INORGANIC CHEMISTRY COMMUNICATIONS
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2025
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IF 5.4
Hamed Veisi,Simzar Hosseinzadeh,Seyed Mahdi Rezayat
Invasive Fungal pulmonary infections caused by opportunistic pathogens pose as significant therapeutic challenges due to the limited efficacy and systemic toxicity of conventional antifungal therapies. This study presents a novel approach for targeted pulmonary drug delivery on Candida albicans and Aspergillus fumigatus as lung infection model. Magnetic quantum dots (Zn0.5 Co0.5 Fe2O4) synthesized by co-precipitation chemical method in hydrothermal condition at rang of quantum dots nearly less than 10 nm. nanoparticles (15 w/w), low molecular weight alginate salt (80 w/w) and amphotericin B (5 w/w); Then suspension was sprayed under a high voltage of 25 kV at a flow rate of 0.4 mL/min. reach a powder in 1–2 µm size is key factor in pulmonary drug delivery. This carriers leverage the dual benefits of controlled drug release and targeting to enhance therapeutic efficacy and reduce systemic side effects. Comprehensive physicochemical characterization revealed the carriers’ spherical morphology, crystalline integrity, and superparamagnetic behavior, as confirmed by TEM, SEM, XRD, and VSM analyses. The carriers demonstrated sustained AmB release over 72 h, as evidenced by UV–Vis spectroscopy, achieving first explosive therapeutic drug availability. Antifungal evaluations showed that the system effectively inhibited the growth with a minimum inhibitory concentration (MIC) of 30 µg/mL: according to clinical and laboratory standards institute (CLSI). Cytotoxicity assays indicated significantly enhanced biocompatibility compared to free AmB, attributed to the protective alginate matrix. In vivo analysis using ICP-OES demonstrated superior localization of magnetic nanoparticles in magnetically targeted lung tissues, underscoring the platform’s potential for precision medicine applications. The integration of biocompatible alginate and magnetic nanoparticles offers a transformative solution for addressing the challenges of antifungal therapy. This platform not only enhances drug targeting and therapeutic efficacy but also aligns with the principles of precision medicine, paving the way for safer and more effective treatments for pulmonary fungal infections.
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高影响因子
JOURNAL OF MEDICINAL CHEMISTRY
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2026
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IF 6.8
Xinyue Zhao,Naijie Wei,Ziyang Fang,Yingyan Xie,Xiaowen Yan,Qiuquan Wang
To address the low cytotoxicity and drug resistance issues of targeted covalent inhibitor (TCI) ibrutinib and severe side effects of chemotherapeutics doxorubicin (DOX), we developed a novel targeted covalently activated chemotherapy strategy. We designed and synthesized a targeted covalently activated chemotherapy drug, Ibt-DOX, which features a targeting ligand of ibrutinib, a DOX, an electrophilic warhead α-methylated acrylamide (α-MAA) and a self-immolative linker p-hydroxybenzyl alcohol. Upon specifically binding to BTK, Ibt-DOX inhibits the BTK-mediated BCR signaling, meanwhile releases DOX and induces immunogenic cell death (ICD), ultimately resulting in not only significantly enhanced targeted B-cell lymphoma cells death compared with ibrutinib, but also reduces the toxic side effects of DOX on BTK- cells. Our work offers a novel strategy through leveraging the synergistic effect of targeted covalent inhibition and the high cytotoxicity of chemotherapy drug, which will inspire the development of new targeted covalent chemotherapeutics for different cancers treatment.
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高影响因子
iScience
·
2023
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IF 5.8
Shi-Jun Wang,Long Wang,Xiang-Ying Tang
B(C 6 F 5 ) 3 ·H 2 O has been long recognized as a common Brønsted acid. The lack of X-ray crystal structure of B(C 6 F 5 ) 3 ·H 2 O with other substrates has greatly limited the development of a new catalytic mode. In this work, a complex of B(C 6 F 5 ) 3 ·H 2 O and amide 2-phenyl-3,4-dihydroisoquinolin-1( 2H )-one with hydrogen bonds and π-π interactions is characterized by X-ray diffraction. Such noncovalent interactions in solution also exist, as verified by NMR, UV-Vis absorption, and fluorescence emission measurements. Moreover, the mixture of amide 2-phenyl-3,4-dihydroisoquinolin-1( 2H )-one and B(C 6 F 5 ) 3 ·H 2 O, instead of other tested Brønsted acids, shows a tailing absorption band in the visible light region (400–450 nm). Based on the photoactive properties of the complex, a photoredox catalysis is developed to construct α -aminoamides under mild conditions.
