is a naturally occurring polyphenol that exhibits anti‑inflammatory and antioxidant properties. Nuclear factor erythroid‑2‑related factor 2/heme oxygenase 1 (Nrf2/HO‑1) pathway regulates occurrence and development of numerous types of diseases through anti‑inflammatory and antioxidant activity. However, it is not clear whether Nrf2/HO‑1 pathway is involved in the treatment of Res in UC. Therefore, the present study aimed to investigate whether Res modulates the Nrf2/HO‑1 signaling pathway to attenuate UC in mice. Dextran sulfate sodium (DSS) was used to induce experimental UC in male C57BL/6J mice. Disease activity index (DAI) and hematoxylin eosin (H&E) staning was used to assessed the magnitude of colonic lesions in UC mice. ELISA) was utilized to quantify inflammatory cytokines (IL‑6, IL‑1β, TNF‑α and IL‑10) in serum and colon tissues. Immunohistochemistry and Western blot were used to evaluate the expression levels of tight junction (TJ) proteins [zonula occludens (ZO)‑1 and Occludin] in colon tissues. Pharmacokinetic (PK) parameters of Res were derived from TCMSP database. Networkpharmacology was employed to identify the biological function and pharmacological mechanism of Res in the process of relieving UC, and the key target was screened. The binding ability of Res and key target was verified by molecular docking. Finally, the effectiveness of key target was substantiated by Western blot. Res decreased DAI, ameliorated histopathological changes such as crypt loss, disappeatance of the mucosal epithelium, and inflammatory infiltration in mice. Additionally, Res decreased expression of pro‑inflammatory cytokines IL‑6, IL‑1β and TNF‑α and increased anti‑inflammatory factor IL‑10 expression. Res also restored the decreased protein expression of ZO‑1 and occludin after DSS treatment, increasing the integrity of the intestinal mucosal barrier. The PK properties of Res suggested that Res possesses the therapeutic potential for oral administration. Network pharmacology revealed that Res alleviated UC through anti‑inflammatory and antioxidant pathways, and confirmed that Nrf2 has a high binding affinity with Res and is a key target of Res against UC. Western blotting demonstrated that Res treatment increased the protein levels of Nrf2 and HO‑1. In conclusion, Res treatment activated the Nrf2/HO‑1 pathway to decrease clinical symptoms, inflammatory responses, and intestinal mucosal barrier damage in experimental UC mice.
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FUEL
·
2024
·
IF 6.7
Fuwen Yang,Jie Zhang,Jinwei Chen,Gang Wang,Tong Yu,Junyu Zhao,Qian Li,Zongbo Shi,Runsheng Zhuo,Ruilin Wang
Propane dehydrogenation (PDH) provides a promising way to meet the requirement of propylene supply, but the commonly-used Pt-based catalysts still suffer from unsatisfactory stability and deactivation. Herein, an interfacial regulation strategy is developed to construct the Cu, Pt, and Zn species modified hollow porous silicalite-1 (CuPt/Zn-HPS-1). Owing to the regulation role of Pt, the electron-deficient [ZnOH] + Lewis acid sites accelerated the C-H activation, which was beneficial to achieve the excellent PDH performance. More importantly, the additionally introduced Cu 2+ further modulated the geometric structure and electronic density of Pt, thus effectively improving the anti-sintering ability and alleviating the coke deposition. Benefiting from the interfacial regulation and Lewis active [ZnOH] + sites, the optimal CuPt/Zn-HPS-1 catalyst exhibited an excellent catalytic PDH performance with the initial propane conversion of 30.4 % and propylene selectivity of 99.0 %. The CuPt/Zn-HPS-1 also demonstrated robust recycling stability in reaction-regeneration cycling test with the smaller deactivation rate constant. This work affords a strategy for improving PDH performance in practical industrial application.
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EUROPEAN JOURNAL OF PHARMACOLOGY
·
2024
·
IF 4.2
Yongmei Li,Fengxin Zheng,Shiqi Zhong,Kunlu Zhao,Hui Liao,Jiacheng Liang,Qiang Zheng,Huicong Wu,Shifan Zhang,Ying Cao,Ting Wu,Jianxin Pang
Hyperuricemic nephropathy (HN) is characterized by renal fibrosis and tubular necrosis caused by elevated uric acid levels. Ferroptosis, an iron-dependent type of cell death, has been implicated in the pathogenesis of kidney diseases. The objective of this study was to explore the role of ferroptosis in HN and the impact of a ferroptosis inhibitor, ferrostatin-1 (Fer-1). The study combined adenine and potassium oxonate administration to establish a HN model in mice and treated HK-2 cells with uric acid to simulate HN conditions. The effects of Fer-1 on the renal function, fibrosis, and ferroptosis-associated molecules were investigated in HN mice and HK-2 cells treated with uric acid. The HN mice presented with renal dysfunction characterized by elevated tissue iron levels and diminished antioxidant capacity. There was a significant decrease in the mRNA and protein expression levels of SLC7A11, GPX4, FTL-1 and FTH-1 in HN mice. Conversely, treatment with Fer-1 reduced serum uric acid, serum creatinine, and blood urea nitrogen, while increasing uric acid levels in urine. Fer-1 administration also ameliorated renal tubule dilatation and reduced renal collagen deposition. Additionally, Fer-1 also upregulated the expression levels of SLC7A11, GPX4, FTL-1, and FTH-1, decreased malondialdehyde and iron levels, and enhanced glutathione in vivo and in vitro . Furthermore, we first found that Fer-1 exhibited a dose-dependent inhibition of URAT1, with the IC 50 value of 7.37 ± 0.66 μM. Collectively, the current study demonstrated that Fer-1 effectively mitigated HN by suppressing ferroptosis, highlighting the potential of targeting ferroptosis as a therapeutic strategy for HN.
