FOOD CHEMISTRY
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2026
·
IF 10.4
Zhuo-Feng Gan,Jia-Ying Li,Ying-Zhi Yao,Hui-Min Lu,Xi-Yang Chen,Ming-Shen Zhu,Duried Alwazeer,Xin-An Zeng,Lan Liao
Carbonyl mapping linked Fenton oxidation to refrigerated MP deterioration. • H₂ modulated the upstream redox microenvironment and reduced the detectable DMPO-OH signal. • H₂ attenuated marker-dependent oxidative modification in tilapia MPs. • H₂ attenuated aggregation, colloidal destabilization, and conformational reorganization. Hydroxyl radical (·OH)-driven oxidation of myofibrillar proteins (MPs) contributes to quality deterioration in refrigerated fish, yet storage-referenced mitigation strategies remain limited. Herein, we established a storage-referenced oxidation framework for tilapia MPs by carbonyl-based equivalence fitting a Fenton-type ·OH-generating system and carbonyl accumulation in vacuum-packaged tilapia muscle during extended refrigerated storage at 4 °C. Within this framework, weeks 1, 4, 6, and 7 corresponded to 20, 50, 80, and 90 mM H₂O₂, respectively, with a maximum absolute prediction error of 8.6%, and 90 mM H₂O₂ was selected as the representative high-oxidation condition. Under this condition, H₂ shifted the system toward a more reducing redox status and reduced the detectable DMPO-OH signal to 24.56% of the 90 mM H₂O₂ control, accompanied by marker-dependent protection against oxidative modification, antioxidant-related readout loss, colloidal destabilization, and secondary-structure deterioration. These findings provide a mechanistic basis for H₂-based reductive preservation of aquatic muscle foods. Download: Download high-res image (202KB) Download: Download full-size image
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COMPOSITES COMMUNICATIONS
·
2026
·
IF 8.6
Xiuwen Gao,Jinhui Tan,Chong Lin,Gao Pan,Huixing Li,Fangwei Qi,Xin Li,Shuping Peng,Cijun Shuai
Photo-thermoelectric-driven vanadium valence cycling enhanced ROS generation. • NIR-triggered electrical stimulation activated calcium signaling for osteogenesis. • Synergistic antitumor and antibacterial efficacy was achieved through self-enhanced chemodynamic and thermoelectric catalysis therapy. • A multifunctional scaffold achieved tumor/bacteria elimination and bone repair. The peroxidase-like activity of vanadium carbide MXene (V 2 C) nanozyme drove the valence transition from V 3+ to V 4+ , and catalyzed hydrogen peroxide to generate reactive oxygen species (ROS) for eliminating tumor and bacteria, exhibiting potential in post-resection osteosarcoma therapy. However, V 4+ could not spontaneously reduce to V 3+ , interrupting the generation of ROS. To address this, a scaffold strategy based on photo-thermoelectric driven valence cycle was proposed. Specifically, Bi 2 Te 3 @V 2 C heterojunction was constructed via electrostatic self-assembly and then incorporated into poly(L-lactic acid) scaffold using additive manufacturing technology. X-ray photoelectron spectroscopy results demonstrated that under near-infrared light irradiation, photo-thermoelectric bismuth telluride (Bi 2 Te 3 ) generated electrons via the Seebeck effect, which efficiently reduced V 4+ to V 3+ , thereby achieving vanadium ion valence cycling and enhancing ROS production. Simultaneously, the photothermal effect of Bi 2 Te 3 enhanced peroxidase-like reaction efficiency. Furthermore, Bi 2 Te 3 triggered redox reactions through thermoelectric catalysis properties, thereby elevating ROS production levels and further enhancing antitumor and antibacterial efficacy. The scaffold-generated ROS induced mitochondrial dysfunction and apoptosis in tumor cells, while also causing the leakage of bacterial intracellular substances to reduce implant-related infection risks. The experimental results showed that both its antitumor and antibacterial rates exceeded 95%. Moreover, the scaffold delivered non-invasive electrical stimulation through photo-thermoelectric conversion, which activated calcium signaling pathways to promote bone repair. This study provided a multifunctional scaffold with antitumor, antibacterial and osteogenic capabilities.
