JOURNAL OF NANOBIOTECHNOLOGY
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2023
·Vol. 21
·期 1
·1-15
·
IF 10.2
Ge Juan,Zuo Miaomiao,Wang Qirong,Li Zhen
Background Photodynamic therapy (PDT) features high biocompatibility and high spatiotemporal selectivity, showing a great potential in glioblastoma (GBM) treatment. However, its application was restricted by the poor therapeutic efficacy and side effect. Results In this study, a therapeutic nanoplatform (UCNPs@Ce6/3HBQ@CM) with combination of PDT and CO therapy was constructed, in which a photoCORM and a photosensitizer were loaded onto the surface of upconversion nanoparticles (UCNPs) functioning as photon transducer. Benefitting from NIR excitation and multicolor emission of UCNPs, the penetration depth of excitation light is enhanced and meanwhile simultaneous generation of CO and ROS in tumor site can be achieved. The as-prepared nanocomposite possessed an elevated therapeutic efficiency with the assistance of CO through influencing mitochondrial respiration and depleting ATP, accompanying with the reduced inflammatory responses. By wrapping a homologous cell membrane, the nanocomposite can target GBM and accumulate in the tumor site, affording a powerful tool for precise and efficient treatment of GBM. Conclusion This therapeutic nanoplatform UCNPs@Ce6/3HBQ@CM, which combines PDT and CO therapy enables precise and efficient treatment of refractory glioblastoma.
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ACS Applied Materials & Interfaces
·
2022
·
IF 10.383
Qiufan Sun,Yuxiang Zhu,Xiang Zhong,Meng Jiang,Yanchen Fan,Jianfeng Yao
In this work, MIL-68(In) functionalized with various ligand substitutions including amine, hydroxyl, bromine, nitro, and methyl groups was prepared, via a one-pot solvothermal reaction for visible-light photocatalytic ammonia synthesis. The diversity of ligands tunes the morphology, geometry, pore environment, and electronic structure of MIL-68(In)-based photocatalysts due to the polarity and intraframework interactions. Amine-inserted MIL-68(In) outperforms its counterparts, presenting a boosted nitrogen photofixation rate of 140.34 μmol gcat–1 h–1 with an apparent quantum efficiency of 5.69% at 420 nm. Further, the size of the batch solvothermal reactor and the amine group content also influence the photocatalytic activity. The combined experimental and theoretical results reveal that amine substituents improve the chemisorption of nitrogen molecules and the conversion of nitrogen into ammonia follows a dual pathway, i.e., a Mars–van Krevelen process and a ligand-to-metal charge transfer mechanism. This work provides a molecular engineering strategy via dual catalysis toward efficient ammonia production.
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Journal of Analysis and Testing
·
2023
·Vol. 7
·期 3
·204-214
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IF 4.7
Zhu Qiming,Li Peizhe,Huang Qiwen,Ding Xinpei,Wang Nan,Yao Weijun,Miao Maozhong,Zhang Zhijun
Building self-assembly nanostructures is an important way to overcome the limitations of paclitaxel in tumor therapy. However, this strategy is also faced with challenges, such as difficulties in efficient release and the potential for drug resistance. Herein, we developed a near-infrared light-activatable melanized paclitaxel self-assembly nanoparticles for synergistic anti-tumor therapy. In this strategy, paclitaxel dimer prodrugs were synthesized and paclitaxel nanoparticles were obtained through self-assembly. Finally, the paclitaxel dimer nanoparticles were capped with polydopamine (PDA, melanoidin) and human serum albumin (HSA). The disulfide bonds in paclitaxel dimeric prodrug specifically respond to high concentrations of glutathione (GSH) and reactive oxygen species (ROS) in tumor cells. PDA enhances the biocompatibility of the drug molecules and imparts near-infrared photothermal conversion capability to the nano–self-assemblies. Both the in vitro and in vivo experiments demonstrated that this paclitaxel nanoprodrug exhibited enhanced tumor therapeutic efficacy under near-infrared light irradiation.