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MICROCHEMICAL JOURNAL
·
2025
·
IF 5.1
Zhiyue Wang,Yaru Wang,Shihong Xin,Xueqing Yong,Qixin Wang,Yunlin Chen
Hydrogen (H 2 ) leakage poses critical safety hazards and environmental risks in clean energy systems, driving urgent demands for cost-effective hydrogen sensors with high sensitivity, high selectivity, and rapid response time. Herein, high-performance hydrogen sensor based on photonic crystals (PCs) assembled by CAU-1, nickel (Ni) -doped CAU-1, and TiO 2 are prepared. Comparing with the CAU-1/TiO 2 and CAU-1Ni 15% /TiO 2 PC sensors, CAU-1Ni 25% /TiO 2 PC sensor shows a high sensitivity of hydrogen response to be 0.083 nm/ppm with a good linear relationship in the concentration range of 9–90 ppm hydrogen. Density-functional theory (DFT) adsorption energy calculations quantitatively validate the enhanced hydrogen adsorption capacity through Ni-induced electronic structure modulation. The CAU-1Ni 25% /TiO 2 PC sensor exhibits an ultrafast optical response time of 3 s and a recovery time of 12 s with exceptional repeatability and reliability. Moreover, the CAU-1Ni 25% /TiO 2 PC sensor displays exceptional selectivity toward H 2 by comparing with CO 2 , NH 3 , and O 2 , which is important for practical hydrogen detection applications. This work presents incorporating Ni into CAU-1 enhances hydrogen adsorption energy through electronic structure modulation, enabling the CAU-1Ni 25% /TiO 2 PC to achieve rapid optical sensing response to hydrogen, which establish a new pathway for developing high-efficiency photonic crystal-based optical hydrogen sensors.
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Phytochemistry Letters
·
2025
·
IF 1.4
Yan-Peng Liang,Qian Gao,Hong Chen,Rui Ma,Xiao-Bo Zhao,Xiao-Jie Jin,Jian Zhang,Yan-Ping Shi,Wei Ha
Alzheimer’s disease, a progressive neurodegenerative disorder of the central nervous system, presents a complex pathological mechanism that limits the efficacy of conventional single-target drugs. Utilizing the unique advantages of natural products in multi-target intervention, this study employed the active component 1- O -acetylbritannilactone (ABL) from Inula britannica L. as the parent structure. Guided by the multi-target directed ligands (MTDLs) strategy, four novel derivatives (ABL-1 to ABL-4) were successfully designed and synthesized by introducing acetylcholinesterase (AChE) inhibitory pharmacophores into the ABL scaffold. In vitro pharmacological evaluation demonstrated that ABL-2, ABL-3, and ABL-4 not only preserved the anti-neuroinflammatory activity of the parent compound but also endowed compound ABL with AChE inhibitory potency. Notably, ABL-4 displayed the most promising dual efficacy profile, achieving an AChE inhibition rate of 40.09 ± 0.73 % at 30 μM and an anti-neuroinflammatory activity (EC 50 = 8.43 ± 0.5 μM). Molecular docking simulations revealed that the dual-target synergistic mechanism of ABL derivatives arises from hydrogen bonding and π-π stacking interactions with key residues of both AChE and inducible nitric oxide synthase (iNOS). This work not only validates the feasibility of the MTDLs strategy in optimizing natural product scaffolds but also provides a structurally novel lead compound with significant potential for developing multi-target anti-AD therapeutics.