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APPLIED SURFACE SCIENCE
·
2026
·
IF 6.6
Ruirui Ma,Xuan Zhu,Zheng Qian,Shunhang Dong,Changjiang Pan,Sen Gu,Qiuyang Zhang,Jie Chen
A three-in-one porous coating was fabricated on an orthopedic Ti surface. • The coating integrated osteogenic, angiogenic, and antibacterial activities. • Simvastatin and Cu 2+ were sustainedly released from the coating. • The coating modulated osteoblast and endothelial cell growth behaviors. • The coating inhibited bacterial adhesion by over 98.53%. To enhance the bioactivity and antimicrobial properties of orthopedic Ti implants, a “three-in-one” coating was well designed and fabricated. A bone-mimicking porous nanofibrous mesh structure (Ti-OH) was first constructed via alkali-heat treatment, followed by sequential biofunctional modifications involving Cu 2+ chelation via phase-transited lysozyme (PTL) (OH-PC) and simvastatin (SV) loading mediated by carboxymethyl-β-cyclodextrin (CM-β-CD) (OH-PCβS). A comprehensive analysis of the as-prepared coatings was conducted using SEM, EDS, XPS, ATR-FTIR, and contact angle measurements. The released concentrations of Cu 2+ and SV were measured with an inductively coupled plasma optical emission spectrometer and a microplate reader, respectively. The angiogenic, osteogenic, and antimicrobial potentials of the coatings were evaluated through cell growth behaviors and antibacterial assays. These results demonstrate that the bone-mimicking porous nanofibrous structure was successfully functionalized with PTL, Cu 2+ , CM-β-CD, and SV. Benefiting from the porous structure and the sustained release of Cu 2+ and SV, the OH-PCβS coating facilitated initial adhesion and proliferation of endothelial cells and osteoblasts, upregulated the expression levels of vascular endothelial growth factor (VEGF), alkaline phosphatase (ALP), osteocalcin (OCN) and runt-related transcription factor 2 (RUNX2), and accelerated biomineralization in osteoblasts. The OH-PCβS coating was demonstrated to possess excellent pro-angiogenic and pro-osteogenic bioactivity. Additionally, the OH-PCβS coating exhibited remarkable antibacterial properties toward S. aureus and E. coli (99.31% and 98.53% inhibition, respectively), owing to the release of Cu 2+ . The OH-PCβS coating developed in this study provides a “three-in-one” strategy for improving the long-term survival of orthopedic Ti implants by integrating angiogenic, osteogenic, and antibacterial functions. Download: Download high-res image (115KB) Download: Download full-size image
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Horticulture Advances
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2026
·Vol. 4
·期 1
·22
·
IF 6.3
Ashraf Muhammad Atiq,Ateeq Muhammad,Du Haowei,Yang Jinzhi,Gao Xusheng,Kaleem Muhammad Mohsin,Daud Muhammad,Khalid Burhan,Asim Muhammad,Nawaz Shumaila,Shabala Sergey,Zhu Kaijie,Liu Junwei
Waterlogging (WL) stress severely affects the growth and productivity of fruit crops. Cytosolic calcium (Ca 2+ ) is recognized as a secondary messenger that initiates adaptive responses to environmental stresses. However, the mechanisms by which exogenously applied Ca 2+ enhances WL tolerance remain poorly understood. In this study, we investigated whether exogenous Ca 2+ , applied as calcium chloride (CaCl 2 ) and calcium oxide nanoparticles (CaO-NPs), might mitigate WL-induced damage in peach ( Prunus persica ) seedlings. We found that both Ca 2+ formulations significantly alleviated WL-induced growth inhibition, restored photosynthetic efficiency, and maintained root system architecture and metabolic activity. Two Ca 2+ treatments markedly reduced intracellular superoxide (SOD) and hydrogen peroxide accumulation, thus attenuating membrane lipid peroxidation and electrolyte leakage. Hormonal profiling demonstrated that Ca 2+ suppressed excessive abscisic acid and salicylic acid accumulation while restoring jasmonate homeostasis under WL conditions. Furthermore, at the transcriptional level, Ca 2+ enhanced stress tolerance by upregulating the expression of genes encoding antioxidant ( PpSOD ; and peroxidase , PpPOD ), photosynthetic ( photosystem II subunit Q , PpPsbQ ; and photosystem I subunit K , PpPsaK ), and Ca 2+ ( CBL-interacting protein kinases , PpCIPK5 and PpCIPK11 ). In line with reduced oxidative stress, Ca 2+ also adaptively downregulated genes related to the fermentative pathway ( alcohol dehydrogenase , PpADH ; and lactate dehydrogenase , PpLDH ), indicating a shift away from anaerobic metabolism. Notably, comparative analysis revealed that ionic Ca 2+ and CaO-NP treatments resulted in largely similar outcomes under WL conditions, with only marginal differences in some parameters. Taken together, these results indicate that Ca 2+ -associated signaling is a putative regulatory network underlying adaptive responses to WL stress in woody fruit crops.