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SEPARATION AND PURIFICATION TECHNOLOGY
·
2026
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IF 9.1
Shaobo Li,Yuejie Li,Ran Chen,Ying Li,Ming Hua,Li Li,Jing Liu
A cobalt oxide-decorated hollow carbon nitride ( g -C 3 N 4 ) photocatalyst was synthesized and evaluated for the degradation of Rhodamine B (RhB) under ultraviolet (UV) irradiation, with particular attention to removal efficiency, matrix tolerance, and stability. Characterization showed that cobalt oxide species were finely dispersed on the g -C 3 N 4 framework, and the modified composite exhibited a narrower band gap and suppressed charge-carrier recombination relative to pristine g -C 3 N 4 . X-ray photoelectron spectroscopy further suggested interfacial Co-N/Co-O interaction and mixed cobalt valence states. The optimized catalyst achieved more than 95% RhB removal within 30 min under the selected conditions. It retained activity in the presence of common coexisting ions, maintained over 80% degradation efficiency after five reuse cycles, and remained effective after 28 days of storage. Effective degradation was also observed in lake water and paper mill effluent, and methyl violet was removed in these complex matrices, indicating the applicability of the catalyst to dye-containing wastewater. Mechanistic studies showed that •O₂ − and •OH were the dominant reactive species. Density functional theory and high-performance liquid chromatography coupled with quadrupole-time-of-flight tandem mass spectrometry (HPLC-Q-TOF-MS/MS) were further combined to identify preferential radical attack sites and elucidate the major transformation pathways of RhB. The degradation proceeded mainly through sequential de-ethylation, chromophore cleavage, and ring-opening reactions, ultimately yielding low-molecular-weight aromatic acids, including benzoic acid and o-phthalic acid. Toxicity estimation using the Toxicity Estimation Software Tool (T.E.S.T) model suggested that the final products were associated with lower ecological risk than the parent dye. These results indicate that cobalt oxide modification enhances the photocatalytic performance of g -C 3 N 4 for dye-containing wastewater treatment.
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RSC Advances
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2026
·Vol. 16
·期 33
·30145-30157
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IF 6.1
Mingchen Zhang,Wei Zhao,Yang Zhou,Ruiting Shen,Yiqiong Sun,Lei Jiang,Jiantao Zhang
Diabetic wounds are a serious and increasingly prevalent complication in patients with diabetes, characterized by impaired skin regeneration. A major challenge for effective healing is recurrent bacterial infection, which often resists conventional treatment strategies. In this study, we grafted polymyxin B onto hyaluronic acid and employed Fe3+–EDTA as a cross-linking agent to fabricate HA-B@Fe hydrogels via ionic interactions. Based on the reversible and dynamic coordination between Fe3+ ions and the carboxyl groups of the hyaluronic acid, the resulting hydrogels exhibited shear-thinning behavior and excellent injectability. Based on the combined effects of polymyxin B and Fe3+, the HA-B@Fe hydrogel exhibited potent antimicrobial activity against a broad spectrum of bacteria, achieving >99% bactericidal rates against Escherichia coli (E. coli) and >94% against Staphylococcus aureus (S. aureus). In addition, the HA-B@Fe hydrogel demonstrated great biocompatibility, and showed significant therapeutic efficacy in a diabetic mouse wound model. The mice treated with HA-B@Fe showed a marked reduction in wound size (down to 19%), compared to a residual wound size of 32% in group treated with commercial dressings at day 7. Histopathological analysis further confirmed that HA-B@Fe treatment promoted epidermal regeneration and collagen fiber deposition, suggesting its potential as a promiseing strategy for the clinical treatment of diabetic wounds.
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BIOMACROMOLECULES
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2012
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IF 5.479
Longlong Chang,Liandong Deng,Weiwei Wang,Zesheng Lv,Fuqiang Hu,Anjie Dong,Jianhua Zhang
A novel biodegradable amphiphilic diblock copolymer methoxy poly(ethylene glycol)-b-poly(ε-caprolactone-co-γ-hydroxyl-ε-caprolactone) (mPEG-b-P(CL-co-HCL)) bearing pendant hydroxyl groups on the PCL block was prepared. The hydroxyl groups were formed through the reduction of ketones by sodium borohydride without protection and deprotection. The obtained polymers were well characterized by 1H NMR, Fourier transform infrared (FT-IR), gel permeation chromatography (GPC), differential scanning calorimetry (DSC), X-ray diffraction (XRD), and contact angle measurement. mPEG-b-P(CL-co-HCL) could self-assemble into stable nanoparticles (NPs) with critical micellar concentrations (CMC) of 6.3 × 10–4 ∼ 8.1 × 10–4 mg/mL. The NPs prepared from mPEG-b-P(CL-co-HCL) were spherical in shape with diameters about 100 to 140 nm. The hydrophobic doxorubicin (DOX) was chosen as a drug model and successfully encapsulated into the NPs. The encapsulation efficiency and release kinetics of DOX were investigated. The results indicated that the introduction of hydroxyl groups onto the core-forming block could decrease the hydrophobicity of copolymers, thus improving the storage stability of NPs in aqueous solution. Moreover, higher loading capacity and slower in vitro release of DOX were observed, which was due to the hydrogen-bonding formation between DOX and hydroxyl groups. Meanwhile, the MTT assay demonstrated that the blank NPs were biocompatible to HepG2 cell,s while free DOX and DOX-loaded NPs showed significant cytotoxicity against the cells. Moreover, Compared to the free DOX, the DOX-loaded NPs were more efficiently internalized by HepG2 cells. In sum, the introduction of hydroxyl groups on the polyester block in mPEG-b-P(CL-co-HCL) exhibited great potentials for modifications in the stability, drug solubilization, and release properties of NPs.
