Nature Communications
·
2021
·Vol. 12
·期 1
·1-10
·
IF 14.919
Zhang Xiankun,Liu Baishan,Gao Li,Yu Huihui,Liu Xiaozhi,Du Junli,Xiao Jiankun,Liu Yihe,Gu Lin,Liao Qingliang,Kang Zhuo,Zhang Zheng,Zhang Yue
The applications of any two-dimensional (2D) semiconductor devices cannot bypass the control of metal-semiconductor interfaces, which can be severely affected by complex Fermi pinning effects and defect states. Here, we report a near-ideal rectifier in the all-2D Schottky junctions composed of the 2D metal 1 T′-MoTe 2 and the semiconducting monolayer MoS 2 . We show that the van der Waals integration of the two 2D materials can efficiently address the severe Fermi pinning effect generated by conventional metals, leading to increased Schottky barrier height. Furthermore, by healing original atom-vacancies and reducing the intrinsic defect doping in MoS 2 , the Schottky barrier width can be effectively enlarged by 59%. The 1 T′-MoTe 2 /healed-MoS 2 rectifier exhibits a near-unity ideality factor of ~1.6, a rectifying ratio of >5 × 10 5 , and high external quantum efficiency exceeding 20%. Finally, we generalize the barrier optimization strategy to other Schottky junctions, defining an alternative solution to enhance the performance of 2D-material-based electronic devices.
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CELLULOSE
·
2021
·Vol. 28
·期 7
·4281-4293
·
IF 5.044
Zhang Tianmeng,Zhang Weiwei,Xi Huan,Li Qingqing,Shen Mingxia,Ying Guobing,Zhang Jianfeng
Incorporation of nanoparticles into a three-dimensional porous framework to enhance adsorption capacity and recyclability of nanomaterial is of great significance for water contamination removal. Herein, a functionalized cellulose/MXene composite aerogel is prepared by the oxidative self-polymerization of dopamine hydrochloride and freeze-drying, which exhibits an excellent adsorption performance for methylene blue (MB). Characterization results show the successful combination of PDA and Ti 3 C 2 T x into the cellulose aerogel with merits of light weight, high structural stability and high porosity. The adsorption process is understood more deeply through the adsorption kinetics. The Langmuir isotherm model was used to better fit the adsorption process, and the maximum adsorption capacity for MB reaches 168.93 mg g −1 . Such a superior adsorption ability for MB is maintained in salt-containing water, or even a little higher when the concentration of NaCl is above 3%, recommending the functionalized cellulose/MXene composite aerogel for efficient removal of dyes in high-salt water environment.
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JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY
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2021
·Vol. 328
·期 1
·481-490
·
IF 1.371
Fu Lingxiao,Pan Xiaohan,Zu Jianhua,He Linfeng
N , N , N ′, N ′-tetramethylmalonamide (TMMA) has been successfully grafted onto the chloroacetylated poly(styrene-co-divinylbenzene) resin to obtain a novel diamide-based resin (PS–TMMA). PS–TMMA exhibited high adsorption capacity and selectivity toward TcO 4 − in 0.1–1 M HCl. The adsorption process of PS–TMMA conforms (Revise: conformed) to Langmuir isotherm and pseudo-second-order kinetics model. The results of column experiments revealed TcO 4 − can be completely separated from the coexisting fission products (Sr(II), Eu(III), Dy(III), and 1 M NH 3 ·H 2 O can re-collect TcO 4 − absorbed in the resin column. The adsorption mechanism of TcO 4 − is considered that PS–TMMA is converted into anion exchange resin in acidic condition.
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JOURNAL OF NANOBIOTECHNOLOGY
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2021
·Vol. 19
·期 1
·1-16
·
IF 10.435
Guo Xiaoming,Li Xiaoying,Chan Leung,Huang Wei,Chen Tianfeng
Background Nanoparticles assembled from food-grade calcium carbonate have attracted attention because of their biocompatibility, digestibility, particle and surface features (such as size, surface area, and partial wettability), and stimuli-responsiveness offered by their acid-labile nature. Results Herein, a type of edible oil-in-water Pickering emulsion was structured by calcium carbonate nanoparticles (CaCO 3 NPs; mean particle size: 80 nm) and medium-chain triglyceride (MCT) for delivery of lipophilic drugs and simultaneous oral supplementation of calcium. The microstructure of the as-made CaCO 3 NPs stabilized Pickering emulsion can be controlled by varying the particle concentration ( c ) and oil volume fraction ( φ ). The emulsification stabilizing capability of the CaCO 3 NPs also favored the formation of high internal phase emulsion at a high φ of 0.7–0.8 with excellent emulsion stability at room temperature and at 4 °C, thus protecting the encapsulated lipophilic bioactive, vitamin D3 (VD3), against degradation. Interestingly, the structured CaCO 3 NP-based Pickering emulsion displayed acid-trigged demulsification because of the disintegration of the CaCO 3 NPs into Ca 2+ in a simulated gastric environment, followed by efficient lipolysis of the lipid in simulated intestinal fluid. With the encapsulation and delivery of the emulsion, VD3 exhibited satisfying bioavailability after simulated gastrointestinal digestion. Conclusions Taken together, the rationally designed CaCO 3 NP emulsion system holds potential as a calcium-fortified formulation for food, pharmaceutical and biomedical applications.