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CHEMICAL ENGINEERING JOURNAL
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2026
·
IF 12.5
Si Zheng,Danping Wang,Zhiyu Kuang,Shengyao Xu,Wenxiao Li,Haiyu Zhao,Jingyi Zhang,Weiyao Li,Zhonggui He,Jin Sun,Lin Li,Bingjun Sun
Fatty acid modification enhances DTX affinity to phospholipids, increasing encapsulation efficiency and in vitro stability. • D-BC PLs with “structure-like” prodrugs enhance lipid interactions, showing modest redox sensitivity, good PK, and tolerance. • D-SC PLs with “length-like” prodrugs show high redox sensitivity, cytotoxicity, tumor suppression yet mild high-dose toxicity. Liposomes are one of the most promising nano-delivery systems to deliver chemotherapeutic drugs. Docetaxel (DTX) is a classic type of taxane drug widely used in clinical practice. However, no liposomal DTX formulation has been approved for marketing. It is speculated that the structure of DTX was highly rigid and hydrophobic, making it hard to encapsulate DTX in either lipid membranes nor aqueous phase. Therefore, designing novel DTX liposomes with high encapsulation efficiency and stability deserves further exploration. Phospholipid molecules have a hydrophilic head and two hydrophobic fatty acids as tail chains. Inspired by the structure of phospholipids, two fatty acid modification strategies were developed to construct length-like DTX prodrug (D-SC) and structure-like DTX prodrug (D-BC). Compared with DTX liposomes, two DTX prodrug liposomes (D-SC PLs and D-BC PLs) were equipped with improved drug-carrier affinity reflecting in higher encapsulation efficiency and stability in vitro. Moreover, both prodrug liposomes exhibited intelligent drug release in tumor cells. Further, D-BC PLs outperformed in the circulation stability and tolerance probably due to the improved affinity by structure-like modification strategy. In turn, D-SC PLs exhibited rapid DTX release to effectively inhibit tumor growth but cause reversible toxicity at high dosage. Overall, this work provides new insights to construct advanced prodrug liposomes for efficient cancer therapy.
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Advanced Science
·
2026
·
IF 14.1
Xin Tao,Cang-Man Zhang,Ru-Jie Yang,Min Ren,Zhuo-Ling Zhong,Kang-Hui Wang,Rui-Xue Hu,Jia-Yue Liu,Jun-Yi Zhou,Hou-Kai Li,Jian-Bo Wan
Understanding disease-associated metabolic reprogramming requires comprehensive interrogation of the chemically diverse metabolome. However, conventional liquid chromatography-mass spectrometry (LC-MS) workflows analyze metabolites in a largely non-discriminatory manner, resulting in systematic underrepresentation of specific functional and reactivity classes due to heterogeneous ionization efficiencies and matrix interference. Here, we report a chemoselective metabolomics strategy based on a modular reactivity-encoding platform (MREP) that enables functional group-resolved stratification of complex metabolomes. Four orthogonally designed alkyne-tagged probes selectively derivatize carboxyl, carbonyl, amine, and thiol functionalities under compatible conditions. The encoded metabolites are subsequently immobilized via azide-alkyne cycloaddition onto a unified solid-phase capture resin, which simultaneously removes matrix components and installs a diagnostic reporter module. This integrated encoding-capture architecture achieves high reaction orthogonality, near-quantitative conversion, and robust quantitative performance across structurally diverse metabolites. The resulting triazole derivatives exhibit markedly enhanced ionization efficiencies and generate a universal reporter-ion, enabling confident submetabolome classification and reconstruction. Application to serum and liver tissues from mice substantially expands the detectable chemical space, yielding 7 208 features and 1 573 annotated metabolites across four functional group-defined layers. Collectively, this work establishes the MREP framework as a versatile platform for reactivity-resolved interrogation of complex small-molecule systems.