研究领域:
高分子科学
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药物递送
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纳米医学
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生物材料
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制药技术
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Frontiers in Environmental Science
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2022
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IF 5.411
Feng Shuna,Yan Zheng,Ni Qianqian,Zhang Yun
As a primary goal, The fast recombination of stimulated excitons and poor visible light response are key problems in the photocatalysis field. Combining with materials with good visible light responses to form heterogeneous structures is still the most effective way. In this study, BiOBr/UiO-66-NH2 photocatalyst was synthesized by a simple method. BiOBr is a 3D spherical structure stacked by nanosheets, which enhance its adsorption capacity for pollutants and catalyze the dark reaction to reach the equilibrium point for too long. Coupling with UiO-66-NH2, its adsorption capacity was inhibited and the dark reaction time was shortened. The excellent removal rate of Rhodamine B (RhB) by BiOBr/UiO-66-NH2 reached 96.79% after 30 min of visible light irradiation and 99.37% after 90 min. With an increase in pollutant concentration, the composite still showed excellent photocatalytic performance. This study also tried to abandon the dark adsorption stage and directly degraded RhB efficiently and quickly under visible light. Finally, the photocatalytic enhancement mechanism was proposed.
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LWT-FOOD SCIENCE AND TECHNOLOGY
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2023
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IF 6
Shiqi Hu,Guanghong Zhou,Xinglian Xu,Wangang Zhang,Chunbao Li
To produce the high quality products and improve the stability of Jinhua hams, the activities of cathepsins and their correlation with processing parameters were explored. The effect of heat treatment on the structure of cathepsin B, together with potential of hydrogen and NaCl concentration, were investigated. At 45 °C, the activity of cathepsin B was maximum and it decreased rapidly at high temperature. The decrease on sulfhydryl group content indicated that the enzyme activity varied due to the breaking of disulfide bond in molecule. Infrared spectroscopy indicated that the secondary structure of cathepsin B had altered. Meanwhile, the root mean squared deviation and the root mean square fluctuation curves reflected that the cathepsin B vitality was in a decline under high temperature. In addition, in the presence of 0.6 mol ⋅ L −1 NaCl, lots of conformational changes were evidenced. Under acidic conditions (pH = 6), there were more formed hydrogen bonds, and the hydrogen bonding interactions became stronger. Simulation results contributed to providing an important theoretical basis for understanding the roles of processing parameters on the quality control of Jinhua ham.
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INTERNATIONAL JOURNAL OF HYDROGEN ENERGY
·
2023
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IF 7.2
Xuecheng Liu,Linjie Yan,Xiting Hu,Hongli Feng,Bingke Guo,Xia Ha,Hui Xu
A facile construction of B and P doped carbon nitride as a potential photo-catalyst for splitting water to generate hydrogen or oxygen and BPA removal under visible light. B and P doping are confirmed by a series of characterizations. As the symmetrical π-conjugated rings of g-C 3 N 4 could be destroyed by B and P doping to enhance the visible-light absorbance and n → π∗ electronic transition to provide a new pathway for the directional separation of photoexcited electrons to boost the photocatalytic activity. Significantly, the CN-BP catalyst demonstrates excellent H 2 and O 2 evolution rates of 4.0 mmol H2 h −1 g −1 and 0.3 mmol O2 h −1 g −1 under visible light, which is about ∼3.8 and 21.6 times higher than that of g-C 3 N 4 , respectively. Notably, without sacrificial agent , the CN-BP could remove BPA completely by oxidation to generate 30 μmol h −1 g −1 H 2 . Both DFT calculations and characteristic results reveal that B and P doped carbon nitride reduce band gap energy , improve light harvesting and separation rate of electron-holes carriers for upgrading the photocatalytic activity.