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INTERNATIONAL JOURNAL OF HYDROGEN ENERGY
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2023
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IF 7.2
Hongwei Wang,Boxiao Zhao,Xiaoming Liu,Liushui Yan,Huiqin Guo,Wang Gong,Jun Lin
Here, a series of Mn x Cd 1-x S sosoloid composite photocatalysts with visible-light activity were first prepared by a solvothermal process. The element ratio of Cd 2+ to Mn 2+ was optimized to be Mn 0.3 Cd 0.7 S in Mn x Cd 1-x S sosoloid on account of its photocatalytic activity for H 2 evolution from H 2 O in response to visible light excitation . And on this basis, the CoO x nanopariticles were loaded on the surface of Mn 0.3 Cd 0.7 S sosoloid composite to obtain a binary p-n heterojunction of CoO x /Mn 0.3 Cd 0.7 S composite through a facile impregnation process and a high temperature sintering procedure. Benefitting from the synergistic effect of the built-in electric field, binary p-n heterojunction structure, and rearrange of the Fermi level equilibrium, the as-synthesized CoO x /Mn 0.3 Cd 0.7 S composite presents a highly enhanced photocatalytic activity for hydrogen production from H 2 O in response to visible light excitation, which is demonstrated to be 53.4 and 4.0 times higher than that of the primitive CdS and Mn 0.3 Cd 0.7 S, respectively. Furthermore, after 4 times circles of photocatalytic H 2 production tests, the CoO x /Mn 0.3 Cd 0.7 S composite still keeps 92.0 % of the original photocatalytic activity. Considering its reasonable photochemistry stability and excellent photocatalytic activity for hydrogen evolution from H 2 O under with visible light excitation, the as-synthesized CoO x /Mn 0.3 Cd 0.7 S composite has potential applications in solar hydrogen production areas.
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Inorganic Chemistry Frontiers
·
2023
·
IF 7
Yi Zhang,Shao Yan,Fang Xiao,Xihui Shan,Xulong Lv,Weili Wang,Yanjie Liang
With the occurrence of global health events such as COVID-19, the development of high-performance ultraviolet-C (UVC) light sources for efficient and convenient sterilization applications holds promising scientific and engineering prospects. However, discovering reliable and stable luminescent materials capable of converting incident excitation energy to UVC radiation remains a challenge. Herein, we report a new Sr2P2O7:Pr3+ phosphor that exhibits exceptional capabilities in X-ray energy absorption, storage, UVC-light conversion, and persistent UVC light emission. Specifically, minutes of X-ray excitation can result in more than 24 h of continuous UVC persistent luminescence when monitored at 222 nm emission, realizing far-UVC afterglow for the first time. Intense UVC persistent light emission could be detected by a UVC corona camera in bright indoor and outdoor environments without interference from artificial light or natural sunlight, in consideration of the avoidance of the spectral overlap with ambient light. The self-sustained UVC persistent luminescence form was demonstrated as an optical-conversion strategy for sterilization application, whereby the charged Sr2P2O7:Pr3+ persistent phosphor could effectively inactivate infectious methicillin-resistant Staphylococcus aureus (MRSA) within 30 min in an excitation-free manner, offering new insights into developing UVC light sources for sterilization applications. This work expands the field of UV persistent luminescence research to the far-UVC spectral region and is expected to bring new and power-free solutions to some important applications where far-UVC light is needed, such as sterilization and photodynamic therapy.
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Solar RRL
·
2023
·Vol. 7
·期 20
·2300369
·
IF 7.9
Haoyu Wang,Shuanghong Wu,Haolin Zhang,Xianghua Yao,Furong Wang,Peng Huang,Xiaodong Liu
The light-soaking (LS) effect has been reported to limit the accuracy and stability of device power output of perovskite solar cells (PSCs) and it is significant to develop effective approaches and strategies to eliminate the LS effect in PSCs. There are very few reports on suppressing the LS effect in CsPbI 2 Br-based all-inorganic PSCs. Herein, a method to eliminate the LS effect by synchronous passivation of anionic and cationic defects in CsPbI 2 Br perovskite film is demonstrated. The 4-(chlorosulfonyl)benzoic acid (CSBA) is added into perovskite precursor and the in situ generation of I 3 − effectively passivates the anionic halogen vacancy defects in CsPbI 2 Br. In the meantime, the Lewis base groups on CSBA coordinate with Cs + and Pb 2+ to passivate the cationic defects. This zwitterionic passivation effect of CSBA remarkably cuts off the path of defect-induced charge recombination and thus eliminates the LS effect. This work offers a deep opinion for future researchers to modulate the LS effect of all-inorganic PSCs.