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CHEMICAL ENGINEERING JOURNAL
·
2026
·
IF 12.5
Chao Chen,Jianhan Wang,Peijun Lin,Kai Shi,Long Zhang,Hongwen Zhang,Dong Wu,Yanlei Hu
Laser-assisted fabrication of a high-performance multifunctional smart window. • Smart window integrating optical modulation and energy harvesting. • Superhydrophobic surface enables self-cleaning and droplet energy conversion. Although hydrogel-based smart windows are promising energy-saving building components, they suffer from contamination-induced performance degradation and limited functionality. In this study, we report a zero-energy-consumption hydrovoltaic smart window (ZEC-HSW) that structurally combines optical regulation, self-cleaning, and droplet-induced energy harvesting. Owing to the reversible phase transition, the ZEC-HSW autonomously switches between transparent and opaque states, achieving a high visible transmittance modulation (ΔT vis = 61.8%) and a large solar modulation ability (ΔT sol = 46.3%). The bioinspired superhydrophobic surface (WCA ≈ 153°, WSA ≈ 3°) enables effective self-cleaning while being intrinsically coupled with raindrop-driven hydrovoltaic energy conversion, delivering an instantaneous voltage of ~30 V with stable output over 10,000 s. Thermal experiments and building simulations demonstrate a 7.5 °C reduction in indoor temperature, accompanied by average decreases of 34.66% in cooling energy consumption and 1756 kg in carbon emissions. This work establishes an integrated smart window strategy that unifies passive optical regulation, environmental self-maintenance, and droplet-enabled energy harvesting, offering a scalable strategy for sustainable buildings. Download: Download high-res image (271KB) Download: Download full-size image
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CHINESE JOURNAL OF POLYMER SCIENCE
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2026
·
IF 4.6
Gao Jing,Chen Liang,Qi Liang-Yuan,Li Su-Hong,Hu Yuan,Wang Xin,Ji Lian-Min,Wang Ying-Jian,Xing Wei-Yi
The flame-retardant monomer PG (P) was synthesized from diethylphosphinic acid and glycidyl methacrylate (GMA). Simultaneously, the phosphorus-containing flame-retardant monomer, TAEP (T), was synthesized from phosphorus oxychloride and 2-hydroxyethyl acrylate. A 50 µm thick transparent UV-cured coating, designated MAAR-P 8 T 4 , was successfully constructed on 0.5 mm thick polycarbonate (PC) films by blending PG and TAEP with melamine acrylate resin (MAAR). The fabricated coating demonstrated a high transmittance of 91.9% in the visible-light spectrum. The incorporation of monofunctional PG effectively regulated the system viscosity and mitigated curing shrinkage stress. Furthermore, the synergistic action of phosphorus in different valence states and nitrogen from MAAR imparted a dual gas-phase-condensed phase flame-retardant mechanism to the coating, enabling the PC substrate to attain a V-0 rating in the UL-94 vertical burning test. This research indicates that the MAAR-P 8 T 4 coating engineered via molecular design and component optimization concurrently overcomes the limitations of PC, namely its low surface hardness and inherent flammability. A straightforward and efficient preparation strategy provides a practical approach for transparent flame-retardant coatings for electronic and electrical applications.
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FOOD CHEMISTRY
·
2026
·
IF 10.4
Jiayu Cheng,Heng An,Xiangdan Meng,Li-Ping Xu
Foodborne microbial contamination is a major global health concern, with conventional methods often being time-consuming and complex. Herein, we developed a novel portable biosensor by integrating microneedle patch technology and a metal-organic framework (Fe/Cu-NBDC MOF) nanozyme, enabling rapid, on-site, visual detection of bacteria in meat. The sensing system works by encapsulating aptamer-functionalized MOF nanozymes within a hydrogel patch, where their catalytic sites are initially blocked by the aptamer. In the presence of Staphylococcus aureus ( S. aureus ) as the target, the specific aptamer's binding to bacteria exposes numerous catalytic sites, further activating the chromogenic reaction of the tetramethylbenzidine‑hydrogen peroxide (TMB-H₂O₂) system, enabling visual detection of S. aureus . The biosensor demonstrates a detection limit of 82 CFU/mL with excellent specificity to successfully apply to commercial mutton. By integrating sampling, enrichment, and visual detection into a single compact device, this platform offers a practical, efficient solution for rapid on-site screening of foodborne pathogens.