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ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
·
2021
·Vol. 28
·期 26
·35113-35125
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IF 4.223
An Shaorong,Jin Qiang
In recent years, the excess discharge of ammonia nitrogen from wastewater into surface water has been regulated by more stringent standard. The air stripping method is successfully used to treatment of high-concentration ammonia nitrogen; however, alkali will be added to keep pH more than 10, which is costly and not environment-friendly operation. In this study, an advanced air stripping (AAS) based on foam separation of removing ammonia nitrogen in low concentration from aqueous solution at low pH was proposed. The effect of conditions such as air flow rate, temperature, SDS dosage, coexisting ionic strength, pH, and initial ammonia nitrogen concentration on the removal efficiency was studied. The advanced air stripping exhibited favorable removal efficiency for NH 4 + -N in low concentration from aqueous solution (20 mg·L −1 ) with a broad range of low pH 3.0–9.0. Besides, for strongly alkaline (pH=11.0) solution, the advanced air stripping can alleviate the decrease of pH to some extent and keep ammonia nitrogen stripping out continuously based on equilibrium shift between NH 4 + and NH 3 . A microcalorimeter was applied to demonstrate the interaction between the negatively charged hydrophilic groups of SDS and NH 4 + ions, helping to understand the mechanisms more clearly. The simple operation and the satisfactory removal efficiency could imply that the advanced air stripping is a promising technology for minimizing low-concentration NH 4 + -N. Graphical abstract
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Nanoscale Research Letters
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2021
·Vol. 16
·期 1
·1-10
·
IF 4.703
Zhu Ping,Xu Zhihui,Cai Ling,Chen Jin
Porphyrin iron molecules (hemin) were successfully grafted on the channeled mesoporous silica of SBA-15 (FeIX-SBA-15), in which attached hemin molecules acted as the enzyme mimic for catalyzing oxidation reactions. In the presence of H 2 O 2 , the prepared FeIX-SBA-15 composite effectively degraded industrial dye Orange II and catalyzed tetramethylbenzidine hydrochloride (TMB) both in the solution and on the membrane, from which the colorimetric H 2 O 2 detection was achieved. Moreover, the hemin-grafted composites showed high loading content of anticancer drug of doxorubicin hydrochloride (DOX) displaying the sustained releasing behavior as monitored by real-time cell analysis, which resulted in improved inhibitory effect on cancer cells growth compared with that DOX/SBA-15. The hemin-modified mesoporous silica nanocomposite provides an integrated nanoplatform with promising biomedical applications.
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Nature Communications
·
2021
·Vol. 12
·期 1
·1-14
·
IF 14.919
Jiang Cheng-Tao,Chen Kai-Ge,Liu An,Huang Hua,Fan Ya-Nan,Zhao Dong-Kun,Ye Qian-Ni,Zhang Hou-Bing,Xu Cong-Fei,Shen Song,Xiong Meng-Hua,Du Jin-Zhi,Yang Xian-Zhu,Wang Jun
Modulating effector immune cells via monoclonal antibodies (mAbs) and facilitating the co-engagement of T cells and tumor cells via chimeric antigen receptor- T cells or bispecific T cell-engaging antibodies are two typical cancer immunotherapy approaches. We speculated that immobilizing two types of mAbs against effector cells and tumor cells on a single nanoparticle could integrate the functions of these two approaches, as the engineered formulation (immunomodulating nano-adaptor, imNA) could potentially associate with both cells and bridge them together like an ‘adaptor’ while maintaining the immunomodulatory properties of the parental mAbs. However, existing mAbs-immobilization strategies mainly rely on a chemical reaction, a process that is rough and difficult to control. Here, we build up a versatile antibody immobilization platform by conjugating anti-IgG (Fc specific) antibody (αFc) onto the nanoparticle surface (αFc-NP), and confirm that αFc-NP could conveniently and efficiently immobilize two types of mAbs through Fc-specific noncovalent interactions to form imNAs. Finally, we validate the superiority of imNAs over the mixture of parental mAbs in T cell-, natural killer cell- and macrophage-mediated antitumor immune responses in multiple murine tumor models.