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International Journal of Nanomedicine
·
2023
·
IF 8
Jianlin Wang,Zhaoyang Wen,Yumei Xu,Xin Ning,Deping Wang,Jimin Cao,Yanlin Feng
Background Wound healing is a continuous and complex process that comprises multiple phases including hemostasis, inflammation, multiplication (proliferation) and remodeling. Although a variety of nanomaterials have been developed to control infection and accelerate wound healing, most of them can only promote one phase but not multiple phases, resulting in lower efficient healing. Although various formulations such as nitric oxide releasing wound dressings were developed for dual action, the nanostructure synthesis and the encapsulation process were complex.Materials and Methods Here, we report on the design of graphene-barium titanate nanosystem to procedural promote the wound healing process. The antibacterial effect was assessed in Gram-negative Escherichia coli bacteria (E. coli) and Gram-positive Staphylococcus aureus bacteria (S. aureus), the cell proliferation and migration experiment was investigated in mouse embryonic fibroblast (NIH-3T3) cells, and the wound healing effect was analyzed in female BALB/c mice with infected skin wound on the back.Results Results showed that graphene-barium titanate nanosystem could generate abundant ROS to kill both E. coli and S. aureus. The growth curves, bacterial viability, colony number formation and scanning electron microscopy (SEM) images of E. coli and S. aureus all confirmed the antibacterial effect. Cell Counting Kit-8 (CCK-8) assay displayed that GBT possesses great biocompatibility. EdU assay showed that GBT plus white light irradiation significantly promoted the proliferation and migration of NIH-3T3 cells. Scratch assay found that GBT could achieve a fast scratch closure compared to the control. In vivo wound healing effect indicates that GBT can accelerate wound repair procedure.Conclusion GBT nanocomposite is capable of programmatically accelerating wound healing through multiple stages, including production of a large amount of ROS after white light exposure to effectively kill E. coli and S. aureus to prevent wound infection and as a scaffold to accelerate fibroblast proliferation and migration to the wound to accelerate wound healing.
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CHEMICAL ENGINEERING JOURNAL
·
2023
·
IF 15.1
Huibo Wang,Sidi Liu,Zhibin Xu,Xiaoyu Weng,Changrui Liao,Jun He,Liwei Liu,Yiping Wang,Junle Qu,Hao Li,Jun Song,Jiaqing Guo
Harmful algal blooms (HABs) pose a significant threat to aquatic ecosystems. Conventional anti-algal methods are associated with low anti-algal efficiency, and absence of treatment of toxins released by algae. Therefore, it is essential to establish effective HAB prevention strategies. Artificial nanozymes have a great potential in combating HABs due to their unique catalytic properties. An ultra-small carbon dots nanozyme (VCN) with oxidase-like activity was synthesized in this study. VCN exerts its catalytic effect by catalyzing the production of reactive oxygen species (ROS) from oxygen. VCN was utilized to inactivate hazardous marine algae based on its catalytic properties. It was found that VCN could rapidly remove more than 90% of harmful algae ( Skeletonema costatum and Phaeocystis globosa ) in just 4 h under environmental visible light. To the best of our knowledge, the algae removal efficacy is greater than that of previous reports. Additionally, VCN could attenuate the toxicity of toxins released by algae to counteract secondary pollution caused by algal fragmentation, which is important for practical applications in water pollution caused by algae. Collectively, under applicable and mild conditions, the VCN-presented enzyme activity can efficiently reduce HABs caused harmful pollution.
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FOOD CHEMISTRY
·
2023
·
IF 8.8
Ziyang He,Jinxin Zhang,Mei Liu,Yonghong Meng
An efficient aptasensor was developed for the colorimetric determination of zearalenone (ZEN) based on polyvalent aptamer scaffold and light-responsive oxidase-like nanozyme. The sensitivity and efficiency of the development method were significantly improved owing to rich aptamers and signal labels (3, 4-dihydroxybenzoic acid, PCA) packed in the scaffold. The scaffold integrated functions of target recognition, surface immobilization and signal transduction. The photoresponsive nanoenzyme of TiO 2 -PCA was formed by PCA coordinated with Ti (IV) on the surface of TiO 2 . TiO 2 -PCA catalyzed dissolved oxygen rather than H 2 O 2 to generate colorimetric signal by stimulating the chromogenic substrate, which made the assay greener and safer. The detection limit of colorimetric mode was 0.0087 ng/mL and the satisfactory recoveries 92.00 %−111.00 % were achieved in spiked food samples. This strategy opens new horizons for sensitive detection of small molecule hazards and promises to be a powerful tool for safeguarding food safety.