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TALANTA
·
2026
·
IF 6.7
Luting Yan,Lei Tian,Zekun Ren,Chao Wang,Xia Sun,Yemin Guo,Maja Milojević-Rakić,Yanyan Zhang
The scarcity of cathodic autoluminescencet restricts the development of coreactant-free electrochemiluminescent sensor for simultaneous detection of two targets. Herein, a novel coreactant-free electrochemiluminescent sensor was prepared based on Zr-DPA@TCPP MOF and AuAgNCs bimetallic nanoclusters served as a cathodic and anodic autoluminescencet emitter respectively. Significantly, this sensor system without any coreactants, effectively overcoming the simultaneous detection issue typically relying on different coreactants for cathode and anode luminescence. Meanwhile, complex matrix components can compromise the specificity and accuracy of the detection. Therefore, highly conductive and electrically neutral hydrogel was obtained to reduce interference from non-target substances. Poly (3,4-ethylenedioxythiophene): polystyrene sulphonate (PEDOT: PSS) was encapsulated in hydrogel to obtain PEDOT: PSS@hydrogel, besides, the crosslinking agents citronellal and TCPP provide a sterilization effect. Dual-function antifouling/sterilization electrically neutral hydrogel effectively addresses the main issues of complex matrix interference and secondary contamination. Under optimal conditions, the linear range was 1 × 10 −3 ∼ 1 × 10 5 ng/L for Cd(II) and 1 ∼ 1 × 10 8 CFU/mL for S. aureus . The biosensor achieves remarkably low limits of detection (LODs) at 1.71 pg/L and 1.36 CFU/mL for Cd(II) and S. aureus , respectively. This work offers a new perspective on the development of coreactant-free ECL technology with high accuracy and stability.
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INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
·
2026
·
IF 3.9
Shucheng Liu,Bo Wang,Ruiheng Lu,Hongxiang Ou,Xuan Zhang
Naringin (NRG) is a bioactive substance with important pharmaceutical and industrial value. However, the major challenges in the separation of NRG arise from the complexity and low concentration of crude extracts. In this work, by integrating the advantages of magnetic separation, MOFs@COFs composite materials, and surface molecular imprinting strategy, a new kind of magnetic MOF@COF-based boronate-affinity molecular imprinted adsorbent (NH2-MIL-68-Fe3O4@COFs@BA-MIPs) was constructed. Magnetic NH2-MIL-68 substrates were prepared by the solvothermal method, aldehyde-functionalized by surface modification with 2,4,6-triformylphloroglucinol (Tp). Then, a covalent organic framework shell was grown on the surface of substrates via the Schiff base reaction. Finally, a boronate-affinity imprinted polymer was prepared via surface-initiated atom transfer radical polymerization (SI-ATRP). The as-prepared adsorbent features rapid magnetic separation. In addition, the high-density boronate-imprinted recognition sites and porous structure endow the material with a fast adsorption rate (reaching equilibrium about 60 min), a high adsorption capacity (57.29 μmol g–1), and good retention performance (92.79%) after six adsorption–desorption cycles at 308 K under pH 8.0. Moreover, the extraction rate of crude NRG by NH2-MIL-68-Fe3O4@COFs@BA-MIPs reached 93.61%. This study provides a design strategy for constructing NRG adsorbents with rapid magnetic response and has important application value in the specific separation and purification of flavonoids.
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SmartMat
·
2026
·Vol. 7
·期 3
·e70093
·
IF 14.3
Yanhua Zhao,Xinglong Zhang,QiRui She,Kexin Li,Yuqing Niu,Tingting Li,Cheng Chen,Haibo Wu,Fanchen Meng,Suoying Zhang,Yun Fan,Rong Sun,Wei Huang,Fengwei Huo,Weina Zhang
Metal ion-enzyme tandem systems hold immense potential for biocatalysis, environmental remediation, and medical therapy, yet their development is hindered by inherent incompatibility, low ion concentration, and spatial distance barriers between metal ions and enzyme, limiting the maximization of metal ion catalytic potential. Here, we developed a convenient one-step doping strategy to achieve spatial separation of high concentration metal ions and enzymes within single metal-organic frameworks (MOFs). Catalytically active metal ions partially replace MOF sites through ligand coordination, while enzymes are in-situ encapsulated (enzyme@M-MOFs), maintaining structural integrity and enhancing stability. This design enables efficient chem-bio tandem reactions by preventing mutual inactivation and accelerating reaction rates due to distance shortening between metal ions and enzymes. The enzyme@M-MOFs exhibit good therapeutic effect in diabetic wound healing, establishing a new paradigm for catalytic medicine applications. The strategy's versatility is demonstrated by its successful application with a range of metal ions (Fe 2+ , Mg 2+ , Cd 2+ …) as catalysts or enzyme promoters. By transforming incompatible systems into compatible tandem platforms, this work offers a universal approach for efficient chemical-enzyme tandem catalysis, unlocking novel possibilities in biocatalysis and beyond.
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