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ACS Applied Nano Materials
·
2023
·
IF 5.9
Junyao Li,Yu Wang,Yiying Yue
The opacity, fragility, and environmental unfriendliness of the traditional photocatalytic matrix cannot fully utilize the properties of photocatalysts and efficiently degrade pollutants. In this work, a transparent wood hydrogel with a core–shell structure was developed using transparent wood (TW) impregnated with polyacrylic acid (PAA) as the core layer and Bi-N-carbon dots/BiOBr (Bi-N-CDs/BiOBr) photocatalyst-initiated polymerization of acrylic acid (AA) monomers as the shell layer. In the shell layer, nanoscale CDs with rich hydrophilic groups built a link between BiOBr and PAA and strengthened the adsorption–photocatalysis synergistic removal for RhB. The original wood backbone well conserved during preparation led to an anisotropic structure in the resultant Bi-N-CDs/BiOBr@TW photocatalytic wood hydrogel. Namely, after introducing Bi-N-CDs/BiOBr as the linker and reinforcing agent, the tensile strength was up to 3.2 and 11.03 MPa along the radial (R-) and axial (A-) directions, which was 1.6- and 1.06-fold of R-TW and A-TW, respectively. Hence, Bi-N-CDs/BiOBr@TW with high strength furnishes multiple separations and reutilizations, and the RhB removal rate is approximately 85% after five cycles. The Bi-N-CDs/BiOBr@TW exhibited light transmittance up to 64.6 and 52.3% at 800 nm along the R- and A-directions, respectively. Moreover, the adsorption–photocatalysis synergistic rate of Bi-N-CDs/BiOBr@TW reached 93% in 300 min at pH = 7. This paper offers a strategy for fabricating wood hydrogels with outstanding stretchability, transparency, dye removal efficiency, and recyclability, opening a significant route for alleviating dye pollution.
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PROGRESS IN ORGANIC COATINGS
·
2023
·
IF 6.6
Jialiang Kang,Xueting Wang,Xiaoxiang He,Cun Lv,Caixia He,Zhanxiong Li
In this study, the perfluoropolyether carboxylic acid (PFPE-COOH) was used to react with polycaprolactone (PCL) to synthesise the hydrophobic block copolymer PCL- b -PFPE. The esterification reaction was performed successfully with the terminated hydroxyl group in the PCL-OH after activation of PFPE-COOH with N, N′ -dicyclohexyl carbon diimide. The PCL- b -PFPE was dissolved in various solvents to prepare microspheres using electrostatic spraying technology, and the flow rate, voltage, temperature and humidity parameters were optimised. The findings demonstrated that the solvent and ambient humidity had a substantial influence on the microspheres' surface morphology . Through smooth surface morphology, chloroform (CF) single solvent formed an ideal microsphere and DMF/CF mixed solvent produced a ‘pit’ surface morphology. Furthermore, the surface roughness of microspheres increases with an increase in humidity. The static contact angles of electrostatic spraying polyester fabric were 147.1° ± 1.8°, 150.9° ± 1.5°, 156.3° ± 2.6° and 155.9° ± 3.3°, under 20 %, 40 %, 60 % and 80 % humidity, respectively. The findings demonstrated that during the electrostatic spraying, the PFPE chain's introduction into PCL helped construct the secondary rough morphology on the microsphere surface and substantially enhanced the hydrophobicity of coatings, providing the finished polyester fabric super-hydrophobicity. The PCL-b-PFPE microspheres were directly sprayed and coated with the developed spray solution via electrostatic spraying. The water contact angle of the finished polyester fabric was found to be ≥140°, which provided hydrophobicity after 5 cycles of laundry. Following the sandpaper abrasion and adhesion tests, the contact angle of the fabrics coated with the microspheres remained ≥145°, indicating a good mechanical stability.
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RSC Advances
·
2022
·Vol. 12
·期 45
·28867-28877
·
IF 4.036
Shuqiong Liu,Zhenyi Xu,Jiapeng Hu,Zhenzeng Wu,Yuying Zheng
Biomimetic scaffolds loaded with drugs can improve the osteogenesis and neovascularisation of scaffolds. A series of PLA/GO/Sal-B drug-loaded scaffolds was prepared by thermally induced phase separation. The addition of Sal-B increased the diameter of the fibres, but the scaffold showed a porous nanofibrous structure after drug release. X-ray diffraction results showed that the addition of Sal-B did not affect the formation of the nanofibre biomimetic structure of the scaffold. FTIR results indicated a certain interaction between Sal-B and PLA/GO. Water absorption and porosity test results revealed that the scaffolds had good hydrophilicity and appropriate porosity. The addition of Sal-B was also conducive to the formation of sediments possibly due to the good water solubility of Sal-B itself. The prepared scaffolds had good blood compatibility and cytocompatibility, and a small additional amount of Sal-B could significantly promote cell proliferation and alkaline phosphatase activity. Their sustained release performance indicated that the biomimetic scaffolds had controlled the release of Sal-B. The kinetic model showed that the PLA/GO/Sal-B drug-loaded biomimetic scaffolds followed the diffusion mechanism.
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