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MICROCHIMICA ACTA
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2021
·Vol. 188
·期 8
·1-9
·
IF 5.833
Yang Jiao,Fu Shilan,Luo Fang,Guo Longhua,Qiu Bin,Lin Zhenyu
MicroRNAs can serve as biomarkers for many cancers, so it is significant to develop simple and sensitive strategies for microRNAs detection. Photoelectrochemical (PEC) detection has the advantages of simple equipment and high sensitivity. But in conventional PEC DNA sensors, tedious immobilization procedures of photoactive materials and capture probes on electrode surfaces are inevitable. To overcome those limitations, a homogeneous PEC biosensor based on target-responsive hydrogels has been developed (miRNA-155 has been chosen as a model target). PEC signal molecules (TiO 2 nanoparticles, TiO 2 NPs) were embedded in DNA hydrogels formed by hyaluronic acid sodium salt, amine-modified DNA double strands, and polyethylenimine rich in amine groups. In the presence of the target, DNA double strands in hydrogel were nicked by endonuclease and TiO 2 NPs were released to the supernate and a high PEC response was obtained when collecting the supernate for PEC test, while almost no TiO 2 NPs released in the absence of the target. Thanks to the exonuclease III and nicking endonuclease Nb.BbvCI-assisted cascaded amplification strategy, the proposed biosensor exhibits high sensitivity toward miRNA-155 with a low detection limit of 0.41 fM and a wide linear range from 1.0 fM to 100 pM. Since this method circumvents tedious electrode modification procedures, the proposed technique exhibits the advantages of simplicity and good reproducibility. Moreover, the prepared hydrogels have outstanding storage stability, so that they can be prepared in advance and shorten detection time. This biosensing platform provides a versatile strategy for the construction of homogeneous PEC biosensors for the detection of diverse targets. Graphical abstract
Photoelectrochemical detection techniques have been coupled with controlled release system to develop an immobilization-free microRNA biosensor. High sensitivity has been realized based on cascaded signal amplification strategy, and the proposed biosensor has been applied to detect the target in real sample with satisfied results. Since no tedious electrode modifications, the proposed homogeneous PEC sensor exhibits high reproducibility and good stability.
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WATER AIR AND SOIL POLLUTION
·
2021
·Vol. 232
·期 7
·1-15
·
IF 2.52
Wang Leiping,Dai Xiaorong,Man Zun,Li Jianrong,Jiang Yifeng,Liu Dezhao,Xiao Hang,Shah Sanjay
Concentrated pig production is a major source of environmental pollution. Metal–organic frameworks (MOFs) show potential for reducing heavy metal pollution. Two zirconium-based octahedral MOFs, UiO-66 and UiO-66-NH 2 , were prepared by solvothermal method and were characterized by XRD, SEM, FT-IR, and BET. The adsorption capacity, treatability, and reusability of the adsorbents were tested in batch experiments. The optimum adsorbent dosage was 4 g/L, and the maximum removal rates at room temperature of chromium (Cr), manganese (Mn), iron (Fe), nickel (Ni), and Arsenic (As) on UiO-66 were 76.93%, 93.73%, 88.81%, 83.30%, and 86.11%, respectively. In the kinetic experiments, the adsorption process achieved equilibrium within 90 min and generally conformed to the quasi-second kinetics model. The results demonstrated that UiO-66 and UiO-66-NH 2 can be used over a wide range of pH for removal of most HMs on a large scale. Meanwhile, the adsorbents maintained excellent adsorption capacity after at least 3 cycles. Overall, UiO-66 and UiO-66-NH 2 have a high potential for practical application on the recovery of heavy metals in the complex wastewater from animal farms.