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SEPARATION AND PURIFICATION TECHNOLOGY
·
2023
·
IF 8.6
Yanan Li,Haiyu Luo,Wenlan Ji,Shuming Li,Pei Nian,Nan Xu,Nong Ye,Yibin Wei
Two-dimensional (2D) Ti 3 C 2 T x MXene nanosheets have been identified as promising for constructing ultrathin laminar nanostructures with nanoscale water transport channels for water purification. Herein, ZnO@Ti 3 C 2 T x MXene nanofiltration (NF) membranes were prepared via coupling ZnO nanoflowers to the Ti 3 C 2 T x MXene-based laminar nanostructure, which exhibited photocatalytic self-cleaning properties driven by visible light for enhanced organic dye removal. The physicochemical properties and NF performance with and without photocatalytic treatment were systematically characterized. The prepared ZnO@Ti 3 C 2 T x MXene NF membrane could reject 95.44% Congo red (CR) and demonstrated an excellent water permeability of 138.81 L·m −2 ·h −1 ·bar −1 (LMH/bar). In comparison to the Ti 3 C 2 T x MXene membrane and the same amount of ZnO powders, the ZnO@Ti 3 C 2 T x MXene membrane demonstrated higher photodegradation performance to 10 ppm MB. Impressively, the membrane showed an enhanced separation performance for 6 cycles with a RhB rejection > 88.48% and a permeability of 138.69 LMH/bar. Lastly, the synergistic photocatalytic mechanism of ZnO@Ti 3 C 2 T x MXene composite nanostructure was investigated. Such results may offer a novel insight for the fabrication of laminar structured Ti 3 C 2 T x MXene-based NF membranes with photocatalytic induced anti-fouling performance for enhanced dye water purification.
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CERAMICS INTERNATIONAL
·
2023
·
IF 5.2
Minhao Shen,Renli Fu,Yunan Liu,Yunjia Hu,Yanlin Jiang,Zhe Zhao,Ming Liu
Inspired by the double-helix structure of biological DNA, low-volume fraction and high-strength Al 2 O 3 twisted honeycomb structures with characteristics similar to those of helical structures in the z -axis were prepared by digital light processing 3D printing technology. As the twist angle increased, the compressive strength of the fabricated Al 2 O 3 structure decreased, and the deformation mechanism of the Al 2 O 3 structures gradually changed from stretching-dominated to bending-dominated, which can be predicted by the Gibson–Ashby model. The relationship between the effective elastic modulus and the volume fraction that can be modified by varying the wall thickness was described by the Pabst–Gregorova exponential relationship. The compressive strength of the Al 2 O 3 structure with a twist angle of 0° can reach 62.4 MPa at a volume fraction of 13.3%, providing guidance to optimize lightweight structures of ceramics.
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Nanomaterials
·
2023
·Vol. 13
·期 14
·2033
·
IF 5.3
Hua Yang,Jialin Zhang,Zhuoran Li,Jinrong Huang,Jun Wu,Yixuan Zhang,Honghua Ge,Yuzeng Zhao
The effect of ZnO nanoparticles (ZnO NPs), with different concentrations in simulated water, on the activity of sulfate-reducing bacteria (SRB) and their adhesion behaviour on stainless-steel surfaces, with and without visible light treatment, were investigated. The results showed that the concentration of ZnO NPs and light treatment greatly influenced the antibacterial performance of the NPs. In the water solution without light treatment, the low concentration (no more than 1 mg/L) of ZnO NPs in the aqueous solution promoted the growth of SRB, and the amount of biofilm attached to the stainless-steel surface increased. As the concentration increased, ZnO NPs exhibited antibacterial effects. In water under visible light irradiation, ZnO NPs showed antibacterial performance at all the concentrations studied (0.5~50 mg/L), and the antibacterial efficiency increased with the increase in the concentration of NPs. The determination results of the reactive oxygen species showed that light treatment can stimulate ZnO NPs in water to generate ·OH and O2·−, which exhibited good antibacterial properties. The adhesion amount of SRB on the stainless-steel surface was inversely proportional to the antibacterial efficiency of ZnO NPs.Keywords:ZnO nanoparticles;sulfate-reducing bacteria;antibacterial activity;biofilm
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