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Food Bioengineering
·
2025
·Vol. 4
·期 2
·166-181
·
IF 2.3
Baoming Tian,Xue Zhou,Shuo Pan,Wei Liu
Tea polysaccharides have attracted widespread attention in regulating gut microbiota. A highly efficient enzymolysis and ultrasonic-assisted extraction method was developed and optimized for the extraction of polysaccharides from Zhonghuang No. 1 etiolated-green tea (GTP) with a-single factor and response surface methodology, i.e, with a pH of 5.5, an enzyme concentration of 7%, an ultrasonic time of 2.5 h, a solid-liquid ratio of 1:20 g/mL, and an ultrasonic temperature of 80°C. GTP exhibited a triple helix structure and demonstrated the ability to bind with Congo red. Its surface was observed to be spherical with slender chain fragments. GTP remained intact throughout the simulated in vitro digestive process, which encompassed the oral, gastric, and small intestinal phases. The relative abundance of Bacteroidota was significantly increased, while the Firmicutes/Bacteroidota ratio was reduced following the administration of GTP. The contents of Faecalibacterium and Bacteroides were increased, while the contents of Escherichia_Shigella and Dorea were reduced after GTP treatment. Furthermore, GTP were degraded and utilized by gut microbiota to produce SCFAs and reducing pH value. GTP regulated the composition of the gut microbiota and has the potential to act as a prebiotic, with the possibility of its use as a functional food.
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JOURNAL OF HAZARDOUS MATERIALS
·
2025
·
IF 11.3
Yao Ji,Tiangang Ma,Xianwang Yang,Renshuo Wang,Ke Wang,Xiyu Liu,Xiaolong Wang,Quan Jin
SO 2 sensors generally face challenges such as gas corrosion, poor selectivity, competition from water molecules, and high recovery costs. Metal-organic frameworks (MOFs), which offer excellent chemical stability, structural diversity, and low-cost reactivation, have emerged as ideal candidates for sensing materials. However, MOFs typically exhibit poor conductivity, making them unsuitable for traditional gas detection devices. In order to solve this problem, in this study, SIFSIX-1-Cu with directionally ordered interconnected nanochannels was synthesized. By optimizing the synergistic effects of mass transfer, chemical recognition and pore-size sieving, the performance limitations of traditional adsorption materials have been overcome. Furthermore, by integrating SIFSIX-1-Cu with a microwave circuit, the microwave gas sensor (MGS) detects target gases by monitoring changes in the electromagnetic properties—such as dielectric constant or resonance frequency—of the sensing material induced by gas adsorption. The unique detection mechanism allows the MOFs to operate without the need for conductivity optimization, effectively preventing the loss of active sites during the material modification process. The results showed that SIFSIX-1-Cu microwave gas sensor has a low limit of detection of 8.9 ppb at room temperature, and can achieve high selectivity (selectivity coefficient SO 2 /CO 2 > 11.87) detection of SO 2 in a wide concentration detection range of 10 ppb to 1000 ppm. Meanwhile, the sensor also exhibits excellent moisture resistance and repeatability.
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JOURNAL OF CHEMICAL AND ENGINEERING DATA
·
2025
·
IF 2.1
Guangjie Chen,Guangying Chen,Ge Gao,Li Sze Lai,Swee Pin Yeap,Wee Horng Tay,Helei Liu
The utilization of biphasic absorbents for CO2 capture can substantially reduce energy consumption. This study investigated the mass transfer kinetics and thermodynamics of the phase separation absorption process using 1-amino-2-propanol (MIPA)/sulfolane (TMS) biphasic solvents. 13C NMR spectroscopy was employed to analyze the species in different CO2-loaded solutions. The direction and extent of species transfer during the absorption process were elucidated and the phase separation mechanism was explored. CO2 absorption kinetics were studied in a wetted-wall column, and the physicochemical properties and the absorption reaction kinetics data under different experimental conditions were obtained. Results showed the overall mass transfer coefficient (KG) was 1.6 times higher than 30 wt % MEA and twice that of DETA/TMS solution. NMR and kinetic data analysis revealed that phase separation is mainly contributing to the deterioration of the mass transfer process in biphasic solution, reducing the liquid-film mass transfer coefficient (KL) by 63.2% during the phase separation stage. Furthermore, the desorption heats of different biphasic solvents with identical amine concentrations were measured using a microcalorimeter. Findings indicated that TMS did not alter the thermodynamic properties of the solution. Since only the CO2-rich phase is regenerated, the energy consumption is significantly reduced compared to that of MEA.