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ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
·
2021
·Vol. 28
·期 39
·54950-54959
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IF 4.223
Xie Yizhen,Li Qiuyi,Qin Lulu,Zhou Xiaobin,Fan Yinming
In this work, the effect of a carrier modified with a carbon-carbon double bond (C=C) on preparing multi-templates surface molecularly imprinted polymer MIP (C=C@MIP) for simultaneous detection of sulfonamides and quinolones was investigated. The results showed that the adsorption capacities of the C=C@MIP were obviously higher than those of MIP, which is the carrier without modified C=C, suggesting that C=C played a key role in preparing MIP with higher adsorption capacities. Then, C=C@MIP was used as adsorbents for solid-phase extraction (SPE) and coupled with high-performance liquid chromatography (HPLC) for the simultaneous determination of sulfonamides and quinolones in water. The method showed excellent applicability, with the adsorption capacities of 19.92, 16.38, 12.92, 18.37, 14.49, 12.01, 16.98, 23.33, and 14.29 mg/g for SDZ, STZ, SMZ, SMX, SDM, ENRO, OFL, LOME, and GATI, respectively. The spiked recoveries and relative standard deviations (RSDs) of sulfonamides and quinolones using C=C@MIP were 81.59–100.7 % and 3.75–7.37 %, respectively. The limits of detection (LODs) for SDZ, STZ, SMZ, SMX, SDM, ENRO, OFL, LOME, and GATI were 0.013, 0.012, 0.012, 0.013, 0.014, 0.012, 0.013, 0.015, and 0.015 μg/L, respectively.
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JOURNAL OF NANOBIOTECHNOLOGY
·
2021
·Vol. 19
·期 1
·1-23
·
IF 10.435
Wang Haijun,Jia Dianlong,Yuan Dandan,Yin Xiaolei,Yuan Fengjiao,Wang Feifei,Shi Wenna,Li Hui,Zhu Li-Min,Fan Qing
Background Solid tumor hypoxic conditions prevent the generation of reactive oxygen species (ROS) and the formation of DNA double-strand breaks (DSBs) induced by ionizing radiation, which ultimately contributes to radiotherapy (RT) resistance. Recently, there have been significant technical advances in nanomedicine to reduce hypoxia by facilitating in situ O 2 production, which in turn serves as a “radiosensitizer” to increase the sensitivity of tumor cells to ionizing radiation. However, off-target damage to the tumor-surrounding healthy tissue by high-energy radiation is often unavoidable, and tumor cells that are further away from the focal point of ionizing radiation may avoid damage. Therefore, there is an urgent need to develop an intelligent targeted nanoplatform to enable precise enhanced RT-induced DNA damage and combined therapy. Results Human epidermal growth factor receptor 2 (Her2)-specific dimeric affibody (Z Her2 ) mediated cisplatin-loaded mesoporous polydopamine/MnO 2 /polydopamine nanoparticles (Pt@mPDA/MnO 2 /PDA-Z Her2 NPs) for MRI and enhanced chemo-radiotherapy of Her2-positive ovarian tumors is reported. These NPs are biodegradable under a simulated tumor microenvironment, resulting in accelerated cisplatin release, as well as localized production of O 2 . Z Her2 , produced using the E. coli expression system, endowed NPs with Her2-dependent binding ability in Her2-positive SKOV-3 cells. An in vivo MRI revealed obvious T 1 contrast enhancement at the tumor site. Moreover, these NPs achieved efficient tumor homing and penetration via the efficient internalization and penetrability of Z Her2 . These NPs exhibited excellent inhibition of tumor growth with X-ray irradiation. An immunofluorescence assay showed that these NPs significantly reduced the expression of HIF-1α and improved ROS levels, resulting in radiosensitization. Conclusions The nanocarriers described in the present study integrated Her2 targeting, diagnosis and RT sensitization into a single platform, thus providing a novel approach for translational tumor theranostics. Graphic abstract
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Nano Research
·
2021
·Vol. 15
·期 2
·1570-1578
·
IF 8.897
Yang Le,Zeng Jinfeng,Zhou Lei,Shao Ruiwen,Utetiwabo Wellars,Tufail Muhammad Khurram,Wang Saisai,Yang Wen,Zhang Jiatao
Artificial defect engineering in transition metal oxides is of important terms for numerous applications. In the present work, we proposed an in-situ gas reduction strategy to introduce ordered defects into titanium niobium oxide embedding on vapor grew carbon fibers (Ti 2 Nb 10 O 29− x @VGCFs). High-resolution transmission electron microscopy (HRTEM) and fast Fourier transform (FFT) simulation indicate that the ordered oxygen defects locate at interval layers, which leads to a new superstructure in Ti 2 Nb 10 O 29 . The ordered defects could provide extra active sites for lithium-ion storage and modulate ionic migration, resulting an enhanced pseudocapacitive performance. In addition, the excellent structural stability of the superstructure was proved by in-situ HRTEM under a harsh electrochemical process. Our work provides a directly observation of orderly defective superstructure in transition metal oxide, and its functionality on electrochemistry was revealed.
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