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Advanced Science
·
2025
·
IF 14.1
Jin-Hui Shi,Qi-Long Tang,Jin-Hong Wang,Yan-Lan Long,Sai-Feng Zhao,Zhen Zhao,Wan-Ting Xie,Zi-Ming Li,Hao-Ming Lu,Tian-Xiao Gao,Zhen-Zhen Fang,Ti Zhou,Bo-Xing Li,Xia Yang,Guo-Quan Gao,Wei-Wei Qi
Maintenance of glutamate homeostasis is essential for synaptic plasticity and cognition. Disrupted glutamate-glutamine cycling causes chronic excitotoxicity, a key driver of cognitive deficits in Alzheimer's disease (AD), though regulatory mechanisms remain unclear. Pigment epithelium-derived factor (PEDF), a neuroprotective protein declining with age, is demonstrated here to play a novel role in synaptic glutamate clearance. Analysis of peripheral blood samples from 19 patients with AD and 75 non-dementia control subjects revealed lower levels of PEDF in patients, and loss of PEDF correlates with cognitive decline. PEDF-deficient mice exhibit defective learning and memory, and higher susceptibility to AD. Furthermore, PEDF deficiency impaired synaptic plasticity and dendritic spine morphology. Mechanistically, PEDF inhibits ubiquitin-proteasome-dependent degradation of astrocytic glutamate transporter-1 (GLT-1) and normally guarantees elimination of synaptic glutamate by modulating the protein kinase C signaling pathway. Strikingly, restoring PEDF rescued cognitive deficits in a mouse model of AD, and upregulation of GLT-1 rescued cognitive impairment in PEDF-deficient mice. Collectively, these findings reveal PEDF is a physiologic regulator of synaptic glutamate homeostasis. Targeting PEDF deficiency-induced neural impairment may provide a novel avenue for the development of new therapeutic applications for neurodegenerative diseases associated with glutamate-induced excitotoxicity.
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ADVANCED FUNCTIONAL MATERIALS
·
2024
·
IF 18.5
Yaping Wang,Pengcheng Yuan,Xiong Xiong Liu,Shengfa Feng,Mufan Cao,Jianxiang Ding,Jiacheng Liu,Song-Zhu Kure-Chu,Takehiko Hihara,Long Pan,ZhengMing Sun
Composite solid electrolytes (CSEs) integrate the fast ion conductivity of inorganic electrolytes and the excellent interfacial compatibility of polymer electrolytes. Typically, fluoropolymers and garnets are promising individuals to formulate cutting-edge CSEs owing to their unique properties. However, the alkaline garnets can induce the dehydrofluorination of fluoropolymers, deteriorating their CSEs performance. Here, for the first time, NH 4 HCO 3 is proposed as a sacrificial inhibitor to effectively prevent the garnet-induced dehydrofluorination, using Li 6.4 La 3 Zr 1.4 Ta 0.6 O 12 (LLZTO) and poly(vinylidene fluoride- co -hexafluoropropylene) (PVH) as symbolic garnets and fluoropolymers, respectively. Various findings demonstrate that NH 4 HCO 3 can buffer the alkalinity of LLZTO, thereby inhibiting the dehydrofluorination of PVH. In addition, NH 4 HCO 3 can completely decompose to volatiles upon drying without compromising the properties of LLZTO and PVH. Additionally, a polymer-in-salt strategy is further introduced by adding high-concentration LiTFSI salt to the above system, resulting in the PVH/LiTFSI/LLZTO (PLL) CSEs. Benefiting from the synergetic coupling of the sacrificial inhibitor and polymer-in-salt strategies, the PLL exhibits an exceptionally high ionic conductivity of 1.2 mS cm −1 at 25 °C and stable voltage of 5.09 V, outperforming other reported CSEs. Consequently, the PLL delivers impressive high-rate cyclability in solid-state lithium-metal batteries with an outstanding capacity retention of 95.4% after 240 cycles at 1 C (25 °C).
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JOURNAL OF MEMBRANE SCIENCE
·
2025
·
IF 9
Yafei Cheng,Chen Wang,Miaomiao Zheng,Lan Yang,Lihai Fan,Longqiang Xiao,Xiaocheng Lin
Diffusion dialysis (DD) shows strong potential for acid reclamation, yet standard anion exchange membranes (AEMs) with compact, low-free-volume matrices impede ion transport, leading to low acid permeability and poor selectivity. To overcome these barriers, we present a new class of PIM-1-based AEMs fabricated through liquid bromine (Br 2 ) bromination followed by simultaneous crosslinking and cationization with 1,4-Diazabicyclo[2.2.2]octane (DABCO). This approach mitigates radical-induced chain scission, thereby better preserving the rigid polymer backbone while introducing a high density of ion-conducting sites with enhanced structural reinforcement. The resulting membranes exhibit interconnected micropores narrowly distributed at 0.4–0.6 nm, enabling molecular sieving between protons and multivalent cations. The optimized PIM-D/10h membrane achieves a proton dialysis coefficient of 37.0 × 10 −3 m/h and a separation factor (H + /Fe 2+ ) of 54.3, exceeding the commercial DF-120 benchmark by more than fourfold and threefold, respectively, while maintaining a tensile strength around 19 MPa and strong acid resistance. These results demonstrate that combining free-volume design with matrix reinforcement resolves the canonical permeability-selectivity compromise, thereby enabling a scalable route to durable AEMs for rapid, selective acid recovery from industrial wastewater.
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